iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000060335.1	ENSRNOT00000077578.1	ENSRNOP00000074395.1
ENSRNOG00000060335.1	ENSRNOT00000088720.1	ENSRNOP00000071600.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.70e-26	90.1	582	612
UBD/Beta-Prp	1.80e-47	162.3	572	791

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclafsd..tllvsGsdDgtikvWDl 30
           Htd v++la+s+  + l+s+s Dgti++W++
   Q: 582  HTDAVWGLAYSGikNQLLSCSADGTIRLWNP 612
           **********666689*************95 PP

UBD/Beta-Prp

   S: 41   tgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsv..lslsfsp.sgdklvsGshdrtirvwdlet 125
           +  l  +l  h+++v+ + +s  ++ l+++s D+ti++w+++ + +c+ t++g ++    +s++f   +  ++v+  +   + ++dlet
   Q: 572  SHVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPQeKLPCICTYNGDKEHGipTSVDFIGcDPAHMVTSFNTGSAIIYDLET 660
           55678899*******************************887699*******7655541245555554449****************** PP
   S: 126  gqclee......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwd 208
            q l           + +  +n vv+hp+  + ++++ Dr ++++d ktgk+++ +   h d+v+sl++d+ng +l+sgs+d +++lw+
   Q: 661  SQSLVMlssqvdSGLQSSNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVA-HLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 748
           ****9988996633334556899999**99**************************98.****************************** PP
   S: 209  lqtgecvrtlnght....dnvksvrfspnderlvsgssDgsir 247
           l +++cv++ ++h+    + +++v+f+p + +++s+++D   +
   Q: 749  LDSKTCVQEITAHRkkldESIYDVAFHPSKAYIASAGADALAK 791
           **************99999*******************97655 PP

Organism

Rattus norvegicus

Functional Description
(View)

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity).

Protein Sequence
(Fasta)

MDELAGGGGG QGMAVPPRPQ QGPGGNLSLP PGANGAPGGG GPPAAETAGP PAGPELSRPQ 60
QYTIPGILHY IQHEWARFEM ERAHWEVERA ELQARIAFLQ GERKGQENLK KDLVRRIKML 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCAGATGG AGGAGGGACT GTAATGGCGG CGGCCGGCAG CTCCCTGCTC TGATCCGCGG 60
CAAGCACACC GCAGCGACCC CCTCCCCGGC CCTCTCCCGG CCGGACCCCC GCCCTGCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013258--Striatin_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08232--Striatin
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005794--C:Golgi apparatus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000159--C:protein phosphatase type 2A complex
GO:0032403--F:protein complex binding
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0032355--P:response to estradiol

KEGG

rno:114520

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002046	Ailuropoda melanoleuca	93.79	0.00e+00	1326.00
IUUC-Apl-003472	Anas platyrhynchos	92.51	0.00e+00	1240.00
IUUC-Aca-005286	Anolis carolinensis	91.54	0.00e+00	1285.00
IUUC-Afl-008585	Aspergillus flavus	27.88	2.00e-36	147.00
IUUC-Ani-009405	Aspergillus nidulans	29.92	4.00e-36	146.00
IUUC-Aor-009982	Aspergillus oryzae	28.11	2.00e-36	147.00
IUUC-Bgr-012143	Blumeria graminis	25.67	6.00e-35	142.00
IUUC-Bta-012797	Bos taurus	93.85	0.00e+00	1372.00
IUUC-Bci-013742	Botrytis cinerea	25.23	2.00e-35	144.00
IUUC-Cel-018443	Caenorhabditis elegans	39.88	2.00e-101	363.00
IUUC-Cja-018786	Callithrix jacchus	94.75	0.00e+00	1351.00
IUUC-Cfa-021098	Canis familiaris	91.80	0.00e+00	1296.00
IUUC-Cpo-022357	Cavia porcellus	92.74	0.00e+00	1312.00
IUUC-Csa-023725	Chlorocebus sabaeus	95.14	0.00e+00	1355.00
IUUC-Cho-024338	Choloepus hoffmanni	89.19	0.00e+00	1170.00
IUUC-Cin-025167	Ciona intestinalis	49.28	0.00e+00	655.00
IUUC-Csv-026143	Ciona savignyi	51.54	0.00e+00	679.00
IUUC-Cgl-026487	Colletotrichum gloeosporioides	25.89	2.00e-31	130.00
IUUC-Cne-026783	Cryptococcus neoformans	32.51	2.00e-56	214.00
IUUC-Dno-029926	Dasypus novemcinctus	94.47	0.00e+00	1349.00
IUUC-Dse-031486	Dothistroma septosporum	27.48	7.00e-38	152.00
IUUC-Dme-032158	Drosophila melanogaster	63.32	6.00e-142	498.00
IUUC-Ete-032770	Echinops telfairi	81.13	0.00e+00	1119.00
IUUC-Eca-033309	Equus caballus	94.49	0.00e+00	1337.00
IUUC-Eeu-034939	Erinaceus europaeus	91.28	0.00e+00	984.00
IUUC-Fca-035719	Felis catus	92.11	0.00e+00	1205.00
IUUC-Fal-037408	Ficedula albicollis	92.07	0.00e+00	1183.00
IUUC-Fox-037678	Fusarium oxysporum	26.08	8.00e-36	145.00
IUUC-Fso-038364	Fusarium solani	25.81	5.00e-37	149.00
IUUC-Gmo-039653	Gadus morhua	63.32	0.00e+00	880.00
IUUC-Ggr-039846	Gaeumannomyces graminis	26.02	5.00e-34	139.00
IUUC-Gga-041218	Gallus gallus	93.15	0.00e+00	1325.00
IUUC-Gac-042142	Gasterosteus aculeatus	71.60	0.00e+00	1059.00
IUUC-Ggo-045607	Gorilla gorilla	78.71	0.00e+00	1040.00
IUUC-Hsa-045717	Homo sapiens	95.28	0.00e+00	1360.00
IUUC-Itr-048177	Ictidomys tridecemlineatus	96.54	0.00e+00	962.00
IUUC-Lch-050441	Latimeria chalumnae	89.52	0.00e+00	1333.00
IUUC-Loc-052193	Lepisosteus oculatus	85.83	0.00e+00	1257.00
IUUC-Lma-053183	Leptosphaeria maculans	28.83	1.00e-39	159.00
IUUC-Laf-053964	Loxodonta africana	93.48	0.00e+00	1327.00
IUUC-Mcc-055639	Macaca mulatta	95.15	0.00e+00	1357.00
IUUC-Mor-057148	Magnaporthe oryzae	42.31	1.00e-17	85.50
IUUC-Mpo-057337	Magnaporthe poae	25.33	2.00e-30	127.00
IUUC-Mla-058988	Melampsora laricipopulina	35.05	1.00e-64	241.00
IUUC-Mmr-061084	Microcebus murinus	95.01	0.00e+00	1354.00
IUUC-Mdo-063016	Monodelphis domestica	94.02	0.00e+00	1359.00
IUUC-Mmu-063914	Mus musculus	98.25	0.00e+00	1404.00
IUUC-Mpu-066348	Mustela putorius furo	86.41	0.00e+00	1216.00
IUUC-Mlu-067303	Myotis lucifugus	92.19	0.00e+00	1286.00
IUUC-Nle-070032	Nomascus leucogenys	95.28	0.00e+00	1361.00
IUUC-Opr-070496	Ochotona princeps	90.24	0.00e+00	648.00
IUUC-Ont-072075	Oreochromis niloticus	70.82	0.00e+00	1038.00
IUUC-Oan-072822	Ornithorhynchus anatinus	92.06	0.00e+00	1184.00
IUUC-Ocu-073876	Oryctolagus cuniculus	92.25	0.00e+00	1316.00
IUUC-Ola-086321	Oryzias latipes	68.88	0.00e+00	993.00
IUUC-Oga-088045	Otolemur garnettii	95.26	0.00e+00	1352.00
IUUC-Oar-089737	Ovis aries	94.33	0.00e+00	1261.00
IUUC-Ptr-090871	Pan troglodytes	95.16	0.00e+00	1280.00
IUUC-Pan-092139	Papio anubis	94.17	0.00e+00	1256.00
IUUC-Psi-093424	Pelodiscus sinensis	92.50	0.00e+00	1254.00
IUUC-Pma-094286	Petromyzon marinus	69.69	0.00e+00	673.00
IUUC-Pno-094905	Phaeosphaeria nodorum	28.16	1.00e-35	145.00
IUUC-Pfo-096564	Poecilia formosa	72.05	0.00e+00	1065.00
IUUC-Pab-098626	Pongo abelii	95.28	0.00e+00	1396.00
IUUC-Pva-102445	Pteropus vampyrus	87.70	0.00e+00	1243.00
IUUC-Ptt-103828	Puccinia triticina	36.50	4.00e-48	187.00
IUUC-Pte-104374	Pyrenophora teres	28.11	2.00e-33	138.00
IUUC-Pyt-104568	Pyrenophora triticirepentis	27.88	7.00e-37	149.00
IUUC-Sha-106786	Sarcophilus harrisii	92.64	0.00e+00	1266.00
IUUC-Ssl-108495	Sclerotinia sclerotiorum	26.08	4.00e-35	143.00
IUUC-Sar-113296	Sorex araneus	74.56	0.00e+00	837.00
IUUC-Sre-115115	Sporisorium reilianum	34.70	1.00e-63	238.00
IUUC-Tgu-117199	Taeniopygia guttata	88.84	0.00e+00	1162.00
IUUC-Tsy-119356	Tarsius syrichta	79.34	0.00e+00	947.00
IUUC-Tre-122113	Trichoderma reesei	27.27	1.00e-38	154.00
IUUC-Tvi-122312	Trichoderma virens	26.13	1.00e-36	148.00
IUUC-Tme-126990	Tuber melanosporum	26.88	2.00e-35	144.00
IUUC-Tbe-127691	Tupaia belangeri	79.34	0.00e+00	778.00
IUUC-Ttr-128600	Tursiops truncatus	87.58	0.00e+00	1233.00
IUUC-Vda-129673	Verticillium dahliae	25.71	1.00e-30	128.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence