iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000016431.3	ENSMMUT00000023077.3	ENSMMUP00000021588.3
ENSMMUG00000016431.3	ENSMMUT00000023075.3	ENSMMUP00000021586.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.60e-06	29.7	211	249
E3 activity/RING/U-box	6.30e-08	33.7	208	275

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C+  f + p+++pCgH+f+++Cl++          +++CPlC+
   Q: 211  CALCMRLFYE-PVTTPCGHTFCLKCLERC------LDHNAKCPLCK 249
           ****999977.***************999......9*********7 PP

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqpl....teedlvPnltlrrliqawc 69
           ++ C++ + l+ +Pv++p+G+t+  +++e++l+++ k cP+++  l    ++++   n  + +li +++
   Q: 208  DLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAK-CPLCKDGLsqclASRKYSKNVIMEELIAKFL 275
           678*********************************9.****876633336777788888888888776 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGFKAHFRKA QALATLGKVE EALREFLYCV SLDGKNKRAR CEAQRLLLSF FSPSVPGDSQ 60
EHSPDILKLL APHPRLKENV ESMTTEVTSH NLPRLLQDNL ELPHCSSQEE AAARGDGSSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCGAGGTA CCAGCCTCTC CTAGGAGGAG TAGGGGGCCG CTGGTCAGCG GCTGGCAGAG 60
GGGACCTGTT TGCTGGCCCG TTTGGACGTG GGATGGGGTG GGGTTTGGAG ACTGAGAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR011990--TPR-like_helical_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51787--LON_N
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02190--LON_substr_bdg

SMART

SM00464--LON
SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001774	Ailuropoda melanoleuca	77.43	0.00e+00	692.00
IUUC-Apl-003916	Anas platyrhynchos	72.63	6.00e-160	557.00
IUUC-Bta-012872	Bos taurus	79.96	0.00e+00	770.00
IUUC-Cel-018356	Caenorhabditis elegans	32.53	9.00e-10	56.20
IUUC-Cja-018747	Callithrix jacchus	89.50	0.00e+00	728.00
IUUC-Cfa-020101	Canis familiaris	78.77	0.00e+00	722.00
IUUC-Cpo-022041	Cavia porcellus	79.96	0.00e+00	765.00
IUUC-Csa-024034	Chlorocebus sabaeus	89.66	0.00e+00	865.00
IUUC-Csv-026364	Ciona savignyi	45.87	3.00e-79	288.00
IUUC-Dno-029518	Dasypus novemcinctus	85.13	0.00e+00	763.00
IUUC-Dor-031132	Dipodomys ordii	67.81	0.00e+00	676.00
IUUC-Dse-031331	Dothistroma septosporum	31.69	2.00e-39	157.00
IUUC-Dme-031919	Drosophila melanogaster	34.16	7.00e-65	242.00
IUUC-Eca-033382	Equus caballus	80.72	0.00e+00	785.00
IUUC-Fca-035777	Felis catus	87.10	0.00e+00	836.00
IUUC-Fal-036730	Ficedula albicollis	66.00	0.00e+00	662.00
IUUC-Gmo-039110	Gadus morhua	69.13	6.00e-126	444.00
IUUC-Gga-041187	Gallus gallus	65.34	0.00e+00	665.00
IUUC-Gac-042201	Gasterosteus aculeatus	66.36	2.00e-133	469.00
IUUC-Ggo-045111	Gorilla gorilla	89.46	0.00e+00	865.00
IUUC-Hsa-045695	Homo sapiens	89.26	0.00e+00	861.00
IUUC-Lch-050429	Latimeria chalumnae	59.84	1.00e-170	593.00
IUUC-Loc-051823	Lepisosteus oculatus	76.92	4.00e-138	485.00
IUUC-Lma-053145	Leptosphaeria maculans	31.55	8.00e-41	161.00
IUUC-Laf-053434	Loxodonta africana	77.53	0.00e+00	705.00
IUUC-Mga-060131	Meleagris gallopavo	63.55	0.00e+00	632.00
IUUC-Mvi-060228	Microbotryum violaceum	34.38	6.00e-47	183.00
IUUC-Mmr-060749	Microcebus murinus	82.70	0.00e+00	811.00
IUUC-Mdo-062261	Monodelphis domestica	69.41	1.00e-149	523.00
IUUC-Mmu-063219	Mus musculus	75.55	0.00e+00	705.00
IUUC-Mpu-066222	Mustela putorius furo	76.24	0.00e+00	707.00
IUUC-Mlu-067769	Myotis lucifugus	77.14	0.00e+00	751.00
IUUC-Nle-069738	Nomascus leucogenys	88.07	0.00e+00	843.00
IUUC-Oan-073179	Ornithorhynchus anatinus	68.32	0.00e+00	672.00
IUUC-Ocu-074884	Oryctolagus cuniculus	80.88	0.00e+00	777.00
IUUC-Ogl-077658	Oryza glaberrima	34.04	6.00e-12	65.10
IUUC-Ome-081482	Oryza meridionalis	34.04	1.00e-11	64.30
IUUC-Osa-085978	Oryza sativa	34.04	7.00e-12	65.10
IUUC-Ola-086698	Oryzias latipes	52.18	2.00e-143	503.00
IUUC-Oga-089109	Otolemur garnettii	79.68	0.00e+00	752.00
IUUC-Oar-089903	Ovis aries	80.56	0.00e+00	775.00
IUUC-Ptr-091238	Pan troglodytes	88.42	0.00e+00	849.00
IUUC-Pan-092379	Papio anubis	99.80	0.00e+00	993.00
IUUC-Psi-093418	Pelodiscus sinensis	73.35	2.00e-162	565.00
IUUC-Pma-094231	Petromyzon marinus	63.60	1.00e-109	389.00
IUUC-Pno-094889	Phaeosphaeria nodorum	38.68	3.00e-41	162.00
IUUC-Pfo-097284	Poecilia formosa	51.40	1.00e-142	500.00
IUUC-Pab-098343	Pongo abelii	98.61	0.00e+00	977.00
IUUC-Pca-100905	Procavia capensis	72.64	4.00e-150	525.00
IUUC-Pva-102242	Pteropus vampyrus	79.16	0.00e+00	725.00
IUUC-Ptt-103898	Puccinia triticina	26.87	6.00e-29	122.00
IUUC-Pyt-104565	Pyrenophora triticirepentis	31.34	1.00e-38	154.00
IUUC-Rno-105899	Rattus norvegicus	85.49	0.00e+00	858.00
IUUC-Sha-107565	Sarcophilus harrisii	66.10	7.00e-142	498.00
IUUC-Sja-107742	Schizosaccharomyces japonicus	36.89	8.00e-31	128.00
IUUC-Spo-108344	Schizosaccharomyces pombe	35.03	8.00e-25	108.00
IUUC-Sar-112999	Sorex araneus	66.67	2.00e-134	472.00
IUUC-Sre-114977	Sporisorium reilianum	34.63	4.00e-35	144.00
IUUC-Ssc-115705	Sus scrofa	80.79	0.00e+00	753.00
IUUC-Tgu-116978	Taeniopygia guttata	60.64	2.00e-171	595.00
IUUC-Tsy-118988	Tarsius syrichta	83.53	0.00e+00	829.00
IUUC-Tbe-127563	Tupaia belangeri	71.18	1.00e-144	506.00
IUUC-Ttr-128875	Tursiops truncatus	78.53	0.00e+00	672.00
IUUC-Vpa-130779	Vicugna pacos	96.17	2.00e-159	555.00
IUUC-Xtr-132508	Xenopus tropicalis	54.83	7.00e-156	544.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence