iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108360

Ensembl Protein ID

SPAPB1E7.02c.1:pep

UniProt Accession

Q9C107; MCL1_SCHPO

Genbank Protein ID

CAC36919.1

Protein Name

Minichromosome loss protein 1; DNA polymerase alpha accessory factor Mcl1

Genbank Nucleotide ID

CU329670

Gene Name

mcl1; slr3; SPAPB1E7.02c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAPB1E7.02c	SPAPB1E7.02c.1	SPAPB1E7.02c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.10e-11	39.9	54	81

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWD 29
           H+d++t++a  +++++++s D t+ v+ 
   Q: 54   HQDPITGIAVAENYFCTCSEDATVCVYP 81
           9********9448************996 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Has a role in regulating DNA replication complexes. Acts as a regulator of post DNA replication initiation. Associates with chromatin during G1 and S phases of mitosis. Required for the transcriptional repression of the outer repeats of the centromeric region. Acts as a polymerase alpha replication accessory factor and is important for S-phase DNA damage survival. Plays a role in lagging-strand synthesis and Ozaki fragment processing, in addition to DNA repair.

Protein Sequence
(Fasta)

MAGNRLVPRY AHTDGLTRLA YTRDGKFLLT VGSNQVIRKF QVGSDEEPDS IDNHQDPITG 60
IAVAENYFCT CSEDATVCVY PIDSPTEHTL LARTTLPIRD VAYSVDGNWI AIASDETAVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATCTCATA TACAAACTCT TCCTCTAGCT ATTATGGCAG GGAATAGGCT AGTTCCTAGA 60
TATGCCCATA CAGATGGACT GACGCGTCTA GCGTATACTC GTGATGGGAA ATTTCTTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR022100--Mcl1_mid
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF12341--Mcl1_mid

SMART

SM00320--WD40

Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0000790--C:nuclear chromatin
GO:0000228--C:nuclear chromosome
GO:0043596--C:nuclear replication fork
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0006974--P:cellular response to DNA damage stimulus
GO:0061641--P:CENP-A containing chromatin organization
GO:0030702--P:chromatin silencing at centromere
GO:0006281--P:DNA repair
GO:1903461--P:Okazaki fragment processing involved in mitotic DNA replication
GO:0006351--P:transcription, DNA-templated

KEGG

spo:SPAPB1E7.02c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000357	Aegilops tauschii	25.80	3.00e-51	194.00
IUUC-Aml-001369	Ailuropoda melanoleuca	25.50	2.00e-55	209.00
IUUC-Atr-002987	Amborella trichopoda	26.58	6.00e-54	204.00
IUUC-Apl-003331	Anas platyrhynchos	24.85	4.00e-55	208.00
IUUC-Aca-004285	Anolis carolinensis	25.86	5.00e-52	197.00
IUUC-Aly-005907	Arabidopsis lyrata	26.36	2.00e-49	189.00
IUUC-Ath-007037	Arabidopsis thaliana	26.73	2.00e-48	186.00
IUUC-Acl-008185	Aspergillus clavatus	36.89	1.00e-156	545.00
IUUC-Afl-008630	Aspergillus flavus	37.80	2.00e-163	567.00
IUUC-Afu-008921	Aspergillus fumigatus	38.90	3.00e-165	573.00
IUUC-Ani-009243	Aspergillus nidulans	37.77	1.00e-150	525.00
IUUC-Ang-009860	Aspergillus niger	38.79	2.00e-151	527.00
IUUC-Aor-010029	Aspergillus oryzae	37.80	2.00e-163	567.00
IUUC-Ate-010570	Aspergillus terreus	37.78	6.00e-166	575.00
IUUC-Bgr-012205	Blumeria graminis	36.20	3.00e-156	543.00
IUUC-Bta-012495	Bos taurus	26.02	9.00e-56	210.00
IUUC-Bci-013848	Botrytis cinerea	32.72	6.00e-127	446.00
IUUC-Bdi-014162	Brachypodium distachyon	25.14	3.00e-55	208.00
IUUC-Bol-015828	Brassica oleracea	27.08	8.00e-27	114.00
IUUC-Bra-016792	Brassica rapa	25.10	1.00e-44	173.00
IUUC-Cja-018995	Callithrix jacchus	25.94	8.00e-52	197.00
IUUC-Cfa-020713	Canis familiaris	25.18	2.00e-44	172.00
IUUC-Cpo-021596	Cavia porcellus	24.64	1.00e-39	156.00
IUUC-Cre-022785	Chlamydomonas reinhardtii	26.89	2.00e-12	66.60
IUUC-Csa-024080	Chlorocebus sabaeus	25.83	4.00e-50	191.00
IUUC-Cho-024295	Choloepus hoffmanni	22.45	7.00e-16	77.80
IUUC-Cin-025123	Ciona intestinalis	23.44	7.00e-20	90.90
IUUC-Csv-025859	Ciona savignyi	26.11	9.00e-18	84.00
IUUC-Cgl-026546	Colletotrichum gloeosporioides	38.90	6.00e-155	539.00
IUUC-Cne-026873	Cryptococcus neoformans	32.75	2.00e-62	232.00
IUUC-Dre-028752	Danio rerio	26.33	2.00e-25	109.00
IUUC-Dno-029844	Dasypus novemcinctus	26.79	4.00e-55	208.00
IUUC-Dse-031515	Dothistroma septosporum	35.23	2.00e-154	537.00
IUUC-Dme-031614	Drosophila melanogaster	24.75	2.00e-17	82.80
IUUC-Ete-032291	Echinops telfairi	26.25	2.00e-18	86.70
IUUC-Eca-033665	Equus caballus	25.87	1.00e-54	206.00
IUUC-Eeu-035036	Erinaceus europaeus	25.68	1.00e-09	57.40
IUUC-Fca-036209	Felis catus	25.50	1.00e-52	199.00
IUUC-Fal-037229	Ficedula albicollis	24.16	1.00e-50	193.00
IUUC-Fox-037686	Fusarium oxysporum	39.53	2.00e-63	233.00
IUUC-Fso-038120	Fusarium solani	37.11	4.00e-167	579.00
IUUC-Gmo-039627	Gadus morhua	24.29	5.00e-30	124.00
IUUC-Ggr-040058	Gaeumannomyces graminis	40.47	2.00e-155	540.00
IUUC-Gga-040825	Gallus gallus	24.45	4.00e-48	185.00
IUUC-Gac-042000	Gasterosteus aculeatus	26.03	7.00e-23	101.00
IUUC-Gma-042961	Glycine max	26.32	2.00e-58	219.00
IUUC-Ggo-044531	Gorilla gorilla	25.95	2.00e-55	209.00
IUUC-Hsa-046362	Homo sapiens	25.95	9.00e-56	210.00
IUUC-Hvu-047719	Hordeum vulgare	26.04	4.00e-52	197.00
IUUC-Itr-048089	Ictidomys tridecemlineatus	24.40	2.00e-28	118.00
IUUC-Lch-050106	Latimeria chalumnae	27.54	2.00e-29	122.00
IUUC-Lpe-050996	Leersia perrieri	25.39	4.00e-52	197.00
IUUC-Loc-051766	Lepisosteus oculatus	28.21	6.00e-27	114.00
IUUC-Lma-053144	Leptosphaeria maculans	37.15	6.00e-133	466.00
IUUC-Laf-054285	Loxodonta africana	25.89	4.00e-53	201.00
IUUC-Mcc-054702	Macaca mulatta	26.22	5.00e-56	211.00
IUUC-Meu-056634	Macropus eugenii	26.60	3.00e-07	49.30
IUUC-Mor-057040	Magnaporthe oryzae	37.88	5.00e-166	576.00
IUUC-Mpo-057395	Magnaporthe poae	37.16	2.00e-155	540.00
IUUC-Mtr-057830	Medicago truncatula	26.40	3.00e-64	238.00
IUUC-Mla-059152	Melampsora laricipopulina	25.83	4.00e-65	241.00
IUUC-Mga-059492	Meleagris gallopavo	25.03	2.00e-50	192.00
IUUC-Mvi-060303	Microbotryum violaceum	33.83	4.00e-54	204.00
IUUC-Mmr-061066	Microcebus murinus	26.71	5.00e-56	211.00
IUUC-Mdo-062039	Monodelphis domestica	27.11	1.00e-27	116.00
IUUC-Mmu-063620	Mus musculus	25.28	2.00e-53	202.00
IUUC-Mac-065638	Musa acuminata	24.85	1.00e-53	202.00
IUUC-Mpu-066212	Mustela putorius furo	25.65	7.00e-56	210.00
IUUC-Mlu-068167	Myotis lucifugus	26.21	9.00e-55	206.00
IUUC-Nfi-068338	Neosartorya fischeri	38.81	4.00e-166	576.00
IUUC-Ncr-068798	Neurospora crassa	37.85	2.00e-159	554.00
IUUC-Nle-069987	Nomascus leucogenys	25.95	9.00e-57	213.00
IUUC-Ont-072317	Oreochromis niloticus	26.78	6.00e-29	121.00
IUUC-Oan-073516	Ornithorhynchus anatinus	28.85	4.00e-24	102.00
IUUC-Ocu-074529	Oryctolagus cuniculus	25.99	2.00e-60	225.00
IUUC-Oba-075044	Oryza barthii	25.93	1.00e-51	196.00
IUUC-Obr-076499	Oryza brachyantha	26.24	1.00e-52	199.00
IUUC-Ogl-077757	Oryza glaberrima	26.03	7.00e-52	197.00
IUUC-Ogu-078878	Oryza glumaepatula	26.03	6.00e-52	197.00
IUUC-Oin-079900	Oryza indica	25.43	2.00e-51	195.00
IUUC-Olo-080741	Oryza longistaminata	25.43	2.00e-51	195.00
IUUC-Ome-081734	Oryza meridionalis	25.93	5.00e-51	194.00
IUUC-Oni-082656	Oryza nivara	25.33	5.00e-51	194.00
IUUC-Opu-083312	Oryza punctata	25.23	3.00e-51	195.00
IUUC-Oru-084507	Oryza rufipogon	26.03	6.00e-52	197.00
IUUC-Osa-085329	Oryza sativa	25.31	7.00e-44	170.00
IUUC-Ola-086433	Oryzias latipes	24.82	8.00e-50	190.00
IUUC-Olu-087690	Ostreococcus lucimarinus	22.84	1.00e-37	149.00
IUUC-Oga-088410	Otolemur garnettii	26.21	9.00e-51	193.00
IUUC-Oar-089993	Ovis aries	25.89	2.00e-52	199.00
IUUC-Ptr-091145	Pan troglodytes	25.92	2.00e-58	219.00
IUUC-Pan-092500	Papio anubis	26.15	9.00e-56	210.00
IUUC-Psi-093984	Pelodiscus sinensis	25.56	3.00e-53	201.00
IUUC-Pma-094567	Petromyzon marinus	24.17	3.00e-32	131.00
IUUC-Pno-095002	Phaeosphaeria nodorum	38.52	5.00e-129	453.00
IUUC-Pfo-097387	Poecilia formosa	27.36	2.00e-26	112.00
IUUC-Pab-097803	Pongo abelii	25.95	3.00e-54	205.00
IUUC-Pop-099165	Populus trichocarpa	26.02	8.00e-56	210.00
IUUC-Pca-100989	Procavia capensis	27.46	2.00e-10	59.70
IUUC-Ppe-102022	Prunus persica	27.28	5.00e-63	234.00
IUUC-Pva-102389	Pteropus vampyrus	25.27	9.00e-39	154.00
IUUC-Pgr-103635	Puccinia graminis	26.47	1.00e-67	249.00
IUUC-Ptt-103730	Puccinia triticina	24.51	2.00e-61	228.00
IUUC-Pte-104320	Pyrenophora teres	37.70	4.00e-134	470.00
IUUC-Pyt-104622	Pyrenophora triticirepentis	37.50	6.00e-131	459.00
IUUC-Rno-105689	Rattus norvegicus	26.09	3.00e-54	205.00
IUUC-Sha-107448	Sarcophilus harrisii	24.15	4.00e-41	161.00
IUUC-Sja-107702	Schizosaccharomyces japonicus	51.02	0.00e+00	843.00
IUUC-Ssl-108529	Sclerotinia sclerotiorum	36.14	1.00e-149	521.00
IUUC-Smo-109178	Selaginella moellendorffii	24.52	2.00e-46	178.00
IUUC-Sit-110790	Setaria italica	25.71	1.00e-50	193.00
IUUC-Sly-111470	Solanum lycopersicum	24.84	1.00e-52	199.00
IUUC-Stu-111945	Solanum tuberosum	24.87	6.00e-58	217.00
IUUC-Sar-113075	Sorex araneus	24.63	7.00e-25	107.00
IUUC-Sbi-114822	Sorghum bicolor	25.25	2.00e-46	179.00
IUUC-Sre-114913	Sporisorium reilianum	25.34	3.00e-54	205.00
IUUC-Ssc-116073	Sus scrofa	24.97	3.00e-46	178.00
IUUC-Tgu-117253	Taeniopygia guttata	24.79	1.00e-53	202.00
IUUC-Tru-117741	Takifugu rubripes	25.25	8.00e-49	187.00
IUUC-Tsy-118834	Tarsius syrichta	26.35	2.00e-23	102.00
IUUC-Tni-120726	Tetraodon nigroviridis	25.09	2.00e-52	199.00
IUUC-Tca-121655	Theobroma cacao	26.84	5.00e-65	241.00
IUUC-Tre-121921	Trichoderma reesei	38.01	3.00e-162	563.00
IUUC-Tvi-122540	Trichoderma virens	37.29	3.00e-160	556.00
IUUC-Tae-123225	Triticum aestivum	25.85	4.00e-53	201.00
IUUC-Tur-126398	Triticum urartu	25.87	2.00e-52	198.00
IUUC-Tme-127075	Tuber melanosporum	44.31	1.00e-99	355.00
IUUC-Tbe-128002	Tupaia belangeri	24.61	2.00e-21	95.90
IUUC-Ttr-129101	Tursiops truncatus	26.10	4.00e-55	207.00
IUUC-Uma-129374	Ustilago maydis	24.45	1.00e-56	213.00
IUUC-Vda-129719	Verticillium dahliae	37.74	2.00e-161	561.00
IUUC-Vpa-130039	Vicugna pacos	25.50	1.00e-50	193.00
IUUC-Vvi-131442	Vitis vinifera	25.76	5.00e-53	201.00
IUUC-Xtr-132599	Xenopus tropicalis	25.37	4.00e-53	201.00
IUUC-Xma-132991	Xiphophorus maculatus	26.87	2.00e-26	113.00
IUUC-Zma-135846	Zea mays	25.10	9.00e-55	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence