iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000017610.7	ENSRNOT00000023890.7	ENSRNOP00000023890.7
ENSRNOG00000017610.7	ENSRNOT00000088624.1	ENSRNOP00000070352.1
ENSRNOG00000017610.7	ENSRNOT00000083363.1	ENSRNOP00000069274.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-135	450.8	627	958

Active Site

Position(s)	Description	Evidence
928	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 627  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 715
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 716  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 799
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 800  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 888
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 889  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 958
           *********************************************************************8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

QGESRILRVK VVSGLTSPKS EPFPCSDPYV KLSLYVADEN RELALVQTKT IKKTLNPKWN 60
EEFYFRVNPS NHRLLFEVFD ENRLTRDDFL GQVDVPLSHL PTEDPTMERP YTFKDFLLRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTATTGG TGTGTTGCTC TGCCAAAAAG GGGGGTGGGA GGCCTGTCGC GGGCGCGGAG 60
TGACAGGCAG GCTGGATGGA GCAGGTAGGA GTGGTTCACC ATCTGGCGGG GTGCGCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0045732--P:positive regulation of protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	95.33	0.00e+00	1699.00
IUUC-Apl-003893	Anas platyrhynchos	93.96	0.00e+00	1701.00
IUUC-Aca-004744	Anolis carolinensis	89.79	0.00e+00	1637.00
IUUC-Ago-007742	Ashbya gossypii	49.08	5.00e-162	565.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	49.01	2.00e-161	562.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	9.00e-164	570.00
IUUC-Ani-009259	Aspergillus nidulans	49.16	1.00e-161	563.00
IUUC-Ang-009738	Aspergillus niger	49.33	3.00e-162	565.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	1.00e-101	362.00
IUUC-Ate-010529	Aspergillus terreus	49.42	3.00e-164	572.00
IUUC-Ame-010810	Astyanax mexicanus	72.35	0.00e+00	1260.00
IUUC-Bgr-012148	Blumeria graminis	47.91	1.00e-154	540.00
IUUC-Bta-012679	Bos taurus	97.04	0.00e+00	1605.00
IUUC-Bci-013785	Botrytis cinerea	47.99	2.00e-156	546.00
IUUC-Cja-018732	Callithrix jacchus	97.09	0.00e+00	1786.00
IUUC-Cfa-021226	Canis familiaris	96.57	0.00e+00	1783.00
IUUC-Cpo-021671	Cavia porcellus	95.21	0.00e+00	1732.00
IUUC-Csa-023344	Chlorocebus sabaeus	95.20	0.00e+00	1769.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	744.00
IUUC-Csv-026098	Ciona savignyi	59.22	0.00e+00	655.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.66	9.00e-156	544.00
IUUC-Cne-026849	Cryptococcus neoformans	48.58	1.00e-158	553.00
IUUC-Dre-027770	Danio rerio	77.62	0.00e+00	1397.00
IUUC-Dno-029466	Dasypus novemcinctus	97.71	0.00e+00	1802.00
IUUC-Dor-030138	Dipodomys ordii	92.62	0.00e+00	1644.00
IUUC-Dse-031241	Dothistroma septosporum	47.86	2.00e-160	559.00
IUUC-Dme-032166	Drosophila melanogaster	67.09	0.00e+00	713.00
IUUC-Ete-033145	Echinops telfairi	89.05	0.00e+00	1285.00
IUUC-Eca-033445	Equus caballus	97.61	0.00e+00	1592.00
IUUC-Eeu-035247	Erinaceus europaeus	88.51	0.00e+00	1497.00
IUUC-Fca-035489	Felis catus	93.90	0.00e+00	1538.00
IUUC-Fal-037604	Ficedula albicollis	91.00	0.00e+00	1691.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	4.00e-159	555.00
IUUC-Fso-038393	Fusarium solani	47.41	3.00e-154	538.00
IUUC-Gmo-039674	Gadus morhua	76.47	0.00e+00	1371.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	2.00e-156	546.00
IUUC-Gga-040703	Gallus gallus	92.70	0.00e+00	1715.00
IUUC-Gac-042020	Gasterosteus aculeatus	79.73	0.00e+00	1399.00
IUUC-Ggo-045332	Gorilla gorilla	96.16	0.00e+00	1730.00
IUUC-Hsa-045968	Homo sapiens	97.09	0.00e+00	1783.00
IUUC-Lch-050443	Latimeria chalumnae	86.88	0.00e+00	1437.00
IUUC-Lpe-050915	Leersia perrieri	44.33	1.00e-91	333.00
IUUC-Loc-052662	Lepisosteus oculatus	79.80	0.00e+00	1414.00
IUUC-Laf-053850	Loxodonta africana	95.73	0.00e+00	1766.00
IUUC-Mcc-055821	Macaca mulatta	96.98	0.00e+00	1776.00
IUUC-Meu-056712	Macropus eugenii	81.61	0.00e+00	771.00
IUUC-Mor-057097	Magnaporthe oryzae	44.54	2.00e-157	549.00
IUUC-Mpo-057442	Magnaporthe poae	52.16	9.00e-146	511.00
IUUC-Mla-058996	Melampsora laricipopulina	47.32	2.00e-155	543.00
IUUC-Mvi-060395	Microbotryum violaceum	53.70	4.00e-150	525.00
IUUC-Mmr-060798	Microcebus murinus	93.25	0.00e+00	1659.00
IUUC-Mdo-062173	Monodelphis domestica	94.18	0.00e+00	1774.00
IUUC-Mmu-064136	Mus musculus	98.54	0.00e+00	1776.00
IUUC-Mpu-066765	Mustela putorius furo	96.56	0.00e+00	1762.00
IUUC-Mlu-067565	Myotis lucifugus	95.00	0.00e+00	1573.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	6.00e-164	571.00
IUUC-Ncr-068918	Neurospora crassa	47.57	1.00e-157	550.00
IUUC-Nle-069070	Nomascus leucogenys	93.14	0.00e+00	1685.00
IUUC-Opr-071044	Ochotona princeps	96.43	0.00e+00	1202.00
IUUC-Ont-072044	Oreochromis niloticus	77.05	0.00e+00	1428.00
IUUC-Oan-073032	Ornithorhynchus anatinus	92.53	0.00e+00	1441.00
IUUC-Ocu-074160	Oryctolagus cuniculus	93.66	0.00e+00	1709.00
IUUC-Oba-075252	Oryza barthii	44.58	8.00e-91	330.00
IUUC-Oin-079663	Oryza indica	44.58	6.00e-91	331.00
IUUC-Olo-080326	Oryza longistaminata	44.33	6.00e-90	327.00
IUUC-Oni-082342	Oryza nivara	44.58	8.00e-91	330.00
IUUC-Oru-084559	Oryza rufipogon	44.58	6.00e-91	330.00
IUUC-Ola-087467	Oryzias latipes	78.67	0.00e+00	1415.00
IUUC-Oga-088460	Otolemur garnettii	93.39	0.00e+00	1570.00
IUUC-Oar-090198	Ovis aries	95.94	0.00e+00	1748.00
IUUC-Ptr-090939	Pan troglodytes	97.09	0.00e+00	1783.00
IUUC-Pan-092284	Papio anubis	97.19	0.00e+00	1786.00
IUUC-Psi-093645	Pelodiscus sinensis	92.92	0.00e+00	1712.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	862.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.17	2.00e-164	573.00
IUUC-Pfo-097145	Poecilia formosa	61.48	0.00e+00	1105.00
IUUC-Pab-098088	Pongo abelii	97.19	0.00e+00	1783.00
IUUC-Pca-100714	Procavia capensis	76.68	0.00e+00	1305.00
IUUC-Pva-102354	Pteropus vampyrus	95.61	0.00e+00	1693.00
IUUC-Pgr-103620	Puccinia graminis	53.53	4.00e-148	518.00
IUUC-Ptt-103806	Puccinia triticina	53.38	7.00e-123	434.00
IUUC-Pte-104016	Pyrenophora teres	49.00	3.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	3.00e-162	565.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	3.00e-164	572.00
IUUC-Sha-107482	Sarcophilus harrisii	96.60	0.00e+00	1622.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	54.23	2.00e-150	526.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.49	7.00e-158	551.00
IUUC-Stu-112582	Solanum tuberosum	35.81	5.00e-55	209.00
IUUC-Sbi-113794	Sorghum bicolor	44.50	1.00e-92	336.00
IUUC-Ssc-115950	Sus scrofa	71.08	0.00e+00	1182.00
IUUC-Tgu-117130	Taeniopygia guttata	93.24	0.00e+00	1720.00
IUUC-Tru-118610	Takifugu rubripes	79.71	0.00e+00	1444.00
IUUC-Tsy-119492	Tarsius syrichta	92.53	0.00e+00	1642.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.23	0.00e+00	1352.00
IUUC-Tre-122203	Trichoderma reesei	45.12	8.00e-153	534.00
IUUC-Tvi-122595	Trichoderma virens	47.44	1.00e-154	540.00
IUUC-Tme-126897	Tuber melanosporum	52.69	9.00e-148	517.00
IUUC-Tbe-127441	Tupaia belangeri	90.04	0.00e+00	793.00
IUUC-Ttr-128235	Tursiops truncatus	99.28	0.00e+00	1088.00
IUUC-Vda-129753	Verticillium dahliae	47.85	2.00e-157	549.00
IUUC-Xtr-132859	Xenopus tropicalis	88.80	0.00e+00	1648.00
IUUC-Xma-133797	Xiphophorus maculatus	80.70	0.00e+00	1430.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	3.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence