iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106553

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Nitric oxide synthase-interacting protein

Genbank Nucleotide ID

AEFK01124042

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000004689.1	ENSSHAT00000005419.1	ENSSHAP00000005366.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	7.30e-14	51.8	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G  y+r++I +++ ++++
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGFLYEREAILEYILHQKR 79
           567789*****************************88876 PP

Organism

Sarcophilus harrisii

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNVRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGFLYEREAI LEYILHQKRE IARQMKAYEK QRGAQQEERR ELSRAAAQDQ LRGFLEKEAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGACCCGT CACGGGAAGA ACTGCACCGC CGGCGCGGTA TACACATATC ACGAGAAGAA 60
AAAAGACACA GGTGATGGCA AAGGGGGCAG TTGGGGCACG GCCCTCCCCC TCGGGGTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0051001--P:negative regulation of nitric-oxide synthase activity

KEGG

shr:100932263

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	45.35	4.00e-16	79.30
IUUC-Aml-002069	Ailuropoda melanoleuca	80.38	7.00e-148	516.00
IUUC-Atr-002661	Amborella trichopoda	33.45	4.00e-31	128.00
IUUC-Aca-004630	Anolis carolinensis	75.42	8.00e-134	469.00
IUUC-Aly-006316	Arabidopsis lyrata	30.90	1.00e-31	130.00
IUUC-Ath-007000	Arabidopsis thaliana	29.53	3.00e-31	128.00
IUUC-Acl-008175	Aspergillus clavatus	33.63	1.00e-06	47.80
IUUC-Afl-008440	Aspergillus flavus	34.21	2.00e-06	46.60
IUUC-Afu-009012	Aspergillus fumigatus	34.21	6.00e-07	48.50
IUUC-Ang-009556	Aspergillus niger	33.33	2.00e-06	46.60
IUUC-Aor-009892	Aspergillus oryzae	34.21	2.00e-06	46.60
IUUC-Ate-010473	Aspergillus terreus	31.30	6.00e-05	43.10
IUUC-Ame-011874	Astyanax mexicanus	63.96	2.00e-108	384.00
IUUC-Bgr-012090	Blumeria graminis	26.00	3.00e-05	42.40
IUUC-Bta-012956	Bos taurus	83.55	3.00e-151	526.00
IUUC-Bci-013897	Botrytis cinerea	41.25	2.00e-09	56.60
IUUC-Bdi-014968	Brachypodium distachyon	30.58	2.00e-34	139.00
IUUC-Bol-015578	Brassica oleracea	29.87	4.00e-35	141.00
IUUC-Bra-017234	Brassica rapa	29.87	4.00e-35	141.00
IUUC-Cel-018637	Caenorhabditis elegans	43.16	4.00e-58	218.00
IUUC-Cja-019632	Callithrix jacchus	82.84	6.00e-150	523.00
IUUC-Cfa-020192	Canis familiaris	82.84	3.00e-149	521.00
IUUC-Cpo-021939	Cavia porcellus	83.78	8.00e-147	512.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	35.97	6.00e-46	177.00
IUUC-Csa-023802	Chlorocebus sabaeus	83.17	6.00e-150	523.00
IUUC-Cho-024637	Choloepus hoffmanni	66.36	9.00e-69	252.00
IUUC-Cin-025180	Ciona intestinalis	50.17	3.00e-83	301.00
IUUC-Csv-026206	Ciona savignyi	45.70	4.00e-43	167.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	27.18	2.00e-14	73.20
IUUC-Cne-026827	Cryptococcus neoformans	36.36	2.00e-06	46.20
IUUC-Dre-028092	Danio rerio	64.80	1.00e-114	405.00
IUUC-Dno-029501	Dasypus novemcinctus	79.28	2.00e-127	448.00
IUUC-Dor-030542	Dipodomys ordii	82.18	1.00e-149	521.00
IUUC-Dse-031188	Dothistroma septosporum	23.97	7.00e-13	67.80
IUUC-Dme-031734	Drosophila melanogaster	45.93	3.00e-78	285.00
IUUC-Eca-033577	Equus caballus	84.49	1.00e-151	528.00
IUUC-Fca-035761	Felis catus	84.16	3.00e-151	527.00
IUUC-Fox-037703	Fusarium oxysporum	28.40	1.00e-09	57.00
IUUC-Fso-038208	Fusarium solani	28.81	1.00e-10	60.10
IUUC-Gmo-038523	Gadus morhua	56.77	6.00e-60	223.00
IUUC-Ggr-040087	Gaeumannomyces graminis	39.74	1.00e-09	56.60
IUUC-Gac-042621	Gasterosteus aculeatus	59.43	2.00e-105	375.00
IUUC-Gma-042698	Glycine max	32.06	8.00e-33	133.00
IUUC-Ggo-045357	Gorilla gorilla	82.84	7.00e-150	522.00
IUUC-Hsa-046195	Homo sapiens	82.84	7.00e-150	522.00
IUUC-Hvu-047174	Hordeum vulgare	31.53	6.00e-36	144.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	82.84	1.00e-146	512.00
IUUC-Lch-050569	Latimeria chalumnae	65.58	5.00e-111	393.00
IUUC-Lpe-050992	Leersia perrieri	35.86	5.00e-23	102.00
IUUC-Loc-052522	Lepisosteus oculatus	70.85	4.00e-118	417.00
IUUC-Lma-053254	Leptosphaeria maculans	34.09	2.00e-09	56.20
IUUC-Laf-053397	Loxodonta africana	84.49	4.00e-154	536.00
IUUC-Mcc-054681	Macaca mulatta	82.84	8.00e-150	523.00
IUUC-Meu-056723	Macropus eugenii	93.02	1.00e-163	568.00
IUUC-Mor-056961	Magnaporthe oryzae	39.29	8.00e-10	57.80
IUUC-Mpo-057359	Magnaporthe poae	26.20	1.00e-07	49.70
IUUC-Mtr-058063	Medicago truncatula	32.64	1.00e-34	140.00
IUUC-Mla-059004	Melampsora laricipopulina	30.06	2.00e-27	115.00
IUUC-Mvi-060460	Microbotryum violaceum	29.55	2.00e-24	106.00
IUUC-Mmr-060847	Microcebus murinus	83.17	2.00e-150	524.00
IUUC-Mdo-062480	Monodelphis domestica	93.36	3.00e-165	573.00
IUUC-Mmu-063809	Mus musculus	83.17	3.00e-149	520.00
IUUC-Mac-064870	Musa acuminata	31.71	1.00e-33	136.00
IUUC-Mpu-066322	Mustela putorius furo	84.16	1.00e-153	535.00
IUUC-Mlu-067556	Myotis lucifugus	81.25	2.00e-146	511.00
IUUC-Nfi-068440	Neosartorya fischeri	34.21	6.00e-07	48.50
IUUC-Ncr-068898	Neurospora crassa	37.18	2.00e-07	50.10
IUUC-Nle-070049	Nomascus leucogenys	82.84	7.00e-150	522.00
IUUC-Opr-070972	Ochotona princeps	80.07	6.00e-142	496.00
IUUC-Ont-071682	Oreochromis niloticus	65.23	4.00e-114	404.00
IUUC-Oan-073296	Ornithorhynchus anatinus	100.00	9.00e-33	132.00
IUUC-Ocu-074218	Oryctolagus cuniculus	82.62	4.00e-121	427.00
IUUC-Oba-075284	Oryza barthii	31.85	1.00e-34	139.00
IUUC-Obr-076651	Oryza brachyantha	31.60	2.00e-37	148.00
IUUC-Ogl-077899	Oryza glaberrima	31.85	1.00e-34	139.00
IUUC-Ogu-078477	Oryza glumaepatula	32.19	7.00e-35	140.00
IUUC-Oin-080011	Oryza indica	31.85	2.00e-34	139.00
IUUC-Olo-080545	Oryza longistaminata	31.52	8.00e-27	114.00
IUUC-Ome-081543	Oryza meridionalis	31.85	2.00e-34	139.00
IUUC-Oni-082955	Oryza nivara	31.85	2.00e-34	139.00
IUUC-Opu-083565	Oryza punctata	31.85	5.00e-34	137.00
IUUC-Oru-084474	Oryza rufipogon	31.85	2.00e-34	139.00
IUUC-Osa-085913	Oryza sativa	31.85	2.00e-34	139.00
IUUC-Ola-086851	Oryzias latipes	65.89	4.00e-117	414.00
IUUC-Olu-087724	Ostreococcus lucimarinus	36.89	4.00e-14	71.60
IUUC-Oga-087970	Otolemur garnettii	83.22	1.00e-148	518.00
IUUC-Oar-089756	Ovis aries	80.33	2.00e-140	491.00
IUUC-Ptr-091485	Pan troglodytes	81.85	2.00e-146	511.00
IUUC-Pan-091832	Papio anubis	82.84	6.00e-150	522.00
IUUC-Pma-094551	Petromyzon marinus	63.43	2.00e-108	384.00
IUUC-Pno-094830	Phaeosphaeria nodorum	34.95	3.00e-09	55.50
IUUC-Ppa-095255	Physcomitrella patens	31.06	2.00e-32	132.00
IUUC-Pfo-096373	Poecilia formosa	63.64	3.00e-115	407.00
IUUC-Pab-098247	Pongo abelii	82.84	9.00e-150	522.00
IUUC-Pop-099186	Populus trichocarpa	30.66	3.00e-31	128.00
IUUC-Pca-100677	Procavia capensis	79.42	6.00e-121	426.00
IUUC-Ppe-101403	Prunus persica	30.56	1.00e-32	132.00
IUUC-Pva-103000	Pteropus vampyrus	85.05	6.00e-153	533.00
IUUC-Pgr-103663	Puccinia graminis	30.96	1.00e-30	127.00
IUUC-Ptt-103712	Puccinia triticina	38.46	3.00e-08	52.40
IUUC-Pte-104287	Pyrenophora teres	27.46	2.00e-17	83.20
IUUC-Pyt-104579	Pyrenophora triticirepentis	26.69	4.00e-13	68.90
IUUC-Rno-106069	Rattus norvegicus	83.17	3.00e-149	520.00
IUUC-Smo-108874	Selaginella moellendorffii	34.01	2.00e-40	159.00
IUUC-Sit-110307	Setaria italica	31.86	1.00e-33	136.00
IUUC-Sly-111094	Solanum lycopersicum	32.87	1.00e-33	136.00
IUUC-Stu-112363	Solanum tuberosum	32.64	2.00e-33	135.00
IUUC-Sar-113480	Sorex araneus	82.39	1.00e-143	501.00
IUUC-Sbi-113939	Sorghum bicolor	32.19	4.00e-34	138.00
IUUC-Ssc-115644	Sus scrofa	84.82	2.00e-153	534.00
IUUC-Tru-118781	Takifugu rubripes	62.87	1.00e-115	409.00
IUUC-Tni-119672	Tetraodon nigroviridis	71.26	1.00e-33	133.00
IUUC-Tca-121795	Theobroma cacao	32.06	1.00e-36	146.00
IUUC-Tre-122037	Trichoderma reesei	26.44	1.00e-12	67.40
IUUC-Tvi-122524	Trichoderma virens	26.64	2.00e-17	83.20
IUUC-Tae-122828	Triticum aestivum	31.86	4.00e-36	144.00
IUUC-Tur-126387	Triticum urartu	31.13	1.00e-27	117.00
IUUC-Tme-127111	Tuber melanosporum	38.75	3.00e-09	55.80
IUUC-Ttr-128227	Tursiops truncatus	83.83	5.00e-151	526.00
IUUC-Vda-129924	Verticillium dahliae	26.36	2.00e-15	76.60
IUUC-Vpa-130802	Vicugna pacos	83.15	1.00e-39	155.00
IUUC-Vvi-131105	Vitis vinifera	32.40	8.00e-35	140.00
IUUC-Xtr-132830	Xenopus tropicalis	64.89	9.00e-121	426.00
IUUC-Xma-133618	Xiphophorus maculatus	63.73	5.00e-109	386.00
IUUC-Zma-135389	Zea mays	31.51	5.00e-32	130.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence