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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063688
Ensembl Protein ID ENSMUSP00000087656.5
UniProt Accession Q9JLZ6; Q3U030; Q3ULP4; Q5K036; Q8BSZ9; Q8C3T5; HIC2_MOUSE
Genbank Protein ID CAI30631.1; BAC39326.1; BAE26404.1; BAE33679.1; BAE34025.1; BAC98076.1; AAH65124.1; AAF28801.1
Protein Name Hypermethylated in cancer 2 protein
Genbank Nucleotide ID AJ868292; AK084975; AK145386; AK156332; AK157276; AK129266; BC065124; AF117382
Gene Name Hic2; Kiaa1020
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000050240.14 ENSMUST00000090190.11 ENSMUSP00000087656.5
ENSMUSG00000050240.14 ENSMUST00000115698.2 ENSMUSP00000111362.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.20e-11 45.9 46 105
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgkl 65
           +Dvi+ v+++ f+ahk vLaasS +F++l l+        + ++++ d v+ +vf+++l+F+Ytgkl
   Q: 46   CDVIIMVENSIFRAHKNVLAASSIYFKSLVLH-------DNLINLDtDmVSSTVFQQILDFIYTGKL 105
           8*****************************99.......5789999889****************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcriptional repressor.
 Transcriptional repressor.
Protein Sequence
(Fasta)
MVSGPLALRW CPWAGHRDMG PDMELPSHSK QLLLQLNQQR AKGFLCDVII MVENSIFRAH 60
KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI YTGKLLPSDQ PSEPNFSTLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063688|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCACAAGCT TCCAAGATGG CGCGGAGCGG GCGGCTGTGA GCAGCGCTCT GGGCGCGCTG 60
GGCGGAGAGC CGAGCGGGGG CCGGCGGAGG GCGGACAGGG CGGGCGCGTG CAGCTCAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063688|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0008022--F:protein C-terminus binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:58180
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004217 Anas platyrhynchos 63.32 0.00e+00 649.00
IUUC-Ame-010754 Astyanax mexicanus 64.81 2.00e-87 316.00
IUUC-Bta-013162 Bos taurus 77.97 0.00e+00 776.00
IUUC-Cfa-020537 Canis familiaris 84.29 0.00e+00 888.00
IUUC-Cpo-021843 Cavia porcellus 84.60 0.00e+00 909.00
IUUC-Csa-023171 Chlorocebus sabaeus 87.42 0.00e+00 833.00
IUUC-Dre-027672 Danio rerio 55.94 2.00e-156 545.00
IUUC-Dno-029125 Dasypus novemcinctus 80.67 0.00e+00 771.00
IUUC-Dor-030484 Dipodomys ordii 81.09 4.00e-117 414.00
IUUC-Ete-033019 Echinops telfairi 75.00 2.00e-119 422.00
IUUC-Eca-033737 Equus caballus 85.40 0.00e+00 846.00
IUUC-Eeu-035190 Erinaceus europaeus 75.48 9.00e-142 496.00
IUUC-Fca-036031 Felis catus 82.38 0.00e+00 831.00
IUUC-Fal-037342 Ficedula albicollis 62.15 0.00e+00 664.00
IUUC-Gmo-039209 Gadus morhua 53.35 2.00e-147 515.00
IUUC-Gga-040433 Gallus gallus 61.22 0.00e+00 645.00
IUUC-Gac-041588 Gasterosteus aculeatus 54.06 4.00e-154 538.00
IUUC-Ggo-045081 Gorilla gorilla 83.28 0.00e+00 768.00
IUUC-Hsa-046397 Homo sapiens 87.42 0.00e+00 832.00
IUUC-Itr-048738 Ictidomys tridecemlineatus 84.92 0.00e+00 864.00
IUUC-Lch-049980 Latimeria chalumnae 54.37 5.00e-132 464.00
IUUC-Loc-052129 Lepisosteus oculatus 61.46 0.00e+00 646.00
IUUC-Mcc-055370 Macaca mulatta 82.93 0.00e+00 817.00
IUUC-Mga-059911 Meleagris gallopavo 60.99 6.00e-178 617.00
IUUC-Mmr-060683 Microcebus murinus 82.54 0.00e+00 815.00
IUUC-Mdo-062271 Monodelphis domestica 68.55 0.00e+00 694.00
IUUC-Mpu-066134 Mustela putorius furo 84.13 0.00e+00 833.00
IUUC-Mlu-067531 Myotis lucifugus 84.08 0.00e+00 874.00
IUUC-Nle-069726 Nomascus leucogenys 76.27 0.00e+00 733.00
IUUC-Opr-071056 Ochotona princeps 78.16 3.00e-162 565.00
IUUC-Ont-071390 Oreochromis niloticus 55.36 3.00e-152 531.00
IUUC-Ocu-073887 Oryctolagus cuniculus 78.22 0.00e+00 756.00
IUUC-Ola-087091 Oryzias latipes 50.56 1.00e-105 376.00
IUUC-Oga-088655 Otolemur garnettii 85.97 0.00e+00 853.00
IUUC-Oar-089691 Ovis aries 72.97 9.00e-39 151.00
IUUC-Ptr-090786 Pan troglodytes 82.91 0.00e+00 806.00
IUUC-Pan-092901 Papio anubis 87.42 0.00e+00 806.00
IUUC-Psi-093684 Pelodiscus sinensis 64.85 0.00e+00 681.00
IUUC-Pfo-096241 Poecilia formosa 52.89 1.00e-141 496.00
IUUC-Pab-098162 Pongo abelii 83.07 0.00e+00 806.00
IUUC-Pca-101051 Procavia capensis 84.84 0.00e+00 833.00
IUUC-Rno-105690 Rattus norvegicus 91.80 0.00e+00 987.00
IUUC-Ssc-116215 Sus scrofa 79.56 0.00e+00 808.00
IUUC-Tgu-116768 Taeniopygia guttata 60.49 0.00e+00 646.00
IUUC-Tru-117833 Takifugu rubripes 53.18 4.00e-141 494.00
IUUC-Tni-119907 Tetraodon nigroviridis 62.36 8.00e-81 294.00
IUUC-Xtr-132400 Xenopus tropicalis 59.00 2.00e-175 608.00
Created Date 25-Jun-2017

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