iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069496

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

ADFV01013964

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000005599.2	ENSNLET00000007115.1	ENSNLEP00000006775.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-125	418.7	538	869

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 538  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 625
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 626  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 711
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 712  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 799
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p+lf  +  + +  lP+sn  fn+L+LP+Y+s+e+l+ekLlyAieet+gF++
   Q: 800  TGTCRLPVGGFAELIgtgkPSLFSPSLLGLTVMLPRSNS-FNRLDLPPYKSYEQLREKLLYAIEETEGFGQ 869
           **************99999******************96.*****************************96 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCATCTG CCAGCTCTAG CCGGGCAGGA GTGGCCCTGC CTTTTGAGAA GTCTCAGCTC 60
ACTTTGAAAG GTGAGTGGCA CTGTATAATA TCTTTATCTT GTCTATGCCC AGGGAAGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051224--P:negative regulation of protein transport
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	93.93	0.00e+00	1590.00
IUUC-Apl-003912	Anas platyrhynchos	75.03	0.00e+00	1196.00
IUUC-Aca-004291	Anolis carolinensis	79.10	0.00e+00	1388.00
IUUC-Bta-013231	Bos taurus	93.23	0.00e+00	1551.00
IUUC-Cja-019455	Callithrix jacchus	95.98	0.00e+00	1665.00
IUUC-Cfa-021017	Canis familiaris	94.26	0.00e+00	1577.00
IUUC-Cpo-021988	Cavia porcellus	94.03	0.00e+00	1626.00
IUUC-Csa-023549	Chlorocebus sabaeus	96.21	0.00e+00	1679.00
IUUC-Dre-028513	Danio rerio	89.14	0.00e+00	1091.00
IUUC-Dno-028976	Dasypus novemcinctus	93.35	0.00e+00	1617.00
IUUC-Dor-030176	Dipodomys ordii	90.32	0.00e+00	1466.00
IUUC-Eca-033949	Equus caballus	94.03	0.00e+00	1597.00
IUUC-Eeu-034529	Erinaceus europaeus	87.60	0.00e+00	1365.00
IUUC-Fca-036236	Felis catus	93.92	0.00e+00	1627.00
IUUC-Fal-036948	Ficedula albicollis	76.76	0.00e+00	1293.00
IUUC-Gmo-038842	Gadus morhua	86.60	0.00e+00	1026.00
IUUC-Gga-040617	Gallus gallus	78.56	0.00e+00	1390.00
IUUC-Gac-041338	Gasterosteus aculeatus	68.10	0.00e+00	1203.00
IUUC-Ggo-045278	Gorilla gorilla	97.24	0.00e+00	1694.00
IUUC-Hsa-046148	Homo sapiens	97.24	0.00e+00	1694.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	95.14	0.00e+00	1077.00
IUUC-Lch-050663	Latimeria chalumnae	76.61	0.00e+00	1346.00
IUUC-Loc-052604	Lepisosteus oculatus	73.30	0.00e+00	1271.00
IUUC-Laf-053944	Loxodonta africana	93.92	0.00e+00	1618.00
IUUC-Mcc-055655	Macaca mulatta	96.44	0.00e+00	1680.00
IUUC-Meu-055953	Macropus eugenii	78.47	0.00e+00	1339.00
IUUC-Mga-060190	Meleagris gallopavo	78.78	0.00e+00	1388.00
IUUC-Mmr-060896	Microcebus murinus	94.80	0.00e+00	1597.00
IUUC-Mdo-062536	Monodelphis domestica	88.89	0.00e+00	1558.00
IUUC-Mmu-064017	Mus musculus	94.03	0.00e+00	1608.00
IUUC-Mpu-066608	Mustela putorius furo	91.87	0.00e+00	1541.00
IUUC-Mlu-067623	Myotis lucifugus	90.70	0.00e+00	1544.00
IUUC-Opr-071054	Ochotona princeps	82.35	0.00e+00	1380.00
IUUC-Ont-071279	Oreochromis niloticus	72.10	0.00e+00	1234.00
IUUC-Oan-073512	Ornithorhynchus anatinus	86.11	0.00e+00	1445.00
IUUC-Ocu-074271	Oryctolagus cuniculus	93.47	0.00e+00	1577.00
IUUC-Ola-087237	Oryzias latipes	67.78	0.00e+00	1185.00
IUUC-Oga-088164	Otolemur garnettii	94.72	0.00e+00	1639.00
IUUC-Oar-089698	Ovis aries	93.57	0.00e+00	1561.00
IUUC-Ptr-091306	Pan troglodytes	95.98	0.00e+00	1662.00
IUUC-Pan-092814	Papio anubis	92.55	0.00e+00	1584.00
IUUC-Pfo-096709	Poecilia formosa	87.76	0.00e+00	1040.00
IUUC-Pab-098494	Pongo abelii	91.43	0.00e+00	1593.00
IUUC-Pca-100596	Procavia capensis	81.70	0.00e+00	1327.00
IUUC-Pva-103154	Pteropus vampyrus	89.30	0.00e+00	1532.00
IUUC-Rno-104954	Rattus norvegicus	93.14	0.00e+00	1368.00
IUUC-Sha-106781	Sarcophilus harrisii	89.23	0.00e+00	1600.00
IUUC-Ssc-116307	Sus scrofa	82.30	0.00e+00	1398.00
IUUC-Tgu-116530	Taeniopygia guttata	74.05	0.00e+00	1145.00
IUUC-Tru-118287	Takifugu rubripes	86.82	0.00e+00	1022.00
IUUC-Tsy-119097	Tarsius syrichta	83.89	0.00e+00	1241.00
IUUC-Tni-120801	Tetraodon nigroviridis	65.85	0.00e+00	1089.00
IUUC-Tbe-127793	Tupaia belangeri	83.70	0.00e+00	1417.00
IUUC-Ttr-128275	Tursiops truncatus	89.32	0.00e+00	1499.00
IUUC-Xtr-132866	Xenopus tropicalis	84.93	0.00e+00	1085.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence