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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046762
Ensembl Protein ID ENSP00000376024.3
UniProt Accession Q9Y5X1; Q9BSI7; Q9BVM1; Q9UJH6; Q9UP20; SNX9_HUMAN
Genbank Protein ID AAD27832.1; AAF04473.1; AAL54871.1; CAI20465.1; CAI20465.1; CAI20465.1; CAI12979.1; CAI12979.1; CAI12979.1; CAI15180.1; CAI15180.1; CAI15180.1; AAH01084.3; AAH05022.1; AAD43001.1
Protein Name Sorting nexin-9; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A
Genbank Nucleotide ID AF121859; AF131214; AF172847; AL035634; AL139330; AL391863; AL139330; AL035634; AL391863; AL391863; AL035634; AL139330; BC001084; BC005022; AF076957
Gene Name SNX9; SH3PX1; SH3PXD3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130340.15 ENST00000392185.7 ENSP00000376024.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.70e-10 42.4 4 60
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaq.nddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           k +v+yd+ a+  ++eLt ++G+++++  + +  +gWl+g ++ +g rGl+P ++ve l
   Q: 4    KARVMYDFAAEpGNNELTVNEGEIITIT-NPDVGGGWLEG-RNIKGERGLVPTDYVEIL 60
           6789******95689************8.99*********.5**************865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
 Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
Protein Sequence
(Fasta)
MATKARVMYD FAAEPGNNEL TVNEGEIITI TNPDVGGGWL EGRNIKGERG LVPTDYVEIL 60
PSDGKDQFSC GNSVADQAFL DSLSASTAQA SSSAASNNHQ VGSGNDPWSA WSASKSGNWE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046762|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACCTCTGACT CTGCGCTGCC ACCCGGCAGT GCGAGGACCA CATACTGACC AGGTGTGGAG 60
CCGATGCCCA GACCCGTGAT GGCAGGTGAG GAATGCCTTC ACGGCCTTCA CAGCTGCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046762|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0333--Golgi apparatus
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR027267--AH/BAR-dom
IPR001683--Phox
IPR001452--SH3_domain
IPR028644--SNX9
IPR014536--Snx9_subfam
IPR019497--Sorting_nexin_WASP-bd-dom
PROSITE

PS50195--PX
PS50002--SH3
Pfam

PF10456--BAR_3_WASP_bdg
PF00787--PX
PF00018--SH3_1
SMART

SM00312--PX
SM00326--SH3
Gene Ontology

GO:0030136--C:clathrin-coated vesicle
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005802--C:trans-Golgi network
GO:0005545--F:1-phosphatidylinositol binding
GO:0071933--F:Arp2/3 complex binding
GO:0045296--F:cadherin binding
GO:0035091--F:phosphatidylinositol binding
GO:0042803--F:protein homodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0036089--P:cleavage furrow formation
GO:0006897--P:endocytosis
GO:0016197--P:endosomal transport
GO:0006886--P:intracellular protein transport
GO:0060988--P:lipid tube assembly
GO:0061024--P:membrane organization
GO:0000281--P:mitotic cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0097320--P:plasma membrane tubulation
GO:0043547--P:positive regulation of GTPase activity
GO:0051044--P:positive regulation of membrane protein ectodomain proteolysis
GO:0045860--P:positive regulation of protein kinase activity
GO:0032461--P:positive regulation of protein oligomerization
GO:0006898--P:receptor-mediated endocytosis
KEGG hsa:51429
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001493 Ailuropoda melanoleuca 93.24 0.00e+00 1087.00
IUUC-Apl-003889 Anas platyrhynchos 83.11 0.00e+00 978.00
IUUC-Ame-011163 Astyanax mexicanus 62.30 0.00e+00 748.00
IUUC-Bta-013027 Bos taurus 92.58 0.00e+00 1088.00
IUUC-Cel-018605 Caenorhabditis elegans 33.09 3.00e-62 233.00
IUUC-Cja-019428 Callithrix jacchus 98.32 0.00e+00 1170.00
IUUC-Cfa-021208 Canis familiaris 93.25 0.00e+00 1089.00
IUUC-Cpo-021353 Cavia porcellus 91.95 0.00e+00 1085.00
IUUC-Cho-025020 Choloepus hoffmanni 94.30 9.00e-152 530.00
IUUC-Cin-025695 Ciona intestinalis 32.89 7.00e-94 338.00
IUUC-Csv-025870 Ciona savignyi 33.55 2.00e-88 320.00
IUUC-Dre-027983 Danio rerio 62.26 0.00e+00 745.00
IUUC-Dme-031845 Drosophila melanogaster 38.30 1.00e-72 267.00
IUUC-Fca-036506 Felis catus 92.63 0.00e+00 1073.00
IUUC-Fal-037443 Ficedula albicollis 76.44 0.00e+00 939.00
IUUC-Gmo-039464 Gadus morhua 56.76 0.00e+00 631.00
IUUC-Gac-041835 Gasterosteus aculeatus 58.39 0.00e+00 655.00
IUUC-Ggo-045438 Gorilla gorilla 95.77 0.00e+00 1117.00
IUUC-Itr-048294 Ictidomys tridecemlineatus 92.40 0.00e+00 1083.00
IUUC-Lch-049906 Latimeria chalumnae 66.52 8.00e-161 560.00
IUUC-Loc-052748 Lepisosteus oculatus 66.45 0.00e+00 764.00
IUUC-Lma-053062 Leptosphaeria maculans 44.26 4.00e-06 46.60
IUUC-Laf-053373 Loxodonta africana 91.95 0.00e+00 1084.00
IUUC-Mcc-054953 Macaca mulatta 98.99 0.00e+00 1145.00
IUUC-Mga-059536 Meleagris gallopavo 80.27 0.00e+00 972.00
IUUC-Mmr-061000 Microcebus murinus 94.48 0.00e+00 1110.00
IUUC-Mdo-061885 Monodelphis domestica 87.63 0.00e+00 1036.00
IUUC-Mmu-063532 Mus musculus 90.60 0.00e+00 1080.00
IUUC-Mlu-067143 Myotis lucifugus 89.15 0.00e+00 1048.00
IUUC-Ont-072028 Oreochromis niloticus 64.82 0.00e+00 776.00
IUUC-Oan-073741 Ornithorhynchus anatinus 74.52 5.00e-55 206.00
IUUC-Ola-086919 Oryzias latipes 62.82 0.00e+00 760.00
IUUC-Oga-088465 Otolemur garnettii 93.46 0.00e+00 1070.00
IUUC-Oar-089562 Ovis aries 92.07 0.00e+00 1085.00
IUUC-Ptr-090632 Pan troglodytes 100.00 0.00e+00 1187.00
IUUC-Pan-092192 Papio anubis 98.99 0.00e+00 1141.00
IUUC-Psi-093346 Pelodiscus sinensis 83.08 0.00e+00 991.00
IUUC-Pma-094619 Petromyzon marinus 36.90 8.00e-76 278.00
IUUC-Pno-094868 Phaeosphaeria nodorum 44.26 3.00e-06 46.60
IUUC-Pfo-096634 Poecilia formosa 64.68 0.00e+00 768.00
IUUC-Pab-097866 Pongo abelii 99.66 0.00e+00 1175.00
IUUC-Pva-102273 Pteropus vampyrus 91.55 0.00e+00 1048.00
IUUC-Pte-104168 Pyrenophora teres 44.26 4.00e-06 46.20
IUUC-Pyt-104443 Pyrenophora triticirepentis 44.26 4.00e-06 46.20
IUUC-Rno-105513 Rattus norvegicus 86.70 0.00e+00 1027.00
IUUC-Ssc-116184 Sus scrofa 93.75 0.00e+00 1091.00
IUUC-Tgu-117370 Taeniopygia guttata 83.03 0.00e+00 996.00
IUUC-Tru-117764 Takifugu rubripes 61.22 0.00e+00 731.00
IUUC-Tni-119947 Tetraodon nigroviridis 65.66 0.00e+00 780.00
IUUC-Ttr-128700 Tursiops truncatus 89.93 0.00e+00 1037.00
IUUC-Xtr-132466 Xenopus tropicalis 68.56 0.00e+00 778.00
Created Date 25-Jun-2017

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