iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012539

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin/ISG15-conjugating enzyme E2 L6; E2 ubiquitin-conjugating enzyme L6; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6

Genbank Nucleotide ID

BC142048

Gene Name

UBE2L6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000012989.5	ENSBTAT00000017267.5	ENSBTAP00000017267.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	4.10e-38	130.4	6	141

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel++l+k+ p++++  +++e+++  w++l+l pe+ pY+ ++F+l i+fp++YPf+PP+vkf+t+i+hPnv+++G+vCl i+ ++
   Q: 6    RVAKELEDLQKELPKYLRNLCSEEDNVLVWHALLL-PERPPYNLKAFRLCISFPREYPFQPPTVKFTTRIYHPNVDRDGRVCLPII-SK 92
           899********************************.**************************************************.59 PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++W++ +   +vl +++ l+++p+p +p++ e ae+l++++e ++++++
   Q: 93   KNWKASTRTCQVLEALNMLVNQPEPGQPVRLELAEQLTQDPELFDQMAQ 141
           *********************************************9986 PP

Organism

Bos taurus

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Protein Sequence
(Fasta)

MTASKRVAKE LEDLQKELPK YLRNLCSEED NVLVWHALLL PERPPYNLKA FRLCISFPRE 60
YPFQPPTVKF TTRIYHPNVD RDGRVCLPII SKKNWKASTR TCQVLEALNM LVNQPEPGQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTGGCGAG TCCCCCGGAG CCCCGCTCTC GGTTCTAAGA TGACGGCGAG CAAGCGGGTG 60
GCGAAGGTAA CCCCTCCCGC GCGGCTCCGC GCGCCTTCCC GGGCCCCCGC TCGTCGCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

bta:509471

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001818	Ailuropoda melanoleuca	69.93	4.00e-61	226.00
IUUC-Cja-019456	Callithrix jacchus	72.55	1.00e-64	238.00
IUUC-Cfa-021275	Canis familiaris	73.86	2.00e-64	238.00
IUUC-Cpo-022261	Cavia porcellus	66.01	4.00e-55	206.00
IUUC-Csa-023794	Chlorocebus sabaeus	71.52	9.00e-62	228.00
IUUC-Cho-024821	Choloepus hoffmanni	71.53	7.00e-59	219.00
IUUC-Dno-029632	Dasypus novemcinctus	75.16	3.00e-66	243.00
IUUC-Dor-030595	Dipodomys ordii	52.94	5.00e-42	163.00
IUUC-Eca-033746	Equus caballus	75.16	2.00e-65	240.00
IUUC-Fca-035417	Felis catus	73.86	2.00e-64	238.00
IUUC-Ggo-045537	Gorilla gorilla	69.28	1.00e-60	224.00
IUUC-Hsa-045943	Homo sapiens	69.93	5.00e-61	226.00
IUUC-Itr-048889	Ictidomys tridecemlineatus	66.01	2.00e-57	214.00
IUUC-Laf-053524	Loxodonta africana	67.97	7.00e-55	205.00
IUUC-Mcc-054818	Macaca mulatta	71.52	1.00e-61	228.00
IUUC-Meu-055936	Macropus eugenii	56.36	4.00e-31	125.00
IUUC-Mmr-060799	Microcebus murinus	74.34	4.00e-64	236.00
IUUC-Mmu-063359	Mus musculus	67.97	7.00e-58	215.00
IUUC-Mpu-066122	Mustela putorius furo	68.92	2.00e-58	217.00
IUUC-Mlu-067283	Myotis lucifugus	69.28	5.00e-58	216.00
IUUC-Nle-069829	Nomascus leucogenys	72.55	6.00e-64	235.00
IUUC-Opr-071062	Ochotona princeps	69.93	2.00e-59	220.00
IUUC-Oan-073297	Ornithorhynchus anatinus	61.11	2.00e-36	144.00
IUUC-Ocu-074709	Oryctolagus cuniculus	68.28	6.00e-55	206.00
IUUC-Oga-088256	Otolemur garnettii	70.39	4.00e-62	229.00
IUUC-Oar-089370	Ovis aries	93.10	2.00e-78	283.00
IUUC-Ptr-091324	Pan troglodytes	69.93	5.00e-61	226.00
IUUC-Pan-092601	Papio anubis	71.03	8.00e-59	218.00
IUUC-Pab-098184	Pongo abelii	71.24	2.00e-62	231.00
IUUC-Pca-101080	Procavia capensis	68.75	3.00e-56	209.00
IUUC-Pva-102211	Pteropus vampyrus	55.56	1.00e-42	165.00
IUUC-Rno-104863	Rattus norvegicus	68.63	2.00e-59	220.00
IUUC-Sha-107162	Sarcophilus harrisii	58.17	3.00e-48	183.00
IUUC-Ssc-115506	Sus scrofa	79.74	5.00e-70	256.00
IUUC-Tsy-118811	Tarsius syrichta	62.24	4.00e-48	183.00
IUUC-Ttr-129266	Tursiops truncatus	81.70	1.00e-71	261.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence