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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063580
UUCD1 version UUC-MuM-00972
Ensembl Protein ID ENSMUSP00000056359.6
UniProt Accession Q9ERF3; Q3U562; Q9CZP1; WDR61_MOUSE
Genbank Protein ID AAG31640.1; BAB28173.1; BAB28657.1; BAE25087.1; BAE32218.1; BAE39750.1; AAH23026.1
Protein Name WD repeat-containing protein 61; Meiotic recombination REC14 protein homolog; WD repeat-containing protein 61, N-terminally processed
Genbank Nucleotide ID AF309554; AK012342; AK013114; AK142498; AK153862; AK167706; BC023026
Gene Name Wdr61
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000061559.15 ENSMUST00000118771.7 ENSMUSP00000112811.1
ENSMUSG00000061559.15 ENSMUST00000051822.12 ENSMUSP00000056359.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
PhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.50e-44 147.3 230 268
UBD/Beta-Prp 1.40e-73 248.9 12 303
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+++v  +af +d t++vs+s D+++kvWD+ t ++++
   Q: 230  GHASWVLNVAFcPDdTHFVSSSSDKSVKVWDVGTRTCIH 268
           8***********777*****************9999887 PP
   

   UBD/Beta-Prp
   S: 6    kghhksvitcvkf....spdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvh 88
           +++h++ i +v++    +++ + ++tgs d+ +kvw+++++ l   +sl+gh+ +v +v++s++ +i +++s D++i++wdl++gk++ 
   Q: 12   EQAHDDAIWSVAWetnkKENIETVVTGSLDDLVKVWKWRDERLelQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQMK 100
           56777788889998666666789******************998899****************************************** PP
   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           ++ +   ++++l+fsp++++l++G+h   ++++ +e+g++ +  l+ + +++ +++++pdg++l+sG+ D++++++d++tgkll+tl+g
   Q: 101  SIDAGPVDAWTLAFSPDSQYLATGTHMGKVNIFGVESGKKEY-SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG 188
           ******************************************.*********************************************9 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
            h  +++sl+f+++++ lv++s+dg++k++d+q+ +   tl gh ++v+ v+f+p+d+++vs ssD+s+++Wd+ ++++++t+  h+++
   Q: 189  -HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCIHTFFDHQDQ 276
           .**************************************************************************************** PP
   S: 267  visvavlsfgdnvlvlgsedskvniwkl 294
           v+ v++ + +++++v++++d++++++++
   Q: 277  VWGVKY-NGNGSKIVSVGDDQEIHVYDC 303
           ******.999****************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (By similarity).
 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (By similarity).
Protein Sequence
(Fasta)
MTNQYSILFK QEQAHDDAIW SVAWETNKKE NIETVVTGSL DDLVKVWKWR DERLELQWSL 60
EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQMK SIDAGPVDAW TLAFSPDSQY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063580|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGCTCCACT GACGTCAGGC GTGCTGTGCG GCTGGCTGTA CGGTGGTGAG TTGGTGTGCT 60
GGGCAGAGTT GGGGAATGGT GGTCTTTGGT GCTGTTGCCT ACTAGGGCGA GAGGGCGACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063580|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0055087--C:Ski complex
GO:0035327--C:transcriptionally active chromatin
GO:0080182--P:histone H3-K4 trimethylation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2001162--P:positive regulation of histone H3-K79 methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG mmu:66317
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000774 Aegilops tauschii 33.33 4.00e-47 181.00
IUUC-Aml-002245 Ailuropoda melanoleuca 97.38 2.00e-166 577.00
IUUC-Atr-003142 Amborella trichopoda 50.93 3.00e-38 151.00
IUUC-Apl-003179 Anas platyrhynchos 88.85 1.00e-154 538.00
IUUC-Aca-004880 Anolis carolinensis 87.54 5.00e-156 543.00
IUUC-Aly-005956 Arabidopsis lyrata 37.50 6.00e-55 207.00
IUUC-Ath-007230 Arabidopsis thaliana 37.18 8.00e-51 194.00
IUUC-Acl-008297 Aspergillus clavatus 29.24 1.00e-24 107.00
IUUC-Ang-009702 Aspergillus niger 29.58 4.00e-30 125.00
IUUC-Ame-011511 Astyanax mexicanus 82.74 6.00e-148 516.00
IUUC-Bgr-012189 Blumeria graminis 30.11 1.00e-28 120.00
IUUC-Bta-012936 Bos taurus 97.05 3.00e-166 577.00
IUUC-Bdi-015020 Brachypodium distachyon 37.24 1.00e-46 180.00
IUUC-Bol-016345 Brassica oleracea 38.14 4.00e-56 211.00
IUUC-Bra-017323 Brassica rapa 38.14 4.00e-56 211.00
IUUC-Cja-019961 Callithrix jacchus 97.38 2.00e-166 578.00
IUUC-Cfa-020862 Canis familiaris 97.05 2.00e-165 574.00
IUUC-Cpo-021356 Cavia porcellus 97.02 1.00e-163 568.00
IUUC-Cre-022602 Chlamydomonas reinhardtii 41.58 2.00e-57 215.00
IUUC-Csa-024067 Chlorocebus sabaeus 97.05 6.00e-166 576.00
IUUC-Cho-024421 Choloepus hoffmanni 82.32 3.00e-82 297.00
IUUC-Cin-025261 Ciona intestinalis 64.26 7.00e-116 409.00
IUUC-Cne-026846 Cryptococcus neoformans 29.51 6.00e-25 108.00
IUUC-Dre-027706 Danio rerio 64.92 1.00e-108 385.00
IUUC-Dno-029084 Dasypus novemcinctus 97.07 1.00e-165 575.00
IUUC-Dor-030353 Dipodomys ordii 81.52 2.00e-122 431.00
IUUC-Dse-031348 Dothistroma septosporum 28.43 7.00e-26 111.00
IUUC-Dme-031836 Drosophila melanogaster 52.00 8.00e-88 317.00
IUUC-Ete-032261 Echinops telfairi 94.75 8.00e-160 556.00
IUUC-Eca-034231 Equus caballus 89.51 1.00e-150 525.00
IUUC-Eeu-034828 Erinaceus europaeus 96.22 5.00e-155 540.00
IUUC-Fca-036569 Felis catus 97.05 1.00e-165 575.00
IUUC-Fal-037469 Ficedula albicollis 90.49 3.00e-158 550.00
IUUC-Fox-038047 Fusarium oxysporum 31.99 3.00e-28 119.00
IUUC-Gmo-039579 Gadus morhua 82.95 2.00e-145 508.00
IUUC-Gga-040808 Gallus gallus 91.10 2.00e-151 528.00
IUUC-Gac-042100 Gasterosteus aculeatus 82.95 3.00e-146 511.00
IUUC-Gma-043509 Glycine max 40.62 2.00e-59 222.00
IUUC-Ggo-045227 Gorilla gorilla 97.38 2.00e-166 578.00
IUUC-Hsa-045839 Homo sapiens 97.38 2.00e-166 578.00
IUUC-Hvu-047591 Hordeum vulgare 37.66 2.00e-49 189.00
IUUC-Itr-048741 Ictidomys tridecemlineatus 97.70 4.00e-167 580.00
IUUC-Lch-049549 Latimeria chalumnae 83.93 8.00e-147 513.00
IUUC-Lpe-050746 Leersia perrieri 38.26 1.00e-47 183.00
IUUC-Loc-052540 Lepisosteus oculatus 85.57 9.00e-148 515.00
IUUC-Lma-052992 Leptosphaeria maculans 27.80 6.00e-27 114.00
IUUC-Laf-053907 Loxodonta africana 97.70 4.00e-167 580.00
IUUC-Mcc-055828 Macaca mulatta 91.08 3.00e-162 564.00
IUUC-Meu-056075 Macropus eugenii 94.12 7.00e-136 476.00
IUUC-Mtr-057728 Medicago truncatula 40.06 4.00e-56 211.00
IUUC-Mga-059872 Meleagris gallopavo 90.82 1.00e-158 552.00
IUUC-Mvi-060564 Microbotryum violaceum 31.77 1.00e-29 123.00
IUUC-Mmr-060985 Microcebus murinus 97.26 1.00e-158 551.00
IUUC-Mdo-062758 Monodelphis domestica 90.13 1.00e-158 551.00
IUUC-Mac-064880 Musa acuminata 39.55 2.00e-57 216.00
IUUC-Mpu-066577 Mustela putorius furo 96.72 2.00e-164 571.00
IUUC-Nle-069573 Nomascus leucogenys 97.38 2.00e-166 578.00
IUUC-Opr-070216 Ochotona princeps 96.68 4.00e-163 566.00
IUUC-Ont-071981 Oreochromis niloticus 84.92 3.00e-149 521.00
IUUC-Oan-073223 Ornithorhynchus anatinus 93.43 1.00e-107 381.00
IUUC-Ocu-074199 Oryctolagus cuniculus 83.61 8.00e-138 483.00
IUUC-Oba-075255 Oryza barthii 39.62 3.00e-41 161.00
IUUC-Obr-076168 Oryza brachyantha 46.58 2.00e-35 142.00
IUUC-Ogl-077777 Oryza glaberrima 38.06 2.00e-48 185.00
IUUC-Ogu-078780 Oryza glumaepatula 38.06 2.00e-48 185.00
IUUC-Oin-079228 Oryza indica 38.06 5.00e-51 194.00
IUUC-Olo-080617 Oryza longistaminata 45.07 4.00e-29 120.00
IUUC-Ome-081421 Oryza meridionalis 38.06 2.00e-47 182.00
IUUC-Oni-082997 Oryza nivara 38.06 5.00e-51 194.00
IUUC-Opu-083931 Oryza punctata 38.39 2.00e-48 186.00
IUUC-Oru-084645 Oryza rufipogon 38.06 2.00e-48 185.00
IUUC-Osa-085842 Oryza sativa 38.06 5.00e-51 194.00
IUUC-Ola-086696 Oryzias latipes 84.26 4.00e-145 506.00
IUUC-Olu-087643 Ostreococcus lucimarinus 39.91 2.00e-41 162.00
IUUC-Oga-088272 Otolemur garnettii 96.05 9.00e-164 568.00
IUUC-Oar-089416 Ovis aries 97.05 3.00e-166 577.00
IUUC-Ptr-090944 Pan troglodytes 97.38 2.00e-166 578.00
IUUC-Pan-091861 Papio anubis 97.38 2.00e-166 578.00
IUUC-Psi-093750 Pelodiscus sinensis 91.80 4.00e-159 553.00
IUUC-Pma-094608 Petromyzon marinus 79.68 2.00e-135 475.00
IUUC-Pno-094832 Phaeosphaeria nodorum 32.14 4.00e-26 112.00
IUUC-Ppa-095737 Physcomitrella patens 41.03 9.00e-57 213.00
IUUC-Pfo-096479 Poecilia formosa 85.57 3.00e-143 501.00
IUUC-Pab-098179 Pongo abelii 97.38 2.00e-166 578.00
IUUC-Pop-099532 Populus trichocarpa 40.21 8.00e-56 210.00
IUUC-Pca-100664 Procavia capensis 75.36 4.00e-105 374.00
IUUC-Ppe-102056 Prunus persica 39.29 2.00e-57 216.00
IUUC-Pva-102859 Pteropus vampyrus 97.05 7.00e-166 575.00
IUUC-Pte-104236 Pyrenophora teres 35.00 2.00e-25 109.00
IUUC-Rno-105826 Rattus norvegicus 99.67 3.00e-170 590.00
IUUC-Sha-106660 Sarcophilus harrisii 91.36 3.00e-152 531.00
IUUC-Sja-107800 Schizosaccharomyces japonicus 34.21 8.00e-37 147.00
IUUC-Spo-108244 Schizosaccharomyces pombe 31.72 1.00e-35 143.00
IUUC-Smo-109382 Selaginella moellendorffii 42.47 4.00e-61 228.00
IUUC-Sit-110048 Setaria italica 37.50 2.00e-40 159.00
IUUC-Sly-111618 Solanum lycopersicum 37.97 8.00e-52 197.00
IUUC-Stu-112543 Solanum tuberosum 38.46 5.00e-55 207.00
IUUC-Sar-113743 Sorex araneus 77.38 1.00e-128 452.00
IUUC-Sbi-114309 Sorghum bicolor 38.89 2.00e-41 162.00
IUUC-Ssc-115560 Sus scrofa 91.48 4.00e-153 533.00
IUUC-Tgu-117300 Taeniopygia guttata 90.82 1.00e-158 551.00
IUUC-Tru-117933 Takifugu rubripes 84.59 4.00e-149 520.00
IUUC-Tsy-119574 Tarsius syrichta 86.89 6.00e-143 499.00
IUUC-Tni-120191 Tetraodon nigroviridis 86.92 3.00e-113 400.00
IUUC-Tca-120983 Theobroma cacao 40.45 1.00e-57 216.00
IUUC-Tae-122888 Triticum aestivum 35.53 3.00e-49 188.00
IUUC-Tur-126711 Triticum urartu 35.74 2.00e-48 185.00
IUUC-Tme-127066 Tuber melanosporum 33.09 1.00e-33 137.00
IUUC-Tbe-127802 Tupaia belangeri 97.05 1.00e-165 575.00
IUUC-Ttr-128861 Tursiops truncatus 95.28 1.00e-54 206.00
IUUC-Vda-129720 Verticillium dahliae 28.92 1.00e-22 100.00
IUUC-Vpa-130618 Vicugna pacos 93.52 2.00e-133 467.00
IUUC-Vvi-130981 Vitis vinifera 39.74 2.00e-55 209.00
IUUC-Xtr-132460 Xenopus tropicalis 85.25 6.00e-145 506.00
IUUC-Xma-134154 Xiphophorus maculatus 85.57 2.00e-143 501.00
Created Date 25-Jun-2017

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