iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000006441.2	ENSCJAT00000012569.2	ENSCJAP00000011917.2
ENSCJAG00000006441.2	ENSCJAT00000012551.2	ENSCJAP00000011900.2
ENSCJAG00000006441.2	ENSCJAT00000012582.1	ENSCJAP00000011930.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.80e-92	309.4	698	1017

Active Site

Position(s)	Description	Evidence
988	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            d+ k+l vef +E   ++gGv++ef++++++e+ +p++ +f+y e+++++++p++ +     e+ ++F ++G+l+g++l++ +l +
   Q: 698  TDFCKVLVVEFIKEIRPEAGGVSSEFFYCIFEEMTKPKYRMFMYPEKGSCMWFPAKPKL----EKKRYF-LFGMLCGLSLFNLNLAN 779
           688899**************************************************998....677888.55*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ ++yk+ll++k sledl+e+ p+l ksl+e+++ + +di ++ l+l fs++     ++++++L+p+G +ipV ++Nk++Yv++
   Q: 780  LPFPLALYKKLLNQKPSLEDLKELSPQLGKSLQEVLNDDADDIGDA-LCLHFSIH----WDQNDVDLIPNGISIPVDQTNKKDYVSK 861
           ************************************9999999997.*****855....5779999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +++y+++ ++k  +e+f++Gf++v+++e+l+ F ++el + i G++++d+++++k+ ky++gy++++p+i+ Fw+++++++ +e+k+
   Q: 862  YIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPKELMTAIIGNTDYDWKQFEKNSKYEHGYQKSHPTIRLFWKAFHKLTLDEKKK 948
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+Tg++rl ++G++e++  +f +++  s+++ P+s TC n L+LP+Ys++e ++e L++Ai++++gF
   Q: 949  FLFFLTGRDRLHVRGIQEIE-IVFRCPETFSERDHPRSITCHNILDLPKYSTMERMEEALQVAINNNRGF 1017
           ********************.77888889****************************************9 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MYFSWGAGSR GLQRRRTEGS PGAELLQAAS GERHALLLLT NSSVHSCGEN SRGQLGRRGA 60
PRGDLPEPVQ ALKTLKFNLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG EFKEINFTPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTGGAAGCT TAGGCGGCGA GAGTTGACGT GGGGTTAGGG CTGCCCTCCT GGGGCGGGTT 60
GAAGGCAGGG TGAGCCTCCC GAAGTCCAGG AAATCGTTGC CTACCCAGTC ACCAGCGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	70.16	0.00e+00	1357.00
IUUC-Aca-004663	Anolis carolinensis	45.75	0.00e+00	850.00
IUUC-Bta-013080	Bos taurus	69.98	0.00e+00	1401.00
IUUC-Cfa-020763	Canis familiaris	70.57	0.00e+00	1331.00
IUUC-Cpo-022346	Cavia porcellus	68.31	0.00e+00	1414.00
IUUC-Csa-023049	Chlorocebus sabaeus	87.18	0.00e+00	1852.00
IUUC-Dno-029093	Dasypus novemcinctus	73.34	0.00e+00	1499.00
IUUC-Eca-034098	Equus caballus	74.22	0.00e+00	1429.00
IUUC-Eeu-035028	Erinaceus europaeus	54.79	7.00e-149	521.00
IUUC-Fca-036283	Felis catus	72.15	0.00e+00	1388.00
IUUC-Ggo-045553	Gorilla gorilla	83.87	0.00e+00	1718.00
IUUC-Hsa-046396	Homo sapiens	86.85	0.00e+00	1798.00
IUUC-Loc-052700	Lepisosteus oculatus	39.61	0.00e+00	767.00
IUUC-Laf-054433	Loxodonta africana	68.38	0.00e+00	1458.00
IUUC-Mcc-055014	Macaca mulatta	83.48	0.00e+00	1788.00
IUUC-Mdo-061839	Monodelphis domestica	54.62	0.00e+00	1014.00
IUUC-Mmu-064378	Mus musculus	65.69	0.00e+00	1279.00
IUUC-Mpu-066293	Mustela putorius furo	68.42	0.00e+00	1304.00
IUUC-Mlu-067407	Myotis lucifugus	70.90	0.00e+00	1417.00
IUUC-Nle-069978	Nomascus leucogenys	86.59	0.00e+00	1842.00
IUUC-Opr-070190	Ochotona princeps	58.48	0.00e+00	690.00
IUUC-Ocu-074640	Oryctolagus cuniculus	70.42	0.00e+00	870.00
IUUC-Oga-088780	Otolemur garnettii	69.32	0.00e+00	1415.00
IUUC-Oar-090307	Ovis aries	70.51	0.00e+00	1410.00
IUUC-Ptr-091567	Pan troglodytes	86.59	0.00e+00	1789.00
IUUC-Pan-091802	Papio anubis	82.71	0.00e+00	1757.00
IUUC-Pab-098024	Pongo abelii	70.43	0.00e+00	1402.00
IUUC-Pva-102382	Pteropus vampyrus	67.91	0.00e+00	1321.00
IUUC-Rno-105768	Rattus norvegicus	60.24	0.00e+00	1199.00
IUUC-Sha-106525	Sarcophilus harrisii	53.56	0.00e+00	1076.00
IUUC-Sar-113014	Sorex araneus	57.68	7.00e-151	527.00
IUUC-Vpa-130214	Vicugna pacos	68.86	0.00e+00	1261.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence