iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066567

Ensembl Protein ID

ENSMPUP00000002184.1

UniProt Accession

M3XSY4; M3XSY4_MUSPF

Genbank Protein ID

ENSMPUP00000002184

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01096023

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000002206.1	ENSMPUT00000002228.1	ENSMPUP00000002184.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-135	450.6	572	901

Active Site

Position(s)	Description	Evidence
871	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 572  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 660
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv+++r
   Q: 661  IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFVIDEELFGQTHQHELKIGGSEIVVTNKNKKEYIYLVIQWR 744
           *********************************99...6666..79******************************************* PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 745  FVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRLLQFVTG 833
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 834  TSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 901
           *******************************************************************8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MATCAVEVFG LPEDEENSRI VRVKVIAGIG LAKKDILGAS DPYVRVTLYD PMNGVFTSVQ 60
TKTIKKTLNP KWNEEILFRV HPQQHRLLFE VFDENRLTRD DFLGQVDVPL YPLPTENPRM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NGGGAGGCGC TGCGGCCGCT GGGGGAGCGC CGCCTCCTCT TCCTCCACCT 60
CCTCCTCCCT CCCGCCTCCT CCCTCTTCTC CTCCTCCACC CCCTCCTCCT CCTCCTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	97.03	0.00e+00	1575.00
IUUC-Apl-003886	Anas platyrhynchos	76.38	0.00e+00	1420.00
IUUC-Ame-011138	Astyanax mexicanus	83.75	0.00e+00	842.00
IUUC-Bta-012453	Bos taurus	92.87	0.00e+00	1462.00
IUUC-Bci-013785	Botrytis cinerea	46.91	2.00e-156	546.00
IUUC-Cja-019034	Callithrix jacchus	93.40	0.00e+00	1400.00
IUUC-Cfa-020258	Canis familiaris	96.53	0.00e+00	1502.00
IUUC-Cpo-021648	Cavia porcellus	89.06	0.00e+00	1607.00
IUUC-Csa-023334	Chlorocebus sabaeus	95.02	0.00e+00	1675.00
IUUC-Cin-025157	Ciona intestinalis	56.19	0.00e+00	979.00
IUUC-Dno-029159	Dasypus novemcinctus	89.61	0.00e+00	1326.00
IUUC-Ete-032409	Echinops telfairi	86.68	0.00e+00	1189.00
IUUC-Eca-033441	Equus caballus	95.36	0.00e+00	1646.00
IUUC-Eeu-034546	Erinaceus europaeus	74.68	0.00e+00	1179.00
IUUC-Fca-036384	Felis catus	96.42	0.00e+00	1555.00
IUUC-Fal-037547	Ficedula albicollis	81.12	0.00e+00	1451.00
IUUC-Gmo-039679	Gadus morhua	68.29	0.00e+00	1226.00
IUUC-Gga-040524	Gallus gallus	82.67	0.00e+00	1482.00
IUUC-Gac-042607	Gasterosteus aculeatus	67.64	0.00e+00	1238.00
IUUC-Hsa-046479	Homo sapiens	95.17	0.00e+00	1536.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	83.09	0.00e+00	1211.00
IUUC-Lch-050445	Latimeria chalumnae	73.55	0.00e+00	1209.00
IUUC-Loc-052645	Lepisosteus oculatus	74.29	0.00e+00	1346.00
IUUC-Lma-052980	Leptosphaeria maculans	45.45	6.00e-88	318.00
IUUC-Laf-053638	Loxodonta africana	84.82	0.00e+00	1350.00
IUUC-Mcc-055585	Macaca mulatta	94.92	0.00e+00	1500.00
IUUC-Meu-056897	Macropus eugenii	95.47	1.00e-169	590.00
IUUC-Mga-059362	Meleagris gallopavo	77.12	0.00e+00	1434.00
IUUC-Mmr-061061	Microcebus murinus	94.42	0.00e+00	1546.00
IUUC-Mmu-063318	Mus musculus	79.87	0.00e+00	1401.00
IUUC-Mlu-068148	Myotis lucifugus	94.67	0.00e+00	1499.00
IUUC-Nle-069225	Nomascus leucogenys	94.80	0.00e+00	1546.00
IUUC-Ont-071664	Oreochromis niloticus	67.29	0.00e+00	1208.00
IUUC-Oan-073019	Ornithorhynchus anatinus	85.06	0.00e+00	1462.00
IUUC-Ocu-074409	Oryctolagus cuniculus	92.57	0.00e+00	1496.00
IUUC-Oga-088241	Otolemur garnettii	87.64	0.00e+00	1344.00
IUUC-Oar-089797	Ovis aries	95.08	0.00e+00	1603.00
IUUC-Ptr-091629	Pan troglodytes	93.94	0.00e+00	1376.00
IUUC-Pan-092285	Papio anubis	93.77	0.00e+00	1162.00
IUUC-Psi-093618	Pelodiscus sinensis	83.04	0.00e+00	1316.00
IUUC-Pfo-097145	Poecilia formosa	69.60	0.00e+00	1212.00
IUUC-Pab-098394	Pongo abelii	94.83	0.00e+00	1654.00
IUUC-Pca-100568	Procavia capensis	77.88	0.00e+00	1140.00
IUUC-Rno-106095	Rattus norvegicus	80.54	0.00e+00	1414.00
IUUC-Sha-107370	Sarcophilus harrisii	79.31	0.00e+00	1338.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.09	8.00e-155	540.00
IUUC-Sre-114929	Sporisorium reilianum	47.69	4.00e-154	538.00
IUUC-Tgu-117474	Taeniopygia guttata	81.44	0.00e+00	1483.00
IUUC-Tru-117675	Takifugu rubripes	66.24	0.00e+00	1211.00
IUUC-Tni-119993	Tetraodon nigroviridis	65.07	0.00e+00	1184.00
IUUC-Tre-122203	Trichoderma reesei	43.07	6.00e-154	538.00
IUUC-Tbe-127408	Tupaia belangeri	87.03	0.00e+00	1159.00
IUUC-Ttr-128437	Tursiops truncatus	85.94	0.00e+00	1201.00
IUUC-Uma-129332	Ustilago maydis	47.86	2.00e-147	516.00
IUUC-Vpa-130503	Vicugna pacos	88.80	0.00e+00	1295.00
IUUC-Xtr-132431	Xenopus tropicalis	71.92	0.00e+00	1333.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence