iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037587

Ensembl Protein ID

ENSFALP00000000476.1

UniProt Accession

U3JCH2; U3JCH2_FICAL

Genbank Protein ID

ENSFALP00000000476

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AGTO01001711

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000000464.1	ENSFALT00000000479.1	ENSFALP00000000476.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-20	72.0	522	912

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l ++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 522  NAYCNCMIQVLYFLEPVRCLVQN---HLCQK------EFCLGCELGLLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlGLILADSDEAT 601
           56*********************...55654......57********************************999944599999****99 PP
   S: 97   afl.ldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetk 183
             + l +l ++ ++   ++  +e++e++  ++ + a ++  ++++s+i +lF  ++++  +c +c+++++r ++ l ++l+ p+++e+ 
   Q: 602  GKVnLGRLIQSWNRfILTQLHQETQEQEGPQAYRGAGSSFGSSGDSVIGQLFSCEMENCSMC-RCGKETVRVSSTLLFTLSYPDSTEKP 689
           65549999999988755555555666666677888999********************9999.8*******************999763 PP
   S: 184  ke..slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts.. 267
            +  ++ ++L+       le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e+     k + +++f +  ++   f ++  
   Q: 690  AKdyEFAQILKRSI---CLEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSSKEA--DFWKTQAEYSFQKAmMKRGGFDITkg 773
           33223444444333...4666778****************************999855444..33478888888755333333444456 PP
   S: 268  .........................................................peekqkekkkYeLiavvvHsG.slssGHYvay 298
                                                                    p+++ ++ ++Y+L+a vvH   s  +G  v +
   Q: 774  keislgewkdlgnpdtghsypsveelkniwiphaikmrltkskeldvsnwsetdelsPTDDPESVYIYDLMATVVHILdSRTGGSLVGH 862
           66667777777777777777777777777777777777766666666666666666644444449*************9********** PP
   S: 299  vkn...........ekgkWllfdDskVtevkeeevleetg..staYvlfY 335
           +k            ++++W+lf+D  +++v++ e +++    + + +l+Y
   Q: 863  IKVgetyhqrkegvTHQQWYLFNDFLIEPVDKCEAVQFDMswKVPAILYY 912
           ***999988877777888*********99998776665444555555555 PP

Organism

Ficedula albicollis

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLNPSL AEFAPPLHPA LEPVLDPHLN PNLVELDPEG VSLEGLPVPD SVHLMEGMYS 60
ELHTAVSEVG VPVSVAHFDL HEEMLWVGNH GGHATSFFGP TLERYSSFQV NSSDDIRQIQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCACCAAT TCCAAGAACC CTGGCTGCCC CTGAGCAGTT CCTCAGGCTC CTTCTCCCTC 60
CCCCAGGCCG GGATTCACCA TGAATTTCGA AGGGCTCAAC CCCTCCCTGG CCGAGTTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	84.31	0.00e+00	1994.00
IUUC-Apl-003500	Anas platyrhynchos	95.09	0.00e+00	2065.00
IUUC-Aca-004930	Anolis carolinensis	89.29	0.00e+00	2094.00
IUUC-Acl-008214	Aspergillus clavatus	32.20	1.00e-154	540.00
IUUC-Afu-009112	Aspergillus fumigatus	31.75	3.00e-144	506.00
IUUC-Ang-009531	Aspergillus niger	31.54	5.00e-147	515.00
IUUC-Ame-011259	Astyanax mexicanus	77.07	0.00e+00	1824.00
IUUC-Bta-012371	Bos taurus	84.71	0.00e+00	1999.00
IUUC-Bci-013684	Botrytis cinerea	47.94	1.00e-70	261.00
IUUC-Cja-019297	Callithrix jacchus	81.65	0.00e+00	1941.00
IUUC-Cfa-020489	Canis familiaris	84.54	0.00e+00	1991.00
IUUC-Cpo-022392	Cavia porcellus	83.98	0.00e+00	2007.00
IUUC-Csa-023220	Chlorocebus sabaeus	84.31	0.00e+00	1999.00
IUUC-Csv-025841	Ciona savignyi	47.01	3.00e-135	476.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.70	2.00e-164	572.00
IUUC-Cne-026932	Cryptococcus neoformans	44.51	1.00e-71	264.00
IUUC-Dre-028482	Danio rerio	75.02	0.00e+00	1780.00
IUUC-Dno-029398	Dasypus novemcinctus	84.51	0.00e+00	1995.00
IUUC-Dor-030307	Dipodomys ordii	77.40	0.00e+00	1088.00
IUUC-Dme-032111	Drosophila melanogaster	41.51	0.00e+00	890.00
IUUC-Eca-033985	Equus caballus	84.79	0.00e+00	2002.00
IUUC-Eeu-034928	Erinaceus europaeus	86.97	0.00e+00	689.00
IUUC-Fca-035587	Felis catus	84.40	0.00e+00	1996.00
IUUC-Fso-038133	Fusarium solani	32.24	1.00e-95	344.00
IUUC-Gmo-039076	Gadus morhua	74.69	0.00e+00	1753.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.06	4.00e-142	499.00
IUUC-Gga-040948	Gallus gallus	95.03	0.00e+00	2222.00
IUUC-Gac-042396	Gasterosteus aculeatus	75.85	0.00e+00	1815.00
IUUC-Ggo-045412	Gorilla gorilla	84.23	0.00e+00	1995.00
IUUC-Hsa-046076	Homo sapiens	84.23	0.00e+00	1999.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	79.45	0.00e+00	1827.00
IUUC-Kpa-049178	Komagataella pastoris	40.18	6.00e-66	245.00
IUUC-Lch-050279	Latimeria chalumnae	75.33	0.00e+00	1749.00
IUUC-Loc-052872	Lepisosteus oculatus	78.43	0.00e+00	1830.00
IUUC-Lma-052986	Leptosphaeria maculans	31.18	1.00e-92	334.00
IUUC-Laf-054181	Loxodonta africana	82.76	0.00e+00	1976.00
IUUC-Mcc-054812	Macaca mulatta	84.54	0.00e+00	1995.00
IUUC-Meu-056325	Macropus eugenii	86.65	0.00e+00	2040.00
IUUC-Mor-057246	Magnaporthe oryzae	29.84	2.00e-122	433.00
IUUC-Mpo-057464	Magnaporthe poae	32.09	5.00e-146	511.00
IUUC-Mla-058911	Melampsora laricipopulina	33.01	9.00e-103	368.00
IUUC-Mga-059335	Meleagris gallopavo	94.81	0.00e+00	2157.00
IUUC-Mvi-060461	Microbotryum violaceum	34.00	5.00e-146	512.00
IUUC-Mmr-060636	Microcebus murinus	84.71	0.00e+00	1999.00
IUUC-Mmu-063503	Mus musculus	84.20	0.00e+00	1984.00
IUUC-Mpu-066670	Mustela putorius furo	84.54	0.00e+00	1993.00
IUUC-Mlu-068119	Myotis lucifugus	83.95	0.00e+00	2040.00
IUUC-Nfi-068398	Neosartorya fischeri	32.73	3.00e-153	535.00
IUUC-Ncr-068927	Neurospora crassa	29.90	2.00e-127	450.00
IUUC-Nle-069651	Nomascus leucogenys	80.64	0.00e+00	1907.00
IUUC-Opr-070614	Ochotona princeps	83.25	0.00e+00	1952.00
IUUC-Ont-072433	Oreochromis niloticus	76.36	0.00e+00	1845.00
IUUC-Oan-073283	Ornithorhynchus anatinus	73.51	0.00e+00	1400.00
IUUC-Ocu-074401	Oryctolagus cuniculus	83.54	0.00e+00	1989.00
IUUC-Ola-087522	Oryzias latipes	76.35	0.00e+00	1796.00
IUUC-Oga-088226	Otolemur garnettii	83.90	0.00e+00	2003.00
IUUC-Oar-089241	Ovis aries	84.48	0.00e+00	2024.00
IUUC-Pan-092297	Papio anubis	85.24	0.00e+00	1791.00
IUUC-Psi-094043	Pelodiscus sinensis	87.27	0.00e+00	2009.00
IUUC-Pma-094394	Petromyzon marinus	70.07	0.00e+00	1572.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.81	2.00e-132	466.00
IUUC-Ppa-095188	Physcomitrella patens	31.71	6.00e-155	541.00
IUUC-Pfo-097517	Poecilia formosa	76.80	0.00e+00	1844.00
IUUC-Pca-100471	Procavia capensis	84.61	0.00e+00	1887.00
IUUC-Pva-102805	Pteropus vampyrus	80.72	0.00e+00	1556.00
IUUC-Pte-104021	Pyrenophora teres	32.53	2.00e-159	556.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	32.35	2.00e-158	553.00
IUUC-Rno-105471	Rattus norvegicus	84.75	0.00e+00	1984.00
IUUC-Sce-106235	Saccharomyces cerevisiae	36.20	6.00e-61	229.00
IUUC-Sha-106883	Sarcophilus harrisii	87.15	0.00e+00	1905.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.17	5.00e-143	501.00
IUUC-Sar-113323	Sorex araneus	84.55	0.00e+00	1479.00
IUUC-Sre-115075	Sporisorium reilianum	39.07	1.00e-61	232.00
IUUC-Ssc-116363	Sus scrofa	83.71	0.00e+00	2013.00
IUUC-Tru-118427	Takifugu rubripes	76.22	0.00e+00	1877.00
IUUC-Tni-120218	Tetraodon nigroviridis	76.44	0.00e+00	1871.00
IUUC-Tre-122177	Trichoderma reesei	30.97	4.00e-152	532.00
IUUC-Tme-127176	Tuber melanosporum	31.92	2.00e-141	496.00
IUUC-Tbe-127641	Tupaia belangeri	76.47	0.00e+00	711.00
IUUC-Ttr-128888	Tursiops truncatus	83.36	0.00e+00	1233.00
IUUC-Uma-129361	Ustilago maydis	38.33	5.00e-62	233.00
IUUC-Xtr-132811	Xenopus tropicalis	81.73	0.00e+00	1941.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence