iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033560

UUCD1 version

UUC-EqC-00022

Ensembl Protein ID

ENSECAP00000009554.1

UniProt Accession

F7AK40; F7AK40_HORSE

Protein Name

Uncharacterized protein

Gene Name

CUL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000011374.1	ENSECAT00000012128.1	ENSECAP00000009554.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.90e-230	766.9	15	643

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeqlLktynreWekfreqlkvlrkifay 89
           l++a+++i+r++++  ++eely+++y+++l+k+g+klY+ l+ev++e++ ++v+++v +s ++++L+t+n++W++++++++++r+i++y
   Q: 15   LKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLiNKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 103
           799*********************************************99*************************************** PP
   S: 90   ldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleat 176
           +dr+yv++ ++v++v++L+l ++r+++v++  i+++l ++ll++i++eRkge+vdr  +++++++l+ L+l+ +++y+e+FEa+fle++
   Q: 104  MDRVYVQQ-NNVENVYNLGLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMS 191
           ********.******************************************************************************** PP
   S: 177  qefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll....aelvallrdkktedlsrmykL 261
           +ef+++es++fl+en+ + Y+kkvear+nee er++++l++ste+++++vve+eli+kh+++++    ++lv++l++ ktedl++mykL
   Q: 192  AEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVemenSGLVHMLKNGKTEDLACMYKL 280
           ****************************************************************99999******************** PP
   S: 262  lsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaakspE 350
           +srv+ngl++++++++s+++eqgka++++e + k+p++y++ ll+lk++++++++e+Fnnd+ F ++++ +fe+f+n n     ++spE
   Q: 281  FSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLN-----SRSPE 364
           *******************************************************************************.....***** PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           +l+ +iD++L+k++kglte+e+e++ldk++++f++++ekdvFe+yYk+hLa+RLl++ks+s+++E+++i+kLk+ecg++ftskLe+Mf+
   Q: 365  YLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFR 453
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekentees.esvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkael. 526
           d+++S++++++F+++ ++t  s  +v+l+v+vL++g+Wpt+s+t+k+++P+  ++++e+f++fYl khsgR+L++qh++g+a+l+a++ 
   Q: 454  DMSISNTTMDEFRQHLQATGVSlGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFy 542
           ********************99889**************************************************************** PP
   S: 527  .....................kkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkepeskei 592
                                +++k++lqVstfQm++L++fnn+ek+++ee++++t++pe+eL r+lqsL+++k  ++vl+kep+skei
   Q: 543  gpvkkedgsevgvggaqvtgsNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEI 631
           *********999999998888888***************************************************************** PP
   S: 593  eeedlfsvNqef 604
           e++++f+vN++f
   Q: 632  ENGHVFTVNDQF 643
           **********99 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MTMDEKYVNS IWDLLKNAIQ EIQRKNNSGL SFEELYRNAY TMVLHKHGEK LYTGLREVVT 60
EHLINKVRED VLNSLNNNFL QTLNQAWNDH QTAMVMIRDI LMYMDRVYVQ QNNVENVYNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCATGG ATGAAAAATA TGTAAACAGC ATTTGGGACC TTCTGAAAAA TGCAATTCAA 60
GAAATCCAGC GTAAGAATAA CAGTGGTCTT AGTTTTGAGG AGCTCTATAG AAATGCATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0005827--C:polar microtubule
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0016477--P:cell migration
GO:0048208--P:COPII vesicle coating
GO:0040016--P:embryonic cleavage
GO:0044346--P:fibroblast apoptotic process
GO:0007369--P:gastrulation
GO:0007229--P:integrin-mediated signaling pathway
GO:0072576--P:liver morphogenesis
GO:0007080--P:mitotic metaphase plate congression
GO:0035024--P:negative regulation of Rho protein signal transduction
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032467--P:positive regulation of cytokinesis
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0017145--P:stem cell division
GO:0043149--P:stress fiber assembly
GO:0001831--P:trophectodermal cellular morphogenesis
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome
GO:0016055--P:Wnt signaling pathway

KEGG

ecb:100061420

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000335	Aegilops tauschii	47.07	0.00e+00	686.00
IUUC-Aml-002278	Ailuropoda melanoleuca	99.33	0.00e+00	1518.00
IUUC-Atr-002616	Amborella trichopoda	53.35	0.00e+00	771.00
IUUC-Apl-004172	Anas platyrhynchos	99.73	0.00e+00	1521.00
IUUC-Aca-004309	Anolis carolinensis	99.73	0.00e+00	1520.00
IUUC-Aly-005566	Arabidopsis lyrata	52.21	0.00e+00	768.00
IUUC-Ath-007587	Arabidopsis thaliana	52.61	0.00e+00	772.00
IUUC-Ago-007795	Ashbya gossypii	25.33	6.00e-48	185.00
IUUC-Acl-008317	Aspergillus clavatus	36.87	3.00e-145	508.00
IUUC-Afl-008727	Aspergillus flavus	36.53	6.00e-145	508.00
IUUC-Afu-008879	Aspergillus fumigatus	37.96	6.00e-133	468.00
IUUC-Ani-009393	Aspergillus nidulans	35.99	2.00e-135	476.00
IUUC-Ang-009626	Aspergillus niger	36.44	3.00e-141	496.00
IUUC-Aor-010207	Aspergillus oryzae	36.53	1.00e-144	506.00
IUUC-Ate-010305	Aspergillus terreus	37.16	1.00e-140	493.00
IUUC-Ame-011805	Astyanax mexicanus	97.45	0.00e+00	1486.00
IUUC-Bgr-012098	Blumeria graminis	36.27	3.00e-121	429.00
IUUC-Bta-013445	Bos taurus	99.87	0.00e+00	1522.00
IUUC-Bci-013612	Botrytis cinerea	36.73	2.00e-139	489.00
IUUC-Bdi-014269	Brachypodium distachyon	53.29	0.00e+00	745.00
IUUC-Bol-015350	Brassica oleracea	52.74	0.00e+00	769.00
IUUC-Bra-016763	Brassica rapa	52.88	0.00e+00	773.00
IUUC-Cel-018641	Caenorhabditis elegans	48.75	0.00e+00	718.00
IUUC-Cja-019175	Callithrix jacchus	99.73	0.00e+00	1519.00
IUUC-Cfa-020905	Canis familiaris	99.87	0.00e+00	1522.00
IUUC-Cpo-021293	Cavia porcellus	99.73	0.00e+00	1520.00
IUUC-Cre-022776	Chlamydomonas reinhardtii	48.74	0.00e+00	697.00
IUUC-Csa-023800	Chlorocebus sabaeus	99.60	0.00e+00	1518.00
IUUC-Cho-024839	Choloepus hoffmanni	98.82	0.00e+00	1354.00
IUUC-Cin-025201	Ciona intestinalis	71.74	0.00e+00	1003.00
IUUC-Csv-026107	Ciona savignyi	71.52	0.00e+00	1092.00
IUUC-Cgl-026630	Colletotrichum gloeosporioides	35.43	9.00e-125	441.00
IUUC-Cne-027048	Cryptococcus neoformans	34.80	2.00e-117	417.00
IUUC-Cme-027254	Cyanidioschyzon merolae	31.23	4.00e-88	319.00
IUUC-Dre-028488	Danio rerio	97.99	0.00e+00	1496.00
IUUC-Dno-029784	Dasypus novemcinctus	99.87	0.00e+00	1522.00
IUUC-Dor-030682	Dipodomys ordii	92.49	0.00e+00	1368.00
IUUC-Dse-031326	Dothistroma septosporum	35.74	2.00e-128	453.00
IUUC-Dme-032112	Drosophila melanogaster	69.63	0.00e+00	1076.00
IUUC-Ete-032347	Echinops telfairi	82.71	0.00e+00	1194.00
IUUC-Eeu-034502	Erinaceus europaeus	97.79	0.00e+00	1345.00
IUUC-Fca-035544	Felis catus	99.87	0.00e+00	1523.00
IUUC-Fal-036751	Ficedula albicollis	99.87	0.00e+00	1523.00
IUUC-Fox-037857	Fusarium oxysporum	36.92	1.00e-137	483.00
IUUC-Fso-038163	Fusarium solani	36.75	2.00e-141	496.00
IUUC-Gmo-039270	Gadus morhua	97.34	0.00e+00	1497.00
IUUC-Ggr-039999	Gaeumannomyces graminis	33.88	5.00e-128	451.00
IUUC-Gga-040329	Gallus gallus	99.73	0.00e+00	1521.00
IUUC-Gac-041510	Gasterosteus aculeatus	97.34	0.00e+00	1490.00
IUUC-Gma-043659	Glycine max	53.08	0.00e+00	746.00
IUUC-Ggo-044903	Gorilla gorilla	99.46	0.00e+00	1513.00
IUUC-Hsa-046000	Homo sapiens	99.60	0.00e+00	1518.00
IUUC-Hvu-047831	Hordeum vulgare	52.46	0.00e+00	701.00
IUUC-Itr-049067	Ictidomys tridecemlineatus	99.78	0.00e+00	942.00
IUUC-Kpa-049372	Komagataella pastoris	34.94	2.00e-115	409.00
IUUC-Lch-050458	Latimeria chalumnae	99.60	0.00e+00	1516.00
IUUC-Lpe-051396	Leersia perrieri	52.62	0.00e+00	756.00
IUUC-Loc-052186	Lepisosteus oculatus	99.33	0.00e+00	1516.00
IUUC-Lma-053030	Leptosphaeria maculans	38.55	5.00e-144	504.00
IUUC-Laf-053684	Loxodonta africana	99.87	0.00e+00	1523.00
IUUC-Mcc-055770	Macaca mulatta	99.60	0.00e+00	1518.00
IUUC-Meu-056852	Macropus eugenii	99.73	0.00e+00	762.00
IUUC-Mor-057273	Magnaporthe oryzae	34.76	4.00e-133	468.00
IUUC-Mpo-057403	Magnaporthe poae	34.00	9.00e-130	457.00
IUUC-Mtr-058317	Medicago truncatula	52.21	0.00e+00	751.00
IUUC-Mla-059055	Melampsora laricipopulina	37.40	3.00e-133	469.00
IUUC-Mga-060076	Meleagris gallopavo	98.12	0.00e+00	1489.00
IUUC-Mvi-060470	Microbotryum violaceum	33.64	1.00e-135	477.00
IUUC-Mmr-060976	Microcebus murinus	99.87	0.00e+00	1522.00
IUUC-Mdo-062741	Monodelphis domestica	99.87	0.00e+00	1522.00
IUUC-Mmu-063905	Mus musculus	99.60	0.00e+00	1518.00
IUUC-Mac-064718	Musa acuminata	51.48	0.00e+00	730.00
IUUC-Mpu-066356	Mustela putorius furo	99.87	0.00e+00	1523.00
IUUC-Mlu-067768	Myotis lucifugus	99.33	0.00e+00	1517.00
IUUC-Nfi-068285	Neosartorya fischeri	37.20	1.00e-146	513.00
IUUC-Ncr-068883	Neurospora crassa	36.54	2.00e-138	486.00
IUUC-Nle-069638	Nomascus leucogenys	99.60	0.00e+00	1517.00
IUUC-Opr-070333	Ochotona princeps	90.75	0.00e+00	1270.00
IUUC-Ont-071601	Oreochromis niloticus	98.53	0.00e+00	1540.00
IUUC-Oan-073281	Ornithorhynchus anatinus	99.68	0.00e+00	1303.00
IUUC-Ocu-074504	Oryctolagus cuniculus	99.87	0.00e+00	1523.00
IUUC-Oba-075332	Oryza barthii	53.04	0.00e+00	748.00
IUUC-Obr-076435	Oryza brachyantha	53.12	0.00e+00	716.00
IUUC-Ogl-077655	Oryza glaberrima	53.02	0.00e+00	757.00
IUUC-Ogu-078458	Oryza glumaepatula	53.04	0.00e+00	749.00
IUUC-Oin-079567	Oryza indica	52.89	0.00e+00	755.00
IUUC-Olo-080930	Oryza longistaminata	53.02	0.00e+00	758.00
IUUC-Ome-081353	Oryza meridionalis	53.02	0.00e+00	757.00
IUUC-Oni-082378	Oryza nivara	53.02	0.00e+00	757.00
IUUC-Opu-084055	Oryza punctata	53.02	0.00e+00	758.00
IUUC-Oru-084202	Oryza rufipogon	53.04	0.00e+00	749.00
IUUC-Osa-085290	Oryza sativa	53.02	0.00e+00	757.00
IUUC-Ola-087562	Oryzias latipes	98.26	0.00e+00	1502.00
IUUC-Olu-087866	Ostreococcus lucimarinus	37.79	1.00e-139	489.00
IUUC-Oga-088833	Otolemur garnettii	99.87	0.00e+00	1523.00
IUUC-Oar-089958	Ovis aries	99.87	0.00e+00	1523.00
IUUC-Ptr-091013	Pan troglodytes	99.60	0.00e+00	1518.00
IUUC-Pan-091796	Papio anubis	98.93	0.00e+00	1506.00
IUUC-Psi-093564	Pelodiscus sinensis	98.12	0.00e+00	1486.00
IUUC-Pno-094939	Phaeosphaeria nodorum	38.22	2.00e-138	486.00
IUUC-Ppa-095920	Physcomitrella patens	52.68	0.00e+00	765.00
IUUC-Pfo-097498	Poecilia formosa	93.97	0.00e+00	1486.00
IUUC-Pab-098164	Pongo abelii	99.60	0.00e+00	1518.00
IUUC-Pop-099497	Populus trichocarpa	53.95	0.00e+00	787.00
IUUC-Pca-100702	Procavia capensis	91.69	0.00e+00	1348.00
IUUC-Ppe-101271	Prunus persica	52.88	0.00e+00	743.00
IUUC-Pva-103129	Pteropus vampyrus	100.00	0.00e+00	1522.00
IUUC-Pgr-103684	Puccinia graminis	36.44	2.00e-110	394.00
IUUC-Ptt-103961	Puccinia triticina	36.62	1.00e-109	390.00
IUUC-Pte-104325	Pyrenophora teres	38.06	8.00e-136	477.00
IUUC-Pyt-104746	Pyrenophora triticirepentis	37.09	7.00e-134	471.00
IUUC-Rno-105935	Rattus norvegicus	99.73	0.00e+00	1521.00
IUUC-Sce-106354	Saccharomyces cerevisiae	26.88	7.00e-53	202.00
IUUC-Sha-106569	Sarcophilus harrisii	99.42	0.00e+00	1385.00
IUUC-Sja-107676	Schizosaccharomyces japonicus	38.75	3.00e-154	538.00
IUUC-Spo-108135	Schizosaccharomyces pombe	37.91	6.00e-138	484.00
IUUC-Smo-109555	Selaginella moellendorffii	53.62	0.00e+00	790.00
IUUC-Sit-110763	Setaria italica	53.69	0.00e+00	761.00
IUUC-Sly-111090	Solanum lycopersicum	52.34	0.00e+00	763.00
IUUC-Stu-112351	Solanum tuberosum	52.48	0.00e+00	765.00
IUUC-Sar-113144	Sorex araneus	100.00	0.00e+00	1119.00
IUUC-Sbi-114690	Sorghum bicolor	52.89	0.00e+00	760.00
IUUC-Sre-115005	Sporisorium reilianum	38.04	3.00e-135	476.00
IUUC-Ssc-116053	Sus scrofa	99.64	0.00e+00	1142.00
IUUC-Tgu-116523	Taeniopygia guttata	99.87	0.00e+00	1523.00
IUUC-Tru-118189	Takifugu rubripes	94.24	0.00e+00	1408.00
IUUC-Tsy-118962	Tarsius syrichta	93.67	0.00e+00	1390.00
IUUC-Tni-120614	Tetraodon nigroviridis	57.49	0.00e+00	874.00
IUUC-Tca-121282	Theobroma cacao	53.27	0.00e+00	768.00
IUUC-Tre-122201	Trichoderma reesei	35.88	3.00e-134	472.00
IUUC-Tvi-122321	Trichoderma virens	36.36	1.00e-134	473.00
IUUC-Tae-124292	Triticum aestivum	52.62	0.00e+00	740.00
IUUC-Tur-126800	Triticum urartu	52.48	0.00e+00	739.00
IUUC-Tme-127053	Tuber melanosporum	40.61	1.00e-156	546.00
IUUC-Tbe-127427	Tupaia belangeri	85.21	0.00e+00	1164.00
IUUC-Ttr-128662	Tursiops truncatus	97.99	0.00e+00	1481.00
IUUC-Uma-129597	Ustilago maydis	38.54	7.00e-135	474.00
IUUC-Vda-129726	Verticillium dahliae	35.26	4.00e-134	472.00
IUUC-Vpa-130809	Vicugna pacos	100.00	0.00e+00	746.00
IUUC-Vvi-131194	Vitis vinifera	52.87	0.00e+00	762.00
IUUC-Xtr-131887	Xenopus tropicalis	98.93	0.00e+00	1508.00
IUUC-Xma-133517	Xiphophorus maculatus	98.39	0.00e+00	1506.00
IUUC-Yli-134576	Yarrowia lipolytica	33.46	3.00e-111	395.00
IUUC-Zma-135030	Zea mays	53.29	0.00e+00	768.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence