iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097965

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF128; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128

Genbank Nucleotide ID

CR857287

Gene Name

RNF128

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000020604.2	ENSPPYT00000024032.2	ENSPPYP00000023062.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.70e-06	26.4	277	318

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e +   d +++l C+H+fh++C+  w         + +CP C+
   Q: 277  CAVCIELYkpNDLVRILTCNHIFHKTCVDPW------LLEHRTCPMCK 318
           *****9985545499****************......9999******6 PP

Organism

Pongo abelii

Functional Description
(View)

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.

Protein Sequence
(Fasta)

MGPPLGAGVS CRGGCGSSRL LAWCFLLALS PQAPGSRGAE AVWTAYLNVS WRVPHTGVNR 60
TVWELSEEGV YGQDSPLEPV AGVLVPPDGP GALNACNPHT NFTVPTVWGS TVQVSWLALI 120

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Nucleotide Sequence
(Fasta)

CGGAGCTTCA CGCTAAAGCC CCAGAGCCCG ACGCGGCAGC CGCGGTAGCG GAGAAGACTG 60
GAGCTCCGAG GAGCTGCATC TGCGGCAACC TGTGTGCTGA CGCTACGTGC CTCCTGGCTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0005770--C:late endosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042036--P:negative regulation of cytokine biosynthetic process
GO:0031647--P:regulation of protein stability

KEGG

pon:100171545

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000408	Aegilops tauschii	48.21	1.00e-12	66.20
IUUC-Aml-001674	Ailuropoda melanoleuca	96.29	0.00e+00	828.00
IUUC-Apl-003776	Anas platyrhynchos	66.56	5.00e-107	380.00
IUUC-Aca-004318	Anolis carolinensis	68.77	1.00e-118	419.00
IUUC-Ani-009454	Aspergillus nidulans	54.17	3.00e-10	59.70
IUUC-Ame-011286	Astyanax mexicanus	45.39	6.00e-84	304.00
IUUC-Bta-013454	Bos taurus	94.20	0.00e+00	811.00
IUUC-Bci-013726	Botrytis cinerea	54.00	9.00e-13	68.20
IUUC-Cja-019864	Callithrix jacchus	98.60	0.00e+00	846.00
IUUC-Cfa-020185	Canis familiaris	96.06	0.00e+00	822.00
IUUC-Cpo-022417	Cavia porcellus	53.17	5.00e-86	310.00
IUUC-Csa-023224	Chlorocebus sabaeus	98.13	0.00e+00	815.00
IUUC-Cho-024710	Choloepus hoffmanni	80.40	3.00e-147	514.00
IUUC-Cne-026951	Cryptococcus neoformans	34.69	7.00e-11	61.60
IUUC-Dre-028249	Danio rerio	52.43	5.00e-90	324.00
IUUC-Dno-029216	Dasypus novemcinctus	95.94	1.00e-135	475.00
IUUC-Dor-030487	Dipodomys ordii	83.50	0.00e+00	668.00
IUUC-Dse-031357	Dothistroma septosporum	45.21	1.00e-12	67.40
IUUC-Ete-032376	Echinops telfairi	95.31	1.00e-136	478.00
IUUC-Eca-034264	Equus caballus	96.06	0.00e+00	824.00
IUUC-Eeu-034606	Erinaceus europaeus	92.13	4.00e-128	451.00
IUUC-Fca-036503	Felis catus	96.52	0.00e+00	827.00
IUUC-Fal-036671	Ficedula albicollis	60.32	9.00e-113	400.00
IUUC-Gmo-039483	Gadus morhua	48.17	1.00e-80	292.00
IUUC-Gga-040248	Gallus gallus	67.13	9.00e-133	466.00
IUUC-Ggo-045319	Gorilla gorilla	51.67	1.00e-92	333.00
IUUC-Hsa-046745	Homo sapiens	98.36	0.00e+00	843.00
IUUC-Itr-048362	Ictidomys tridecemlineatus	96.96	0.00e+00	833.00
IUUC-Kpa-049143	Komagataella pastoris	49.02	3.00e-11	63.20
IUUC-Lch-050549	Latimeria chalumnae	56.72	2.00e-120	425.00
IUUC-Loc-051929	Lepisosteus oculatus	55.99	1.00e-96	346.00
IUUC-Laf-054197	Loxodonta africana	94.66	0.00e+00	783.00
IUUC-Mcc-055146	Macaca mulatta	98.13	0.00e+00	814.00
IUUC-Meu-056649	Macropus eugenii	76.23	6.00e-164	570.00
IUUC-Mga-059520	Meleagris gallopavo	66.22	1.00e-132	466.00
IUUC-Mmr-061502	Microcebus murinus	96.96	0.00e+00	801.00
IUUC-Mdo-062875	Monodelphis domestica	63.43	1.00e-123	436.00
IUUC-Mmu-064235	Mus musculus	95.56	0.00e+00	824.00
IUUC-Mpu-066452	Mustela putorius furo	91.82	9.00e-171	592.00
IUUC-Mlu-067189	Myotis lucifugus	94.66	0.00e+00	798.00
IUUC-Ncr-068771	Neurospora crassa	41.18	2.00e-13	70.50
IUUC-Nle-070026	Nomascus leucogenys	99.07	0.00e+00	820.00
IUUC-Opr-070435	Ochotona princeps	71.80	7.00e-96	343.00
IUUC-Oan-073238	Ornithorhynchus anatinus	74.50	6.00e-117	413.00
IUUC-Ocu-074960	Oryctolagus cuniculus	96.50	0.00e+00	792.00
IUUC-Ola-086348	Oryzias latipes	47.04	2.00e-77	281.00
IUUC-Oga-088543	Otolemur garnettii	95.33	0.00e+00	818.00
IUUC-Oar-089599	Ovis aries	94.20	0.00e+00	810.00
IUUC-Ptr-091576	Pan troglodytes	94.67	2.00e-172	597.00
IUUC-Pan-091690	Papio anubis	97.90	0.00e+00	809.00
IUUC-Psi-093642	Pelodiscus sinensis	75.91	5.00e-105	373.00
IUUC-Pfo-096270	Poecilia formosa	41.94	6.00e-77	280.00
IUUC-Pva-102991	Pteropus vampyrus	85.23	3.00e-176	610.00
IUUC-Rno-105667	Rattus norvegicus	95.56	0.00e+00	825.00
IUUC-Sha-107293	Sarcophilus harrisii	77.75	6.00e-156	543.00
IUUC-Ssl-108451	Sclerotinia sclerotiorum	54.00	1.00e-12	67.80
IUUC-Sar-113682	Sorex araneus	95.11	5.00e-143	499.00
IUUC-Ssc-115583	Sus scrofa	96.29	0.00e+00	825.00
IUUC-Tgu-117406	Taeniopygia guttata	57.95	3.00e-81	294.00
IUUC-Tru-118147	Takifugu rubripes	44.05	1.00e-73	269.00
IUUC-Tsy-118918	Tarsius syrichta	95.79	0.00e+00	772.00
IUUC-Tni-120865	Tetraodon nigroviridis	45.60	5.00e-69	254.00
IUUC-Tbe-127498	Tupaia belangeri	53.33	9.00e-107	380.00
IUUC-Ttr-128640	Tursiops truncatus	96.29	0.00e+00	800.00
IUUC-Vpa-130536	Vicugna pacos	87.73	0.00e+00	728.00
IUUC-Xma-133114	Xiphophorus maculatus	48.14	4.00e-78	284.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence