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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046739
UUCD1 version UUC-HoS-00756
Ensembl Protein ID ENSP00000311343.3
UniProt Accession Q8IV35; Q8N297; WDR49_HUMAN
Genbank Protein ID BAC03552.1; AAH35512.1
Protein Name WD repeat-containing protein 49
Genbank Nucleotide ID AK090939; BC035512
Gene Name WDR49
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000174776.10 ENST00000308378.7 ENSP00000311343.3
ENSG00000174776.10 ENST00000472600.5 ENSP00000419130.1
ENSG00000174776.10 ENST00000479765.5 ENSP00000419749.1
ENSG00000174776.10 ENST00000493061.1 ENSP00000418539.1
ENSG00000174776.10 ENST00000460448.5 ENSP00000417090.1
ENSG00000174776.10 ENST00000466760.5 ENSP00000418718.1
ENSG00000174776.10 ENST00000488012.5 ENSP00000419917.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Disease-associated Variation
ClinVarGWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.20e-25 88.1 282 313
UBD/Beta-Prp 7.10e-45 155.1 147 501
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sdtllvsGsdDgtikvWDlrt 32
           H d++ c af +  +lv+Gs+Dg i +W+ +t
   Q: 282  HHDDILCAAFlPPQTLVTGSYDGEIVLWNNST 313
           8999******955889************9665 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgh..eaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
           h++ +tcv +    ++++++ + +t+  w ++tg++++++ g+  +ae++++ ++ ++  l+tgs+D+t+k+wd++ g c htl+  +d ++
   Q: 147  HEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGChgNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLNVGQDGAV 237
           5667899***889999************************87622567*********99****************7.568899995555555 PP
   S: 99   slsfsp.sgdklvsGshdrtirvwdletgqclee.......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl....... 175
           ++s     ++k++++++ r i v+  ++   +           + hd++ + + ++p  + lv+Gs+D+ + lW+ +t++  + l       
   Q: 238  DISQILiLKKKILVTGWERAITVFRPQNFNQFFIqpeewkgGIQHHDDILCAAFLPP--QTLVTGSYDGEIVLWNNSTENAHHVLhpdyqrl 327
           555444377**************8777776665567777756667777777777777..99***************9999999997666666 PP
   S: 176  ..tgghtdsvyslsfdsng...........................................kelvsgsldgtvklwdlqtgecvrtlnght 222
             ++ +t++ + ls  +++                                             lvs++  g+v++wd+ +++ + ++ +h+
   Q: 328  lkSKLDTKPQKLLSAGRSQpshpmadhsttgvrnfeidtegknavmrlcflkarkntavtggANLVSCGGSGYVRFWDIYKKQLLAEFLAHS 419
           664445555556653333355566666666677777777779999999999999999*********************************** PP
   S: 223  dnvksvrfspnderlvsgs.sDgsiriW.......dlrsgdllktlqlhn......ssvisvavlsfgdnvlvlgse.dskv 289
              + +  +++ +r+++++  Dg ++iW       ++ +++++k+ +l +      ++++s  + ++g++ l+  s+ d+++
   Q: 420  GVGSIIMSTDKMNRYLTTGdLDGWLKIWnieeyclNSSKNKITKAPTLIRsfqpheDRISSLEMCEPGGQLLIISSSaDCSI 501
           988887777777777777769*******77777776566655555444447777779****999999988776666659887 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MAWREKSKKR LNMTSFNIAQ GIHAFDYHSR LNLIATAGIN NKVCLWNPYV VSKPVGVLWG 60
HSASVIAVQF FVERKQLFSF SKDKVLRLWD IQHQLSIQRI ACSFPKSQDF RCLFHFDEAH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046739|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAACAGATG AAACAAACAA CTCCACATTG CTGGGAAGGT GGCATTCAGA GTCAAGTACT 60
TCATTGGTAG GGAAACTCTG CAGCTTTGTC ATCTAACTCT TCCAGACAAG AAAGTGGAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046739|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
KEGG hsa:151790
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002386 Ailuropoda melanoleuca 84.56 0.00e+00 926.00
IUUC-Aca-005140 Anolis carolinensis 54.43 0.00e+00 722.00
IUUC-Ame-011677 Astyanax mexicanus 57.25 2.00e-121 429.00
IUUC-Bta-013449 Bos taurus 80.65 0.00e+00 1167.00
IUUC-Cja-019381 Callithrix jacchus 90.97 0.00e+00 1310.00
IUUC-Cfa-020449 Canis familiaris 79.80 0.00e+00 1122.00
IUUC-Csa-023219 Chlorocebus sabaeus 95.64 0.00e+00 969.00
IUUC-Cho-024437 Choloepus hoffmanni 94.47 1.00e-120 427.00
IUUC-Cin-025263 Ciona intestinalis 41.98 5.00e-159 555.00
IUUC-Csv-026326 Ciona savignyi 25.56 5.00e-42 165.00
IUUC-Dno-029512 Dasypus novemcinctus 79.37 0.00e+00 1103.00
IUUC-Dor-030182 Dipodomys ordii 69.23 0.00e+00 973.00
IUUC-Ete-033152 Echinops telfairi 76.01 0.00e+00 1057.00
IUUC-Eca-033848 Equus caballus 72.32 7.00e-159 553.00
IUUC-Eeu-034535 Erinaceus europaeus 65.24 0.00e+00 806.00
IUUC-Fca-036363 Felis catus 87.02 0.00e+00 943.00
IUUC-Gmo-039551 Gadus morhua 32.58 5.00e-35 142.00
IUUC-Gac-041482 Gasterosteus aculeatus 24.66 6.00e-40 158.00
IUUC-Ggo-045225 Gorilla gorilla 98.13 0.00e+00 1403.00
IUUC-Itr-047862 Ictidomys tridecemlineatus 82.02 0.00e+00 829.00
IUUC-Lch-049722 Latimeria chalumnae 53.28 0.00e+00 744.00
IUUC-Loc-052665 Lepisosteus oculatus 51.61 0.00e+00 725.00
IUUC-Laf-054050 Loxodonta africana 79.16 0.00e+00 1003.00
IUUC-Meu-056792 Macropus eugenii 63.90 0.00e+00 652.00
IUUC-Mmr-060714 Microcebus murinus 94.51 2.00e-91 329.00
IUUC-Mdo-062938 Monodelphis domestica 65.67 0.00e+00 917.00
IUUC-Mmu-063645 Mus musculus 75.96 0.00e+00 1106.00
IUUC-Mpu-066015 Mustela putorius furo 78.93 0.00e+00 1149.00
IUUC-Mlu-068140 Myotis lucifugus 80.61 0.00e+00 1084.00
IUUC-Nle-069533 Nomascus leucogenys 96.54 0.00e+00 1334.00
IUUC-Opr-070439 Ochotona princeps 63.87 0.00e+00 902.00
IUUC-Oan-073400 Ornithorhynchus anatinus 56.69 1.00e-95 342.00
IUUC-Ocu-074202 Oryctolagus cuniculus 93.12 3.00e-121 429.00
IUUC-Ola-086449 Oryzias latipes 25.90 5.00e-34 139.00
IUUC-Oga-087999 Otolemur garnettii 73.23 0.00e+00 792.00
IUUC-Oar-090438 Ovis aries 80.65 0.00e+00 1164.00
IUUC-Ptr-090859 Pan troglodytes 98.71 0.00e+00 1369.00
IUUC-Pan-092049 Papio anubis 95.40 0.00e+00 879.00
IUUC-Psi-093625 Pelodiscus sinensis 60.70 0.00e+00 852.00
IUUC-Pma-094599 Petromyzon marinus 28.12 7.00e-55 208.00
IUUC-Pfo-096408 Poecilia formosa 24.59 1.00e-43 171.00
IUUC-Pab-098444 Pongo abelii 97.56 0.00e+00 918.00
IUUC-Pca-100464 Procavia capensis 71.19 0.00e+00 665.00
IUUC-Pva-102863 Pteropus vampyrus 80.09 0.00e+00 1154.00
IUUC-Rno-105493 Rattus norvegicus 74.22 0.00e+00 1068.00
IUUC-Sha-107206 Sarcophilus harrisii 61.24 0.00e+00 832.00
IUUC-Sar-113119 Sorex araneus 64.07 0.00e+00 748.00
IUUC-Ssc-116181 Sus scrofa 85.52 0.00e+00 940.00
IUUC-Tru-117666 Takifugu rubripes 26.12 3.00e-39 156.00
IUUC-Tsy-119608 Tarsius syrichta 71.45 0.00e+00 1001.00
IUUC-Tni-120461 Tetraodon nigroviridis 43.20 9.00e-26 111.00
IUUC-Tbe-127509 Tupaia belangeri 71.69 0.00e+00 983.00
IUUC-Ttr-128571 Tursiops truncatus 82.67 0.00e+00 778.00
IUUC-Vpa-130340 Vicugna pacos 77.29 0.00e+00 1106.00
Created Date 25-Jun-2017

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