iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ang-009720

Ensembl Protein ID

CAK37985

UniProt Accession

A2QFL7; A2QFL7_ASPNC

Genbank Protein ID

CAK37985.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AM270041

Gene Name

An02g14990

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
An02g14990	CAK37985	CAK37985

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-56	190.1	303	778
UBD/Alpha-Helix/UBA	3.90e-19	67.6	648	686

Active Site

Position(s)	Description	Evidence
312	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
733	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel...................wkskkkavsprellkalkkeae 82
           tGl+NlgN+CY+ Sv+QcL+++pe+++ + +  +++ +++  + p ++l ++l+kl   +                      ++k  +p ++++ +++ +e
   Q: 303  TGLTNLGNSCYLSSVVQCLFALPEFQKRYYH-PNSEPPHT--QRPAEDLETQLRKLADGIlsgrysrpdsdvrsspdsaEVPHQKGLAPAMFKHLVGRNHE 400
           7******************************.66666665..679999***********95555555555555544432255556**************** PP
   S: 83   efsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetk 183
           efs+++qqDa Ef+ +l++q++ +                           ++   +++i + F+++++++++cl+c++v  r +    +s+pvp ++  +
   Q: 401  EFSTMRQQDAFEFMLHLFKQINLSK--------------------------HPGGLDNPI-TSFGFSMQQRLQCLQCKKVRYRADAQDNISIPVPARRLPD 474
           *******************997644..........................566666666.67********************************999777 PP
   S: 184  ke...........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts..... 267
            +           +l +cL++ft+ee +e    ++c++c +    +k+ ++k+lP+ L+++  Rf  +  +++++k+n  ve+ +e +d   +++s     
   Q: 475  ANasgstneyesvTLAECLDAFTAEEVVE----FSCPSCGSTEGFNKQSSFKTLPQKLVINARRF--ELINWVPTKLNIPVEVDEEpIDFGTYLSSgpnpd 569
           6689999999999***************9....********************************..6677*************************88888 PP
   S: 268  ............................................................................peekqke.................. 274
                                                                                       +     +                  
   Q: 570  eellpdiqepentfkpneiameqlvgmgfpntrceralyvtgnsdveaamnwlfahmedpdidepldkvvtstsgsQ-----Qdpakvaqltemginsgha 665
           88888877777777777777777777777766666666666666666666666666666666666666666555550.....0555556666666666666 PP
   S: 275  ...............................................kkkYeLiavvvHsG.slssGHYvayvkn.....ekgkWllfdDskVtevkeeev 322
                                                          + kY+L ++v+H+G s++ GHYva+v++     +  +W+ f+D+kV +v+  ++
   Q: 666  rralaategdlnraidwvfthpedsmdigsdsdipessdihldsdatPAKYQLQSIVCHKGsSVHAGHYVAIVRKavpgsNGTRWVMFNDEKVVQVD--DI 764
           66666666666666777777777777777777777777777888888****************************888755666*********9995..66 PP
   S: 323  leetgstaYvlfYkr 337
           +e++ + aY++++ r
   Q: 765  QEMK-KFAYIYVFSR 778
           6643.7899998876 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           d  k++ql+eMG++  +a++aL+a+ ++l++A+++++++
   Q: 648  DPAKVAQLTEMGINSGHARRALAATEGDLNRAIDWVFTH 686
           6789*********************************98 PP

Organism

Aspergillus niger

Protein Sequence
(Fasta)

MASCCHVTSE GLRIPASSQV VYREDCTQCF DSIDEEHGLN VCLTCFNGGC AGDRNHAFLH 60
YERCSHPLAL NIKRSRKNVQ RDEPPQKISK LAIAAETDED RYVTKTRVVC YPCCQNDLDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTCTT GTTGCCATGT CACGTCTGAA GGTCAGTGAC GTCTGTTGTT AAAGCTGGAG 60
TACGGTGCTC ATACAGGTAA CTAACCATAT CTATATCGCA GGGCTGAGGA TTCCAGCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ang:ANI_1_2082024

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	31.89	5.00e-95	340.00
IUUC-Aml-002104	Ailuropoda melanoleuca	34.11	5.00e-126	443.00
IUUC-Atr-002580	Amborella trichopoda	34.14	2.00e-113	401.00
IUUC-Apl-003774	Anas platyrhynchos	34.45	2.00e-122	431.00
IUUC-Aca-005368	Anolis carolinensis	34.63	4.00e-132	463.00
IUUC-Aly-005727	Arabidopsis lyrata	34.51	3.00e-116	410.00
IUUC-Ath-006974	Arabidopsis thaliana	35.12	3.00e-118	417.00
IUUC-Ago-007890	Ashbya gossypii	32.77	3.00e-112	397.00
IUUC-Acl-008057	Aspergillus clavatus	69.21	0.00e+00	1106.00
IUUC-Afl-008547	Aspergillus flavus	71.34	0.00e+00	984.00
IUUC-Afu-008805	Aspergillus fumigatus	64.84	0.00e+00	988.00
IUUC-Ani-009441	Aspergillus nidulans	64.87	0.00e+00	909.00
IUUC-Aor-010111	Aspergillus oryzae	71.39	0.00e+00	1177.00
IUUC-Ate-010531	Aspergillus terreus	64.19	0.00e+00	1014.00
IUUC-Ame-011470	Astyanax mexicanus	31.90	4.00e-111	394.00
IUUC-Bgr-012183	Blumeria graminis	56.78	0.00e+00	915.00
IUUC-Bta-013179	Bos taurus	33.64	5.00e-124	436.00
IUUC-Bci-013858	Botrytis cinerea	59.18	0.00e+00	980.00
IUUC-Bdi-014904	Brachypodium distachyon	33.94	6.00e-103	366.00
IUUC-Bol-015536	Brassica oleracea	35.09	2.00e-115	407.00
IUUC-Bra-017939	Brassica rapa	35.17	3.00e-117	414.00
IUUC-Cel-018625	Caenorhabditis elegans	30.48	1.00e-85	309.00
IUUC-Cja-019063	Callithrix jacchus	33.91	1.00e-123	435.00
IUUC-Cfa-020976	Canis familiaris	34.68	9.00e-129	452.00
IUUC-Cpo-022265	Cavia porcellus	34.28	1.00e-127	448.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	32.59	6.00e-68	250.00
IUUC-Csa-024177	Chlorocebus sabaeus	34.75	1.00e-115	409.00
IUUC-Cho-024702	Choloepus hoffmanni	33.45	6.00e-79	286.00
IUUC-Cin-025411	Ciona intestinalis	31.91	2.00e-103	368.00
IUUC-Csv-026347	Ciona savignyi	30.46	1.00e-97	349.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	57.69	0.00e+00	868.00
IUUC-Cne-026831	Cryptococcus neoformans	43.53	2.00e-177	614.00
IUUC-Cme-027335	Cyanidioschyzon merolae	30.82	2.00e-83	302.00
IUUC-Dre-027982	Danio rerio	32.25	1.00e-105	376.00
IUUC-Dno-029034	Dasypus novemcinctus	34.10	2.00e-128	451.00
IUUC-Dor-030479	Dipodomys ordii	35.52	7.00e-57	214.00
IUUC-Dse-031467	Dothistroma septosporum	53.28	0.00e+00	848.00
IUUC-Dme-032075	Drosophila melanogaster	32.89	4.00e-111	394.00
IUUC-Ete-032865	Echinops telfairi	30.97	2.00e-103	368.00
IUUC-Eca-034059	Equus caballus	33.64	7.00e-124	436.00
IUUC-Eeu-035304	Erinaceus europaeus	34.89	4.00e-115	407.00
IUUC-Fca-035515	Felis catus	33.87	3.00e-126	444.00
IUUC-Fal-037271	Ficedula albicollis	35.56	6.00e-122	429.00
IUUC-Fox-037745	Fusarium oxysporum	57.82	0.00e+00	932.00
IUUC-Fso-038158	Fusarium solani	59.11	0.00e+00	939.00
IUUC-Gmo-039071	Gadus morhua	32.22	1.00e-109	389.00
IUUC-Ggr-040098	Gaeumannomyces graminis	56.98	0.00e+00	873.00
IUUC-Gga-040635	Gallus gallus	33.91	6.00e-128	449.00
IUUC-Gac-042528	Gasterosteus aculeatus	32.94	2.00e-110	391.00
IUUC-Gma-043614	Glycine max	34.61	3.00e-114	404.00
IUUC-Ggo-044602	Gorilla gorilla	33.87	2.00e-125	441.00
IUUC-Hsa-045959	Homo sapiens	33.87	2.00e-125	441.00
IUUC-Hvu-047563	Hordeum vulgare	35.91	7.00e-98	349.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	33.83	4.00e-126	444.00
IUUC-Kpa-049156	Komagataella pastoris	39.16	4.00e-170	589.00
IUUC-Lch-049648	Latimeria chalumnae	34.05	2.00e-119	421.00
IUUC-Lpe-051523	Leersia perrieri	33.98	9.00e-110	389.00
IUUC-Loc-052072	Lepisosteus oculatus	31.77	3.00e-113	400.00
IUUC-Lma-053216	Leptosphaeria maculans	59.14	0.00e+00	931.00
IUUC-Laf-054327	Loxodonta africana	33.64	8.00e-125	439.00
IUUC-Mcc-055443	Macaca mulatta	33.76	3.00e-125	441.00
IUUC-Meu-056298	Macropus eugenii	33.16	1.00e-83	302.00
IUUC-Mor-057106	Magnaporthe oryzae	58.14	0.00e+00	920.00
IUUC-Mpo-057589	Magnaporthe poae	57.22	0.00e+00	880.00
IUUC-Mtr-058680	Medicago truncatula	35.13	3.00e-118	417.00
IUUC-Mla-058903	Melampsora laricipopulina	42.40	3.00e-174	603.00
IUUC-Mga-059669	Meleagris gallopavo	34.28	2.00e-118	418.00
IUUC-Mvi-060476	Microbotryum violaceum	44.86	2.00e-178	617.00
IUUC-Mmr-060575	Microcebus murinus	33.68	1.00e-125	442.00
IUUC-Mdo-062183	Monodelphis domestica	34.00	5.00e-127	447.00
IUUC-Mmu-063592	Mus musculus	33.56	5.00e-126	443.00
IUUC-Mac-065634	Musa acuminata	36.01	4.00e-64	238.00
IUUC-Mpu-066082	Mustela putorius furo	34.72	9.00e-129	452.00
IUUC-Mlu-067345	Myotis lucifugus	33.60	2.00e-122	431.00
IUUC-Nfi-068558	Neosartorya fischeri	68.54	0.00e+00	1065.00
IUUC-Ncr-068960	Neurospora crassa	58.17	0.00e+00	889.00
IUUC-Nle-070173	Nomascus leucogenys	34.56	3.00e-127	447.00
IUUC-Opr-070556	Ochotona princeps	33.68	1.00e-125	442.00
IUUC-Ont-071502	Oreochromis niloticus	33.13	7.00e-113	399.00
IUUC-Oan-072959	Ornithorhynchus anatinus	41.96	9.00e-46	174.00
IUUC-Ocu-074861	Oryctolagus cuniculus	34.84	1.00e-127	448.00
IUUC-Oba-075109	Oryza barthii	34.28	2.00e-112	398.00
IUUC-Obr-076292	Oryza brachyantha	34.64	1.00e-106	379.00
IUUC-Ogl-077065	Oryza glaberrima	34.98	1.00e-117	416.00
IUUC-Ogu-078776	Oryza glumaepatula	34.41	5.00e-114	403.00
IUUC-Oin-080048	Oryza indica	34.85	4.00e-115	407.00
IUUC-Olo-080711	Oryza longistaminata	33.46	9.00e-102	362.00
IUUC-Ome-081506	Oryza meridionalis	34.20	2.00e-104	371.00
IUUC-Oni-082320	Oryza nivara	33.61	1.00e-110	392.00
IUUC-Opu-083801	Oryza punctata	33.37	3.00e-102	364.00
IUUC-Oru-085139	Oryza rufipogon	33.49	8.00e-110	389.00
IUUC-Osa-085713	Oryza sativa	35.10	6.00e-119	420.00
IUUC-Ola-086951	Oryzias latipes	31.77	2.00e-105	375.00
IUUC-Olu-087822	Ostreococcus lucimarinus	30.80	8.00e-92	330.00
IUUC-Oga-088625	Otolemur garnettii	33.53	7.00e-125	439.00
IUUC-Oar-089995	Ovis aries	33.72	5.00e-123	433.00
IUUC-Ptr-090640	Pan troglodytes	34.86	1.00e-128	452.00
IUUC-Pan-091974	Papio anubis	33.95	5.00e-125	440.00
IUUC-Psi-093957	Pelodiscus sinensis	34.49	6.00e-130	456.00
IUUC-Pma-094242	Petromyzon marinus	37.63	7.00e-66	242.00
IUUC-Pno-094835	Phaeosphaeria nodorum	59.52	0.00e+00	849.00
IUUC-Ppa-095901	Physcomitrella patens	35.84	2.00e-129	454.00
IUUC-Pfo-097148	Poecilia formosa	32.17	7.00e-111	393.00
IUUC-Pab-098068	Pongo abelii	32.10	3.00e-108	384.00
IUUC-Pop-098943	Populus trichocarpa	34.68	6.00e-114	403.00
IUUC-Pca-100738	Procavia capensis	35.16	1.00e-91	329.00
IUUC-Ppe-101315	Prunus persica	33.05	6.00e-110	390.00
IUUC-Pva-102154	Pteropus vampyrus	33.06	2.00e-121	428.00
IUUC-Pgr-103343	Puccinia graminis	43.12	3.00e-147	513.00
IUUC-Ptt-103928	Puccinia triticina	36.29	1.00e-136	478.00
IUUC-Pte-104306	Pyrenophora teres	58.86	0.00e+00	891.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	58.57	0.00e+00	908.00
IUUC-Rno-105801	Rattus norvegicus	33.87	6.00e-127	446.00
IUUC-Sce-106304	Saccharomyces cerevisiae	33.74	5.00e-118	417.00
IUUC-Sha-107635	Sarcophilus harrisii	33.93	4.00e-127	447.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	41.51	5.00e-177	612.00
IUUC-Spo-108144	Schizosaccharomyces pombe	42.55	0.00e+00	630.00
IUUC-Smo-108848	Selaginella moellendorffii	35.44	2.00e-115	408.00
IUUC-Sit-110728	Setaria italica	33.13	3.00e-113	400.00
IUUC-Sly-111523	Solanum lycopersicum	34.60	4.00e-120	424.00
IUUC-Stu-112122	Solanum tuberosum	35.42	3.00e-09	54.30
IUUC-Sar-113733	Sorex araneus	35.29	1.00e-62	233.00
IUUC-Sbi-114419	Sorghum bicolor	33.13	3.00e-110	390.00
IUUC-Sre-115225	Sporisorium reilianum	42.63	8.00e-177	612.00
IUUC-Ssc-115686	Sus scrofa	33.83	9.00e-126	442.00
IUUC-Tgu-117346	Taeniopygia guttata	33.91	8.00e-124	436.00
IUUC-Tru-118350	Takifugu rubripes	31.51	3.00e-110	391.00
IUUC-Tsy-119278	Tarsius syrichta	31.44	2.00e-92	332.00
IUUC-Tni-120658	Tetraodon nigroviridis	32.01	1.00e-105	375.00
IUUC-Tca-121585	Theobroma cacao	34.19	2.00e-110	391.00
IUUC-Tre-122043	Trichoderma reesei	57.31	0.00e+00	881.00
IUUC-Tvi-122303	Trichoderma virens	57.58	0.00e+00	908.00
IUUC-Tae-123798	Triticum aestivum	34.40	3.00e-113	400.00
IUUC-Tur-126732	Triticum urartu	31.22	1.00e-98	352.00
IUUC-Tme-126909	Tuber melanosporum	58.56	0.00e+00	917.00
IUUC-Tbe-127261	Tupaia belangeri	31.55	1.00e-44	173.00
IUUC-Ttr-128295	Tursiops truncatus	28.74	1.00e-87	316.00
IUUC-Uma-129599	Ustilago maydis	42.22	4.00e-179	619.00
IUUC-Vda-129688	Verticillium dahliae	56.70	0.00e+00	884.00
IUUC-Vpa-130170	Vicugna pacos	34.19	2.00e-49	189.00
IUUC-Vvi-131116	Vitis vinifera	33.99	4.00e-111	394.00
IUUC-Xtr-131953	Xenopus tropicalis	32.26	9.00e-109	386.00
IUUC-Xma-133837	Xiphophorus maculatus	32.29	1.00e-111	395.00
IUUC-Yli-134510	Yarrowia lipolytica	45.68	3.00e-178	616.00
IUUC-Zma-135786	Zea mays	33.50	3.00e-108	384.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence