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Tag Content
UUCD2 ID IUUC-Laf-054558
UUCD1 version UUC-LoA-00545
Ensembl Protein ID ENSLAFP00000013096.3
UniProt Accession G3TFI5; G3TFI5_LOXAF
Protein Name Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39
Gene Name CIAO1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLAFG00000015623.3 ENSLAFT00000015622.3 ENSLAFP00000013096.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.50e-44 147.7 192 222
UBD/Beta-Prp 2.70e-61 207.7 13 222
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
    gH++ v++laf ++ +l+s+sdD t+++W
   Q: 192 GHESTVWSLAFdPSgQRLASCSDDRTVRIWQ 222
    8***********6669**************5 PP
   


   UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtl 90
    +h++s++ +++ p ++lla+ + d+++++w ++ + + l gh+ +v+ v +sp g++l+++s D+t ++w + + ++cv tl
   Q: 13 AHPDSRCWYLAWNPAGTLLASCGGDRRVRIWGTEGDSWvcKSVLsDGHQRTVRKVAWSPCGNYLASASFDATTCIWkrNQDGFECVTTL 101
    588888999999*********************97665436667789*****************************99999******** PP
   S: 91 kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llrtl 175
    +ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e +ls h++ v +vv+hp++ ll+s+s+D tv+l++ + ++ + tl
   Q: 102 EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLSSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDwvCCATL 190
    *********************************9987776566*********************************99777544999** PP
   S: 176 tgghtdsvyslsfdsngkelvsgsldgtvklwd 208
    +g h++ v sl+fd++g++l+s+s+d+tv++w+
   Q: 191 EG-HESTVWSLAFDPSGQRLASCSDDRTVRIWQ 222
    *9.*****************************5 PP
   

Organism Loxodonta africana
Functional Description
(View)

Functional Description



     Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
Protein Sequence
(Fasta)
MKDSLVLLGR VPAHPDSRCW YLAWNPAGTL LASCGGDRRV RIWGTEGDSW VCKSVLSDGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKR NQDGFECVTT LEGHENEVKS VAWAPSGNLL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Laf-054558|E3,WD_repeat;UBD,Beta-Prp|Loxodonta africana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAAGGACT CCCTGGTGCT GCTGGGCCGT GTCCCGGCGC ACCCGGACTC CCGCTGCTGG 60
TACCTGGCCT GGAACCCGGC GGGGACCCTG CTGGCCTCGT GCGGGGGCGA CCGGAGGGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Laf-054558|E3,WD_repeat;UBD,Beta-Prp|Loxodonta africana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

KEGG lav:100663843
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000874 Aegilops tauschii 42.94 3.00e-66 246.00
IUUC-Aml-001317 Ailuropoda melanoleuca 94.99 6.00e-180 622.00
IUUC-Atr-003029 Amborella trichopoda 51.03 3.00e-91 328.00
IUUC-Apl-004042 Anas platyrhynchos 77.27 1.00e-55 207.00
IUUC-Aly-006458 Arabidopsis lyrata 48.12 5.00e-84 304.00
IUUC-Ath-006671 Arabidopsis thaliana 47.97 2.00e-84 305.00
IUUC-Ago-007820 Ashbya gossypii 40.29 3.00e-58 218.00
IUUC-Acl-008042 Aspergillus clavatus 32.26 1.00e-50 193.00
IUUC-Afl-008639 Aspergillus flavus 33.81 1.00e-53 203.00
IUUC-Afu-008899 Aspergillus fumigatus 35.80 5.00e-49 188.00
IUUC-Ani-009453 Aspergillus nidulans 32.30 3.00e-49 189.00
IUUC-Ang-009758 Aspergillus niger 34.66 3.00e-50 192.00
IUUC-Aor-010212 Aspergillus oryzae 33.81 1.00e-53 203.00
IUUC-Ate-010314 Aspergillus terreus 33.09 4.00e-52 198.00
IUUC-Ame-010676 Astyanax mexicanus 77.25 2.00e-157 547.00
IUUC-Bgr-012095 Blumeria graminis 30.94 3.00e-38 152.00
IUUC-Bta-012884 Bos taurus 92.33 6.00e-175 606.00
IUUC-Bci-013622 Botrytis cinerea 33.14 3.00e-39 155.00
IUUC-Bdi-014614 Brachypodium distachyon 48.80 3.00e-84 305.00
IUUC-Bol-016439 Brassica oleracea 46.76 5.00e-81 294.00
IUUC-Bra-016830 Brassica rapa 45.72 4.00e-80 291.00
IUUC-Cel-018709 Caenorhabditis elegans 40.06 5.00e-63 234.00
IUUC-Cja-019822 Callithrix jacchus 95.28 7.00e-180 622.00
IUUC-Cfa-020823 Canis familiaris 94.99 2.00e-180 624.00
IUUC-Cre-022811 Chlamydomonas reinhardtii 48.14 1.00e-79 289.00
IUUC-Csa-023754 Chlorocebus sabaeus 95.28 1.00e-180 624.00
IUUC-Cin-025395 Ciona intestinalis 57.01 8.00e-114 403.00
IUUC-Csv-025943 Ciona savignyi 55.26 4.00e-111 394.00
IUUC-Cgl-026435 Colletotrichum gloeosporioides 29.82 5.00e-35 142.00
IUUC-Cne-026939 Cryptococcus neoformans 32.14 9.00e-49 187.00
IUUC-Cme-027239 Cyanidioschyzon merolae 42.19 9.00e-46 177.00
IUUC-Dre-028172 Danio rerio 76.65 9.00e-156 542.00
IUUC-Dno-029472 Dasypus novemcinctus 95.22 5.00e-152 530.00
IUUC-Dor-031134 Dipodomys ordii 82.30 2.00e-148 518.00
IUUC-Dse-031535 Dothistroma septosporum 30.26 2.00e-45 176.00
IUUC-Dme-032020 Drosophila melanogaster 58.48 2.00e-116 411.00
IUUC-Eca-033700 Equus caballus 95.28 1.00e-180 625.00
IUUC-Eeu-035010 Erinaceus europaeus 93.22 6.00e-174 602.00
IUUC-Fca-036309 Felis catus 86.76 8.00e-169 585.00
IUUC-Fal-037243 Ficedula albicollis 75.35 8.00e-87 312.00
IUUC-Fox-038058 Fusarium oxysporum 32.91 7.00e-44 172.00
IUUC-Fso-038459 Fusarium solani 32.73 3.00e-39 155.00
IUUC-Gmo-039375 Gadus morhua 74.93 3.00e-140 490.00
IUUC-Ggr-040002 Gaeumannomyces graminis 35.67 1.00e-40 160.00
IUUC-Gga-040294 Gallus gallus 78.59 1.00e-129 455.00
IUUC-Gac-042499 Gasterosteus aculeatus 73.89 6.00e-138 483.00
IUUC-Gma-043543 Glycine max 48.38 3.00e-85 308.00
IUUC-Ggo-045181 Gorilla gorilla 95.28 1.00e-180 624.00
IUUC-Hsa-046528 Homo sapiens 95.28 1.00e-180 624.00
IUUC-Hvu-047341 Hordeum vulgare 57.45 4.00e-55 207.00
IUUC-Itr-048790 Ictidomys tridecemlineatus 94.40 8.00e-179 619.00
IUUC-Kpa-049353 Komagataella pastoris 36.16 5.00e-57 214.00
IUUC-Lch-049763 Latimeria chalumnae 80.24 2.00e-160 558.00
IUUC-Lpe-051500 Leersia perrieri 44.74 5.00e-80 291.00
IUUC-Loc-052021 Lepisosteus oculatus 79.64 6.00e-151 526.00
IUUC-Lma-053331 Leptosphaeria maculans 35.25 2.00e-54 207.00
IUUC-Mcc-055374 Macaca mulatta 94.99 1.00e-179 622.00
IUUC-Meu-056042 Macropus eugenii 75.86 1.00e-108 385.00
IUUC-Mor-057187 Magnaporthe oryzae 35.81 7.00e-39 154.00
IUUC-Mtr-058072 Medicago truncatula 48.51 2.00e-85 308.00
IUUC-Mla-059108 Melampsora laricipopulina 31.59 2.00e-51 196.00
IUUC-Mga-059370 Meleagris gallopavo 65.78 4.00e-103 367.00
IUUC-Mvi-060495 Microbotryum violaceum 37.37 7.00e-57 214.00
IUUC-Mmr-060902 Microcebus murinus 95.28 1.00e-180 625.00
IUUC-Mdo-062510 Monodelphis domestica 90.27 1.00e-165 575.00
IUUC-Mmu-063575 Mus musculus 92.33 8.00e-176 609.00
IUUC-Mac-065322 Musa acuminata 50.74 9.00e-90 323.00
IUUC-Mpu-065925 Mustela putorius furo 94.40 6.00e-179 619.00
IUUC-Mlu-067755 Myotis lucifugus 94.69 1.00e-179 621.00
IUUC-Nfi-068327 Neosartorya fischeri 31.90 2.00e-48 186.00
IUUC-Ncr-068845 Neurospora crassa 32.92 1.00e-32 134.00
IUUC-Nle-069406 Nomascus leucogenys 93.22 6.00e-175 606.00
IUUC-Opr-070416 Ochotona princeps 74.63 3.00e-130 457.00
IUUC-Ont-071936 Oreochromis niloticus 74.18 1.00e-140 491.00
IUUC-Oan-073452 Ornithorhynchus anatinus 89.70 3.00e-73 266.00
IUUC-Ocu-074791 Oryctolagus cuniculus 93.81 9.00e-177 612.00
IUUC-Oba-075636 Oryza barthii 49.55 3.00e-87 315.00
IUUC-Obr-076742 Oryza brachyantha 48.25 2.00e-75 275.00
IUUC-Ogl-077766 Oryza glaberrima 49.55 3.00e-87 315.00
IUUC-Ogu-079039 Oryza glumaepatula 49.55 1.00e-87 316.00
IUUC-Oin-079315 Oryza indica 48.97 2.00e-76 278.00
IUUC-Olo-080669 Oryza longistaminata 44.01 2.00e-79 289.00
IUUC-Ome-081490 Oryza meridionalis 49.55 1.00e-87 316.00
IUUC-Oni-082572 Oryza nivara 49.55 3.00e-87 315.00
IUUC-Opu-083732 Oryza punctata 50.00 8.00e-88 317.00
IUUC-Oru-084763 Oryza rufipogon 49.55 3.00e-87 315.00
IUUC-Osa-085372 Oryza sativa 49.55 3.00e-87 315.00
IUUC-Ola-087379 Oryzias latipes 72.94 3.00e-137 481.00
IUUC-Olu-087801 Ostreococcus lucimarinus 36.61 2.00e-45 176.00
IUUC-Oga-089076 Otolemur garnettii 93.51 2.00e-177 614.00
IUUC-Oar-090022 Ovis aries 92.33 4.00e-174 603.00
IUUC-Ptr-090809 Pan troglodytes 95.28 1.00e-180 624.00
IUUC-Pan-091685 Papio anubis 95.28 0.00e+00 631.00
IUUC-Psi-093046 Pelodiscus sinensis 86.69 2.00e-166 578.00
IUUC-Pma-094181 Petromyzon marinus 64.71 3.00e-131 461.00
IUUC-Pno-094882 Phaeosphaeria nodorum 34.14 4.00e-55 208.00
IUUC-Ppa-095172 Physcomitrella patens 47.67 1.00e-83 303.00
IUUC-Pfo-096396 Poecilia formosa 71.22 8.00e-138 483.00
IUUC-Pab-098427 Pongo abelii 94.69 5.00e-178 616.00
IUUC-Pop-100016 Populus trichocarpa 51.04 1.00e-89 322.00
IUUC-Pca-101048 Procavia capensis 97.64 0.00e+00 637.00
IUUC-Ppe-102050 Prunus persica 47.29 2.00e-85 308.00
IUUC-Pva-103117 Pteropus vampyrus 94.69 2.00e-179 621.00
IUUC-Pgr-103307 Puccinia graminis 34.02 8.00e-57 214.00
IUUC-Ptt-103938 Puccinia triticina 40.14 4.00e-50 191.00
IUUC-Pte-104315 Pyrenophora teres 33.81 1.00e-56 213.00
IUUC-Pyt-104825 Pyrenophora triticirepentis 33.81 1.00e-56 213.00
IUUC-Rno-105523 Rattus norvegicus 92.04 2.00e-175 607.00
IUUC-Sce-106297 Saccharomyces cerevisiae 41.69 3.00e-63 235.00
IUUC-Sha-106981 Sarcophilus harrisii 90.10 7.00e-139 486.00
IUUC-Sja-107715 Schizosaccharomyces japonicus 38.33 3.00e-55 209.00
IUUC-Spo-108214 Schizosaccharomyces pombe 41.39 2.00e-57 216.00
IUUC-Smo-109034 Selaginella moellendorffii 46.54 4.00e-81 294.00
IUUC-Sit-110663 Setaria italica 50.45 1.00e-88 319.00
IUUC-Sly-110898 Solanum lycopersicum 47.51 3.00e-81 295.00
IUUC-Stu-112647 Solanum tuberosum 50.37 3.00e-69 254.00
IUUC-Sbi-114288 Sorghum bicolor 48.07 2.00e-84 305.00
IUUC-Sre-115065 Sporisorium reilianum 43.69 1.00e-75 276.00
IUUC-Ssc-115960 Sus scrofa 88.13 2.00e-177 614.00
IUUC-Tru-118382 Takifugu rubripes 71.51 3.00e-147 514.00
IUUC-Tsy-119585 Tarsius syrichta 86.43 6.00e-159 553.00
IUUC-Tni-120133 Tetraodon nigroviridis 74.55 3.00e-143 501.00
IUUC-Tca-121167 Theobroma cacao 48.37 7.00e-80 290.00
IUUC-Tre-122119 Trichoderma reesei 30.34 3.00e-41 162.00
IUUC-Tvi-122407 Trichoderma virens 29.83 6.00e-41 161.00
IUUC-Tae-124500 Triticum aestivum 47.77 6.00e-80 290.00
IUUC-Tur-126682 Triticum urartu 47.76 2.00e-66 245.00
IUUC-Tme-127095 Tuber melanosporum 36.49 5.00e-61 228.00
IUUC-Tbe-128004 Tupaia belangeri 94.69 9.00e-180 622.00
IUUC-Ttr-129284 Tursiops truncatus 89.77 5.00e-168 583.00
IUUC-Uma-129527 Ustilago maydis 43.62 6.00e-75 274.00
IUUC-Vda-129854 Verticillium dahliae 30.71 1.00e-37 150.00
IUUC-Vpa-130681 Vicugna pacos 93.10 9.00e-48 183.00
IUUC-Vvi-131004 Vitis vinifera 52.55 7.00e-86 310.00
IUUC-Xtr-131928 Xenopus tropicalis 80.42 3.00e-153 533.00
IUUC-Xma-134290 Xiphophorus maculatus 70.62 1.00e-134 472.00
IUUC-Yli-134364 Yarrowia lipolytica 43.60 2.00e-66 245.00
IUUC-Zma-135658 Zea mays 49.26 8.00e-86 310.00
Created Date 25-Jun-2017

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