iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006974

UUCD1 version

UUC-ArT-01612

Ensembl Protein ID

AT3G20630.1

UniProt Accession

Q8L6Y1; Q0WV77; Q9FPT0; Q9LJT6; UBP14_ARATH

Genbank Protein ID

AAG42755.1; BAB01171.1; BAB01171.1; AEE76405.1; AAM98237.1; BAE98971.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; TITAN-6 protein; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14

Genbank Nucleotide ID

AF302664; AP000410; AP002034; CP002686; AY140096; AK226894

Gene Name

UBP14; TTN6; At3g20630; F3H11_1; K10D20.17; K10D20.26

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT3G20630	AT3G20630.1	AT3G20630.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	19969521
UBD/Alpha-Helix/UBA	UBA	11576424; 11788751

Classification

Family	E-value	Score	Start	End
DUB/USP	1.70e-52	179.6	308	795
UBD/Alpha-Helix/UBA	2.50e-17	63.3	614	654

Active Site

Position(s)	Description	Evidence
317	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
758	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkekln.eenpkepkgellkslqklfeel..............w..kskkkavsprellkalkkea 81
           tGl NlgN+CY+ +++Q  ++++++ + ++++++ k++ e +p +p+ +l ++l+kl + l              +  + +++ + pr++++++++ +
   Q: 308  TGLVNLGNSCYLAATMQIVFSTHSFISRYFSHQSLKMAfEMAPADPTLDLNMQLTKLGHGLlsgkysmpatqkdaTtgDPRQEGIPPRMFKNVIAASH 405
           7************************99888856555551456789999*************7777766666555414677777*************** PP
   S: 82   eefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
            efs+++qqDa +f+ +l+ ++e++                            ++  +   s+ F++ ++++i c++ +  ++++e+ + lsl++p +
   Q: 406  AEFSSMRQQDALDFFLHLVGKVERAS---------------------------NTTPDLDPSRSFKFGIEEKILCPSGKVGYNKRED-CILSLNIPLH 475
           ************************99...........................44566668999************99888855543.5555555555 PP
   S: 180  eetkke..............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           e t+k                                l+ cL++f++ e +e+   yy++  k+ ++a k+++l+++P++L+lh+ +f + ee+++++
   Q: 476  EATNKDeleafhkqkagkgleendmrssdeivrprvPLEACLANFASSEPIED---YYSSALKGMTTAIKTTGLTSFPDYLVLHMRKF-VMEEGWVPK 569
           555444569*******************************************7...********************************.67889**** PP
   S: 248  kinkkvefpleLdlspfcts.............................................................................. 267
           k++ ++++p+ +d+s++ ++                                                                              
   Q: 570  KLDVYIDVPDVIDISHMRSKglqpgeellpdgvpeevmesaqpvaneeivaqlvsmgfsqlhcqkaaintsnagveeamnwllshmddpdidapishq 667
           ***************99999999999999999988888888888888888888888888887777777777777777777777777776666666666 PP
   S: 268  .......................peekqke.............................................kkkYeLiavvvHsG.slssGHYv 296
                                  +                                                     kY+L+++v+H+G s+++GHYv
   Q: 668  tsdidqssvdtllsfgfaedvarK-----AlkasggdiekatdwvfnnpnasvsdmdvsssnsaqtpaqsglpdgGGKYKLFGIVSHMGtSVHCGHYV 760
           666655555555555555555550.....05555555555555556666666666666667777788889999999********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           a++ + +g+W+ f+D+kV  +  ++  +   + +Yv+f++r
   Q: 761  AHILK-EGRWVIFNDDKVGIS--TDPPK---DMGYVYFFQR 795
           *****.9***********999..78889...99*****997 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++e++++qlv+MGF++ ++++a  ++ n  +e+A+++Ll++
   Q: 614  ANEEIVAQLVSMGFSQLHCQKAAINTsNAGVEEAMNWLLSH 654
           589************************************97 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Involved in seed and embryo development.

Protein Sequence
(Fasta)

MELLRSNLSR VQIPEPTHRI YKHECCISFD TPRSEGGLFV DMNSFLAFGK DYVSWNYEKT 60
GNPVYLHIKQ TRKSIPEDRP LKKPTLLAIG VDGGFDNNEP EYEESYSIVI LPDFVSLPFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCCCCAAA TTGACAACAA CTTTTGCTTT ATTGCAATTC TCCCCAAAAC CTCAGGCAAT 60
AAGAAAGGAA TTTAGAAGGA CGACGACGTT TCTCATCATC CGTACCTTCC TTGTTAAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0009793--P:embryo development ending in seed dormancy
GO:0016579--P:protein deubiquitination
GO:0048767--P:root hair elongation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT3G20630

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	65.24	0.00e+00	1018.00
IUUC-Aml-002104	Ailuropoda melanoleuca	47.02	0.00e+00	737.00
IUUC-Atr-002580	Amborella trichopoda	66.16	0.00e+00	1151.00
IUUC-Apl-003774	Anas platyrhynchos	47.69	0.00e+00	733.00
IUUC-Aca-005368	Anolis carolinensis	48.50	0.00e+00	775.00
IUUC-Aly-005727	Arabidopsis lyrata	97.74	0.00e+00	1568.00
IUUC-Ago-007890	Ashbya gossypii	27.12	4.00e-70	258.00
IUUC-Acl-008057	Aspergillus clavatus	34.47	4.00e-120	424.00
IUUC-Afl-008547	Aspergillus flavus	36.99	1.00e-114	406.00
IUUC-Afu-008805	Aspergillus fumigatus	34.33	9.00e-111	393.00
IUUC-Ani-009441	Aspergillus nidulans	34.04	7.00e-97	347.00
IUUC-Ang-009720	Aspergillus niger	35.24	2.00e-114	406.00
IUUC-Aor-010111	Aspergillus oryzae	35.02	4.00e-125	441.00
IUUC-Ate-010531	Aspergillus terreus	32.92	6.00e-100	357.00
IUUC-Ame-011470	Astyanax mexicanus	41.98	0.00e+00	657.00
IUUC-Bgr-012183	Blumeria graminis	32.64	1.00e-110	393.00
IUUC-Bta-013179	Bos taurus	47.13	0.00e+00	741.00
IUUC-Bci-013858	Botrytis cinerea	34.57	7.00e-125	440.00
IUUC-Bdi-014904	Brachypodium distachyon	70.11	0.00e+00	1117.00
IUUC-Bol-015536	Brassica oleracea	90.11	0.00e+00	1468.00
IUUC-Bra-017939	Brassica rapa	90.84	0.00e+00	1477.00
IUUC-Cel-018625	Caenorhabditis elegans	34.14	1.00e-121	430.00
IUUC-Cja-019063	Callithrix jacchus	46.90	0.00e+00	733.00
IUUC-Cfa-020976	Canis familiaris	48.67	0.00e+00	756.00
IUUC-Cpo-022265	Cavia porcellus	48.44	0.00e+00	757.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.12	4.00e-113	401.00
IUUC-Csa-024177	Chlorocebus sabaeus	48.64	0.00e+00	666.00
IUUC-Cho-024702	Choloepus hoffmanni	41.15	2.00e-113	402.00
IUUC-Cin-025411	Ciona intestinalis	42.33	7.00e-178	617.00
IUUC-Csv-026347	Ciona savignyi	40.15	1.00e-172	599.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.96	5.00e-112	398.00
IUUC-Cne-026831	Cryptococcus neoformans	35.81	1.00e-123	436.00
IUUC-Cme-027335	Cyanidioschyzon merolae	35.74	2.00e-38	154.00
IUUC-Dre-027982	Danio rerio	43.99	0.00e+00	645.00
IUUC-Dno-029034	Dasypus novemcinctus	47.36	0.00e+00	743.00
IUUC-Dor-030130	Dipodomys ordii	41.74	4.00e-95	341.00
IUUC-Dse-031467	Dothistroma septosporum	35.41	3.00e-118	418.00
IUUC-Dme-032075	Drosophila melanogaster	44.03	0.00e+00	652.00
IUUC-Ete-032865	Echinops telfairi	43.81	0.00e+00	657.00
IUUC-Eca-034059	Equus caballus	47.15	0.00e+00	743.00
IUUC-Eeu-035304	Erinaceus europaeus	45.02	0.00e+00	668.00
IUUC-Fca-035515	Felis catus	47.25	0.00e+00	743.00
IUUC-Fal-037271	Ficedula albicollis	49.24	0.00e+00	726.00
IUUC-Fox-037745	Fusarium oxysporum	36.61	2.00e-127	449.00
IUUC-Fso-038158	Fusarium solani	35.94	4.00e-122	431.00
IUUC-Gmo-039071	Gadus morhua	44.62	0.00e+00	661.00
IUUC-Ggr-040098	Gaeumannomyces graminis	35.46	2.00e-120	426.00
IUUC-Gga-040635	Gallus gallus	47.49	0.00e+00	766.00
IUUC-Gac-042528	Gasterosteus aculeatus	44.10	0.00e+00	668.00
IUUC-Gma-043614	Glycine max	75.87	0.00e+00	1208.00
IUUC-Ggo-044602	Gorilla gorilla	47.13	0.00e+00	744.00
IUUC-Hsa-045959	Homo sapiens	47.13	0.00e+00	744.00
IUUC-Hvu-047563	Hordeum vulgare	68.28	0.00e+00	873.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	47.25	0.00e+00	743.00
IUUC-Kpa-049156	Komagataella pastoris	32.45	1.00e-106	380.00
IUUC-Lch-049648	Latimeria chalumnae	48.19	0.00e+00	752.00
IUUC-Lpe-051523	Leersia perrieri	67.40	0.00e+00	1100.00
IUUC-Loc-052072	Lepisosteus oculatus	43.53	0.00e+00	670.00
IUUC-Lma-053216	Leptosphaeria maculans	34.90	3.00e-108	387.00
IUUC-Laf-054327	Loxodonta africana	47.36	0.00e+00	746.00
IUUC-Mcc-055443	Macaca mulatta	47.13	0.00e+00	744.00
IUUC-Meu-056298	Macropus eugenii	50.09	3.00e-153	535.00
IUUC-Mor-057106	Magnaporthe oryzae	35.50	2.00e-121	429.00
IUUC-Mpo-057589	Magnaporthe poae	35.42	2.00e-118	419.00
IUUC-Mtr-058680	Medicago truncatula	75.25	0.00e+00	1236.00
IUUC-Mla-058903	Melampsora laricipopulina	33.33	8.00e-109	387.00
IUUC-Mga-059669	Meleagris gallopavo	47.47	0.00e+00	723.00
IUUC-Mvi-060476	Microbotryum violaceum	33.88	2.00e-104	372.00
IUUC-Mmr-060575	Microcebus murinus	47.13	0.00e+00	742.00
IUUC-Mdo-062183	Monodelphis domestica	47.73	0.00e+00	746.00
IUUC-Mmu-063592	Mus musculus	47.25	0.00e+00	746.00
IUUC-Mac-065446	Musa acuminata	65.35	0.00e+00	1112.00
IUUC-Mpu-066082	Mustela putorius furo	48.55	0.00e+00	751.00
IUUC-Mlu-067345	Myotis lucifugus	46.90	0.00e+00	734.00
IUUC-Nfi-068558	Neosartorya fischeri	35.42	6.00e-123	434.00
IUUC-Ncr-068960	Neurospora crassa	33.37	5.00e-111	394.00
IUUC-Nle-070173	Nomascus leucogenys	48.55	0.00e+00	754.00
IUUC-Opr-070556	Ochotona princeps	47.48	0.00e+00	753.00
IUUC-Ont-071502	Oreochromis niloticus	46.05	0.00e+00	676.00
IUUC-Oan-072959	Ornithorhynchus anatinus	54.08	1.00e-70	258.00
IUUC-Ocu-074861	Oryctolagus cuniculus	48.67	0.00e+00	763.00
IUUC-Oba-075109	Oryza barthii	67.41	0.00e+00	1101.00
IUUC-Obr-076292	Oryza brachyantha	67.87	0.00e+00	1095.00
IUUC-Ogl-077065	Oryza glaberrima	69.03	0.00e+00	1146.00
IUUC-Ogu-078776	Oryza glumaepatula	67.29	0.00e+00	1120.00
IUUC-Oin-080048	Oryza indica	68.78	0.00e+00	1139.00
IUUC-Olo-080711	Oryza longistaminata	65.77	0.00e+00	1024.00
IUUC-Ome-081506	Oryza meridionalis	67.10	0.00e+00	1032.00
IUUC-Oni-082320	Oryza nivara	65.54	0.00e+00	1092.00
IUUC-Opu-083801	Oryza punctata	67.78	0.00e+00	1088.00
IUUC-Oru-085139	Oryza rufipogon	65.54	0.00e+00	1091.00
IUUC-Osa-085713	Oryza sativa	69.15	0.00e+00	1151.00
IUUC-Ola-086951	Oryzias latipes	42.86	0.00e+00	640.00
IUUC-Olu-087822	Ostreococcus lucimarinus	39.20	1.00e-162	566.00
IUUC-Oga-088625	Otolemur garnettii	47.07	0.00e+00	739.00
IUUC-Oar-089995	Ovis aries	46.72	0.00e+00	733.00
IUUC-Ptr-090640	Pan troglodytes	46.42	0.00e+00	744.00
IUUC-Pan-091974	Papio anubis	47.02	0.00e+00	736.00
IUUC-Psi-093957	Pelodiscus sinensis	47.26	0.00e+00	773.00
IUUC-Pma-094242	Petromyzon marinus	47.94	9.00e-103	365.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.85	6.00e-106	377.00
IUUC-Ppa-095901	Physcomitrella patens	64.39	0.00e+00	1077.00
IUUC-Pfo-097148	Poecilia formosa	45.81	0.00e+00	674.00
IUUC-Pab-098068	Pongo abelii	42.62	1.00e-178	619.00
IUUC-Pop-098943	Populus trichocarpa	77.88	0.00e+00	1259.00
IUUC-Pca-100738	Procavia capensis	44.55	5.00e-142	497.00
IUUC-Ppe-101315	Prunus persica	78.14	0.00e+00	1248.00
IUUC-Pva-102154	Pteropus vampyrus	46.42	0.00e+00	729.00
IUUC-Pgr-103343	Puccinia graminis	33.97	4.00e-97	348.00
IUUC-Ptt-103928	Puccinia triticina	28.10	8.00e-88	317.00
IUUC-Pte-104306	Pyrenophora teres	33.82	8.00e-101	360.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.89	7.00e-108	384.00
IUUC-Rno-105801	Rattus norvegicus	47.36	0.00e+00	746.00
IUUC-Sce-106304	Saccharomyces cerevisiae	31.49	5.00e-69	255.00
IUUC-Sha-107635	Sarcophilus harrisii	48.49	0.00e+00	748.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	33.46	2.00e-97	349.00
IUUC-Spo-108144	Schizosaccharomyces pombe	34.23	2.00e-112	399.00
IUUC-Smo-108848	Selaginella moellendorffii	61.93	0.00e+00	970.00
IUUC-Sit-110728	Setaria italica	70.95	0.00e+00	1176.00
IUUC-Sly-111523	Solanum lycopersicum	71.82	0.00e+00	1217.00
IUUC-Sar-113733	Sorex araneus	46.23	1.00e-95	343.00
IUUC-Sbi-114419	Sorghum bicolor	70.61	0.00e+00	1158.00
IUUC-Sre-115225	Sporisorium reilianum	33.26	2.00e-108	386.00
IUUC-Ssc-115686	Sus scrofa	46.89	0.00e+00	739.00
IUUC-Tgu-117346	Taeniopygia guttata	47.55	0.00e+00	750.00
IUUC-Tru-118350	Takifugu rubripes	43.85	0.00e+00	666.00
IUUC-Tsy-119278	Tarsius syrichta	39.14	7.00e-159	553.00
IUUC-Tni-120658	Tetraodon nigroviridis	43.99	0.00e+00	653.00
IUUC-Tca-121585	Theobroma cacao	78.54	0.00e+00	1261.00
IUUC-Tre-122043	Trichoderma reesei	35.54	3.00e-116	412.00
IUUC-Tvi-122303	Trichoderma virens	36.76	3.00e-123	435.00
IUUC-Tae-123798	Triticum aestivum	69.61	0.00e+00	1139.00
IUUC-Tur-126732	Triticum urartu	65.13	0.00e+00	1063.00
IUUC-Tme-126909	Tuber melanosporum	33.98	3.00e-104	372.00
IUUC-Tbe-127261	Tupaia belangeri	40.07	1.00e-118	419.00
IUUC-Ttr-128295	Tursiops truncatus	37.63	5.00e-162	564.00
IUUC-Uma-129599	Ustilago maydis	33.07	6.00e-115	407.00
IUUC-Vda-129688	Verticillium dahliae	34.83	2.00e-116	412.00
IUUC-Vpa-130170	Vicugna pacos	36.86	4.00e-141	494.00
IUUC-Vvi-131116	Vitis vinifera	76.49	0.00e+00	1227.00
IUUC-Xtr-131953	Xenopus tropicalis	46.14	0.00e+00	716.00
IUUC-Xma-133837	Xiphophorus maculatus	45.81	0.00e+00	674.00
IUUC-Yli-134510	Yarrowia lipolytica	33.71	1.00e-107	383.00
IUUC-Zma-135786	Zea mays	68.49	0.00e+00	1117.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence