iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000008436.4	ENSCAFT00000049773.2	ENSCAFP00000040642.1
ENSCAFG00000008436.4	ENSCAFT00000013398.3	ENSCAFP00000012398.3
ENSCAFG00000008436.4	ENSCAFT00000013403.4	ENSCAFP00000012403.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.61	5.00e-153	538.00	IUUC-Hsa-046179
E3 activity/RING/RING	99.61	1.00e-152	536.00	IUUC-Mmu-063206
E3 activity/RING/RING	99.61	9.00e-153	536.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

XXSKPCSKPP PPQHAPSPAA PPAAATISAA GPGSAAVPAA AAVISGPGGG GGGGGGGGAG 60
PVSPQHHELT SLFECPVCFD YVLPPILQCQ AGHLVCNQCR QKLSCCPTCR GALTPSIRNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNTAG CAAGCCGTGC 60
AGCAAGCCGC CGCCGCCCCA GCACGCCCCG TCCCCGGCTG CGCCCCCGGC CGCCGCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	99.61	1.00e-155	542.00
IUUC-Ame-011678	Astyanax mexicanus	91.70	6.00e-141	493.00
IUUC-Bta-012750	Bos taurus	99.22	8.00e-154	536.00
IUUC-Cja-019800	Callithrix jacchus	99.61	5.00e-154	536.00
IUUC-Cpo-021394	Cavia porcellus	98.84	3.00e-153	534.00
IUUC-Csa-023374	Chlorocebus sabaeus	99.61	5.00e-154	536.00
IUUC-Cho-024933	Choloepus hoffmanni	99.61	4.00e-154	536.00
IUUC-Dre-027711	Danio rerio	91.30	8.00e-141	493.00
IUUC-Dno-029260	Dasypus novemcinctus	99.59	1.00e-147	515.00
IUUC-Dor-030489	Dipodomys ordii	96.76	1.00e-107	381.00
IUUC-Ete-032946	Echinops telfairi	98.84	5.00e-156	543.00
IUUC-Eca-033546	Equus caballus	99.22	3.00e-155	540.00
IUUC-Eeu-034861	Erinaceus europaeus	95.74	4.00e-148	517.00
IUUC-Fal-037160	Ficedula albicollis	88.05	2.00e-132	464.00
IUUC-Gmo-039091	Gadus morhua	90.12	2.00e-139	488.00
IUUC-Gga-040252	Gallus gallus	97.67	2.00e-151	528.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.33	3.00e-139	487.00
IUUC-Ggo-044618	Gorilla gorilla	99.61	5.00e-154	536.00
IUUC-Hsa-046179	Homo sapiens	99.61	5.00e-154	536.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.45	6.00e-154	536.00
IUUC-Lch-049496	Latimeria chalumnae	95.33	3.00e-149	520.00
IUUC-Loc-052107	Lepisosteus oculatus	92.40	5.00e-141	493.00
IUUC-Laf-054257	Loxodonta africana	99.22	4.00e-153	533.00
IUUC-Mcc-055023	Macaca mulatta	99.61	5.00e-154	536.00
IUUC-Meu-055922	Macropus eugenii	97.65	2.00e-149	521.00
IUUC-Mga-060070	Meleagris gallopavo	96.11	7.00e-148	516.00
IUUC-Mmr-061494	Microcebus murinus	99.61	5.00e-154	536.00
IUUC-Mdo-061971	Monodelphis domestica	99.22	2.00e-153	534.00
IUUC-Mmu-063206	Mus musculus	99.61	1.00e-153	535.00
IUUC-Mpu-066597	Mustela putorius furo	99.61	5.00e-154	536.00
IUUC-Mlu-067199	Myotis lucifugus	99.22	2.00e-153	535.00
IUUC-Nle-069342	Nomascus leucogenys	99.61	5.00e-154	536.00
IUUC-Opr-070341	Ochotona princeps	56.86	5.00e-50	190.00
IUUC-Ont-071906	Oreochromis niloticus	89.72	4.00e-140	490.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	1.00e-49	189.00
IUUC-Ocu-073950	Oryctolagus cuniculus	99.23	6.00e-156	543.00
IUUC-Oga-089154	Otolemur garnettii	99.61	5.00e-154	536.00
IUUC-Oar-089446	Ovis aries	98.47	4.00e-156	543.00
IUUC-Ptr-091088	Pan troglodytes	99.61	5.00e-154	536.00
IUUC-Psi-093079	Pelodiscus sinensis	98.86	3.00e-158	550.00
IUUC-Pfo-097007	Poecilia formosa	85.77	2.00e-133	468.00
IUUC-Pab-098092	Pongo abelii	99.61	5.00e-154	536.00
IUUC-Pca-100328	Procavia capensis	96.47	6.00e-148	516.00
IUUC-Pva-102368	Pteropus vampyrus	99.11	1.00e-63	236.00
IUUC-Rno-105477	Rattus norvegicus	99.61	1.00e-153	535.00
IUUC-Sha-107630	Sarcophilus harrisii	99.24	2.00e-158	551.00
IUUC-Ssc-116441	Sus scrofa	99.22	7.00e-154	536.00
IUUC-Tru-118004	Takifugu rubripes	86.96	2.00e-134	471.00
IUUC-Tsy-119548	Tarsius syrichta	88.72	6.00e-67	246.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.54	6.00e-137	479.00
IUUC-Vpa-130799	Vicugna pacos	98.84	2.00e-103	367.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence