iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040876

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine signaling 5

Genbank Nucleotide ID

AADN04000139

Gene Name

SOCS5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000010016.3	ENSGALT00000016269.3	ENSGALP00000016250.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.20e-15	57.5	475	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            l r+ p+SLq++CR +I+rc++++++   d LPLP++L+d+L++++y+
   Q: 475  SLNRTFPFSLQYICRAVICRCTTYDGI---DDLPLPSMLQDFLKEYHYK 520
           577899*********************...****************985 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MDKVGKMWNN FKYRCQNLFS HEGGSQNENV VVNSSSCSSA KDRTVQITGL AQQQPSSPLR 60
ENIALQLGLS PSKNSVRRNQ NCVTEIPQIV EISIEKENDS CVTTGARLAR RDSYSRHAPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAGTTCATG CTGAGGTATA TTCTCAAGTC AAGATCCAGT GGCTCATGTG TTTCTGGGTA 60
AGAAAGATAT CTATATGCTC TTAACTATGA CAAAAAGTAA TTAAACTTTT GGAAAGTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0006469--P:negative regulation of protein kinase activity
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

gga:428570

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	32.65	1.10e-01	29.30
IUUC-Apl-003815	Anas platyrhynchos	97.76	0.00e+00	1055.00
IUUC-Aca-004504	Anolis carolinensis	85.26	0.00e+00	860.00
IUUC-Ame-010677	Astyanax mexicanus	62.89	0.00e+00	631.00
IUUC-Bta-012338	Bos taurus	90.86	0.00e+00	966.00
IUUC-Cja-019828	Callithrix jacchus	90.86	0.00e+00	950.00
IUUC-Cfa-020369	Canis familiaris	90.86	0.00e+00	970.00
IUUC-Cpo-021397	Cavia porcellus	88.99	0.00e+00	976.00
IUUC-Csa-023856	Chlorocebus sabaeus	90.67	0.00e+00	966.00
IUUC-Dre-028262	Danio rerio	62.57	6.00e-169	587.00
IUUC-Dno-029019	Dasypus novemcinctus	90.86	0.00e+00	992.00
IUUC-Dme-031965	Drosophila melanogaster	67.44	1.00e-69	257.00
IUUC-Eca-033867	Equus caballus	90.30	0.00e+00	983.00
IUUC-Fca-035806	Felis catus	91.04	0.00e+00	969.00
IUUC-Fal-037117	Ficedula albicollis	96.27	0.00e+00	1038.00
IUUC-Gmo-039066	Gadus morhua	83.49	2.00e-107	382.00
IUUC-Gac-042149	Gasterosteus aculeatus	66.30	0.00e+00	635.00
IUUC-Ggo-045169	Gorilla gorilla	89.93	0.00e+00	960.00
IUUC-Hsa-045805	Homo sapiens	91.04	0.00e+00	968.00
IUUC-Hvu-047122	Hordeum vulgare	39.02	9.00e-03	33.50
IUUC-Itr-049048	Ictidomys tridecemlineatus	90.30	0.00e+00	988.00
IUUC-Lch-049686	Latimeria chalumnae	80.71	0.00e+00	843.00
IUUC-Lpe-051639	Leersia perrieri	29.23	1.90e-01	30.80
IUUC-Loc-051745	Lepisosteus oculatus	72.66	0.00e+00	721.00
IUUC-Laf-054124	Loxodonta africana	89.20	0.00e+00	966.00
IUUC-Mcc-055175	Macaca mulatta	90.67	0.00e+00	966.00
IUUC-Meu-056557	Macropus eugenii	90.35	0.00e+00	978.00
IUUC-Mga-059214	Meleagris gallopavo	98.69	0.00e+00	1059.00
IUUC-Mmr-060613	Microcebus murinus	76.12	0.00e+00	750.00
IUUC-Mdo-062788	Monodelphis domestica	90.35	0.00e+00	952.00
IUUC-Mmu-064333	Mus musculus	89.18	0.00e+00	956.00
IUUC-Mpu-066048	Mustela putorius furo	91.42	0.00e+00	972.00
IUUC-Mlu-067430	Myotis lucifugus	90.67	0.00e+00	947.00
IUUC-Nle-069086	Nomascus leucogenys	90.67	0.00e+00	989.00
IUUC-Opr-070312	Ochotona princeps	86.57	0.00e+00	919.00
IUUC-Ont-072299	Oreochromis niloticus	63.89	0.00e+00	635.00
IUUC-Ocu-074123	Oryctolagus cuniculus	85.63	0.00e+00	906.00
IUUC-Ola-086934	Oryzias latipes	67.28	0.00e+00	660.00
IUUC-Oga-088535	Otolemur garnettii	91.04	0.00e+00	993.00
IUUC-Oar-089875	Ovis aries	90.67	0.00e+00	969.00
IUUC-Ptr-090541	Pan troglodytes	91.04	0.00e+00	968.00
IUUC-Pan-092416	Papio anubis	90.67	0.00e+00	966.00
IUUC-Psi-092960	Pelodiscus sinensis	90.49	0.00e+00	985.00
IUUC-Pma-094222	Petromyzon marinus	52.73	5.00e-137	481.00
IUUC-Pfo-096930	Poecilia formosa	64.07	0.00e+00	648.00
IUUC-Pab-098659	Pongo abelii	90.86	0.00e+00	968.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.40e-01	30.40
IUUC-Pca-100222	Procavia capensis	88.08	0.00e+00	954.00
IUUC-Pva-102387	Pteropus vampyrus	90.67	0.00e+00	965.00
IUUC-Rno-105698	Rattus norvegicus	89.74	0.00e+00	956.00
IUUC-Sha-107234	Sarcophilus harrisii	89.24	0.00e+00	944.00
IUUC-Sar-113698	Sorex araneus	85.07	0.00e+00	863.00
IUUC-Ssc-115985	Sus scrofa	89.93	0.00e+00	984.00
IUUC-Tgu-116676	Taeniopygia guttata	96.08	0.00e+00	1035.00
IUUC-Tru-118441	Takifugu rubripes	59.85	1.00e-151	529.00
IUUC-Tsy-119163	Tarsius syrichta	84.51	0.00e+00	917.00
IUUC-Tni-120436	Tetraodon nigroviridis	65.74	0.00e+00	637.00
IUUC-Tae-124846	Triticum aestivum	32.65	1.90e-01	28.90
IUUC-Tbe-127353	Tupaia belangeri	91.23	0.00e+00	970.00
IUUC-Ttr-128907	Tursiops truncatus	91.04	0.00e+00	952.00
IUUC-Vpa-130140	Vicugna pacos	90.67	0.00e+00	971.00
IUUC-Vvi-131327	Vitis vinifera	43.75	1.20e-01	30.80
IUUC-Xtr-132817	Xenopus tropicalis	79.70	0.00e+00	855.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence