iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062209

UUCD1 version

UUC-MoD-00670

Ensembl Protein ID

ENSMODP00000018933.2

UniProt Accession

F7CFT5; F7CFT5_MONDO

Protein Name

Breast cancer type 1 susceptibility protein homolog

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000015150.2	ENSMODT00000019275.2	ENSMODP00000018933.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-07	31.7	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+ ++k  +++  +CPlC+
   Q: 24   CPICLELIKE-PVSTTCDHIFCRFCMLKL-LSK--KKGPSQCPLCK 65
           ********99.**************9888.555..99999*****7 PP

Organism

Monodelphis domestica

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

MDLPTVTIEE VKNVLIGMQK ILECPICLEL IKEPVSTTCD HIFCRFCMLK LLSKKKGPSQ 60
CPLCKNNITK RSLRESTRFN QLVEGLLKTI RAFELDTGFQ FSNTQDFSKW ERRTPEPLKK 120

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Nucleotide Sequence
(Fasta)

GTACAGTGGA GAGTAAAGAA ATGGATTTGC CTACAGTCAC TATTGAAGAA GTAAAGAATG 60
TCCTAATTGG GATGCAGAAA ATTTTAGAAT GTCCTATCTG GTAAGTCTGA GGGCTTGTCA 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0035066--P:positive regulation of histone acetylation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	45.74	0.00e+00	1304.00
IUUC-Apl-003252	Anas platyrhynchos	38.97	9.00e-135	475.00
IUUC-Aca-004526	Anolis carolinensis	62.09	3.00e-76	280.00
IUUC-Ame-011720	Astyanax mexicanus	52.22	3.00e-57	217.00
IUUC-Bta-013433	Bos taurus	45.43	0.00e+00	1313.00
IUUC-Bol-016476	Brassica oleracea	31.28	4.00e-18	87.00
IUUC-Cel-018208	Caenorhabditis elegans	39.24	8.00e-12	65.50
IUUC-Cja-019149	Callithrix jacchus	46.41	0.00e+00	1292.00
IUUC-Cfa-020322	Canis familiaris	44.71	0.00e+00	1283.00
IUUC-Cpo-021583	Cavia porcellus	36.04	0.00e+00	778.00
IUUC-Cre-022955	Chlamydomonas reinhardtii	28.85	3.00e-09	58.20
IUUC-Csa-024227	Chlorocebus sabaeus	59.18	7.00e-84	305.00
IUUC-Cho-024530	Choloepus hoffmanni	42.93	2.00e-177	617.00
IUUC-Cin-025364	Ciona intestinalis	42.86	4.00e-14	72.00
IUUC-Csv-026245	Ciona savignyi	37.18	3.00e-12	65.10
IUUC-Dno-029247	Dasypus novemcinctus	42.66	0.00e+00	899.00
IUUC-Dme-032032	Drosophila melanogaster	50.00	4.00e-10	56.20
IUUC-Ete-032472	Echinops telfairi	38.08	0.00e+00	838.00
IUUC-Eca-033446	Equus caballus	47.06	0.00e+00	1393.00
IUUC-Eeu-034858	Erinaceus europaeus	37.93	6.00e-120	426.00
IUUC-Fca-035991	Felis catus	45.04	0.00e+00	1291.00
IUUC-Fal-036803	Ficedula albicollis	34.25	0.00e+00	658.00
IUUC-Gmo-038782	Gadus morhua	49.48	3.00e-48	187.00
IUUC-Gga-040969	Gallus gallus	62.50	3.00e-84	307.00
IUUC-Gac-042296	Gasterosteus aculeatus	47.17	5.00e-51	196.00
IUUC-Ggo-044740	Gorilla gorilla	44.75	0.00e+00	1214.00
IUUC-Hsa-046086	Homo sapiens	46.00	0.00e+00	1233.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	46.21	0.00e+00	1329.00
IUUC-Lch-049789	Latimeria chalumnae	60.66	2.00e-77	285.00
IUUC-Lpe-050895	Leersia perrieri	29.03	6.00e-17	83.20
IUUC-Loc-051952	Lepisosteus oculatus	53.22	2.00e-69	258.00
IUUC-Laf-053648	Loxodonta africana	46.65	0.00e+00	1294.00
IUUC-Mcc-055210	Macaca mulatta	46.21	0.00e+00	1300.00
IUUC-Meu-056342	Macropus eugenii	66.57	0.00e+00	1095.00
IUUC-Mor-057034	Magnaporthe oryzae	38.78	2.00e-08	53.50
IUUC-Mga-060163	Meleagris gallopavo	56.65	7.00e-85	309.00
IUUC-Mmr-061402	Microcebus murinus	42.11	1.00e-102	367.00
IUUC-Mmu-064003	Mus musculus	40.60	0.00e+00	1000.00
IUUC-Mpu-065825	Mustela putorius furo	55.42	4.00e-142	498.00
IUUC-Mlu-068176	Myotis lucifugus	44.59	0.00e+00	1219.00
IUUC-Nle-069178	Nomascus leucogenys	46.19	0.00e+00	1266.00
IUUC-Opr-070574	Ochotona princeps	39.22	0.00e+00	983.00
IUUC-Ont-072380	Oreochromis niloticus	52.91	8.00e-60	226.00
IUUC-Oan-073243	Ornithorhynchus anatinus	72.94	2.00e-34	137.00
IUUC-Ocu-074424	Oryctolagus cuniculus	44.17	0.00e+00	1234.00
IUUC-Ola-086863	Oryzias latipes	49.54	2.00e-53	204.00
IUUC-Oar-089938	Ovis aries	45.29	0.00e+00	1332.00
IUUC-Ptr-090960	Pan troglodytes	46.21	0.00e+00	1260.00
IUUC-Pan-092609	Papio anubis	43.39	0.00e+00	1012.00
IUUC-Psi-093889	Pelodiscus sinensis	31.80	4.00e-57	216.00
IUUC-Pfo-096328	Poecilia formosa	53.85	3.00e-60	227.00
IUUC-Pab-097982	Pongo abelii	46.51	0.00e+00	1290.00
IUUC-Pca-100698	Procavia capensis	50.43	1.00e-116	415.00
IUUC-Pva-102631	Pteropus vampyrus	46.50	9.00e-175	608.00
IUUC-Rno-105879	Rattus norvegicus	39.70	0.00e+00	954.00
IUUC-Sha-106701	Sarcophilus harrisii	62.28	0.00e+00	1524.00
IUUC-Sit-110609	Setaria italica	28.00	1.00e-17	85.50
IUUC-Sar-113047	Sorex araneus	41.57	0.00e+00	688.00
IUUC-Ssc-115846	Sus scrofa	46.50	0.00e+00	1344.00
IUUC-Tgu-116785	Taeniopygia guttata	32.13	1.00e-105	378.00
IUUC-Tru-117895	Takifugu rubripes	46.70	2.00e-53	205.00
IUUC-Tsy-118885	Tarsius syrichta	46.21	4.00e-82	300.00
IUUC-Tni-119654	Tetraodon nigroviridis	45.89	7.00e-49	189.00
IUUC-Tbe-127421	Tupaia belangeri	41.49	4.00e-82	300.00
IUUC-Ttr-128685	Tursiops truncatus	45.16	0.00e+00	1244.00
IUUC-Vpa-130216	Vicugna pacos	55.13	5.00e-127	449.00
IUUC-Vvi-131586	Vitis vinifera	33.33	9.00e-12	66.60
IUUC-Xtr-132398	Xenopus tropicalis	40.08	2.00e-67	251.00
IUUC-Xma-133651	Xiphophorus maculatus	55.76	8.00e-47	182.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence