iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000012938.2	ENSCJAT00000025266.2	ENSCJAP00000023883.2
ENSCJAG00000012938.2	ENSCJAT00000025234.2	ENSCJAP00000023852.2
ENSCJAG00000012938.2	ENSCJAT00000025249.2	ENSCJAP00000023866.2
ENSCJAG00000012938.2	ENSCJAT00000025116.2	ENSCJAP00000023742.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.00e-07	31.1	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 65
           ********99.**************9666...68899********7 PP

Organism

Callithrix jacchus

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

MDLSAVHVEE VQNVLNAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 60
CPLCKNDITK RSLQESTRFS QLVEELLKII HAFELDTGLQ FANSYNFAKK ENNSPEHLKD 120

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Nucleotide Sequence
(Fasta)

AGCTCGCTGA GACTCTGAAT GGTGGACGGG GCGTGAGGTT TCTCAGATAA CTGGGCCCCT 60
GGTCCCAAGA GGTCCTGACG CCTGTACGCT CTGCTCTGGG TAAAGGTAAT AGAACCCCGG 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	74.05	0.00e+00	2598.00
IUUC-Apl-003252	Anas platyrhynchos	35.61	2.00e-125	444.00
IUUC-Aca-004526	Anolis carolinensis	55.56	4.00e-75	276.00
IUUC-Ame-011720	Astyanax mexicanus	47.00	2.00e-49	191.00
IUUC-Bta-013433	Bos taurus	70.71	0.00e+00	2443.00
IUUC-Cel-018208	Caenorhabditis elegans	35.44	2.00e-10	60.80
IUUC-Cfa-020322	Canis familiaris	72.46	0.00e+00	2497.00
IUUC-Cpo-021583	Cavia porcellus	46.50	0.00e+00	1319.00
IUUC-Csa-024227	Chlorocebus sabaeus	87.91	0.00e+00	636.00
IUUC-Cho-024530	Choloepus hoffmanni	68.24	0.00e+00	1204.00
IUUC-Cin-025364	Ciona intestinalis	34.06	2.00e-15	76.30
IUUC-Csv-026245	Ciona savignyi	39.74	2.00e-13	68.90
IUUC-Dno-029247	Dasypus novemcinctus	69.77	0.00e+00	2015.00
IUUC-Dme-032032	Drosophila melanogaster	54.35	7.00e-11	58.50
IUUC-Ete-032472	Echinops telfairi	55.17	0.00e+00	1675.00
IUUC-Eca-033446	Equus caballus	74.83	0.00e+00	2677.00
IUUC-Eeu-034858	Erinaceus europaeus	60.35	0.00e+00	956.00
IUUC-Fca-035991	Felis catus	74.52	0.00e+00	2621.00
IUUC-Fal-036803	Ficedula albicollis	29.56	1.00e-103	371.00
IUUC-Gmo-038782	Gadus morhua	45.31	1.00e-44	175.00
IUUC-Ggr-039833	Gaeumannomyces graminis	36.73	9.00e-08	51.60
IUUC-Gga-040969	Gallus gallus	52.55	2.00e-78	288.00
IUUC-Gac-042296	Gasterosteus aculeatus	44.17	6.00e-48	186.00
IUUC-Ggo-044740	Gorilla gorilla	84.10	0.00e+00	2939.00
IUUC-Hsa-046086	Homo sapiens	87.52	0.00e+00	3063.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	72.67	0.00e+00	2602.00
IUUC-Lch-049789	Latimeria chalumnae	37.95	1.00e-94	342.00
IUUC-Loc-051952	Lepisosteus oculatus	48.81	6.00e-68	253.00
IUUC-Laf-053648	Loxodonta africana	72.06	0.00e+00	2429.00
IUUC-Mcc-055210	Macaca mulatta	86.48	0.00e+00	3140.00
IUUC-Meu-056342	Macropus eugenii	38.43	8.00e-121	429.00
IUUC-Mor-057034	Magnaporthe oryzae	38.78	2.00e-08	53.50
IUUC-Mga-060163	Meleagris gallopavo	30.89	2.00e-104	374.00
IUUC-Mmr-061402	Microcebus murinus	73.13	0.00e+00	864.00
IUUC-Mdo-062209	Monodelphis domestica	45.20	0.00e+00	1254.00
IUUC-Mmu-064003	Mus musculus	54.98	0.00e+00	1793.00
IUUC-Mpu-065825	Mustela putorius furo	77.11	0.00e+00	795.00
IUUC-Mlu-068176	Myotis lucifugus	70.46	0.00e+00	2309.00
IUUC-Nle-069178	Nomascus leucogenys	87.68	0.00e+00	3122.00
IUUC-Opr-070574	Ochotona princeps	60.14	0.00e+00	1929.00
IUUC-Ont-072380	Oreochromis niloticus	48.28	3.00e-55	210.00
IUUC-Oan-073243	Ornithorhynchus anatinus	77.38	3.00e-35	140.00
IUUC-Ocu-074424	Oryctolagus cuniculus	68.01	0.00e+00	2315.00
IUUC-Ola-086863	Oryzias latipes	47.32	1.00e-52	202.00
IUUC-Oar-089938	Ovis aries	71.02	0.00e+00	2497.00
IUUC-Ptr-090960	Pan troglodytes	88.22	0.00e+00	3111.00
IUUC-Pan-092609	Papio anubis	86.37	0.00e+00	2768.00
IUUC-Psi-093889	Pelodiscus sinensis	30.43	1.00e-54	208.00
IUUC-Pfo-096328	Poecilia formosa	42.51	1.00e-57	218.00
IUUC-Pab-097982	Pongo abelii	88.16	0.00e+00	3143.00
IUUC-Pca-100698	Procavia capensis	66.48	0.00e+00	702.00
IUUC-Pva-102631	Pteropus vampyrus	74.69	0.00e+00	1161.00
IUUC-Rno-105879	Rattus norvegicus	54.89	0.00e+00	1756.00
IUUC-Sha-106701	Sarcophilus harrisii	38.44	0.00e+00	653.00
IUUC-Spo-108335	Schizosaccharomyces pombe	33.71	1.00e-09	58.20
IUUC-Sar-113047	Sorex araneus	62.83	0.00e+00	1484.00
IUUC-Ssc-115846	Sus scrofa	72.93	0.00e+00	2564.00
IUUC-Tgu-116785	Taeniopygia guttata	29.63	6.00e-95	343.00
IUUC-Tru-117895	Takifugu rubripes	38.79	2.00e-52	201.00
IUUC-Tsy-118885	Tarsius syrichta	58.22	0.00e+00	680.00
IUUC-Tni-119654	Tetraodon nigroviridis	44.04	1.00e-48	189.00
IUUC-Tbe-127421	Tupaia belangeri	62.00	5.00e-159	555.00
IUUC-Ttr-128685	Tursiops truncatus	73.38	0.00e+00	2441.00
IUUC-Vpa-130216	Vicugna pacos	69.16	0.00e+00	820.00
IUUC-Xtr-132398	Xenopus tropicalis	53.66	9.00e-56	213.00
IUUC-Xma-133651	Xiphophorus maculatus	52.47	4.00e-43	170.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence