iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055353

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

JSUE03037886

Gene Name

OTUD7A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000012838.3	ENSMMUT00000018009.3	ENSMMUP00000016862.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.30e-40	140.1	200	374
UBD/ZnF/ZnF_A20	2.70e-15	57.1	883	917

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek....edekefcqklvepe.....ak.g.. 77
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++++r+ +++++ k+++++++++++k    e+e++++ kl+++e     +k g  
   Q: 200  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYTMMRTGAEREALKRRWRWQQTQQNKeeewEREWTELLKLASSEprthfSKnGgt 288
           6899********************************************************999999************88777444377 PP
   S: 78   ...............eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
                          ee+h+f+La+iL+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++aLv++
   Q: 289  gggvdnsedpvyeslEEFHVFVLAHILRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPPNRcHCSPLVLAYDQAHFSALVSM 374
           899********************************************************************************986 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrrr 35
           p++++C++ +C+fYG++et++yCS+Cyreelrrrr
   Q: 883  PAQRRCQReNCAFYGRAETEHYCSYCYREELRRRR 917
           99*******************************97 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MVSSVLPNPT SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL 60
SDYEQLRQVH TANLPHVFNE GRGPKQPERE PQPGHKVERP CPQRQDDIAQ EKRLSRGISH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTTTCTA GTGTGCTTCC AAACCCCACC TCGGCTGAGT GTTGGGCAGC ACTTCTACAT 60
GATCCTATGA CTCTTGATAT GGACGCAGTC CTGTCAGACT TTGTTCGGTC CACAGGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001551	Ailuropoda melanoleuca	97.46	0.00e+00	1026.00
IUUC-Apl-003825	Anas platyrhynchos	72.55	0.00e+00	1149.00
IUUC-Aca-004392	Anolis carolinensis	74.65	0.00e+00	1162.00
IUUC-Ame-011052	Astyanax mexicanus	82.26	0.00e+00	975.00
IUUC-Bta-013296	Bos taurus	88.95	0.00e+00	1231.00
IUUC-Bol-015805	Brassica oleracea	34.21	3.90e-01	30.00
IUUC-Cja-019141	Callithrix jacchus	95.18	0.00e+00	1085.00
IUUC-Cfa-020447	Canis familiaris	96.18	0.00e+00	1109.00
IUUC-Cpo-022059	Cavia porcellus	95.17	0.00e+00	960.00
IUUC-Csa-023263	Chlorocebus sabaeus	98.53	0.00e+00	1132.00
IUUC-Cho-024611	Choloepus hoffmanni	84.97	1.00e-161	563.00
IUUC-Dre-028617	Danio rerio	80.45	0.00e+00	959.00
IUUC-Dno-029121	Dasypus novemcinctus	90.55	0.00e+00	1028.00
IUUC-Ete-033068	Echinops telfairi	74.39	0.00e+00	1031.00
IUUC-Eca-034413	Equus caballus	96.98	0.00e+00	1062.00
IUUC-Fca-036487	Felis catus	91.48	0.00e+00	982.00
IUUC-Fal-037145	Ficedula albicollis	77.22	0.00e+00	1153.00
IUUC-Gmo-038786	Gadus morhua	63.56	0.00e+00	975.00
IUUC-Gga-040512	Gallus gallus	76.97	0.00e+00	1199.00
IUUC-Gac-041599	Gasterosteus aculeatus	68.78	0.00e+00	1058.00
IUUC-Ggo-044819	Gorilla gorilla	94.50	0.00e+00	1320.00
IUUC-Hsa-046781	Homo sapiens	95.94	0.00e+00	1437.00
IUUC-Itr-047999	Ictidomys tridecemlineatus	89.08	0.00e+00	752.00
IUUC-Lch-050666	Latimeria chalumnae	72.99	0.00e+00	1105.00
IUUC-Loc-052841	Lepisosteus oculatus	70.34	0.00e+00	1114.00
IUUC-Laf-053437	Loxodonta africana	90.94	0.00e+00	1097.00
IUUC-Meu-056510	Macropus eugenii	73.29	1.00e-111	397.00
IUUC-Mga-059741	Meleagris gallopavo	74.94	0.00e+00	1166.00
IUUC-Mmr-061437	Microcebus murinus	93.46	0.00e+00	1405.00
IUUC-Mdo-061907	Monodelphis domestica	77.90	0.00e+00	1225.00
IUUC-Mmu-064074	Mus musculus	88.93	0.00e+00	1341.00
IUUC-Mpu-066004	Mustela putorius furo	94.44	0.00e+00	998.00
IUUC-Nle-069182	Nomascus leucogenys	97.95	0.00e+00	1189.00
IUUC-Opr-070701	Ochotona princeps	87.93	0.00e+00	908.00
IUUC-Ont-072431	Oreochromis niloticus	76.37	0.00e+00	955.00
IUUC-Oan-073235	Ornithorhynchus anatinus	72.31	0.00e+00	1048.00
IUUC-Ocu-073935	Oryctolagus cuniculus	95.75	0.00e+00	1047.00
IUUC-Ola-087026	Oryzias latipes	66.92	0.00e+00	1070.00
IUUC-Oga-088249	Otolemur garnettii	95.57	0.00e+00	1120.00
IUUC-Oar-089476	Ovis aries	88.90	0.00e+00	1335.00
IUUC-Ptr-090548	Pan troglodytes	98.27	0.00e+00	1039.00
IUUC-Pan-092616	Papio anubis	93.54	0.00e+00	1345.00
IUUC-Psi-093126	Pelodiscus sinensis	76.79	0.00e+00	1176.00
IUUC-Pfo-096785	Poecilia formosa	79.07	0.00e+00	936.00
IUUC-Pab-098336	Pongo abelii	93.57	0.00e+00	1252.00
IUUC-Pca-100206	Procavia capensis	83.36	0.00e+00	790.00
IUUC-Rno-105483	Rattus norvegicus	87.28	0.00e+00	972.00
IUUC-Sha-106617	Sarcophilus harrisii	86.86	0.00e+00	904.00
IUUC-Ssc-115415	Sus scrofa	91.39	0.00e+00	987.00
IUUC-Tgu-117218	Taeniopygia guttata	85.52	0.00e+00	1035.00
IUUC-Tru-118720	Takifugu rubripes	87.92	0.00e+00	845.00
IUUC-Tni-120795	Tetraodon nigroviridis	80.09	0.00e+00	922.00
IUUC-Xtr-132158	Xenopus tropicalis	68.70	0.00e+00	1149.00
IUUC-Xma-133941	Xiphophorus maculatus	79.60	0.00e+00	924.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence