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Tag Content
UUCD2 ID IUUC-Dre-027699
UUCD1 version UUC-DaR-00425
Ensembl Protein ID ENSDARP00000101787.2
UniProt Accession E7FAM5; F8W380; LIN41_DANRE
Genbank Protein ID ENSDARP00000101787
Protein Name E3 ubiquitin-protein ligase TRIM71; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71
Genbank Nucleotide ID BX511173
Gene Name trim71; lin41
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000075593.5 ENSDART00000113483.4 ENSDARP00000101787.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 71.61 0.00e+00 1191.00 IUUC-Mmu-064351
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Danio rerio
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development.
 E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development.
Protein Sequence
(Fasta)
MCEVILWSSA QMASFPDSDL QTCPLCKELC GCSAPISSNS STSSSSSQTS NSSSTSSTRR 60
LHVLPCLHAF CRQCLEGQRS PGDPLKLRCP TCDQKVSLSE SGVDALPSSN FLFSNLLDVV 120
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Protein Fasta Sequence


>IUUC-Dre-027699|E3,RING|Danio rerio
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Nucleotide Sequence
(Fasta)
CGCGCTGTTG AGTTGTTGTC CGCGGCGGCG TCATTCATTC CCAATAAAAA TGAAGGCGGA 60
TTGAAGAGGT GCGCGGGGAG AGCGTTGGTT TCACGCTGCA GACGCGAGAC GAATATGGTT 120
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Nucleotide Fasta Sequence


>IUUC-Dre-027699|E3,RING|Danio rerio
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Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
SMART

SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING
Gene Ontology

GO:0000932--C:P-body
GO:0035198--F:miRNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0010172--P:embryonic body morphogenesis
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035278--P:miRNA mediated inhibition of translation
GO:0010586--P:miRNA metabolic process
GO:0021915--P:neural tube development
GO:0051865--P:protein autoubiquitination
GO:0060964--P:regulation of gene silencing by miRNA
GO:2000177--P:regulation of neural precursor cell proliferation
GO:0072089--P:stem cell proliferation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001234 Ailuropoda melanoleuca 81.65 0.00e+00 1035.00
IUUC-Apl-003905 Anas platyrhynchos 83.39 0.00e+00 1041.00
IUUC-Aca-004326 Anolis carolinensis 76.57 0.00e+00 1103.00
IUUC-Ani-009171 Aspergillus nidulans 28.79 1.00e-02 35.00
IUUC-Ame-011573 Astyanax mexicanus 88.48 0.00e+00 1439.00
IUUC-Bta-013395 Bos taurus 78.80 0.00e+00 1122.00
IUUC-Cel-018188 Caenorhabditis elegans 35.98 5.00e-115 409.00
IUUC-Cja-019863 Callithrix jacchus 79.20 0.00e+00 1127.00
IUUC-Cpo-021879 Cavia porcellus 71.44 0.00e+00 1221.00
IUUC-Cho-024376 Choloepus hoffmanni 82.02 0.00e+00 1023.00
IUUC-Cin-025406 Ciona intestinalis 49.12 0.00e+00 642.00
IUUC-Dno-029022 Dasypus novemcinctus 82.71 0.00e+00 1029.00
IUUC-Dor-031072 Dipodomys ordii 79.64 0.00e+00 1128.00
IUUC-Dme-031997 Drosophila melanogaster 48.71 8.00e-69 255.00
IUUC-Ete-032228 Echinops telfairi 83.29 0.00e+00 714.00
IUUC-Eca-033373 Equus caballus 83.07 0.00e+00 915.00
IUUC-Eeu-034463 Erinaceus europaeus 83.22 0.00e+00 1001.00
IUUC-Fca-036184 Felis catus 81.82 0.00e+00 1033.00
IUUC-Fal-036918 Ficedula albicollis 74.82 0.00e+00 1060.00
IUUC-Fox-038003 Fusarium oxysporum 32.20 3.00e-03 36.20
IUUC-Gmo-039415 Gadus morhua 74.96 0.00e+00 932.00
IUUC-Gga-040379 Gallus gallus 78.72 0.00e+00 1131.00
IUUC-Gac-042330 Gasterosteus aculeatus 72.66 0.00e+00 1167.00
IUUC-Gma-043819 Glycine max 23.18 2.00e-11 65.50
IUUC-Itr-048371 Ictidomys tridecemlineatus 82.53 0.00e+00 1031.00
IUUC-Lch-050324 Latimeria chalumnae 75.12 0.00e+00 1243.00
IUUC-Loc-052322 Lepisosteus oculatus 85.63 0.00e+00 1434.00
IUUC-Laf-054272 Loxodonta africana 78.87 0.00e+00 1094.00
IUUC-Mcc-055125 Macaca mulatta 78.90 0.00e+00 1123.00
IUUC-Meu-055934 Macropus eugenii 72.23 0.00e+00 1010.00
IUUC-Mga-059930 Meleagris gallopavo 83.05 0.00e+00 1035.00
IUUC-Mdo-062918 Monodelphis domestica 77.97 0.00e+00 1141.00
IUUC-Mmu-064351 Mus musculus 71.46 0.00e+00 1196.00
IUUC-Mpu-066325 Mustela putorius furo 83.07 0.00e+00 912.00
IUUC-Mlu-067171 Myotis lucifugus 68.61 0.00e+00 1149.00
IUUC-Opr-070354 Ochotona princeps 81.51 0.00e+00 1018.00
IUUC-Ont-072125 Oreochromis niloticus 78.12 0.00e+00 1308.00
IUUC-Oan-073079 Ornithorhynchus anatinus 83.90 0.00e+00 1041.00
IUUC-Ocu-073910 Oryctolagus cuniculus 72.20 0.00e+00 1192.00
IUUC-Ola-087162 Oryzias latipes 78.94 0.00e+00 1299.00
IUUC-Oga-088523 Otolemur garnettii 67.86 0.00e+00 1114.00
IUUC-Oar-090009 Ovis aries 77.68 3.00e-163 567.00
IUUC-Ptr-091173 Pan troglodytes 79.05 0.00e+00 1126.00
IUUC-Psi-093053 Pelodiscus sinensis 79.62 0.00e+00 983.00
IUUC-Pma-094227 Petromyzon marinus 56.94 3.00e-172 598.00
IUUC-Pfo-096980 Poecilia formosa 74.40 0.00e+00 1241.00
IUUC-Pab-098189 Pongo abelii 79.05 0.00e+00 1128.00
IUUC-Pva-103126 Pteropus vampyrus 79.20 0.00e+00 1117.00
IUUC-Rno-105653 Rattus norvegicus 71.69 0.00e+00 1204.00
IUUC-Sha-107178 Sarcophilus harrisii 83.19 0.00e+00 1040.00
IUUC-Sly-111723 Solanum lycopersicum 38.03 3.00e-04 40.80
IUUC-Stu-112510 Solanum tuberosum 35.11 9.00e-10 56.60
IUUC-Sar-113613 Sorex araneus 73.14 0.00e+00 854.00
IUUC-Tgu-116963 Taeniopygia guttata 82.53 0.00e+00 1034.00
IUUC-Tru-117942 Takifugu rubripes 77.26 0.00e+00 1284.00
IUUC-Tsy-119075 Tarsius syrichta 74.66 0.00e+00 911.00
IUUC-Tni-120704 Tetraodon nigroviridis 84.96 0.00e+00 1057.00
IUUC-Tbe-128141 Tupaia belangeri 66.73 0.00e+00 715.00
IUUC-Ttr-128908 Tursiops truncatus 70.17 1.00e-165 576.00
IUUC-Xtr-132272 Xenopus tropicalis 73.58 0.00e+00 1225.00
Created Date 25-Jun-2017

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