iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-14	54.9	70	125

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea + d+Lt++kG++ +++  ++++ +W+++ +  +g rG +P+n+v+ ++
   Q: 70   FVALYDYEARTGDDLTFTKGEKFHIL--NNTEYDWWEARSLSSGHRGYVPSNYVAPVD 125
           789***********************..889999********************9987 PP

Organism

Mus musculus

Functional Description
(View)

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes (PubMed:11672534). Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages (PubMed:8666673 and PubMed:9687507). Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation (PubMed:15561106). Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling (PubMed:21746961). Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

Protein Sequence
(Fasta)

MGCVFCKKLE PASKEDVGLE GDFRSQTAEE RYFPDPTQGR TSSVFPQPTS PAFLNTGNMR 60
SISGTGVTIF VALYDYEART GDDLTFTKGE KFHILNNTEY DWWEARSLSS GHRGYVPSNY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCACCAAA ATAAGAGAAG TCCGAGACGG CTTCCTCCTC CCTCCCCAGA GTAGGTAGTA 60
GGGGCAGAGG CGGGTAGCAC CTCACTTTAC CCCCCACATC GCCTCTCCTG GTTGCTGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0391--Immunity
KW-0399--Innate immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0016235--C:aggresome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005743--C:mitochondrial inner membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005886--C:plasma membrane
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0034988--F:Fc-gamma receptor I complex binding
GO:0034987--F:immunoglobulin receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0001784--F:phosphotyrosine binding
GO:0019901--F:protein kinase binding
GO:0004713--F:protein tyrosine kinase activity
GO:0030154--P:cell differentiation
GO:0050830--P:defense response to Gram-positive bacterium
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0046777--P:protein autophosphorylation
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mmu:14191

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001938	Ailuropoda melanoleuca	86.50	0.00e+00	956.00
IUUC-Bta-012607	Bos taurus	86.53	0.00e+00	955.00
IUUC-Cja-018914	Callithrix jacchus	82.75	0.00e+00	916.00
IUUC-Cfa-020165	Canis familiaris	84.63	0.00e+00	937.00
IUUC-Cpo-021476	Cavia porcellus	85.20	0.00e+00	920.00
IUUC-Csa-023692	Chlorocebus sabaeus	84.12	0.00e+00	935.00
IUUC-Dno-028920	Dasypus novemcinctus	83.87	0.00e+00	927.00
IUUC-Eca-033581	Equus caballus	85.96	0.00e+00	954.00
IUUC-Fca-036499	Felis catus	85.20	0.00e+00	943.00
IUUC-Ggo-044640	Gorilla gorilla	84.31	0.00e+00	933.00
IUUC-Hsa-046751	Homo sapiens	84.12	0.00e+00	930.00
IUUC-Itr-048218	Ictidomys tridecemlineatus	88.78	0.00e+00	972.00
IUUC-Laf-054128	Loxodonta africana	83.68	0.00e+00	936.00
IUUC-Mcc-054715	Macaca mulatta	83.93	0.00e+00	931.00
IUUC-Meu-056155	Macropus eugenii	79.91	0.00e+00	763.00
IUUC-Mmr-060615	Microcebus murinus	85.31	0.00e+00	947.00
IUUC-Mpu-066641	Mustela putorius furo	86.69	0.00e+00	958.00
IUUC-Oan-073486	Ornithorhynchus anatinus	74.53	0.00e+00	828.00
IUUC-Ocu-074552	Oryctolagus cuniculus	85.55	0.00e+00	931.00
IUUC-Oga-088731	Otolemur garnettii	86.34	0.00e+00	958.00
IUUC-Oar-090207	Ovis aries	87.55	0.00e+00	957.00
IUUC-Ptr-090979	Pan troglodytes	84.31	0.00e+00	932.00
IUUC-Pan-092188	Papio anubis	84.31	0.00e+00	934.00
IUUC-Pab-098617	Pongo abelii	84.12	0.00e+00	931.00
IUUC-Pca-100834	Procavia capensis	75.90	0.00e+00	800.00
IUUC-Rno-104945	Rattus norvegicus	94.58	0.00e+00	1013.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence