iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-117311

Ensembl Protein ID

ENSTGUP00000003757.1

UniProt Accession

H0YZM3; H0YZM3_TAEGU

Genbank Protein ID

ENSTGUP00000003757

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

ABQF01036761

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000003654.1	ENSTGUT00000003799.1	ENSTGUP00000003757.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	37.63	3.00e-14	71.20	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Taeniopygia guttata

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

FRGGAELLFD GVKKHQVTLP CQPEPWDIRN LLKWIKQNLL KERPELFLQG ESVRPGILVL 60
INEADWELMG ELDYKLQDQD NVLFISTLHG G 91

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Nucleotide Sequence
(Fasta)

TTCAGAGGTG GTGCAGAACT CTTATTCGAT GGTGTCAAAA AGCATCAGGT GACTTTGCCC 60
TGTCAACCAG AGCCTTGTGA GTATCAGAAC CTGTTGGATA ACTTCACAGA GTAACAACAA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	85.71	1.00e-42	163.00
IUUC-Atr-003089	Amborella trichopoda	58.06	8.00e-28	114.00
IUUC-Apl-003382	Anas platyrhynchos	95.60	2.00e-47	179.00
IUUC-Aca-004981	Anolis carolinensis	84.62	3.00e-43	165.00
IUUC-Aly-005517	Arabidopsis lyrata	52.17	2.00e-26	109.00
IUUC-Ath-006718	Arabidopsis thaliana	51.19	3.00e-23	99.00
IUUC-Ago-007917	Ashbya gossypii	41.94	4.00e-18	82.40
IUUC-Acl-008054	Aspergillus clavatus	64.00	1.00e-14	70.50
IUUC-Afl-008704	Aspergillus flavus	52.81	2.00e-20	89.40
IUUC-Aor-009890	Aspergillus oryzae	53.68	1.00e-22	97.80
IUUC-Bta-012448	Bos taurus	85.71	2.00e-42	162.00
IUUC-Bci-013865	Botrytis cinerea	44.21	2.00e-19	87.00
IUUC-Bdi-014980	Brachypodium distachyon	55.17	5.00e-23	98.20
IUUC-Bol-016055	Brassica oleracea	50.00	2.00e-22	96.30
IUUC-Bra-016845	Brassica rapa	50.00	2.00e-22	96.30
IUUC-Cel-018485	Caenorhabditis elegans	34.74	4.00e-11	58.50
IUUC-Cja-019587	Callithrix jacchus	87.91	5.00e-43	164.00
IUUC-Cfa-020653	Canis familiaris	84.62	3.00e-42	162.00
IUUC-Cpo-021622	Cavia porcellus	87.91	5.00e-43	164.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	54.35	3.00e-24	102.00
IUUC-Csa-023756	Chlorocebus sabaeus	85.51	2.00e-30	124.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	45.26	9.00e-20	87.80
IUUC-Cne-026953	Cryptococcus neoformans	56.70	7.00e-27	112.00
IUUC-Cme-027314	Cyanidioschyzon merolae	42.39	5.00e-18	81.60
IUUC-Dre-027884	Danio rerio	78.02	1.00e-39	153.00
IUUC-Dno-029262	Dasypus novemcinctus	82.86	2.00e-29	120.00
IUUC-Dor-030601	Dipodomys ordii	76.92	2.00e-21	93.20
IUUC-Dme-031893	Drosophila melanogaster	65.93	1.00e-30	123.00
IUUC-Ete-032773	Echinops telfairi	82.42	2.00e-40	156.00
IUUC-Eca-034187	Equus caballus	86.81	8.00e-43	164.00
IUUC-Eeu-034808	Erinaceus europaeus	82.42	1.00e-41	159.00
IUUC-Fca-036107	Felis catus	85.71	5.00e-43	164.00
IUUC-Fal-036607	Ficedula albicollis	98.90	3.00e-49	185.00
IUUC-Fox-037698	Fusarium oxysporum	48.42	5.00e-21	92.00
IUUC-Gmo-039492	Gadus morhua	79.12	1.00e-39	153.00
IUUC-Ggr-039965	Gaeumannomyces graminis	48.42	1.00e-18	85.10
IUUC-Gga-041268	Gallus gallus	95.60	3.00e-47	179.00
IUUC-Gac-042111	Gasterosteus aculeatus	80.22	2.00e-40	155.00
IUUC-Gma-043240	Glycine max	59.38	1.00e-21	93.60
IUUC-Ggo-045176	Gorilla gorilla	84.06	7.00e-23	99.00
IUUC-Hsa-046077	Homo sapiens	85.71	2.00e-35	139.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	89.89	1.00e-35	139.00
IUUC-Kpa-049157	Komagataella pastoris	45.16	1.00e-17	80.10
IUUC-Lch-049889	Latimeria chalumnae	80.22	3.00e-40	155.00
IUUC-Lpe-050783	Leersia perrieri	55.95	1.00e-21	94.00
IUUC-Loc-052400	Lepisosteus oculatus	79.12	8.00e-40	154.00
IUUC-Lma-053259	Leptosphaeria maculans	48.42	3.00e-20	89.70
IUUC-Laf-053596	Loxodonta africana	84.95	6.00e-41	158.00
IUUC-Mcc-054845	Macaca mulatta	86.52	1.00e-41	160.00
IUUC-Meu-055968	Macropus eugenii	86.81	4.00e-43	165.00
IUUC-Mor-057126	Magnaporthe oryzae	47.37	7.00e-18	82.00
IUUC-Mpo-057311	Magnaporthe poae	48.42	7.00e-20	89.00
IUUC-Mtr-058266	Medicago truncatula	57.81	8.00e-21	90.90
IUUC-Mla-058847	Melampsora laricipopulina	40.00	3.00e-10	56.60
IUUC-Mga-059468	Meleagris gallopavo	96.70	5.00e-48	181.00
IUUC-Mvi-060235	Microbotryum violaceum	61.19	6.00e-18	82.80
IUUC-Mdo-061948	Monodelphis domestica	84.62	2.00e-42	162.00
IUUC-Mmu-063946	Mus musculus	85.71	3.00e-42	162.00
IUUC-Mac-064812	Musa acuminata	55.42	1.00e-23	100.00
IUUC-Mpu-066763	Mustela putorius furo	84.62	2.00e-41	159.00
IUUC-Mlu-066970	Myotis lucifugus	86.96	1.00e-30	123.00
IUUC-Ncr-068824	Neurospora crassa	47.37	6.00e-19	85.10
IUUC-Nle-069849	Nomascus leucogenys	84.06	7.00e-30	122.00
IUUC-Opr-070227	Ochotona princeps	87.91	5.00e-43	164.00
IUUC-Ont-072530	Oreochromis niloticus	82.42	4.00e-41	158.00
IUUC-Oan-073191	Ornithorhynchus anatinus	82.22	2.00e-40	155.00
IUUC-Ocu-074460	Oryctolagus cuniculus	86.81	5.00e-43	164.00
IUUC-Oba-075499	Oryza barthii	57.65	4.00e-22	96.70
IUUC-Obr-076896	Oryza brachyantha	64.06	2.00e-21	95.50
IUUC-Ogl-077834	Oryza glaberrima	58.33	1.00e-22	97.40
IUUC-Ogu-078622	Oryza glumaepatula	58.33	1.00e-22	97.40
IUUC-Oin-079358	Oryza indica	58.33	4.00e-22	97.10
IUUC-Olo-081035	Oryza longistaminata	55.21	2.00e-23	101.00
IUUC-Oni-082425	Oryza nivara	58.33	1.00e-22	97.40
IUUC-Opu-083461	Oryza punctata	56.63	1.00e-21	94.70
IUUC-Oru-084875	Oryza rufipogon	59.15	5.00e-20	88.20
IUUC-Oga-089128	Otolemur garnettii	86.81	8.00e-43	164.00
IUUC-Oar-089896	Ovis aries	85.71	2.00e-42	162.00
IUUC-Ptr-091618	Pan troglodytes	84.06	7.00e-23	99.00
IUUC-Pan-092238	Papio anubis	85.51	2.00e-30	124.00
IUUC-Psi-093879	Pelodiscus sinensis	91.21	1.00e-46	176.00
IUUC-Pma-094484	Petromyzon marinus	73.42	5.00e-31	125.00
IUUC-Ppa-095801	Physcomitrella patens	56.79	9.00e-22	94.40
IUUC-Pfo-097192	Poecilia formosa	79.12	5.00e-40	154.00
IUUC-Pab-098203	Pongo abelii	85.71	2.00e-35	139.00
IUUC-Pop-099614	Populus trichocarpa	52.38	7.00e-22	94.70
IUUC-Pca-100507	Procavia capensis	85.51	1.00e-30	123.00
IUUC-Ppe-101174	Prunus persica	53.76	5.00e-26	108.00
IUUC-Pva-102735	Pteropus vampyrus	85.71	3.00e-39	152.00
IUUC-Pgr-103510	Puccinia graminis	38.14	7.00e-10	55.10
IUUC-Ptt-103918	Puccinia triticina	35.05	1.00e-08	51.20
IUUC-Pte-104173	Pyrenophora teres	48.42	2.00e-21	92.80
IUUC-Pyt-104806	Pyrenophora triticirepentis	48.42	3.00e-21	92.80
IUUC-Rno-105820	Rattus norvegicus	86.81	1.00e-42	163.00
IUUC-Sce-106366	Saccharomyces cerevisiae	37.63	7.00e-15	71.20
IUUC-Sja-107727	Schizosaccharomyces japonicus	40.91	1.00e-14	70.90
IUUC-Spo-108074	Schizosaccharomyces pombe	38.89	2.00e-08	49.70
IUUC-Smo-108944	Selaginella moellendorffii	59.55	3.00e-25	105.00
IUUC-Sit-110277	Setaria italica	53.57	2.00e-22	96.30
IUUC-Sly-111505	Solanum lycopersicum	52.38	1.00e-23	100.00
IUUC-Stu-112076	Solanum tuberosum	53.57	4.00e-24	102.00
IUUC-Sbi-114274	Sorghum bicolor	55.84	5.00e-22	95.50
IUUC-Sre-114953	Sporisorium reilianum	58.33	9.00e-26	107.00
IUUC-Ssc-115418	Sus scrofa	85.71	1.00e-42	163.00
IUUC-Tru-118598	Takifugu rubripes	82.02	1.00e-39	153.00
IUUC-Tni-120109	Tetraodon nigroviridis	78.26	2.00e-37	146.00
IUUC-Tca-120942	Theobroma cacao	55.42	3.00e-23	99.00
IUUC-Tre-122099	Trichoderma reesei	47.31	2.00e-15	73.20
IUUC-Tvi-122285	Trichoderma virens	49.47	4.00e-17	79.30
IUUC-Tae-125193	Triticum aestivum	64.06	1.00e-21	94.00
IUUC-Tur-126677	Triticum urartu	53.95	4.00e-19	85.90
IUUC-Tme-127120	Tuber melanosporum	47.37	2.00e-20	90.50
IUUC-Tbe-128050	Tupaia belangeri	61.54	4.00e-25	105.00
IUUC-Ttr-129019	Tursiops truncatus	83.52	2.00e-39	152.00
IUUC-Uma-129483	Ustilago maydis	56.25	2.00e-22	96.70
IUUC-Vda-129690	Verticillium dahliae	39.29	1.00e-15	74.70
IUUC-Vvi-131174	Vitis vinifera	53.01	9.00e-23	97.40
IUUC-Xma-133862	Xiphophorus maculatus	79.12	5.00e-40	154.00
IUUC-Yli-134398	Yarrowia lipolytica	48.96	7.00e-18	81.30
IUUC-Zma-134964	Zea mays	56.79	9.00e-22	94.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence