iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000052583.1	ENSRNOT00000081074.1	ENSRNOP00000068586.1
ENSRNOG00000052583.1	ENSRNOT00000078893.1	ENSRNOP00000072228.1
ENSRNOG00000052583.1	ENSRNOT00000089857.1	ENSRNOP00000070083.1

Annotation

Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-16	60.8	1567	1606
UBD/Beta-Prp	2.20e-40	139.1	1667	1801

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sd..tllvsGsdDgtikvWDlrtgvl 35
           gH ++v+cl     s+    l +Gs D+ti++++++t  +
   Q: 1567 GHISKVNCLLVthtSGknSVLYTGSSDHTIRCYNVKTREC 1606
           89******9558873342569**************99877 PP

UBD/Beta-Prp

   S: 21   dksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
            ++ll++gs+d ti v d+++g llr+l+gh+++v ++k  +d  +  +gs+D+ ++  ++ tg+ v+++kgh++ v+ +++    +
   Q: 1667 ARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTVLCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILG--K 1749
           5689***************************************..9*************************************9..* PP
   S: 108  klvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvr 162
           ++v++  d+ +rv++l++   l+ +  gh+++++c+++h+  +++ +G++D+ ++
   Q: 1750 VMVTACLDKFVRVYELQSHDRLQ-VYGGHKDMIMCMTIHK--SVIYTGCYDGSIQ 1801
           ***********************.****************..**********997 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MVRERKCILC HIVYGSKKEM DEHMRSMLHH RELENLKGRD ISHECRVCRV TEVGLSAYAK 60
HISGQSHKDN VDAQEREDDG KEEEEEDYFD KELQLITGKK EPKRQDKPSG NNQEGNSDDR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTACGAG AGCGAAAATG CATATTGTGC CACATCGTGT ACGGCTCAAA AAAGGTAACA 60
ACAAAGAGAC AGTGCCTGGA TCATCTAAGA TAGCTTAAAC TTGGTATTTA GGAATTTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR018391--PQQ_beta_propeller_repeat
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR013087--Znf_C2H2_type

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00028--ZINC_FINGER_C2H2_1

Pfam

PF00400--WD40

SMART

SM00564--PQQ
SM00320--WD40
SM00355--ZnF_C2H2

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0046872--F:metal ion binding
GO:0003723--F:RNA binding
GO:0017124--F:SH3 domain binding
GO:0008286--P:insulin receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001928	Ailuropoda melanoleuca	69.42	0.00e+00	2347.00
IUUC-Apl-003674	Anas platyrhynchos	51.82	0.00e+00	1558.00
IUUC-Aca-005018	Anolis carolinensis	75.88	0.00e+00	853.00
IUUC-Ame-011431	Astyanax mexicanus	68.52	0.00e+00	667.00
IUUC-Bta-013436	Bos taurus	70.88	0.00e+00	2384.00
IUUC-Cfa-020278	Canis familiaris	66.65	0.00e+00	1907.00
IUUC-Cpo-022278	Cavia porcellus	67.31	0.00e+00	2330.00
IUUC-Csa-023115	Chlorocebus sabaeus	69.32	0.00e+00	1363.00
IUUC-Cho-024829	Choloepus hoffmanni	62.08	0.00e+00	1522.00
IUUC-Dre-028112	Danio rerio	65.39	0.00e+00	658.00
IUUC-Dno-029127	Dasypus novemcinctus	69.52	0.00e+00	2291.00
IUUC-Dor-030367	Dipodomys ordii	68.79	0.00e+00	972.00
IUUC-Ete-032500	Echinops telfairi	60.32	0.00e+00	942.00
IUUC-Eca-034319	Equus caballus	71.51	0.00e+00	2400.00
IUUC-Eeu-034754	Erinaceus europaeus	63.25	0.00e+00	1835.00
IUUC-Fca-036181	Felis catus	70.05	0.00e+00	2305.00
IUUC-Fal-036865	Ficedula albicollis	79.73	0.00e+00	826.00
IUUC-Gmo-039227	Gadus morhua	64.24	5.00e-172	597.00
IUUC-Gga-041178	Gallus gallus	56.45	0.00e+00	1271.00
IUUC-Gac-042209	Gasterosteus aculeatus	57.35	3.00e-164	572.00
IUUC-Ggo-044636	Gorilla gorilla	71.56	0.00e+00	2474.00
IUUC-Hsa-045949	Homo sapiens	72.02	0.00e+00	2398.00
IUUC-Itr-048628	Ictidomys tridecemlineatus	72.25	0.00e+00	2395.00
IUUC-Lch-049753	Latimeria chalumnae	71.46	0.00e+00	737.00
IUUC-Loc-052333	Lepisosteus oculatus	65.64	0.00e+00	707.00
IUUC-Laf-053530	Loxodonta africana	68.06	0.00e+00	2352.00
IUUC-Mcc-054664	Macaca mulatta	71.74	0.00e+00	2380.00
IUUC-Meu-056609	Macropus eugenii	62.28	0.00e+00	867.00
IUUC-Mga-059632	Meleagris gallopavo	55.89	0.00e+00	1224.00
IUUC-Mmr-060742	Microcebus murinus	70.38	0.00e+00	2325.00
IUUC-Mdo-061831	Monodelphis domestica	66.31	0.00e+00	1077.00
IUUC-Mmu-064055	Mus musculus	83.44	0.00e+00	2889.00
IUUC-Mpu-066458	Mustela putorius furo	72.03	0.00e+00	1186.00
IUUC-Mlu-067767	Myotis lucifugus	69.39	0.00e+00	2338.00
IUUC-Nle-069728	Nomascus leucogenys	71.65	0.00e+00	2390.00
IUUC-Opr-070914	Ochotona princeps	65.79	0.00e+00	2104.00
IUUC-Ont-072353	Oreochromis niloticus	67.63	0.00e+00	637.00
IUUC-Ocu-073827	Oryctolagus cuniculus	70.61	0.00e+00	2232.00
IUUC-Ola-087573	Oryzias latipes	66.57	5.00e-158	551.00
IUUC-Oga-088664	Otolemur garnettii	71.12	0.00e+00	1409.00
IUUC-Oar-090256	Ovis aries	66.06	0.00e+00	1753.00
IUUC-Ptr-090884	Pan troglodytes	69.43	0.00e+00	1992.00
IUUC-Pan-091779	Papio anubis	69.41	0.00e+00	1365.00
IUUC-Psi-093267	Pelodiscus sinensis	90.55	1.00e-159	555.00
IUUC-Pma-094414	Petromyzon marinus	40.89	1.00e-53	204.00
IUUC-Pfo-097009	Poecilia formosa	63.42	4.00e-157	550.00
IUUC-Pca-100820	Procavia capensis	64.06	0.00e+00	1202.00
IUUC-Pva-103044	Pteropus vampyrus	66.88	0.00e+00	935.00
IUUC-Sar-113018	Sorex araneus	62.59	0.00e+00	1023.00
IUUC-Ssc-115278	Sus scrofa	71.11	0.00e+00	2410.00
IUUC-Tgu-117231	Taeniopygia guttata	78.67	0.00e+00	832.00
IUUC-Tru-118472	Takifugu rubripes	54.73	2.00e-161	564.00
IUUC-Tsy-118877	Tarsius syrichta	78.17	0.00e+00	949.00
IUUC-Tni-119881	Tetraodon nigroviridis	43.76	0.00e+00	655.00
IUUC-Tbe-127499	Tupaia belangeri	60.22	0.00e+00	1092.00
IUUC-Ttr-128962	Tursiops truncatus	70.48	0.00e+00	2266.00
IUUC-Vpa-130089	Vicugna pacos	60.44	0.00e+00	913.00
IUUC-Xtr-132940	Xenopus tropicalis	43.75	0.00e+00	1238.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence