iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048525

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01010823

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000009522.2	ENSSTOT00000009550.2	ENSSTOP00000008566.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	2.90e-146	488.7	953	1494

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++i+ed +++ll+l+++l+ a+R+++++++++l++++++    
   Q: 953  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRSLLHLSSRLNGALRQEQNFADHFLPDDEAA---- 1017
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve++++a       ++
   Q: 1018 ----QALGKTCWEALVSPLVQNITSPDEDGISPLgWLLDQYLECREASHNPQSRAAAFSSRVRRLTHLLVHVEPCEMA-------PP 1093
           ....**************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           +va +r k++++ +++++L++r+l+  ++++l+++++++++eq++++lt+ ++++d   +V+r++e+++ lqk++se+F+++a+Fl 
   Q: 1094 VVAAPRPKGRNRSHDWSSLATRGLPssIMRNLTRCWQAVVEEQVNNFLTSYWRDND---FVPRYCEHYYNLQKSSSELFGPRAAFLL 1177
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ ++++ s+l+aa+++E++Ar+iDq++++s ++g++++e++aql+++l+ +  +s++++   Fe+yY++++a+RLl   + 
   Q: 1178 ALQNGCAGALLRLSFLRAAHVSEQFARHIDQRIQGSrIGGARGMEMLAQLQRCLETVLNFSGLEIattFEHYYQQYMADRLLG--VG 1262
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+++l++Se+l+rqF+                                            
   Q: 1263 SSWLEGAVLEQI----GPCFPNRLpQQMLRSLSTSEELQRQFHvyqlqqldqellkledtekkiqvgheasgkehkngkeedageav 1345
           ************....*********************************************************************** PP
   S: 453  ..........eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqhtl 517
                     e+++ ++e +++e+svlvLs+++Wp+a  +++  + ++LP++l+ t++++++fY        le++s+R+LqW++ l
   Q: 1346 aadvvegeeeENEDLYYEGAMPEVSVLVLSPRCWPVAsiCHMlnPGTCLPSYLRGTLNRYSNFYnksqrhpaLERGSQRQLQWTW-L 1431
           ********99899999*********************999999999***************************************.* PP
   S: 518  graelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqv 582
           grae+++    g ++l+Vst+Qm++LL +nn ++vsve+l + ++lp e+L++++++L+ss+   ++
   Q: 1432 GRAEVQF----GDQTLHVSTMQMWLLLNLNNLKAVSVESLLALSGLPLEMLNQAIGPLTSSRgpLDL 1494
           *******....*************************************************9944444 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDD GEGASSQVDC 60
KAEHILLWMS DDEIYANCHK MLGEDGQVIG PSRESAEAGA LDKTVLGEME TDVKSLIQRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGGGG AACTCCGCTA CAGGGAATTC AGGGTGCCCC TTGGGCCTGG CTTGCATGCC 60
TATCCTGATG AGCTGATCCG CCAACGGGTG GGCCATGATG GGCACCCTGA GTACCAGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	86.78	0.00e+00	2767.00
IUUC-Bta-013285	Bos taurus	83.82	0.00e+00	2699.00
IUUC-Cja-019033	Callithrix jacchus	83.25	0.00e+00	2612.00
IUUC-Cfa-020695	Canis familiaris	86.89	0.00e+00	1717.00
IUUC-Cpo-021513	Cavia porcellus	80.73	0.00e+00	2532.00
IUUC-Csa-023798	Chlorocebus sabaeus	87.05	0.00e+00	2719.00
IUUC-Dno-029587	Dasypus novemcinctus	83.01	0.00e+00	1501.00
IUUC-Dor-030234	Dipodomys ordii	86.17	0.00e+00	2810.00
IUUC-Ete-032612	Echinops telfairi	78.97	0.00e+00	892.00
IUUC-Eca-033408	Equus caballus	87.61	0.00e+00	2735.00
IUUC-Fca-035483	Felis catus	86.95	0.00e+00	2753.00
IUUC-Gmo-038795	Gadus morhua	45.94	0.00e+00	939.00
IUUC-Gac-041628	Gasterosteus aculeatus	45.40	0.00e+00	1290.00
IUUC-Ggo-044721	Gorilla gorilla	86.99	0.00e+00	2725.00
IUUC-Hsa-046406	Homo sapiens	87.05	0.00e+00	2744.00
IUUC-Lch-049956	Latimeria chalumnae	43.59	0.00e+00	1035.00
IUUC-Laf-054068	Loxodonta africana	86.02	0.00e+00	2753.00
IUUC-Mcc-055464	Macaca mulatta	86.87	0.00e+00	2702.00
IUUC-Meu-056198	Macropus eugenii	55.83	0.00e+00	1588.00
IUUC-Mmr-061464	Microcebus murinus	86.27	0.00e+00	2690.00
IUUC-Mdo-062018	Monodelphis domestica	58.52	0.00e+00	1411.00
IUUC-Mmu-063413	Mus musculus	80.05	0.00e+00	2462.00
IUUC-Mpu-066146	Mustela putorius furo	88.21	0.00e+00	2712.00
IUUC-Mlu-067036	Myotis lucifugus	85.12	0.00e+00	2715.00
IUUC-Opr-070670	Ochotona princeps	78.83	0.00e+00	2479.00
IUUC-Oan-073451	Ornithorhynchus anatinus	50.11	0.00e+00	1155.00
IUUC-Ocu-074155	Oryctolagus cuniculus	85.33	0.00e+00	2682.00
IUUC-Oga-089084	Otolemur garnettii	85.97	0.00e+00	2783.00
IUUC-Oar-090029	Ovis aries	85.54	0.00e+00	2723.00
IUUC-Ptr-091282	Pan troglodytes	85.62	0.00e+00	2728.00
IUUC-Pan-091883	Papio anubis	87.10	0.00e+00	2737.00
IUUC-Pab-098383	Pongo abelii	84.00	0.00e+00	2662.00
IUUC-Pca-100519	Procavia capensis	85.31	0.00e+00	811.00
IUUC-Pva-102417	Pteropus vampyrus	83.94	0.00e+00	2161.00
IUUC-Rno-105962	Rattus norvegicus	81.82	0.00e+00	2613.00
IUUC-Sar-113750	Sorex araneus	79.90	1.00e-169	590.00
IUUC-Ssc-115899	Sus scrofa	80.12	0.00e+00	2437.00
IUUC-Tsy-118860	Tarsius syrichta	83.88	0.00e+00	1097.00
IUUC-Tbe-127660	Tupaia belangeri	82.65	0.00e+00	1409.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence