iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005368

UUCD1 version

UUC-AnC-01019

Ensembl Protein ID

ENSACAP00000005647.3

UniProt Accession

H9GAJ7; H9GAJ7_ANOCA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000005682.3	ENSACAT00000005770.3	ENSACAP00000005647.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-60	205.4	325	829
UBD/Alpha-Helix/UBA	3.10e-23	81.1	698	736

Active Site

Position(s)	Description	Evidence
334	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
792	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel..........wkskkk............a 67
           tG++NlgN+CY+NSv+Q++++ip++++ + + k ek+ +++p +p++++ ++++kl + l               +             
   Q: 325  TGIRNLGNSCYLNSVVQVIFSIPDFQQKYVD-KLEKIFQSSPADPTQDFNTQVAKLGHGLlsgeyskpssA----EgeqqpeqkdiqdG 408
           7******************************.8899999999******************55554444440....0445555556666* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           ++pr++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             ++++  +++F++ +++++kc
   Q: 409  IAPRMFKSLVGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSENPNEVFRFLVEEKLKC 468
           ****************************************.............................6788899************* PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
           l+ ++v+ ++   + ++lpvp++   +k                             +++cLe++ ++e++++   ++++  ++k+ a 
   Q: 469  LATEKVKYTQRVDYIMQLPVPMEAALNKDelleyeekkrqaeeekqplpelvrakvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAL 554
           *********************99988777999***************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k++++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s    +                                        
   Q: 555  KTTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPDELDISALQGTglqadeeempdiapplvtpdepkapmldesvitqlvemgf 642
           *********************997.*******************877666666666666666666666666666666666666666666 PP
   S: 268  .......................................peekqke........................................... 274
                                                  p                                                 
   Q: 643  pmdacrkavyytgnsgaeaamnwvmshmddpdfanplvlP-----Gssgpgstitcpdppsedsvativsmgfsrdqamkalratnnsl 726
           6666666666655555555555555555555555555550.....05555555555555555555666666666666666667777777 PP
   S: 275  .............................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtev 317
                                                        + kY+L+a ++H+G s+ +GHYv+++k+ + +W+ ++D+kV ++
   Q: 727  eravdwifshiddldaeaamdisegrsaaesipesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCHIKK-DSRWVIYNDQKVCAS 814
           777777777777777888888888888888888889999999999****************************.899*********999 PP
   S: 318  keeevleetgstaYvlfYkr 337
             e+  +   + +Y++fY+r
   Q: 815  --EKPPK---DLGYIYFYQR 829
           ..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +ed ++ +v+MGF+r++a +aLra+nn+le+Av++++++
   Q: 698  SEDSVATIVSMGFSRDQAMKALRATNNSLERAVDWIFSH 736
           699**********************************97 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MAELNEALLS VLPSIRVPKA GDRVHKDECA FSFDTPESDG GLYICMNTFL GFGRQYVTKH 60
YEKTGQRVYL HLKKTRKLKE EDTNSSAGDP PRKKPTRLAI GVEGGFDIPE EKYEYDEHVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAGC TGAACGAAGC GTTACTCTCT GTGCTGCCCT CCATCCGGGT GCCCAAGGCC 60
GGGGACCGCG TCCATAAGGA TGAGTGCGCC TTCTCCTTCG ATACCCCGGT AAGGCGCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	46.19	0.00e+00	677.00
IUUC-Aml-002104	Ailuropoda melanoleuca	86.22	0.00e+00	1459.00
IUUC-Apl-003774	Anas platyrhynchos	91.29	0.00e+00	1525.00
IUUC-Aly-005727	Arabidopsis lyrata	48.14	0.00e+00	758.00
IUUC-Ath-006974	Arabidopsis thaliana	48.38	0.00e+00	759.00
IUUC-Ago-007890	Ashbya gossypii	28.47	7.00e-79	288.00
IUUC-Acl-008057	Aspergillus clavatus	35.74	2.00e-128	452.00
IUUC-Afl-008547	Aspergillus flavus	36.29	3.00e-117	415.00
IUUC-Afu-008805	Aspergillus fumigatus	33.76	2.00e-117	416.00
IUUC-Ani-009441	Aspergillus nidulans	34.09	2.00e-102	366.00
IUUC-Ang-009720	Aspergillus niger	34.95	1.00e-123	437.00
IUUC-Aor-010111	Aspergillus oryzae	33.89	4.00e-127	448.00
IUUC-Ate-010531	Aspergillus terreus	32.78	1.00e-107	383.00
IUUC-Ame-011893	Astyanax mexicanus	65.62	0.00e+00	1006.00
IUUC-Bgr-012183	Blumeria graminis	35.17	3.00e-127	449.00
IUUC-Bta-013179	Bos taurus	86.19	0.00e+00	1460.00
IUUC-Bci-013858	Botrytis cinerea	35.12	2.00e-131	463.00
IUUC-Bdi-014904	Brachypodium distachyon	48.14	0.00e+00	731.00
IUUC-Bol-015536	Brassica oleracea	48.68	0.00e+00	767.00
IUUC-Bra-017939	Brassica rapa	49.04	0.00e+00	774.00
IUUC-Cel-018625	Caenorhabditis elegans	35.22	1.00e-134	473.00
IUUC-Cja-019063	Callithrix jacchus	84.71	0.00e+00	1430.00
IUUC-Cfa-020976	Canis familiaris	89.08	0.00e+00	1486.00
IUUC-Cpo-022265	Cavia porcellus	88.85	0.00e+00	1478.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.21	6.00e-117	414.00
IUUC-Csa-024177	Chlorocebus sabaeus	88.50	0.00e+00	1357.00
IUUC-Cho-024702	Choloepus hoffmanni	81.16	0.00e+00	885.00
IUUC-Cin-025411	Ciona intestinalis	51.52	0.00e+00	849.00
IUUC-Csv-026347	Ciona savignyi	47.21	0.00e+00	804.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.28	3.00e-115	409.00
IUUC-Cne-026831	Cryptococcus neoformans	35.87	2.00e-133	469.00
IUUC-Dre-027982	Danio rerio	63.70	0.00e+00	1078.00
IUUC-Dno-029034	Dasypus novemcinctus	86.78	0.00e+00	1474.00
IUUC-Dse-031467	Dothistroma septosporum	35.57	7.00e-134	471.00
IUUC-Dme-032075	Drosophila melanogaster	50.83	0.00e+00	827.00
IUUC-Ete-032865	Echinops telfairi	77.39	0.00e+00	1292.00
IUUC-Eca-034059	Equus caballus	86.62	0.00e+00	1471.00
IUUC-Eeu-035304	Erinaceus europaeus	81.82	0.00e+00	1339.00
IUUC-Fca-035515	Felis catus	86.54	0.00e+00	1467.00
IUUC-Fal-037271	Ficedula albicollis	94.54	0.00e+00	1513.00
IUUC-Fox-037745	Fusarium oxysporum	35.60	6.00e-131	461.00
IUUC-Fso-038158	Fusarium solani	35.05	1.00e-128	454.00
IUUC-Gmo-039071	Gadus morhua	64.57	0.00e+00	1078.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.21	3.00e-123	436.00
IUUC-Gga-040635	Gallus gallus	91.81	0.00e+00	1609.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.45	0.00e+00	1097.00
IUUC-Gma-043614	Glycine max	47.96	0.00e+00	733.00
IUUC-Ggo-044602	Gorilla gorilla	86.19	0.00e+00	1459.00
IUUC-Hsa-045959	Homo sapiens	86.19	0.00e+00	1459.00
IUUC-Hvu-047563	Hordeum vulgare	49.77	2.00e-175	608.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	85.26	0.00e+00	1461.00
IUUC-Kpa-049156	Komagataella pastoris	33.69	4.00e-116	412.00
IUUC-Lch-049648	Latimeria chalumnae	82.97	0.00e+00	1391.00
IUUC-Lpe-051523	Leersia perrieri	48.22	0.00e+00	736.00
IUUC-Lma-053216	Leptosphaeria maculans	33.78	2.00e-116	414.00
IUUC-Laf-054327	Loxodonta africana	85.71	0.00e+00	1454.00
IUUC-Mcc-055443	Macaca mulatta	86.30	0.00e+00	1463.00
IUUC-Meu-056298	Macropus eugenii	88.37	0.00e+00	1014.00
IUUC-Mor-057106	Magnaporthe oryzae	36.58	1.00e-132	466.00
IUUC-Mpo-057589	Magnaporthe poae	34.49	2.00e-126	446.00
IUUC-Mtr-058680	Medicago truncatula	48.98	0.00e+00	741.00
IUUC-Mla-058903	Melampsora laricipopulina	33.06	3.00e-124	439.00
IUUC-Mga-059669	Meleagris gallopavo	90.89	0.00e+00	1522.00
IUUC-Mvi-060476	Microbotryum violaceum	35.51	1.00e-126	446.00
IUUC-Mmr-060575	Microcebus murinus	85.83	0.00e+00	1459.00
IUUC-Mdo-062183	Monodelphis domestica	88.05	0.00e+00	1463.00
IUUC-Mmu-063592	Mus musculus	86.42	0.00e+00	1468.00
IUUC-Mac-065634	Musa acuminata	43.82	0.00e+00	699.00
IUUC-Mpu-066082	Mustela putorius furo	88.59	0.00e+00	1480.00
IUUC-Mlu-067345	Myotis lucifugus	84.59	0.00e+00	1446.00
IUUC-Nfi-068558	Neosartorya fischeri	35.20	3.00e-128	452.00
IUUC-Ncr-068960	Neurospora crassa	35.55	3.00e-119	422.00
IUUC-Nle-070173	Nomascus leucogenys	88.71	0.00e+00	1473.00
IUUC-Opr-070556	Ochotona princeps	85.83	0.00e+00	1470.00
IUUC-Ont-071502	Oreochromis niloticus	65.99	0.00e+00	1100.00
IUUC-Ocu-074861	Oryctolagus cuniculus	88.47	0.00e+00	1492.00
IUUC-Oba-075109	Oryza barthii	48.55	0.00e+00	740.00
IUUC-Obr-076292	Oryza brachyantha	49.64	0.00e+00	748.00
IUUC-Ogl-077065	Oryza glaberrima	49.64	0.00e+00	771.00
IUUC-Ogu-078776	Oryza glumaepatula	48.55	0.00e+00	754.00
IUUC-Oin-080048	Oryza indica	49.40	0.00e+00	763.00
IUUC-Olo-080711	Oryza longistaminata	46.84	0.00e+00	683.00
IUUC-Ome-081506	Oryza meridionalis	48.23	0.00e+00	694.00
IUUC-Oni-082320	Oryza nivara	47.58	0.00e+00	739.00
IUUC-Opu-083801	Oryza punctata	48.19	0.00e+00	730.00
IUUC-Oru-085139	Oryza rufipogon	47.58	0.00e+00	744.00
IUUC-Osa-085713	Oryza sativa	49.76	0.00e+00	773.00
IUUC-Ola-086951	Oryzias latipes	62.91	0.00e+00	1053.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.55	2.00e-180	625.00
IUUC-Oga-088625	Otolemur garnettii	85.50	0.00e+00	1450.00
IUUC-Oar-089995	Ovis aries	83.65	0.00e+00	1435.00
IUUC-Ptr-090640	Pan troglodytes	83.94	0.00e+00	1452.00
IUUC-Pan-091974	Papio anubis	85.41	0.00e+00	1444.00
IUUC-Psi-093957	Pelodiscus sinensis	90.20	0.00e+00	1617.00
IUUC-Pma-094242	Petromyzon marinus	71.80	6.00e-170	589.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.68	1.00e-109	390.00
IUUC-Ppa-095901	Physcomitrella patens	50.06	0.00e+00	810.00
IUUC-Pfo-097148	Poecilia formosa	67.14	0.00e+00	1107.00
IUUC-Pab-098068	Pongo abelii	79.60	0.00e+00	1294.00
IUUC-Pop-098943	Populus trichocarpa	47.95	0.00e+00	735.00
IUUC-Pca-100738	Procavia capensis	86.86	0.00e+00	1018.00
IUUC-Ppe-101315	Prunus persica	48.14	0.00e+00	751.00
IUUC-Pva-102154	Pteropus vampyrus	85.44	0.00e+00	1442.00
IUUC-Pgr-103343	Puccinia graminis	34.34	9.00e-109	387.00
IUUC-Ptt-103928	Puccinia triticina	30.49	1.00e-106	380.00
IUUC-Pte-104306	Pyrenophora teres	33.25	9.00e-108	384.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.97	4.00e-110	392.00
IUUC-Rno-105801	Rattus norvegicus	86.07	0.00e+00	1464.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.75	3.00e-78	286.00
IUUC-Sha-107635	Sarcophilus harrisii	89.68	0.00e+00	1480.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.69	9.00e-107	380.00
IUUC-Spo-108144	Schizosaccharomyces pombe	33.05	2.00e-116	413.00
IUUC-Smo-108848	Selaginella moellendorffii	49.39	0.00e+00	772.00
IUUC-Sit-110728	Setaria italica	48.86	0.00e+00	788.00
IUUC-Sly-111523	Solanum lycopersicum	48.62	0.00e+00	792.00
IUUC-Sbi-114419	Sorghum bicolor	48.31	0.00e+00	775.00
IUUC-Sre-115225	Sporisorium reilianum	34.62	3.00e-127	449.00
IUUC-Ssc-115686	Sus scrofa	84.55	0.00e+00	1452.00
IUUC-Tgu-117346	Taeniopygia guttata	91.82	0.00e+00	1580.00
IUUC-Tru-118350	Takifugu rubripes	61.97	0.00e+00	1087.00
IUUC-Tni-120658	Tetraodon nigroviridis	63.73	0.00e+00	1076.00
IUUC-Tca-121585	Theobroma cacao	48.22	0.00e+00	744.00
IUUC-Tre-122043	Trichoderma reesei	34.64	2.00e-122	433.00
IUUC-Tvi-122303	Trichoderma virens	34.45	9.00e-125	440.00
IUUC-Tae-125686	Triticum aestivum	49.10	0.00e+00	758.00
IUUC-Tur-126732	Triticum urartu	46.55	0.00e+00	715.00
IUUC-Tme-126909	Tuber melanosporum	35.09	3.00e-120	425.00
IUUC-Tbe-127261	Tupaia belangeri	80.87	0.00e+00	912.00
IUUC-Uma-129599	Ustilago maydis	34.56	8.00e-133	467.00
IUUC-Vda-129688	Verticillium dahliae	34.54	4.00e-121	428.00
IUUC-Vvi-131116	Vitis vinifera	47.98	0.00e+00	724.00
IUUC-Xtr-131953	Xenopus tropicalis	77.71	0.00e+00	1326.00
IUUC-Xma-133837	Xiphophorus maculatus	67.26	0.00e+00	1108.00
IUUC-Yli-134510	Yarrowia lipolytica	36.21	1.00e-130	459.00
IUUC-Zma-135786	Zea mays	48.19	0.00e+00	741.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence