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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046315
UUCD1 version UUC-HoS-00188
Ensembl Protein ID ENSP00000284637.9
UniProt Accession Q7Z6J0; Q05BT2; Q8IW46; Q9HAM2; Q9P234; SH3R1_HUMAN
Genbank Protein ID AAH33203.1; AAH41023.1; AAH53671.1; BAB13822.1; BAA96018.1
Protein Name E3 ubiquitin-protein ligase SH3RF1; Plenty of SH3s; RING finger protein 142; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains protein 2
Genbank Nucleotide ID BC033203; BC041023; BC053671; AK021429; AB040927
Gene Name SH3RF1; KIAA1494; POSH; RNF142; SH3MD2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000154447.14 ENST00000284637.13 ENSP00000284637.9
ENSG00000154447.14 ENST00000511421.5 ENSP00000426418.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19393081; 16084064; 17420289
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.80e-07 33.2 12 53
UBD/SH3 1.50e-47 161.0 449 504
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle+++   +vlpC+H+f++ Cl  +      s++e rCP Cr
   Q: 12   CPVCLERLDASAKVLPCQHTFCKRCLLGI----VGSRNELRCPECR 53
           **********9**************9777....899*********8 PP
   

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +  ++y+y++ ++deL+l+kG++ lv  + +   gW kg++  + k G+fP n+v+ +
   Q: 449  VYVAIYPYTPRKEDELELRKGEMFLVF-ERC-QDGWFKGTSMHTSKIGVFPGNYVAPV 504
           5679**********************9.555.569********************988 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with Rac; in a GTP-dependent manner (By similarity). Interacts with MAP3K10 and MAP3K11. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Interacts with HERP1. Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4, MAP2K7, MAPK8, MAPK9, AKT1 and AKT2.
 Interacts with Rac; in a GTP-dependent manner (By similarity). Interacts with MAP3K10 and MAP3K11. Interacts with MAPK8IP; this interaction leads to the PJAC complex (POSH-JIP or SH3RF1/MAPK8IP apoptotic complex) with a 1:1 ratio. Interacts with SIAH1. Interacts with HERP1. Probably part of a signaling complex that may contain SH3RF1, MAPK8IP, DLK1, MAP2K4, MAP2K7, MAPK8, MAPK9, AKT1 and AKT2.
Protein Sequence
(Fasta)
MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP ECRTLVGSGV 60
EELPSNILLV RLLDGIKQRP WKPGPGGGSG TNCTNALRSQ SSTVANCSSK DLQSSQGGQQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046315|E3,RING;UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCCCGGGC GCCGGCTGCG TCCCGGCCTC CTCCTCCTCT TCCTCCGCCC TCCTTGGCTG 60
GGAAAGTGGG AGGCGGCGGC GGCGGCGTGG TGTGTGTGCG CGCGTGAGGG GGGCAGCAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046315|E3,RING;UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001452--SH3_domain
IPR028502--SH3RF1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00018--SH3_1
PF14604--SH3_9
PF00097--zf-C3HC4
PRINTS

PR00452--SH3DOMAIN
SMART

SM00184--RING
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0030027--C:lamellipodium
GO:0048471--C:perinuclear region of cytoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0016567--P:protein ubiquitination
GO:0046328--P:regulation of JNK cascade
KEGG hsa:57630
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001528 Ailuropoda melanoleuca 89.79 0.00e+00 1345.00
IUUC-Apl-003961 Anas platyrhynchos 80.29 0.00e+00 1168.00
IUUC-Aca-004386 Anolis carolinensis 76.21 0.00e+00 1169.00
IUUC-Bta-012563 Bos taurus 71.33 0.00e+00 795.00
IUUC-Cja-019730 Callithrix jacchus 94.49 0.00e+00 1346.00
IUUC-Cfa-020992 Canis familiaris 90.68 0.00e+00 1382.00
IUUC-Cpo-021304 Cavia porcellus 92.46 0.00e+00 1431.00
IUUC-Csa-023925 Chlorocebus sabaeus 98.54 0.00e+00 1413.00
IUUC-Cho-024630 Choloepus hoffmanni 84.21 0.00e+00 857.00
IUUC-Cin-025274 Ciona intestinalis 48.71 6.00e-71 260.00
IUUC-Dre-028290 Danio rerio 61.02 0.00e+00 880.00
IUUC-Dno-029083 Dasypus novemcinctus 87.85 0.00e+00 1269.00
IUUC-Dor-030388 Dipodomys ordii 94.66 0.00e+00 676.00
IUUC-Ete-032809 Echinops telfairi 79.05 0.00e+00 823.00
IUUC-Eca-034185 Equus caballus 91.96 0.00e+00 1118.00
IUUC-Eeu-034816 Erinaceus europaeus 77.94 0.00e+00 1131.00
IUUC-Fca-036439 Felis catus 89.91 0.00e+00 1397.00
IUUC-Fal-037074 Ficedula albicollis 78.94 0.00e+00 1168.00
IUUC-Gmo-039443 Gadus morhua 60.21 5.00e-118 419.00
IUUC-Gga-040749 Gallus gallus 78.49 0.00e+00 1115.00
IUUC-Gac-041420 Gasterosteus aculeatus 73.57 1.00e-147 516.00
IUUC-Ggo-045215 Gorilla gorilla 98.54 0.00e+00 1482.00
IUUC-Itr-048265 Ictidomys tridecemlineatus 91.02 3.00e-158 551.00
IUUC-Lch-049453 Latimeria chalumnae 69.33 0.00e+00 865.00
IUUC-Laf-053651 Loxodonta africana 89.89 0.00e+00 1319.00
IUUC-Mcc-054688 Macaca mulatta 97.75 0.00e+00 1447.00
IUUC-Meu-056291 Macropus eugenii 74.67 0.00e+00 781.00
IUUC-Mga-059944 Meleagris gallopavo 77.59 0.00e+00 1139.00
IUUC-Mmr-061553 Microcebus murinus 91.44 0.00e+00 1270.00
IUUC-Mdo-062313 Monodelphis domestica 77.65 0.00e+00 1176.00
IUUC-Mmu-063516 Mus musculus 89.93 0.00e+00 1380.00
IUUC-Mpu-066064 Mustela putorius furo 90.65 0.00e+00 1360.00
IUUC-Mlu-067312 Myotis lucifugus 88.96 0.00e+00 1274.00
IUUC-Nle-069035 Nomascus leucogenys 98.09 0.00e+00 1476.00
IUUC-Opr-070690 Ochotona princeps 86.92 0.00e+00 676.00
IUUC-Ont-071484 Oreochromis niloticus 57.86 0.00e+00 854.00
IUUC-Oan-073305 Ornithorhynchus anatinus 82.00 0.00e+00 1209.00
IUUC-Ocu-074936 Oryctolagus cuniculus 90.74 0.00e+00 1369.00
IUUC-Ola-086675 Oryzias latipes 60.00 3.00e-172 598.00
IUUC-Oga-087933 Otolemur garnettii 81.89 0.00e+00 1001.00
IUUC-Oar-090408 Ovis aries 69.51 0.00e+00 742.00
IUUC-Ptr-090865 Pan troglodytes 99.55 0.00e+00 1489.00
IUUC-Pan-092362 Papio anubis 98.65 0.00e+00 1412.00
IUUC-Psi-093876 Pelodiscus sinensis 79.08 0.00e+00 1182.00
IUUC-Pfo-097116 Poecilia formosa 59.51 0.00e+00 841.00
IUUC-Pab-098127 Pongo abelii 99.21 0.00e+00 1483.00
IUUC-Pca-100485 Procavia capensis 88.91 0.00e+00 993.00
IUUC-Pva-102661 Pteropus vampyrus 89.08 0.00e+00 1290.00
IUUC-Rno-105728 Rattus norvegicus 88.96 0.00e+00 1375.00
IUUC-Sha-106515 Sarcophilus harrisii 85.83 0.00e+00 860.00
IUUC-Sar-113161 Sorex araneus 95.79 0.00e+00 669.00
IUUC-Ssc-115314 Sus scrofa 77.14 0.00e+00 1087.00
IUUC-Tgu-117012 Taeniopygia guttata 79.50 0.00e+00 1154.00
IUUC-Tru-118467 Takifugu rubripes 61.31 3.00e-159 556.00
IUUC-Tsy-119566 Tarsius syrichta 83.76 2.00e-175 609.00
IUUC-Tni-120830 Tetraodon nigroviridis 58.77 5.00e-162 565.00
IUUC-Tbe-128070 Tupaia belangeri 88.00 0.00e+00 908.00
IUUC-Ttr-128161 Tursiops truncatus 94.12 1.00e-142 500.00
IUUC-Xtr-132628 Xenopus tropicalis 72.09 0.00e+00 1065.00
Created Date 25-Jun-2017

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