iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000007697.1	ENSONIT00000009708.1	ENSONIP00000009702.1
ENSONIG00000007697.1	ENSONIT00000009709.1	ENSONIP00000009703.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-135	452.7	684	1015

Active Site

Position(s)	Description	Evidence
985	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+ll
   Q: 684  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVFHGKLL 770
           57899********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           d ++ ++fyk++lgk++sl+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++e+++g+t++++Lkp+G+++ Vtn+Nk+eY++
   Q: 771  DGFFIRPFYKMMLGKQISLKDMESVDSEYYNSLKWILEN---DPTE--LDLRFCIDEDNFGQTYQVDLKPSGSDMVVTNDNKKEYID 852
           *************************************99...6666..7************************************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r+ +++++q++af eGf+e+i+++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+v+  +++e+r 
   Q: 853  LVIQWRFVNRVQKQMNAFLEGFTELIQIDLIKIFDENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKVVLLMDAEKRI 939
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           ++LqFvTg+sr+P++Gfael     p+lf+i++++++d+lP+++TCfn+L+LP+Y+s e l+ekLl+A+e+++gFe
   Q: 940  RLLQFVTGTSRVPMNGFAELYgsngPQLFTIEQWGTPDKLPRAHTCFNRLDLPTYESFEDLREKLLMAVENAQGFE 1015
           ***************************************************************************8 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MAANYEPIYG LSEDEHETRV LRVKVIAGID LAKKDILGAS DPYVKLSLYV ADETRELALV 60
QTKTIKKTLN PKWNEEFYFR VCPQNHRLLF EVFDENRLAT SKNGLFHLGQ TRDDFLGQVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAACAGTGAG ACATGGTTAT ACATAACATA AAAAGAGCGA GAAAAATATA AACGACCCAC 60
TTAATTTACA CGTCCTCTTC TTATTTAATT GGCCAGCCAG GAGCGTTAGG GAAATTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	76.49	0.00e+00	1405.00
IUUC-Apl-003893	Anas platyrhynchos	78.05	0.00e+00	1453.00
IUUC-Aca-004744	Anolis carolinensis	75.75	0.00e+00	1401.00
IUUC-Aor-010053	Aspergillus oryzae	57.38	3.00e-100	358.00
IUUC-Ame-010810	Astyanax mexicanus	89.38	0.00e+00	1080.00
IUUC-Bta-012679	Bos taurus	77.84	0.00e+00	1322.00
IUUC-Cja-018732	Callithrix jacchus	78.30	0.00e+00	1500.00
IUUC-Cfa-021226	Canis familiaris	78.05	0.00e+00	1484.00
IUUC-Cpo-021671	Cavia porcellus	76.73	0.00e+00	1453.00
IUUC-Csa-023344	Chlorocebus sabaeus	76.49	0.00e+00	1481.00
IUUC-Cho-024832	Choloepus hoffmanni	94.32	0.00e+00	714.00
IUUC-Dre-027770	Danio rerio	85.24	0.00e+00	1569.00
IUUC-Dno-029466	Dasypus novemcinctus	77.84	0.00e+00	1492.00
IUUC-Dor-030138	Dipodomys ordii	74.49	0.00e+00	1362.00
IUUC-Dme-032166	Drosophila melanogaster	68.34	0.00e+00	719.00
IUUC-Ete-033145	Echinops telfairi	72.07	0.00e+00	1058.00
IUUC-Eca-033445	Equus caballus	77.88	0.00e+00	1312.00
IUUC-Eeu-035247	Erinaceus europaeus	76.31	0.00e+00	1176.00
IUUC-Fca-035489	Felis catus	75.81	0.00e+00	1262.00
IUUC-Fal-037604	Ficedula albicollis	75.34	0.00e+00	1476.00
IUUC-Gmo-039674	Gadus morhua	83.56	0.00e+00	1567.00
IUUC-Gga-040703	Gallus gallus	78.03	0.00e+00	1507.00
IUUC-Gac-042020	Gasterosteus aculeatus	89.81	0.00e+00	1660.00
IUUC-Ggo-045332	Gorilla gorilla	76.82	0.00e+00	1420.00
IUUC-Hsa-045968	Homo sapiens	77.84	0.00e+00	1492.00
IUUC-Lch-050443	Latimeria chalumnae	79.36	0.00e+00	1339.00
IUUC-Loc-052662	Lepisosteus oculatus	82.62	0.00e+00	1532.00
IUUC-Laf-053850	Loxodonta africana	77.11	0.00e+00	1464.00
IUUC-Mcc-055821	Macaca mulatta	77.90	0.00e+00	1474.00
IUUC-Meu-056712	Macropus eugenii	59.77	8.00e-166	578.00
IUUC-Mga-059264	Meleagris gallopavo	62.07	0.00e+00	895.00
IUUC-Mvi-060395	Microbotryum violaceum	54.94	7.00e-153	534.00
IUUC-Mmr-060798	Microcebus murinus	73.81	0.00e+00	1361.00
IUUC-Mdo-062173	Monodelphis domestica	76.80	0.00e+00	1501.00
IUUC-Mmu-064136	Mus musculus	77.06	0.00e+00	1471.00
IUUC-Mpu-066765	Mustela putorius furo	78.32	0.00e+00	1466.00
IUUC-Mlu-067565	Myotis lucifugus	77.52	0.00e+00	1317.00
IUUC-Nle-069070	Nomascus leucogenys	75.29	0.00e+00	1421.00
IUUC-Opr-071044	Ochotona princeps	82.05	0.00e+00	1077.00
IUUC-Oan-073032	Ornithorhynchus anatinus	74.12	0.00e+00	1186.00
IUUC-Ocu-074160	Oryctolagus cuniculus	76.58	0.00e+00	1447.00
IUUC-Ola-087467	Oryzias latipes	89.76	0.00e+00	1701.00
IUUC-Oga-088460	Otolemur garnettii	76.23	0.00e+00	1303.00
IUUC-Oar-090198	Ovis aries	77.82	0.00e+00	1462.00
IUUC-Ptr-090939	Pan troglodytes	77.84	0.00e+00	1492.00
IUUC-Pan-092284	Papio anubis	77.94	0.00e+00	1491.00
IUUC-Psi-093645	Pelodiscus sinensis	77.75	0.00e+00	1484.00
IUUC-Pma-094364	Petromyzon marinus	82.74	0.00e+00	838.00
IUUC-Pfo-096768	Poecilia formosa	98.71	0.00e+00	1020.00
IUUC-Pab-098088	Pongo abelii	77.64	0.00e+00	1479.00
IUUC-Pca-100714	Procavia capensis	63.20	0.00e+00	1088.00
IUUC-Pva-102354	Pteropus vampyrus	76.24	0.00e+00	1396.00
IUUC-Pgr-103620	Puccinia graminis	53.53	4.00e-148	518.00
IUUC-Ptt-103806	Puccinia triticina	53.86	2.00e-124	440.00
IUUC-Rno-105318	Rattus norvegicus	76.41	0.00e+00	1437.00
IUUC-Sha-107482	Sarcophilus harrisii	78.18	0.00e+00	1360.00
IUUC-Ssc-115950	Sus scrofa	62.75	0.00e+00	1052.00
IUUC-Tgu-117130	Taeniopygia guttata	77.80	0.00e+00	1492.00
IUUC-Tru-118610	Takifugu rubripes	90.52	0.00e+00	1749.00
IUUC-Tsy-119492	Tarsius syrichta	73.56	0.00e+00	1327.00
IUUC-Tni-120113	Tetraodon nigroviridis	83.85	0.00e+00	1578.00
IUUC-Ttr-128235	Tursiops truncatus	90.76	0.00e+00	994.00
IUUC-Xtr-132859	Xenopus tropicalis	77.04	0.00e+00	1457.00
IUUC-Xma-133797	Xiphophorus maculatus	89.95	0.00e+00	1699.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence