iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090025

Ensembl Protein ID

ENSOARP00000022484.1

UniProt Accession

W5QID2; W5QID2_SHEEP

Genbank Protein ID

ENSOARP00000022484

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01077067

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000020923.1	ENSOART00000022794.1	ENSOARP00000022484.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-42	142.9	164	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL++ kG++++viek e+d +W+++ ++++g+ Gl+P+n+v+ l+
   Q: 164  LQVVQTLYPFSSVTEEELNFDKGETMEVIEKPENDPEWWRC-RNARGQVGLVPKNYVVVLS 223
           679**************************************.5**************9886 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN IKDTLGLGRT RRKTSARDAS PTPSTDAEFP TNGGGADRIY DLSIPAVVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTCCTGCG TTCCTTTCCT TCGAGCAACT TCCTGGATCG CCACTCTCTG CTGAGATTTG 60
AATTAGATAG AATTTGGAGA ACTCCAGCAG CCTGGTGACT TCAGGTGCAG TCAGCTGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	83.68	0.00e+00	628.00
IUUC-Apl-003456	Anas platyrhynchos	80.00	3.00e-175	607.00
IUUC-Aca-005105	Anolis carolinensis	80.00	5.00e-176	610.00
IUUC-Ame-010966	Astyanax mexicanus	73.04	6.00e-159	553.00
IUUC-Bta-012424	Bos taurus	90.96	7.00e-178	616.00
IUUC-Cja-019898	Callithrix jacchus	82.89	2.00e-180	624.00
IUUC-Cfa-020830	Canis familiaris	83.95	0.00e+00	629.00
IUUC-Cpo-021487	Cavia porcellus	82.80	3.00e-175	607.00
IUUC-Csa-023693	Chlorocebus sabaeus	82.89	2.00e-180	624.00
IUUC-Dre-028334	Danio rerio	74.54	4.00e-162	563.00
IUUC-Dno-028973	Dasypus novemcinctus	81.58	2.00e-178	617.00
IUUC-Dor-031003	Dipodomys ordii	81.05	6.00e-172	596.00
IUUC-Ete-032792	Echinops telfairi	72.66	2.00e-154	538.00
IUUC-Eca-033656	Equus caballus	83.42	0.00e+00	626.00
IUUC-Fca-036347	Felis catus	83.68	0.00e+00	628.00
IUUC-Fal-037095	Ficedula albicollis	79.74	1.00e-175	608.00
IUUC-Gmo-039410	Gadus morhua	68.62	7.00e-152	530.00
IUUC-Gga-040155	Gallus gallus	80.00	2.00e-175	608.00
IUUC-Gac-041787	Gasterosteus aculeatus	70.56	5.00e-161	560.00
IUUC-Ggo-044805	Gorilla gorilla	83.16	0.00e+00	625.00
IUUC-Hsa-046585	Homo sapiens	83.16	0.00e+00	625.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	82.11	3.00e-178	617.00
IUUC-Lch-049795	Latimeria chalumnae	78.16	2.00e-170	591.00
IUUC-Loc-051985	Lepisosteus oculatus	77.11	1.00e-165	575.00
IUUC-Laf-054228	Loxodonta africana	81.53	8.00e-178	615.00
IUUC-Mcc-055402	Macaca mulatta	82.89	2.00e-180	624.00
IUUC-Mla-058934	Melampsora laricipopulina	42.19	2.00e-07	50.40
IUUC-Mga-059374	Meleagris gallopavo	80.00	2.00e-175	608.00
IUUC-Mmr-061453	Microcebus murinus	82.63	1.00e-179	622.00
IUUC-Mdo-063080	Monodelphis domestica	79.47	3.00e-175	607.00
IUUC-Mmu-063529	Mus musculus	81.32	2.00e-176	611.00
IUUC-Mpu-066815	Mustela putorius furo	83.68	0.00e+00	628.00
IUUC-Nle-069371	Nomascus leucogenys	83.16	0.00e+00	625.00
IUUC-Opr-070948	Ochotona princeps	81.70	1.00e-171	595.00
IUUC-Ont-071410	Oreochromis niloticus	70.78	1.00e-154	538.00
IUUC-Oan-073304	Ornithorhynchus anatinus	76.47	2.00e-130	458.00
IUUC-Ocu-074783	Oryctolagus cuniculus	82.63	1.00e-178	618.00
IUUC-Ola-086808	Oryzias latipes	71.21	4.00e-152	530.00
IUUC-Oga-088391	Otolemur garnettii	83.16	6.00e-180	623.00
IUUC-Ptr-090975	Pan troglodytes	83.16	0.00e+00	625.00
IUUC-Pan-092287	Papio anubis	82.89	2.00e-180	624.00
IUUC-Psi-093413	Pelodiscus sinensis	80.53	3.00e-176	610.00
IUUC-Pfo-097129	Poecilia formosa	71.43	1.00e-155	542.00
IUUC-Pab-098756	Pongo abelii	83.16	0.00e+00	625.00
IUUC-Pca-100235	Procavia capensis	70.00	8.00e-154	536.00
IUUC-Pva-102294	Pteropus vampyrus	79.74	2.00e-170	591.00
IUUC-Rno-105090	Rattus norvegicus	81.32	2.00e-176	611.00
IUUC-Sha-107521	Sarcophilus harrisii	79.47	6.00e-176	609.00
IUUC-Sit-110528	Setaria italica	52.17	8.80e-01	27.70
IUUC-Sar-113697	Sorex araneus	82.29	2.00e-176	611.00
IUUC-Ssc-115958	Sus scrofa	86.86	1.00e-157	548.00
IUUC-Tgu-116559	Taeniopygia guttata	77.89	7.00e-168	583.00
IUUC-Tru-117677	Takifugu rubripes	71.39	9.00e-154	536.00
IUUC-Tni-120434	Tetraodon nigroviridis	73.64	2.00e-157	548.00
IUUC-Tbe-127931	Tupaia belangeri	78.80	2.00e-144	505.00
IUUC-Ttr-128993	Tursiops truncatus	87.23	1.00e-180	625.00
IUUC-Xtr-132543	Xenopus tropicalis	73.75	1.00e-163	568.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence