iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oni-082891

Ensembl Protein ID

ONIVA03G40700.1

UniProt Accession

A0A0E0GVN2; A0A0E0GVN2_ORYNI

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ONIVA03G40700	ONIVA03G40700.1	ONIVA03G40700.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.90e-96	323.4	16	508

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahe 94
           YDRQ+r+wG+++q++l++a+++l+ +g++G+E  KnLvl+Gvgs+tvvD d              ae  g+s+A++++ +l+eln+ vn++++e
   Q: 16   YDRQLRIWGDQGQAALEKASICLLTCGPTGTEAMKNLVLGGVGSVTVVDVD--------------AECLGQSRAKSVCSFLQELNDAVNAKFVE 95
           *************************************************65..............7889************************* PP
   S: 95   esiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn... 181
           es+ +l ++++ Ff++f+vV++++ ++ + +k++++c++a++ l+ ++++Gl G vr+++k++ +++s++d   d++++ +P+++lk++     
   Q: 96   ESPLALIDTNPsFFSQFTVVIATQLPERSLLKLDDICRKANIVLVAARSYGLTGLVRISVKEHNVIESKPDhflDDLRLHNPWVELKQFAKsid 189
           *****************************************************************************************88899 PP
   S: 182  ......aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtks 268
                 +++++++++v++  l+e++a +++++ +++++ek e+k ++++ + + deen++ea+e + k   +  i++ i+q++++ + ++v++s
   Q: 190  indkdpVVHKHTPYIVILVRLAEKWADAHDGRLPSTRQEKNEFKALIREHMLNLDEENYKEAVESSYKVSVTPGISDeIRQIIDD-SSAEVNSS 282
           999999******************************************************************************9.78899*** PP
   S: 269  kspfwv...........................................................................sfcsnaealq... 284
           +s+fwv                                                                           +fc+na++l+   
   Q: 283  SSDFWVlvaalkefianegngelplegtipdmtslteyyvslqkiyqakaesdclalehhvkdilkridrdpdsisrayikTFCKNARKLRvcr 376
           *******************************************************************************************666 PP
   S: 285  ........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagn 364
                   + +   + +++++++++     +y+llra++r++++++r pg ++ e d+d +++l+taa +  ++++g+++ +l++dli+e++++
   Q: 377  yrsmeeefSSPVLSEVQKYFTDEDYcfamnFYVLLRAVDRLAANYNRCPGIFESEIDED-VPRLKTAAVSV-MSEMGMNGaPLSEDLITEMCRF 468
           666655553355666666667777788888*******************9999999999.9****988875.6********************* PP
   S: 365  iipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           + ++i++++a++gG+a+qEviK+v+++f+pl  +f+f+++
   Q: 469  GGAEIHPVAAFIGGVASQEVIKLVTKQFVPLLGTFIFNGI 508
           *************************************986 PP

Organism

Oryza nivara

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAATAAAFA EPKTKYDRQL RIWGDQGQAA LEKASICLLT CGPTGTEAMK NLVLGGVGSV 60
TVVDVDAECL GQSRAKSVCS FLQELNDAVN AKFVEESPLA LIDTNPSFFS QFTVVIATQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGCCTCCA AAGCCCACGA TCCCCTTCTC CTTGCTCCGC CTCCACTTAG CTTGAGACCG 60
CTTTATTCCT CGCTCAGGGA GGAGAAGGAG AAGGCGAAGG CGAAGCGAAG CAAAGCAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	85.36	0.00e+00	889.00
IUUC-Aml-002333	Ailuropoda melanoleuca	41.83	2.00e-120	426.00
IUUC-Atr-002644	Amborella trichopoda	69.87	0.00e+00	728.00
IUUC-Apl-003446	Anas platyrhynchos	40.38	3.00e-110	391.00
IUUC-Aca-004450	Anolis carolinensis	40.30	4.00e-115	407.00
IUUC-Aly-005466	Arabidopsis lyrata	66.28	0.00e+00	727.00
IUUC-Ath-006692	Arabidopsis thaliana	66.67	0.00e+00	725.00
IUUC-Ago-007900	Ashbya gossypii	27.69	1.00e-40	159.00
IUUC-Acl-008333	Aspergillus clavatus	31.15	5.00e-61	228.00
IUUC-Afl-008529	Aspergillus flavus	31.22	6.00e-65	241.00
IUUC-Afu-009071	Aspergillus fumigatus	30.78	6.00e-60	224.00
IUUC-Ani-009443	Aspergillus nidulans	30.67	4.00e-55	208.00
IUUC-Ang-009669	Aspergillus niger	30.25	1.00e-62	233.00
IUUC-Aor-009914	Aspergillus oryzae	30.94	6.00e-63	234.00
IUUC-Ate-010450	Aspergillus terreus	30.31	1.00e-60	227.00
IUUC-Ame-011183	Astyanax mexicanus	38.93	2.00e-113	402.00
IUUC-Bgr-012111	Blumeria graminis	30.84	6.00e-53	201.00
IUUC-Bta-012583	Bos taurus	41.79	2.00e-121	429.00
IUUC-Bci-013892	Botrytis cinerea	30.39	6.00e-51	194.00
IUUC-Bdi-014592	Brachypodium distachyon	86.18	0.00e+00	900.00
IUUC-Bol-016401	Brassica oleracea	65.90	0.00e+00	720.00
IUUC-Bra-017506	Brassica rapa	64.63	0.00e+00	701.00
IUUC-Cel-018456	Caenorhabditis elegans	28.94	1.00e-62	233.00
IUUC-Cja-020007	Callithrix jacchus	41.94	3.00e-120	424.00
IUUC-Cfa-020324	Canis familiaris	41.60	7.00e-122	430.00
IUUC-Cpo-022248	Cavia porcellus	41.87	2.00e-70	258.00
IUUC-Csa-023149	Chlorocebus sabaeus	40.17	2.00e-101	362.00
IUUC-Cho-024537	Choloepus hoffmanni	35.89	6.00e-86	310.00
IUUC-Cin-025763	Ciona intestinalis	40.00	2.00e-102	365.00
IUUC-Csv-026113	Ciona savignyi	37.87	9.00e-94	337.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	28.83	6.00e-50	191.00
IUUC-Cne-026884	Cryptococcus neoformans	30.33	3.00e-59	222.00
IUUC-Dre-028140	Danio rerio	39.89	8.00e-117	413.00
IUUC-Dno-030033	Dasypus novemcinctus	41.09	2.00e-103	369.00
IUUC-Dor-030513	Dipodomys ordii	33.61	5.00e-31	128.00
IUUC-Dse-031536	Dothistroma septosporum	29.11	6.00e-55	207.00
IUUC-Dme-031683	Drosophila melanogaster	37.19	6.00e-88	317.00
IUUC-Ete-032420	Echinops telfairi	36.73	4.00e-101	361.00
IUUC-Eca-033992	Equus caballus	41.22	4.00e-100	357.00
IUUC-Eeu-034713	Erinaceus europaeus	33.19	7.00e-36	144.00
IUUC-Fca-036548	Felis catus	41.22	5.00e-121	427.00
IUUC-Fal-037600	Ficedula albicollis	40.00	9.00e-108	383.00
IUUC-Fox-038037	Fusarium oxysporum	31.12	4.00e-62	231.00
IUUC-Fso-038387	Fusarium solani	31.52	6.00e-62	231.00
IUUC-Gmo-038562	Gadus morhua	39.20	2.00e-110	392.00
IUUC-Ggr-040005	Gaeumannomyces graminis	30.59	1.00e-57	217.00
IUUC-Gga-041129	Gallus gallus	40.46	5.00e-111	394.00
IUUC-Gac-042558	Gasterosteus aculeatus	39.73	2.00e-114	405.00
IUUC-Gma-043610	Glycine max	68.14	0.00e+00	721.00
IUUC-Ggo-045611	Gorilla gorilla	41.37	3.00e-119	421.00
IUUC-Hsa-046563	Homo sapiens	41.60	2.00e-120	425.00
IUUC-Hvu-047790	Hordeum vulgare	88.43	0.00e+00	683.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	41.98	2.00e-120	425.00
IUUC-Kpa-049309	Komagataella pastoris	33.78	2.00e-69	255.00
IUUC-Lch-050038	Latimeria chalumnae	40.61	5.00e-114	404.00
IUUC-Lpe-051535	Leersia perrieri	93.17	0.00e+00	880.00
IUUC-Loc-051917	Lepisosteus oculatus	38.29	2.00e-105	375.00
IUUC-Lma-053112	Leptosphaeria maculans	31.47	9.00e-63	234.00
IUUC-Laf-053690	Loxodonta africana	42.37	6.00e-123	434.00
IUUC-Mcc-055117	Macaca mulatta	41.48	3.00e-120	424.00
IUUC-Meu-056761	Macropus eugenii	35.55	2.00e-91	329.00
IUUC-Mor-057230	Magnaporthe oryzae	30.02	6.00e-61	228.00
IUUC-Mpo-057514	Magnaporthe poae	30.20	1.00e-53	203.00
IUUC-Mtr-058551	Medicago truncatula	64.99	0.00e+00	693.00
IUUC-Mla-059183	Melampsora laricipopulina	33.09	9.00e-79	287.00
IUUC-Mga-060144	Meleagris gallopavo	39.73	2.00e-107	382.00
IUUC-Mvi-060221	Microbotryum violaceum	31.99	4.00e-52	198.00
IUUC-Mmr-061325	Microcebus murinus	41.56	2.00e-119	421.00
IUUC-Mdo-062532	Monodelphis domestica	41.41	2.00e-119	422.00
IUUC-Mmu-063956	Mus musculus	41.03	5.00e-120	424.00
IUUC-Mac-064521	Musa acuminata	71.29	0.00e+00	772.00
IUUC-Mpu-066716	Mustela putorius furo	41.67	4.00e-112	397.00
IUUC-Mlu-067459	Myotis lucifugus	42.10	3.00e-122	431.00
IUUC-Nfi-068245	Neosartorya fischeri	31.34	3.00e-60	225.00
IUUC-Ncr-068910	Neurospora crassa	29.68	3.00e-56	212.00
IUUC-Nle-070034	Nomascus leucogenys	40.96	2.00e-115	408.00
IUUC-Opr-070552	Ochotona princeps	38.37	2.00e-92	332.00
IUUC-Ont-071426	Oreochromis niloticus	39.69	7.00e-117	413.00
IUUC-Oan-073389	Ornithorhynchus anatinus	38.96	4.00e-87	314.00
IUUC-Ocu-074911	Oryctolagus cuniculus	42.18	5.00e-122	430.00
IUUC-Oba-075437	Oryza barthii	96.93	0.00e+00	973.00
IUUC-Obr-076684	Oryza brachyantha	89.44	0.00e+00	869.00
IUUC-Ogl-077170	Oryza glaberrima	96.93	0.00e+00	973.00
IUUC-Ogu-078844	Oryza glumaepatula	95.98	0.00e+00	919.00
IUUC-Oin-079105	Oryza indica	97.12	0.00e+00	977.00
IUUC-Olo-080943	Oryza longistaminata	99.79	0.00e+00	925.00
IUUC-Opu-083457	Oryza punctata	94.26	0.00e+00	968.00
IUUC-Oru-084960	Oryza rufipogon	99.79	0.00e+00	925.00
IUUC-Osa-085358	Oryza sativa	96.74	0.00e+00	972.00
IUUC-Ola-086420	Oryzias latipes	39.36	4.00e-77	280.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.91	5.00e-58	218.00
IUUC-Oga-088810	Otolemur garnettii	41.79	3.00e-121	428.00
IUUC-Oar-089196	Ovis aries	41.56	7.00e-120	423.00
IUUC-Ptr-090617	Pan troglodytes	41.60	9.00e-121	426.00
IUUC-Pan-092761	Papio anubis	41.79	1.00e-121	429.00
IUUC-Psi-093191	Pelodiscus sinensis	38.46	3.00e-112	398.00
IUUC-Pma-094380	Petromyzon marinus	38.83	4.00e-100	357.00
IUUC-Pno-095084	Phaeosphaeria nodorum	30.19	2.00e-54	207.00
IUUC-Ppa-095798	Physcomitrella patens	54.01	2.00e-166	578.00
IUUC-Pfo-096467	Poecilia formosa	39.66	5.00e-112	397.00
IUUC-Pab-098255	Pongo abelii	42.96	3.00e-99	355.00
IUUC-Pop-099722	Populus trichocarpa	69.10	0.00e+00	753.00
IUUC-Pca-100807	Procavia capensis	48.13	2.00e-45	176.00
IUUC-Ppe-101280	Prunus persica	68.33	0.00e+00	742.00
IUUC-Pva-102333	Pteropus vampyrus	40.23	2.00e-114	405.00
IUUC-Pgr-103401	Puccinia graminis	28.14	1.00e-59	223.00
IUUC-Ptt-103889	Puccinia triticina	25.84	2.00e-52	199.00
IUUC-Pte-104355	Pyrenophora teres	30.98	2.00e-60	226.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	31.46	2.00e-61	229.00
IUUC-Rno-105810	Rattus norvegicus	41.60	5.00e-120	424.00
IUUC-Sce-106397	Saccharomyces cerevisiae	28.16	2.00e-35	142.00
IUUC-Sha-106770	Sarcophilus harrisii	46.15	4.00e-63	234.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.18	9.00e-74	270.00
IUUC-Spo-108276	Schizosaccharomyces pombe	32.95	5.00e-78	284.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.20	3.00e-53	202.00
IUUC-Smo-109296	Selaginella moellendorffii	52.50	2.00e-157	548.00
IUUC-Sit-110157	Setaria italica	85.99	0.00e+00	915.00
IUUC-Sly-111105	Solanum lycopersicum	65.61	0.00e+00	714.00
IUUC-Stu-112469	Solanum tuberosum	66.54	0.00e+00	728.00
IUUC-Sar-113083	Sorex araneus	32.30	3.00e-78	285.00
IUUC-Sbi-113813	Sorghum bicolor	86.76	0.00e+00	923.00
IUUC-Sre-115058	Sporisorium reilianum	32.51	2.00e-58	219.00
IUUC-Tgu-116772	Taeniopygia guttata	41.37	2.00e-110	392.00
IUUC-Tru-118686	Takifugu rubripes	38.78	2.00e-114	405.00
IUUC-Tsy-119111	Tarsius syrichta	44.49	4.00e-58	218.00
IUUC-Tni-120231	Tetraodon nigroviridis	37.81	6.00e-101	360.00
IUUC-Tca-121491	Theobroma cacao	68.52	0.00e+00	711.00
IUUC-Tre-122103	Trichoderma reesei	31.53	8.00e-65	240.00
IUUC-Tvi-122672	Trichoderma virens	30.45	1.00e-60	226.00
IUUC-Tae-125316	Triticum aestivum	86.18	0.00e+00	895.00
IUUC-Tur-126487	Triticum urartu	84.72	0.00e+00	866.00
IUUC-Tme-127097	Tuber melanosporum	32.79	2.00e-71	262.00
IUUC-Ttr-128465	Tursiops truncatus	38.52	3.00e-105	375.00
IUUC-Uma-129645	Ustilago maydis	31.01	7.00e-56	211.00
IUUC-Vda-129989	Verticillium dahliae	27.78	5.00e-41	161.00
IUUC-Vpa-130529	Vicugna pacos	39.47	2.00e-110	392.00
IUUC-Vvi-131059	Vitis vinifera	69.67	0.00e+00	754.00
IUUC-Xtr-132002	Xenopus tropicalis	41.63	4.00e-118	417.00
IUUC-Xma-133930	Xiphophorus maculatus	40.19	1.00e-115	409.00
IUUC-Yli-134505	Yarrowia lipolytica	33.20	3.00e-73	268.00
IUUC-Zma-135895	Zea mays	84.84	0.00e+00	904.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence