iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063597

UUCD1 version

UUC-MuM-00161

Ensembl Protein ID

ENSMUSP00000075376.6

UniProt Accession

Q69ZS0; Q91Z03; Q9QY54; Q9QY55; PZRN3_MOUSE

Genbank Protein ID

ADK56111.1; AAF22131.1; AAF22132.1; BAD32376.1; AAH10329.1

Protein Name

E3 ubiquitin-protein ligase PDZRN3; PDZ domain-containing RING finger protein 3; RING-type E3 ubiquitin transferase PDZRN3; Semaphorin cytoplasmic domain-associated protein 3

Genbank Nucleotide ID

HM560981; AF127084; AF127085; AK173098; BC010329

Gene Name

Pdzrn3; Kiaa1095; Semcap3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000035357.16	ENSMUST00000075994.10	ENSMUSP00000075376.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.20e-06	28.0	18	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCP.lC 45
           Ca+C+  ++d pl++pCgHvf+a C+  w        +e +CP  C
   Q: 18   CALCHKVLED-PLTTPCGHVFCAGCVLPW------VVQEGSCPaRC 56
           **********.******************......88888888445 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.

Protein Sequence
(Fasta)

MGFELDRFDG DVDPDLKCAL CHKVLEDPLT TPCGHVFCAG CVLPWVVQEG SCPARCRGRL 60
SAKELNHVLP LKRLILKLDI KCAHAARGCG RVVKLQDLPE HLERCDFAPA RCRHAGCGQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCCACCA TGGGTTTCGA GTTGGATCGC TTCGACGGCG ACGTGGACCC TGATCTGAAG 60
TGCGCCTTGT GCCACAAGGT CCTGGAGGAC CCGCTGACCA CCCCGTGCGG CCACGTATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001478--PDZ
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50106--PDZ
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00595--PDZ

SMART

SM00228--PDZ
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0031594--C:neuromuscular junction
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007528--P:neuromuscular junction development
GO:0016567--P:protein ubiquitination

KEGG

mmu:55983

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001910	Ailuropoda melanoleuca	89.68	0.00e+00	1520.00
IUUC-Apl-003623	Anas platyrhynchos	85.23	0.00e+00	1315.00
IUUC-Ame-011171	Astyanax mexicanus	49.35	0.00e+00	721.00
IUUC-Bta-012364	Bos taurus	91.10	0.00e+00	1855.00
IUUC-Cja-019726	Callithrix jacchus	93.11	0.00e+00	1482.00
IUUC-Cpo-021680	Cavia porcellus	92.62	0.00e+00	1870.00
IUUC-Csa-023684	Chlorocebus sabaeus	94.56	0.00e+00	1956.00
IUUC-Cho-024555	Choloepus hoffmanni	75.27	2.00e-107	383.00
IUUC-Dre-027462	Danio rerio	71.04	0.00e+00	1420.00
IUUC-Dno-029974	Dasypus novemcinctus	97.59	4.00e-47	180.00
IUUC-Dor-031125	Dipodomys ordii	90.05	0.00e+00	1743.00
IUUC-Ete-032745	Echinops telfairi	81.50	0.00e+00	874.00
IUUC-Eca-034276	Equus caballus	91.83	0.00e+00	1474.00
IUUC-Fal-037334	Ficedula albicollis	78.59	0.00e+00	1548.00
IUUC-Gmo-038706	Gadus morhua	69.81	0.00e+00	1356.00
IUUC-Gga-040586	Gallus gallus	82.54	0.00e+00	1600.00
IUUC-Gac-041605	Gasterosteus aculeatus	68.07	0.00e+00	1344.00
IUUC-Ggo-044706	Gorilla gorilla	94.56	0.00e+00	1956.00
IUUC-Hsa-046677	Homo sapiens	94.47	0.00e+00	1955.00
IUUC-Itr-048660	Ictidomys tridecemlineatus	89.46	0.00e+00	1790.00
IUUC-Lch-049637	Latimeria chalumnae	68.73	1.00e-129	455.00
IUUC-Loc-052305	Lepisosteus oculatus	74.44	0.00e+00	1514.00
IUUC-Mcc-055573	Macaca mulatta	94.66	0.00e+00	1960.00
IUUC-Meu-056805	Macropus eugenii	81.44	0.00e+00	1637.00
IUUC-Mdo-062581	Monodelphis domestica	85.34	0.00e+00	1736.00
IUUC-Mpu-065685	Mustela putorius furo	92.64	0.00e+00	1432.00
IUUC-Mlu-067150	Myotis lucifugus	73.88	0.00e+00	1023.00
IUUC-Nle-068997	Nomascus leucogenys	94.58	0.00e+00	1925.00
IUUC-Ont-071534	Oreochromis niloticus	69.67	0.00e+00	1353.00
IUUC-Ola-086381	Oryzias latipes	67.91	0.00e+00	1358.00
IUUC-Oga-089068	Otolemur garnettii	94.54	0.00e+00	1902.00
IUUC-Oar-089252	Ovis aries	97.78	3.00e-79	288.00
IUUC-Pan-092366	Papio anubis	94.66	0.00e+00	1961.00
IUUC-Psi-093611	Pelodiscus sinensis	55.56	2.00e-82	298.00
IUUC-Pfo-096576	Poecilia formosa	67.63	1.00e-123	436.00
IUUC-Pab-098239	Pongo abelii	94.47	0.00e+00	1954.00
IUUC-Pca-100484	Procavia capensis	95.38	0.00e+00	860.00
IUUC-Pva-103202	Pteropus vampyrus	52.41	0.00e+00	867.00
IUUC-Rno-105931	Rattus norvegicus	98.31	0.00e+00	2038.00
IUUC-Tgu-116615	Taeniopygia guttata	79.80	2.00e-109	389.00
IUUC-Tru-118175	Takifugu rubripes	70.16	0.00e+00	1391.00
IUUC-Tsy-119569	Tarsius syrichta	86.65	0.00e+00	1441.00
IUUC-Tbe-127819	Tupaia belangeri	87.49	0.00e+00	1390.00
IUUC-Ttr-128328	Tursiops truncatus	90.02	0.00e+00	1476.00
IUUC-Xtr-132339	Xenopus tropicalis	76.54	0.00e+00	1548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence