iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000000699.5	ENSGALT00000000991.4	ENSGALP00000000989.4
ENSGALG00000000699.5	ENSGALT00000077253.1	ENSGALP00000049801.1
ENSGALG00000000699.5	ENSGALT00000055498.1	ENSGALP00000049054.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.10e-136	453.2	591	923

Active Site

Position(s)	Description	Evidence
892	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 591  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 678
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ + ken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 679  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWTKEN---SLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 764
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 765  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 852
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 853  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 923
           *********************************************************************96 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MASASSSRAR AGLPCEKSQL SVKVVSVKPK AHSRQSRMNC YVEVAGDGLP SETKKTGKQM 60
GSSELLWNEI LILNVTAQSH LDLKVWSCHT LRNELLGTAS VSLWNLLKNG GKLENKQLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAACGGAG CGGCTGCCGG TGAGGTGGGT GAGGGCCGGG CGGTGTGGAG CGGCGCGGTC 60
TGGCGGGGGG TTCTGGCGGT CGCGAGTGCG GGGAGCTGTT TCGTTTCGTT CCGTTCCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	79.69	0.00e+00	1444.00
IUUC-Apl-003912	Anas platyrhynchos	74.04	0.00e+00	1258.00
IUUC-Aca-004291	Anolis carolinensis	76.55	0.00e+00	1413.00
IUUC-Bta-013231	Bos taurus	79.45	0.00e+00	1426.00
IUUC-Cja-019455	Callithrix jacchus	79.98	0.00e+00	1471.00
IUUC-Cfa-021017	Canis familiaris	79.54	0.00e+00	1439.00
IUUC-Cpo-021988	Cavia porcellus	79.54	0.00e+00	1457.00
IUUC-Csa-023549	Chlorocebus sabaeus	79.87	0.00e+00	1470.00
IUUC-Dre-028513	Danio rerio	93.17	0.00e+00	1155.00
IUUC-Dno-028976	Dasypus novemcinctus	81.00	0.00e+00	1466.00
IUUC-Dor-030176	Dipodomys ordii	75.47	0.00e+00	1300.00
IUUC-Eca-033949	Equus caballus	80.31	0.00e+00	1454.00
IUUC-Eeu-034529	Erinaceus europaeus	82.83	0.00e+00	1052.00
IUUC-Fca-036236	Felis catus	79.98	0.00e+00	1465.00
IUUC-Fal-036948	Ficedula albicollis	85.36	0.00e+00	1459.00
IUUC-Gmo-038842	Gadus morhua	89.95	0.00e+00	1079.00
IUUC-Gac-041338	Gasterosteus aculeatus	72.30	0.00e+00	1300.00
IUUC-Ggo-045278	Gorilla gorilla	80.09	0.00e+00	1479.00
IUUC-Hsa-046148	Homo sapiens	80.09	0.00e+00	1480.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	95.52	0.00e+00	1093.00
IUUC-Lch-050663	Latimeria chalumnae	73.95	0.00e+00	1365.00
IUUC-Loc-052604	Lepisosteus oculatus	72.84	0.00e+00	1312.00
IUUC-Laf-053944	Loxodonta africana	80.09	0.00e+00	1464.00
IUUC-Mcc-055655	Macaca mulatta	79.87	0.00e+00	1474.00
IUUC-Meu-055953	Macropus eugenii	71.40	0.00e+00	1278.00
IUUC-Mga-060190	Meleagris gallopavo	96.71	0.00e+00	1744.00
IUUC-Mmr-060896	Microcebus murinus	79.87	0.00e+00	1455.00
IUUC-Mdo-062536	Monodelphis domestica	81.11	0.00e+00	1504.00
IUUC-Mmu-064017	Mus musculus	80.22	0.00e+00	1454.00
IUUC-Mpu-066608	Mustela putorius furo	77.62	0.00e+00	1387.00
IUUC-Mlu-067623	Myotis lucifugus	79.15	0.00e+00	1409.00
IUUC-Nle-069496	Nomascus leucogenys	78.23	0.00e+00	1431.00
IUUC-Opr-071054	Ochotona princeps	95.59	0.00e+00	1161.00
IUUC-Ont-071279	Oreochromis niloticus	89.20	0.00e+00	1117.00
IUUC-Oan-073512	Ornithorhynchus anatinus	78.38	0.00e+00	1417.00
IUUC-Ocu-074271	Oryctolagus cuniculus	79.93	0.00e+00	1436.00
IUUC-Ola-087237	Oryzias latipes	71.77	0.00e+00	1277.00
IUUC-Oga-088164	Otolemur garnettii	80.57	0.00e+00	1460.00
IUUC-Oar-089698	Ovis aries	79.65	0.00e+00	1431.00
IUUC-Ptr-091306	Pan troglodytes	78.77	0.00e+00	1447.00
IUUC-Pan-092814	Papio anubis	76.64	0.00e+00	1384.00
IUUC-Pfo-096709	Poecilia formosa	70.59	0.00e+00	1256.00
IUUC-Pab-098494	Pongo abelii	79.26	0.00e+00	1444.00
IUUC-Pca-100596	Procavia capensis	77.81	0.00e+00	1075.00
IUUC-Pva-103154	Pteropus vampyrus	74.35	0.00e+00	1314.00
IUUC-Rno-104954	Rattus norvegicus	79.31	0.00e+00	1275.00
IUUC-Sha-106781	Sarcophilus harrisii	80.90	0.00e+00	1509.00
IUUC-Ssc-116307	Sus scrofa	77.68	0.00e+00	1366.00
IUUC-Tgu-116530	Taeniopygia guttata	81.23	0.00e+00	1264.00
IUUC-Tru-118287	Takifugu rubripes	91.21	0.00e+00	1092.00
IUUC-Tni-120801	Tetraodon nigroviridis	70.10	0.00e+00	1224.00
IUUC-Tbe-127793	Tupaia belangeri	76.57	0.00e+00	1097.00
IUUC-Ttr-128275	Tursiops truncatus	83.94	0.00e+00	1189.00
IUUC-Uma-129332	Ustilago maydis	46.11	1.00e-142	500.00
IUUC-Xtr-132866	Xenopus tropicalis	84.69	0.00e+00	1136.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence