iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-32	110.9	118	155
UBD/Beta-Prp	5.40e-58	196.9	119	336

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 118  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 155
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s ++cv+f + ++ ++tgs+d  +k+w +++g ll++l gh ae++++  + +  +++ gs D++i+vw l+t+ ++ +l+gh++s+
   Q: 119  HLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASI 207
           5567889************************************************99******************************** PP
   S: 98   lslsfsp....sgdklvsGshdrtirvwdletgqclee......tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl..lr 173
           +sl+fsp    s+ +l s+++d ti  w ++ g+   +      t++++ gv ++ ++ + g   l++Gs+D ++r++   +g+   + 
   Q: 208  TSLQFSPlcsgSKRYLSSTGADGTICFWLWDAGTLKINprptkfTERPRPGVQMICSSFSAGgMFLATGSTDHIIRVYFFGSGQPekIS 296
           *********877799************8888888887788************9988877777799*************99666651166 PP
   S: 174  tltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec 214
           +l+  htd+v s++f+ +++++vsgs+dgt ++w++++ e 
   Q: 297  ELEF-HTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREW 336
           7788.*******************************97654 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

VKYYRHLAPD HLLQICHRLG PLLEQEIPQS VPGVQTLLGA GRQSLLRTNK SCKHVVWKGS 60
ALAALHCGRP PESPVNYGSP PNIADTLFSR KLNGKYRLER LVPTAVYQHM KMHKRILGHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGTATT ATAGACACCT TGCACCTGAT CACTTGCTGC AAATCTGTCA TCGACTAGGA 60
CCTCTTCTTG AGCAAGAAAT TCCTCAGAGT GTTCCTGGAG TACAAACTTT ATTAGGAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002299	Ailuropoda melanoleuca	93.06	0.00e+00	3067.00
IUUC-Apl-003700	Anas platyrhynchos	84.46	0.00e+00	2815.00
IUUC-Aca-004474	Anolis carolinensis	80.93	0.00e+00	2674.00
IUUC-Bta-013125	Bos taurus	92.95	0.00e+00	3035.00
IUUC-Cja-018868	Callithrix jacchus	91.30	0.00e+00	3105.00
IUUC-Cfa-021179	Canis familiaris	93.41	0.00e+00	3001.00
IUUC-Cpo-022077	Cavia porcellus	89.02	0.00e+00	3001.00
IUUC-Csa-023618	Chlorocebus sabaeus	93.52	0.00e+00	3123.00
IUUC-Cho-024794	Choloepus hoffmanni	84.30	0.00e+00	807.00
IUUC-Dre-028029	Danio rerio	78.98	0.00e+00	1217.00
IUUC-Dno-030048	Dasypus novemcinctus	93.02	0.00e+00	3041.00
IUUC-Dor-030195	Dipodomys ordii	87.52	0.00e+00	1418.00
IUUC-Ete-032748	Echinops telfairi	80.42	0.00e+00	1113.00
IUUC-Eca-034274	Equus caballus	93.86	0.00e+00	3085.00
IUUC-Eeu-034688	Erinaceus europaeus	83.18	0.00e+00	1383.00
IUUC-Fca-035451	Felis catus	92.42	0.00e+00	2964.00
IUUC-Fal-037465	Ficedula albicollis	84.11	0.00e+00	2767.00
IUUC-Gmo-039451	Gadus morhua	68.77	0.00e+00	723.00
IUUC-Gga-040798	Gallus gallus	84.23	0.00e+00	2803.00
IUUC-Ggo-045347	Gorilla gorilla	91.60	0.00e+00	3101.00
IUUC-Hsa-046757	Homo sapiens	93.41	0.00e+00	3096.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	90.50	0.00e+00	1144.00
IUUC-Lch-050646	Latimeria chalumnae	76.82	0.00e+00	2578.00
IUUC-Loc-052672	Lepisosteus oculatus	69.69	0.00e+00	2296.00
IUUC-Laf-054140	Loxodonta africana	93.30	0.00e+00	3132.00
IUUC-Mcc-055061	Macaca mulatta	93.58	0.00e+00	3122.00
IUUC-Mmr-060837	Microcebus murinus	93.64	0.00e+00	3095.00
IUUC-Mdo-061903	Monodelphis domestica	88.89	0.00e+00	2974.00
IUUC-Mmu-063772	Mus musculus	96.76	0.00e+00	3210.00
IUUC-Mpu-066359	Mustela putorius furo	92.97	0.00e+00	2858.00
IUUC-Mlu-067928	Myotis lucifugus	91.88	0.00e+00	3058.00
IUUC-Nle-070094	Nomascus leucogenys	93.52	0.00e+00	3100.00
IUUC-Opr-070971	Ochotona princeps	70.16	0.00e+00	891.00
IUUC-Ont-072221	Oreochromis niloticus	74.08	0.00e+00	1196.00
IUUC-Oan-073185	Ornithorhynchus anatinus	86.14	0.00e+00	2815.00
IUUC-Ocu-074033	Oryctolagus cuniculus	91.71	0.00e+00	2792.00
IUUC-Oga-088578	Otolemur garnettii	93.52	0.00e+00	3086.00
IUUC-Oar-090247	Ovis aries	93.06	0.00e+00	3033.00
IUUC-Ptr-091266	Pan troglodytes	93.12	0.00e+00	3073.00
IUUC-Pan-092734	Papio anubis	93.46	0.00e+00	3118.00
IUUC-Pfo-096191	Poecilia formosa	71.80	0.00e+00	1961.00
IUUC-Pab-098402	Pongo abelii	93.35	0.00e+00	3095.00
IUUC-Pca-101128	Procavia capensis	84.04	0.00e+00	2780.00
IUUC-Pva-103058	Pteropus vampyrus	91.94	0.00e+00	1536.00
IUUC-Sha-107496	Sarcophilus harrisii	89.13	0.00e+00	2990.00
IUUC-Sar-113520	Sorex araneus	88.54	0.00e+00	1493.00
IUUC-Ssc-115461	Sus scrofa	89.72	0.00e+00	2938.00
IUUC-Tgu-116821	Taeniopygia guttata	83.95	0.00e+00	2765.00
IUUC-Tsy-119132	Tarsius syrichta	81.34	0.00e+00	2490.00
IUUC-Tbe-127479	Tupaia belangeri	89.80	0.00e+00	1422.00
IUUC-Ttr-128427	Tursiops truncatus	89.20	0.00e+00	2904.00
IUUC-Vpa-130160	Vicugna pacos	89.66	0.00e+00	2934.00
IUUC-Xtr-132717	Xenopus tropicalis	77.26	0.00e+00	2335.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence