iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.00e-40	138.1	17	149

Active Site

Position(s)	Description	Evidence
95	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 3    kkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeek 91
           +ke+++l++dpp+gi++ p++e dlt+++v+i+Gpe+tpY+gg+F++++ + +d+P++PPk  fltkifhPnv +nG++C+++lk  ++
   Q: 17   YKEVTTLTADPPDGIKVFPNEE-DLTDLQVTIEGPEGTPYAGGLFRMKLLLGKDFPASPPKGYFLTKIFHPNVGPNGEICVNVLK--RD 102
           79********************.9************************************************************9..** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           W++ l +++vll+i+ ll +pnpes+lneea +ll +n eey  ++r
   Q: 103  WTAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARAR 149
           ******************************************99876 PP

Organism

Rattus norvegicus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MNSNVENLPP HIIRLVYKEV TTLTADPPDG IKVFPNEEDL TDLQVTIEGP EGTPYAGGLF 60
RMKLLLGKDF PASPPKGYFL TKIFHPNVGP NGEICVNVLK RDWTAELGIR HVLLTIKCLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGGAGCGG AGCGGGCCCT CGGGGGCCTC GCTAGGGCCA CAGCGGCCGG CAGTTGGGCC 60
CCCCGCCCCG GCCGGCGGTC CGAGGAGTGC AGGAAGGGGG CCGGGGGGAC CCGCCCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0010458--P:exit from mitosis
GO:0010994--P:free ubiquitin chain polymerization
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:292588

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000818	Aegilops tauschii	53.57	3.00e-49	187.00
IUUC-Aml-001979	Ailuropoda melanoleuca	92.12	3.00e-92	330.00
IUUC-Atr-002706	Amborella trichopoda	64.24	1.00e-47	182.00
IUUC-Aca-004432	Anolis carolinensis	79.21	8.00e-89	319.00
IUUC-Aly-005779	Arabidopsis lyrata	64.10	1.00e-57	216.00
IUUC-Ath-007162	Arabidopsis thaliana	64.74	6.00e-58	217.00
IUUC-Acl-008107	Aspergillus clavatus	50.40	1.00e-33	137.00
IUUC-Afl-008578	Aspergillus flavus	56.88	4.00e-34	139.00
IUUC-Afu-009034	Aspergillus fumigatus	52.34	2.00e-34	139.00
IUUC-Ani-009151	Aspergillus nidulans	51.94	2.00e-35	143.00
IUUC-Ang-009649	Aspergillus niger	50.77	2.00e-35	143.00
IUUC-Ame-010836	Astyanax mexicanus	68.47	2.00e-77	281.00
IUUC-Bta-012740	Bos taurus	99.35	1.00e-88	318.00
IUUC-Bdi-014057	Brachypodium distachyon	64.24	2.00e-48	185.00
IUUC-Bol-015087	Brassica oleracea	55.84	4.00e-58	217.00
IUUC-Bra-016867	Brassica rapa	55.84	2.00e-58	219.00
IUUC-Cja-019763	Callithrix jacchus	92.61	2.00e-99	354.00
IUUC-Cfa-020216	Canis familiaris	92.12	1.00e-93	335.00
IUUC-Cpo-021720	Cavia porcellus	82.84	6.00e-91	326.00
IUUC-Cre-022676	Chlamydomonas reinhardtii	60.93	9.00e-56	208.00
IUUC-Csa-023751	Chlorocebus sabaeus	93.10	9.00e-100	355.00
IUUC-Cho-024620	Choloepus hoffmanni	97.35	9.00e-63	231.00
IUUC-Cin-025632	Ciona intestinalis	57.42	7.00e-66	243.00
IUUC-Csv-025984	Ciona savignyi	66.03	1.00e-62	232.00
IUUC-Cne-026844	Cryptococcus neoformans	54.05	1.00e-47	182.00
IUUC-Cme-027294	Cyanidioschyzon merolae	51.30	4.00e-52	197.00
IUUC-Dre-027674	Danio rerio	67.49	9.00e-78	282.00
IUUC-Dno-029886	Dasypus novemcinctus	92.12	2.00e-89	321.00
IUUC-Dor-030440	Dipodomys ordii	93.60	9.00e-103	365.00
IUUC-Dse-031211	Dothistroma septosporum	47.90	6.00e-32	129.00
IUUC-Dme-031888	Drosophila melanogaster	66.88	3.00e-62	231.00
IUUC-Ete-032365	Echinops telfairi	84.42	3.00e-62	230.00
IUUC-Eca-033733	Equus caballus	90.64	2.00e-92	331.00
IUUC-Eeu-035342	Erinaceus europaeus	97.40	1.00e-86	311.00
IUUC-Fca-035964	Felis catus	99.09	3.00e-62	231.00
IUUC-Gmo-039357	Gadus morhua	67.82	2.00e-76	278.00
IUUC-Gga-040261	Gallus gallus	64.94	1.00e-49	188.00
IUUC-Gac-042593	Gasterosteus aculeatus	67.98	6.00e-78	283.00
IUUC-Gma-043597	Glycine max	63.58	1.00e-57	216.00
IUUC-Ggo-044626	Gorilla gorilla	91.56	2.00e-70	257.00
IUUC-Hsa-046058	Homo sapiens	93.60	4.00e-100	356.00
IUUC-Hvu-047281	Hordeum vulgare	52.97	3.00e-49	188.00
IUUC-Itr-048739	Ictidomys tridecemlineatus	88.67	1.00e-97	348.00
IUUC-Lch-049415	Latimeria chalumnae	71.88	4.00e-60	223.00
IUUC-Lpe-050956	Leersia perrieri	45.08	5.00e-33	134.00
IUUC-Lma-052996	Leptosphaeria maculans	52.29	8.00e-32	131.00
IUUC-Laf-053337	Loxodonta africana	91.63	2.00e-92	331.00
IUUC-Mcc-055485	Macaca mulatta	83.33	3.00e-96	344.00
IUUC-Meu-056123	Macropus eugenii	96.75	7.00e-86	309.00
IUUC-Mtr-058300	Medicago truncatula	63.58	1.00e-55	209.00
IUUC-Mla-059060	Melampsora laricipopulina	54.30	2.00e-50	191.00
IUUC-Mmr-061005	Microcebus murinus	90.15	5.00e-90	323.00
IUUC-Mdo-062979	Monodelphis domestica	96.80	1.00e-68	251.00
IUUC-Mmu-063778	Mus musculus	98.01	2.00e-109	387.00
IUUC-Mac-064680	Musa acuminata	64.24	3.00e-57	215.00
IUUC-Mpu-065829	Mustela putorius furo	92.61	7.00e-98	349.00
IUUC-Mlu-067498	Myotis lucifugus	94.81	4.00e-80	290.00
IUUC-Nfi-068520	Neosartorya fischeri	52.34	3.00e-34	139.00
IUUC-Nle-069727	Nomascus leucogenys	94.09	7.00e-101	359.00
IUUC-Opr-071066	Ochotona princeps	97.37	8.00e-63	231.00
IUUC-Ont-072363	Oreochromis niloticus	67.16	9.00e-76	276.00
IUUC-Oan-073383	Ornithorhynchus anatinus	73.38	3.00e-57	213.00
IUUC-Ocu-074599	Oryctolagus cuniculus	97.74	2.00e-74	271.00
IUUC-Oba-075186	Oryza barthii	56.54	2.00e-50	192.00
IUUC-Obr-076104	Oryza brachyantha	56.54	5.00e-49	187.00
IUUC-Ogl-077835	Oryza glaberrima	64.90	2.00e-50	192.00
IUUC-Ogu-078690	Oryza glumaepatula	64.90	2.00e-50	192.00
IUUC-Oin-080215	Oryza indica	56.54	2.00e-50	192.00
IUUC-Olo-080816	Oryza longistaminata	56.54	2.00e-50	192.00
IUUC-Ome-081657	Oryza meridionalis	56.54	3.00e-50	192.00
IUUC-Oni-082601	Oryza nivara	56.54	1.00e-50	192.00
IUUC-Opu-083367	Oryza punctata	65.56	4.00e-50	191.00
IUUC-Oru-084477	Oryza rufipogon	56.54	1.00e-50	192.00
IUUC-Osa-086119	Oryza sativa	56.54	2.00e-50	192.00
IUUC-Ola-086702	Oryzias latipes	67.98	5.00e-78	283.00
IUUC-Olu-087576	Ostreococcus lucimarinus	55.26	6.00e-48	183.00
IUUC-Oga-088946	Otolemur garnettii	90.64	6.00e-94	336.00
IUUC-Oar-089564	Ovis aries	92.08	6.00e-93	333.00
IUUC-Ptr-090620	Pan troglodytes	93.56	2.00e-99	355.00
IUUC-Pan-092382	Papio anubis	83.33	4.00e-96	343.00
IUUC-Psi-093891	Pelodiscus sinensis	88.60	6.00e-60	221.00
IUUC-Pma-094344	Petromyzon marinus	82.35	9.00e-75	272.00
IUUC-Ppa-095452	Physcomitrella patens	60.00	1.00e-46	179.00
IUUC-Pfo-097288	Poecilia formosa	68.47	3.00e-78	284.00
IUUC-Pab-098506	Pongo abelii	93.10	1.00e-99	355.00
IUUC-Pop-098882	Populus trichocarpa	62.91	6.00e-57	213.00
IUUC-Pca-100749	Procavia capensis	94.09	4.00e-102	363.00
IUUC-Ppe-102084	Prunus persica	63.58	6.00e-57	213.00
IUUC-Pva-102755	Pteropus vampyrus	93.60	3.00e-100	357.00
IUUC-Pgr-103394	Puccinia graminis	54.61	6.00e-49	187.00
IUUC-Ptt-103750	Puccinia triticina	54.61	7.00e-49	187.00
IUUC-Pte-104240	Pyrenophora teres	48.46	1.00e-30	127.00
IUUC-Pyt-104483	Pyrenophora triticirepentis	40.80	4.00e-30	125.00
IUUC-Smo-108939	Selaginella moellendorffii	59.60	8.00e-46	176.00
IUUC-Sit-110303	Setaria italica	56.77	3.00e-50	192.00
IUUC-Sly-111764	Solanum lycopersicum	55.49	4.00e-57	214.00
IUUC-Stu-111968	Solanum tuberosum	55.49	4.00e-57	214.00
IUUC-Sar-113093	Sorex araneus	64.04	1.00e-61	229.00
IUUC-Sbi-114015	Sorghum bicolor	56.77	2.00e-50	191.00
IUUC-Sre-115036	Sporisorium reilianum	42.42	2.00e-33	135.00
IUUC-Tru-117716	Takifugu rubripes	68.97	4.00e-78	284.00
IUUC-Tni-120210	Tetraodon nigroviridis	68.47	9.00e-78	282.00
IUUC-Tca-121315	Theobroma cacao	55.15	2.00e-57	215.00
IUUC-Tae-124051	Triticum aestivum	53.57	3.00e-49	188.00
IUUC-Tur-126669	Triticum urartu	63.58	2.00e-48	186.00
IUUC-Tme-127125	Tuber melanosporum	44.79	1.00e-40	159.00
IUUC-Tbe-128157	Tupaia belangeri	92.16	8.00e-89	319.00
IUUC-Ttr-128593	Tursiops truncatus	93.10	3.00e-106	377.00
IUUC-Uma-129592	Ustilago maydis	48.99	4.00e-40	157.00
IUUC-Vvi-131716	Vitis vinifera	62.91	2.00e-57	215.00
IUUC-Xtr-132592	Xenopus tropicalis	76.73	4.00e-87	313.00
IUUC-Xma-133064	Xiphophorus maculatus	66.02	9.00e-70	256.00
IUUC-Yli-134575	Yarrowia lipolytica	50.00	2.00e-38	152.00
IUUC-Zma-135328	Zea mays	56.25	2.00e-50	191.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence