iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 6    kewleLesdPglftllvedfg........vkrdi.......qveelysLdpenlglyqepvegllllFkinekressrksqvtsndlev 79
           k+wleLesdPglftllvedfg                    qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v
   Q: 3    KGWLELESDPGLFTLLVEDFGknpftpdrR---AlagvkgvQVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSV 84
           89******************8333333220...13444455************....******************************** PP
   S: 80   vdediiktiffakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqde 168
           +d+di++++ffa+q+i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q++
   Q: 85   IDDDIVNSMFFAHQLIPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNG 171
           *********************************99..**************************************************** PP
   S: 169  dneqytkeafhfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrl 253
           +++++t+eafhfvsyv+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drrv++++rl
   Q: 172  LSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRVKYEARL 258
           ****************************************************..*********************************** PP
   S: 254  nvlkid................................................................................... 259
           +vlk +                                                                                   
   Q: 259  HVLKGNrqtvlealqqlirvtqpeliqthksqesqlpeeskpasskspfgleagrtpaasecthtdgaeevagscpqttthsppskskl 347
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 348  vvkpsgsslngvpptptpivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrpqqysddeedyedeeedvqntssairykrkgtgk 436
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 437  pgslsnssdgqlsvlqpntinvlteklqesqkdlsiplsiktssgagspavavpthsqpsptpsnestdtaseigsafnsplrspirsa 525
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 526  nptrpsspvtshiskvlfgeddsllrvdcirynravrdlgpvistgllhlaedgvlsplalteggkgsspstrssqgsqgsssleekev 614
           ***************************************************************************************** PP
   S: 260  ..........................keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklv 322
                                     keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lv
   Q: 615  vevtdsrdksglnrsseplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLV 703
           ***************************************************************************************** PP
   S: 323  eetisevrefgvnegrlakqrkqgrekkirplkrkrk 359
           e++is++r++gv++grl+kqrk++r+k++rp+k+kr+
   Q: 704  EQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ 740
           ***********************************97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGKNPFTPD RRALAGVKGV QVEEIYDLQS KCQGPVYGFI 60
FLFKWIEERR SRRKVSTLVD DTSVIDDDIV NSMFFAHQLI PNSCATHALL SVLLNCSNVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCCGCCC CGCGCGGTGA CTGCGCCGTC GAAGGAGGCG AGCGCGCTAA CGGGGGATGG 60
GTCACGCGGA CTGTGGCCCG CGGGCACCTC AGCGTTGCAG ACAGTTGTCA AAACGGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:306257

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	89.85	0.00e+00	1186.00
IUUC-Apl-003405	Anas platyrhynchos	68.08	0.00e+00	626.00
IUUC-Aca-004836	Anolis carolinensis	78.27	0.00e+00	1130.00
IUUC-Ago-007999	Ashbya gossypii	34.86	2.00e-25	109.00
IUUC-Ame-011946	Astyanax mexicanus	63.44	0.00e+00	886.00
IUUC-Bta-013131	Bos taurus	87.70	0.00e+00	1048.00
IUUC-Cja-019599	Callithrix jacchus	93.13	0.00e+00	1288.00
IUUC-Cfa-021003	Canis familiaris	91.91	0.00e+00	1181.00
IUUC-Cpo-022143	Cavia porcellus	91.37	0.00e+00	1258.00
IUUC-Csa-023477	Chlorocebus sabaeus	92.45	0.00e+00	1252.00
IUUC-Cho-024734	Choloepus hoffmanni	81.05	0.00e+00	737.00
IUUC-Csv-025842	Ciona savignyi	54.63	1.00e-91	330.00
IUUC-Dre-027793	Danio rerio	63.47	0.00e+00	899.00
IUUC-Dno-029253	Dasypus novemcinctus	91.29	0.00e+00	1239.00
IUUC-Dor-030891	Dipodomys ordii	86.39	0.00e+00	1178.00
IUUC-Dme-031796	Drosophila melanogaster	58.36	1.00e-89	323.00
IUUC-Ete-032646	Echinops telfairi	83.56	4.00e-166	578.00
IUUC-Eca-033805	Equus caballus	91.51	0.00e+00	1239.00
IUUC-Eeu-035216	Erinaceus europaeus	91.50	5.00e-142	498.00
IUUC-Fca-035611	Felis catus	91.38	0.00e+00	1131.00
IUUC-Fal-037186	Ficedula albicollis	79.26	0.00e+00	993.00
IUUC-Gmo-038824	Gadus morhua	66.94	1.00e-177	616.00
IUUC-Gga-040875	Gallus gallus	80.62	0.00e+00	1103.00
IUUC-Gac-042226	Gasterosteus aculeatus	66.80	0.00e+00	927.00
IUUC-Ggo-045122	Gorilla gorilla	92.05	0.00e+00	1282.00
IUUC-Hsa-045882	Homo sapiens	92.05	0.00e+00	1282.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	93.67	0.00e+00	1270.00
IUUC-Lch-049960	Latimeria chalumnae	70.93	0.00e+00	998.00
IUUC-Loc-052408	Lepisosteus oculatus	73.70	0.00e+00	649.00
IUUC-Laf-054187	Loxodonta africana	92.05	0.00e+00	1226.00
IUUC-Mcc-055273	Macaca mulatta	91.78	0.00e+00	1257.00
IUUC-Meu-056267	Macropus eugenii	80.32	0.00e+00	1135.00
IUUC-Mga-059958	Meleagris gallopavo	83.18	5.00e-152	530.00
IUUC-Mmr-061280	Microcebus murinus	91.92	0.00e+00	1231.00
IUUC-Mdo-062625	Monodelphis domestica	86.79	0.00e+00	1241.00
IUUC-Mmu-063853	Mus musculus	95.41	0.00e+00	1310.00
IUUC-Mlu-067771	Myotis lucifugus	91.51	0.00e+00	1218.00
IUUC-Opr-070741	Ochotona princeps	90.43	0.00e+00	1262.00
IUUC-Ont-072172	Oreochromis niloticus	65.17	0.00e+00	931.00
IUUC-Oan-073167	Ornithorhynchus anatinus	77.76	0.00e+00	1122.00
IUUC-Ocu-074176	Oryctolagus cuniculus	91.22	0.00e+00	1210.00
IUUC-Ola-087203	Oryzias latipes	81.23	2.00e-132	464.00
IUUC-Oga-089153	Otolemur garnettii	91.43	0.00e+00	1246.00
IUUC-Oar-090008	Ovis aries	90.27	0.00e+00	1226.00
IUUC-Ptr-091234	Pan troglodytes	92.32	0.00e+00	1287.00
IUUC-Pan-092005	Papio anubis	92.45	0.00e+00	1277.00
IUUC-Psi-093995	Pelodiscus sinensis	80.65	0.00e+00	643.00
IUUC-Pma-094110	Petromyzon marinus	88.19	3.00e-65	242.00
IUUC-Pfo-097418	Poecilia formosa	63.87	0.00e+00	912.00
IUUC-Pab-098267	Pongo abelii	91.64	0.00e+00	1261.00
IUUC-Pca-101084	Procavia capensis	90.26	0.00e+00	1185.00
IUUC-Pva-102292	Pteropus vampyrus	90.72	0.00e+00	882.00
IUUC-Sha-107100	Sarcophilus harrisii	85.54	0.00e+00	1238.00
IUUC-Sar-113559	Sorex araneus	84.30	0.00e+00	1052.00
IUUC-Ssc-115688	Sus scrofa	91.24	0.00e+00	1241.00
IUUC-Tgu-117424	Taeniopygia guttata	77.70	0.00e+00	1098.00
IUUC-Tru-118585	Takifugu rubripes	67.15	0.00e+00	927.00
IUUC-Tsy-119299	Tarsius syrichta	81.01	0.00e+00	931.00
IUUC-Tni-120808	Tetraodon nigroviridis	66.49	0.00e+00	917.00
IUUC-Tbe-127705	Tupaia belangeri	90.91	6.00e-178	616.00
IUUC-Ttr-128225	Tursiops truncatus	90.57	0.00e+00	1214.00
IUUC-Vpa-130193	Vicugna pacos	93.14	1.00e-129	457.00
IUUC-Xtr-132449	Xenopus tropicalis	69.78	0.00e+00	925.00
IUUC-Xma-133232	Xiphophorus maculatus	63.23	0.00e+00	904.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence