iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048066

Ensembl Protein ID

ENSSTOP00000020190.1

UniProt Accession

I3N744; I3N744_ICTTR

Genbank Protein ID

ENSSTOP00000020190

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AGTP01009760

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000029230.1	ENSSTOT00000027900.1	ENSSTOP00000020190.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.10e-132	443.1	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l+ a+++G+E+lKnLvl G+gs+t+vD+++v+ ++ +++F+++++++gk++Ae+a+e+l+eln dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLIHATATGTEILKNLVLPGIGSFTIVDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNNDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ees+++l ++++ Ff++f+vVv+++  +++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEESPENLLDNDPsFFCRFTVVVATQLHESTLLRLADVLWNSEIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldhmekKDHSHTPWIVIVAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
           *****99999999998***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk+++pfw+                                                              
   Q: 280  QIPSsIEDIFNDDRCINITKQTPPFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v            ++++kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  +
   Q: 369  gqapesisekelkLLCSNSAFLRVVrcrslaeeyglDTINKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIgkL 457
           *************99********7777777888888**************9***********************************999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t ++    +++g++ +++dd+i+e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTGFL----QEYGLSVMVKDDYIHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           ********....********************************************************9776 PP

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQPGKLLKE QKYDRQLRLW GDHGQEALES AHVCLIHATA TGTEILKNLV LPGIGSFTIV 60
DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNNDV SGSFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCTGGGC TGGTGGCGCG GCGGGCGCGG CCATGGCGCA GCCGGGGAAG CTGCTCAAGG 60
AGCAGAAGTA CGACCGGCAG CTGAGGTGAG ACGGGACTCA CTGAGCCGAG CGGGAGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.72	2.00e-125	442.00
IUUC-Aml-002333	Ailuropoda melanoleuca	96.64	0.00e+00	1083.00
IUUC-Atr-002644	Amborella trichopoda	40.94	3.00e-114	405.00
IUUC-Apl-003446	Anas platyrhynchos	84.01	0.00e+00	915.00
IUUC-Aca-004450	Anolis carolinensis	80.90	0.00e+00	921.00
IUUC-Aly-006187	Arabidopsis lyrata	40.19	4.00e-125	441.00
IUUC-Ath-007600	Arabidopsis thaliana	40.75	1.00e-126	446.00
IUUC-Ago-007900	Ashbya gossypii	25.92	3.00e-39	155.00
IUUC-Acl-008333	Aspergillus clavatus	34.70	3.00e-81	295.00
IUUC-Afl-008529	Aspergillus flavus	36.74	7.00e-87	314.00
IUUC-Afu-009071	Aspergillus fumigatus	34.05	5.00e-82	298.00
IUUC-Ani-009443	Aspergillus nidulans	33.69	1.00e-78	286.00
IUUC-Ang-009669	Aspergillus niger	34.05	5.00e-82	298.00
IUUC-Aor-009914	Aspergillus oryzae	36.06	1.00e-83	303.00
IUUC-Ate-010450	Aspergillus terreus	34.89	5.00e-84	305.00
IUUC-Ame-011183	Astyanax mexicanus	71.46	0.00e+00	822.00
IUUC-Bgr-012111	Blumeria graminis	32.61	2.00e-65	242.00
IUUC-Bta-012583	Bos taurus	97.94	0.00e+00	1095.00
IUUC-Bci-013892	Botrytis cinerea	32.97	1.00e-65	243.00
IUUC-Bdi-014592	Brachypodium distachyon	43.13	9.00e-128	449.00
IUUC-Bol-016399	Brassica oleracea	40.11	1.00e-123	436.00
IUUC-Bra-017506	Brassica rapa	38.81	2.00e-119	422.00
IUUC-Cel-018456	Caenorhabditis elegans	36.72	8.00e-96	343.00
IUUC-Cja-020007	Callithrix jacchus	97.02	0.00e+00	1087.00
IUUC-Cfa-020324	Canis familiaris	97.19	0.00e+00	1087.00
IUUC-Cpo-022248	Cavia porcellus	66.91	0.00e+00	649.00
IUUC-Csa-023149	Chlorocebus sabaeus	98.45	0.00e+00	930.00
IUUC-Cho-024537	Choloepus hoffmanni	85.25	0.00e+00	807.00
IUUC-Cin-025763	Ciona intestinalis	49.53	7.00e-155	540.00
IUUC-Csv-026113	Ciona savignyi	46.48	2.00e-145	508.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.47	8.00e-65	241.00
IUUC-Cne-026884	Cryptococcus neoformans	30.07	2.00e-71	263.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.56	3.00e-19	89.70
IUUC-Dre-028140	Danio rerio	73.03	0.00e+00	845.00
IUUC-Dno-030033	Dasypus novemcinctus	97.46	0.00e+00	959.00
IUUC-Dor-030513	Dipodomys ordii	69.01	8.00e-116	410.00
IUUC-Dse-031536	Dothistroma septosporum	35.47	1.00e-86	313.00
IUUC-Dme-031683	Drosophila melanogaster	44.47	2.00e-126	446.00
IUUC-Ete-032420	Echinops telfairi	82.95	0.00e+00	890.00
IUUC-Eca-033992	Equus caballus	97.98	0.00e+00	916.00
IUUC-Eeu-034713	Erinaceus europaeus	80.31	3.00e-119	421.00
IUUC-Fca-036548	Felis catus	96.44	0.00e+00	1077.00
IUUC-Fal-037600	Ficedula albicollis	80.46	0.00e+00	881.00
IUUC-Fox-038037	Fusarium oxysporum	33.51	4.00e-75	275.00
IUUC-Fso-038387	Fusarium solani	34.41	4.00e-77	281.00
IUUC-Gmo-038562	Gadus morhua	70.83	0.00e+00	818.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.75	5.00e-72	265.00
IUUC-Gga-041129	Gallus gallus	84.49	0.00e+00	942.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.50	0.00e+00	827.00
IUUC-Gma-043610	Glycine max	41.34	6.00e-121	427.00
IUUC-Ggo-045611	Gorilla gorilla	97.39	0.00e+00	1087.00
IUUC-Hsa-046563	Homo sapiens	97.94	0.00e+00	1091.00
IUUC-Hvu-047790	Hordeum vulgare	38.36	3.00e-77	281.00
IUUC-Kpa-049309	Komagataella pastoris	35.86	2.00e-84	305.00
IUUC-Lch-050038	Latimeria chalumnae	76.46	0.00e+00	856.00
IUUC-Lpe-051535	Leersia perrieri	41.85	3.00e-111	395.00
IUUC-Loc-051917	Lepisosteus oculatus	69.37	0.00e+00	790.00
IUUC-Lma-053112	Leptosphaeria maculans	35.04	7.00e-87	314.00
IUUC-Laf-053690	Loxodonta africana	95.69	0.00e+00	1078.00
IUUC-Mcc-055117	Macaca mulatta	96.10	0.00e+00	1074.00
IUUC-Meu-056761	Macropus eugenii	77.37	0.00e+00	830.00
IUUC-Mor-057230	Magnaporthe oryzae	33.63	3.00e-77	282.00
IUUC-Mpo-057514	Magnaporthe poae	33.51	3.00e-70	258.00
IUUC-Mtr-058551	Medicago truncatula	40.65	1.00e-117	416.00
IUUC-Mla-059183	Melampsora laricipopulina	37.34	1.00e-97	350.00
IUUC-Mga-060144	Meleagris gallopavo	82.77	0.00e+00	912.00
IUUC-Mvi-060221	Microbotryum violaceum	35.99	7.00e-83	301.00
IUUC-Mmr-061325	Microcebus murinus	94.79	0.00e+00	1059.00
IUUC-Mdo-062532	Monodelphis domestica	91.18	0.00e+00	1022.00
IUUC-Mmu-063956	Mus musculus	96.44	0.00e+00	1083.00
IUUC-Mac-064521	Musa acuminata	40.75	4.00e-123	434.00
IUUC-Mpu-066716	Mustela putorius furo	96.61	0.00e+00	1021.00
IUUC-Mlu-067459	Myotis lucifugus	94.96	0.00e+00	1062.00
IUUC-Nfi-068245	Neosartorya fischeri	34.41	3.00e-82	298.00
IUUC-Ncr-068910	Neurospora crassa	33.82	3.00e-76	278.00
IUUC-Nle-070034	Nomascus leucogenys	95.43	0.00e+00	1045.00
IUUC-Opr-070552	Ochotona princeps	87.82	0.00e+00	888.00
IUUC-Ont-071426	Oreochromis niloticus	73.35	0.00e+00	845.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.82	0.00e+00	776.00
IUUC-Ocu-074911	Oryctolagus cuniculus	96.44	0.00e+00	1083.00
IUUC-Oba-075437	Oryza barthii	43.32	3.00e-118	418.00
IUUC-Obr-076684	Oryza brachyantha	43.35	1.00e-113	402.00
IUUC-Ogl-077170	Oryza glaberrima	43.32	3.00e-118	418.00
IUUC-Ogu-078844	Oryza glumaepatula	44.11	2.00e-111	395.00
IUUC-Oin-079105	Oryza indica	43.32	1.00e-117	416.00
IUUC-Olo-080943	Oryza longistaminata	40.64	5.00e-106	377.00
IUUC-Oni-082891	Oryza nivara	40.27	2.00e-111	395.00
IUUC-Opu-083457	Oryza punctata	43.32	1.00e-117	416.00
IUUC-Oru-084960	Oryza rufipogon	40.64	6.00e-106	377.00
IUUC-Osa-085358	Oryza sativa	43.51	2.00e-118	418.00
IUUC-Ola-086420	Oryzias latipes	72.12	8.00e-170	589.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.24	3.00e-61	229.00
IUUC-Oga-088810	Otolemur garnettii	95.88	0.00e+00	1076.00
IUUC-Oar-089196	Ovis aries	97.39	0.00e+00	1092.00
IUUC-Ptr-090617	Pan troglodytes	97.94	0.00e+00	1091.00
IUUC-Pan-092761	Papio anubis	98.13	0.00e+00	1096.00
IUUC-Psi-093191	Pelodiscus sinensis	86.85	0.00e+00	961.00
IUUC-Pma-094380	Petromyzon marinus	61.87	0.00e+00	658.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.31	4.00e-74	273.00
IUUC-Ppa-095875	Physcomitrella patens	40.42	9.00e-120	423.00
IUUC-Pfo-096467	Poecilia formosa	72.40	0.00e+00	825.00
IUUC-Pab-098255	Pongo abelii	97.75	0.00e+00	910.00
IUUC-Pop-099722	Populus trichocarpa	40.56	1.00e-124	439.00
IUUC-Pca-100807	Procavia capensis	78.11	3.00e-117	414.00
IUUC-Ppe-101280	Prunus persica	40.22	2.00e-123	435.00
IUUC-Pva-102333	Pteropus vampyrus	92.55	0.00e+00	1023.00
IUUC-Pgr-103401	Puccinia graminis	31.96	1.00e-80	293.00
IUUC-Ptt-103889	Puccinia triticina	27.67	4.00e-58	219.00
IUUC-Pte-104355	Pyrenophora teres	36.19	3.00e-90	325.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.19	2.00e-91	329.00
IUUC-Rno-105810	Rattus norvegicus	95.51	0.00e+00	1074.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.62	2.00e-37	149.00
IUUC-Sha-106770	Sarcophilus harrisii	90.46	1.00e-153	535.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.77	4.00e-77	281.00
IUUC-Spo-108276	Schizosaccharomyces pombe	35.27	4.00e-84	305.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.36	4.00e-68	251.00
IUUC-Smo-109296	Selaginella moellendorffii	42.42	1.00e-123	436.00
IUUC-Sit-110157	Setaria italica	44.59	2.00e-134	472.00
IUUC-Sly-111105	Solanum lycopersicum	40.11	2.00e-122	432.00
IUUC-Stu-112469	Solanum tuberosum	40.62	3.00e-124	438.00
IUUC-Sar-113083	Sorex araneus	72.67	0.00e+00	746.00
IUUC-Sbi-113813	Sorghum bicolor	44.59	7.00e-134	470.00
IUUC-Sre-115058	Sporisorium reilianum	38.89	1.00e-84	307.00
IUUC-Tgu-116772	Taeniopygia guttata	80.27	0.00e+00	880.00
IUUC-Tru-118686	Takifugu rubripes	71.46	0.00e+00	829.00
IUUC-Tsy-119111	Tarsius syrichta	89.05	5.00e-149	520.00
IUUC-Tni-120231	Tetraodon nigroviridis	65.85	0.00e+00	745.00
IUUC-Tca-121491	Theobroma cacao	40.78	3.00e-117	414.00
IUUC-Tre-122103	Trichoderma reesei	36.40	1.00e-82	300.00
IUUC-Tvi-122672	Trichoderma virens	36.28	3.00e-74	272.00
IUUC-Tae-125679	Triticum aestivum	43.32	2.00e-127	449.00
IUUC-Tur-126487	Triticum urartu	41.60	1.00e-120	426.00
IUUC-Tme-127097	Tuber melanosporum	39.09	5.00e-94	338.00
IUUC-Ttr-128465	Tursiops truncatus	89.76	0.00e+00	996.00
IUUC-Uma-129645	Ustilago maydis	33.50	3.00e-89	322.00
IUUC-Vda-129989	Verticillium dahliae	30.54	2.00e-55	209.00
IUUC-Vpa-130529	Vicugna pacos	92.74	0.00e+00	1031.00
IUUC-Vvi-131059	Vitis vinifera	41.15	5.00e-122	431.00
IUUC-Xtr-132002	Xenopus tropicalis	78.94	0.00e+00	902.00
IUUC-Xma-133930	Xiphophorus maculatus	72.81	0.00e+00	831.00
IUUC-Yli-134505	Yarrowia lipolytica	35.24	9.00e-86	310.00
IUUC-Zma-135895	Zea mays	44.47	1.00e-132	466.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence