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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063114
Ensembl Protein ID ENSMUSP00000110115.1
UniProt Accession Q3TTA7; E9QMY2; CBLB_MOUSE
Genbank Protein ID BAE36418.1
Protein Name E3 ubiquitin-protein ligase CBL-B; Casitas B-lineage lymphoma proto-oncogene b; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; Signal transduction protein CBL-B
Genbank Nucleotide ID AK147367; AC117780
Gene Name Cblb
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022637.10 ENSMUST00000114471.1 ENSMUSP00000110115.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 11070165; 15308098
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.70e-07 32.7 373 412
UBD/Alpha-Helix/UBA 0.00032 21.8 891 923
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    ++s ++  CP Cr
   Q: 373  CKICAENDKD-VKIEPCGHLMCTSCLTAW----QESDGQ-GCPFCR 412
           99********.******************....555555.5****8 PP
   

   UBD/Alpha-Helix/UBA
   S: 6    kleqlveMGFdreealqaLraannnleaAveyL 38
           k+++l+  G+ +ee+++aL+ a nn+e+A   L
   Q: 891  KIAKLMGEGYAFEEVKRALEIAQNNVEVARSIL 923
           89***************************7766 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
 E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Protein Sequence
(Fasta)
MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC 60
QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063114|UBD,UBA;E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
CTCCGCCCCA CGCCTTGGTC TCCGGGGATG GCTCAGGGGT GGGGTGGCCA GTGAGTGGTC 60
TCCTCCTCCG GCGGGCGCTG CGGCGGCCTC CCGAGTGTGG CGCGGGACTG CCGGGCGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063114|UBD,UBA;E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
SMART

SM00184--RING
SM00165--UBA
Gene Ontology

GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0006955--P:immune response
GO:0035556--P:intracellular signal transduction
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050860--P:negative regulation of T cell receptor signaling pathway
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0006508--P:proteolysis
GO:0042110--P:T cell activation
KEGG mmu:208650
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001412 Ailuropoda melanoleuca 89.93 0.00e+00 1565.00
IUUC-Apl-004148 Anas platyrhynchos 82.24 0.00e+00 1431.00
IUUC-Aca-005204 Anolis carolinensis 80.12 0.00e+00 1373.00
IUUC-Ame-011919 Astyanax mexicanus 64.01 0.00e+00 1016.00
IUUC-Bta-013044 Bos taurus 90.23 0.00e+00 1563.00
IUUC-Cel-018674 Caenorhabditis elegans 56.92 2.00e-133 469.00
IUUC-Cja-018813 Callithrix jacchus 83.16 0.00e+00 1441.00
IUUC-Cfa-021054 Canis familiaris 89.83 0.00e+00 1597.00
IUUC-Cpo-022514 Cavia porcellus 87.04 0.00e+00 1546.00
IUUC-Csa-024110 Chlorocebus sabaeus 90.64 0.00e+00 1588.00
IUUC-Cho-024886 Choloepus hoffmanni 73.01 0.00e+00 1050.00
IUUC-Dre-027480 Danio rerio 64.06 0.00e+00 1000.00
IUUC-Dno-028923 Dasypus novemcinctus 90.03 0.00e+00 1560.00
IUUC-Dor-031040 Dipodomys ordii 89.34 0.00e+00 806.00
IUUC-Ete-032406 Echinops telfairi 85.11 0.00e+00 1422.00
IUUC-Eca-033849 Equus caballus 89.22 0.00e+00 1587.00
IUUC-Fca-036224 Felis catus 90.35 0.00e+00 1569.00
IUUC-Fal-036860 Ficedula albicollis 97.09 0.00e+00 1009.00
IUUC-Gga-040159 Gallus gallus 84.40 0.00e+00 1411.00
IUUC-Gac-042312 Gasterosteus aculeatus 58.53 0.00e+00 950.00
IUUC-Ggo-045175 Gorilla gorilla 83.55 0.00e+00 1449.00
IUUC-Hsa-046306 Homo sapiens 90.44 0.00e+00 1585.00
IUUC-Lch-049931 Latimeria chalumnae 56.99 0.00e+00 796.00
IUUC-Loc-052524 Lepisosteus oculatus 68.57 0.00e+00 1071.00
IUUC-Laf-053635 Loxodonta africana 86.08 0.00e+00 1507.00
IUUC-Mcc-055536 Macaca mulatta 90.54 0.00e+00 1587.00
IUUC-Meu-056045 Macropus eugenii 75.55 0.00e+00 1236.00
IUUC-Mga-060177 Meleagris gallopavo 91.98 0.00e+00 1117.00
IUUC-Mmr-061088 Microcebus murinus 90.95 0.00e+00 1602.00
IUUC-Mdo-062020 Monodelphis domestica 86.07 0.00e+00 1500.00
IUUC-Mpu-066632 Mustela putorius furo 90.54 0.00e+00 1604.00
IUUC-Mlu-067145 Myotis lucifugus 90.13 0.00e+00 1592.00
IUUC-Ont-072323 Oreochromis niloticus 74.24 0.00e+00 892.00
IUUC-Oan-073165 Ornithorhynchus anatinus 81.88 0.00e+00 1471.00
IUUC-Ocu-074723 Oryctolagus cuniculus 90.23 0.00e+00 1597.00
IUUC-Oga-088021 Otolemur garnettii 89.84 0.00e+00 1578.00
IUUC-Oar-089809 Ovis aries 90.03 0.00e+00 1563.00
IUUC-Ptr-090834 Pan troglodytes 90.34 0.00e+00 1583.00
IUUC-Pan-092225 Papio anubis 90.54 0.00e+00 1587.00
IUUC-Psi-093317 Pelodiscus sinensis 82.59 0.00e+00 1458.00
IUUC-Pma-094249 Petromyzon marinus 77.61 6.00e-127 446.00
IUUC-Pab-097595 Pongo abelii 90.44 0.00e+00 1585.00
IUUC-Pca-100844 Procavia capensis 74.87 0.00e+00 1245.00
IUUC-Pva-103216 Pteropus vampyrus 83.72 0.00e+00 1486.00
IUUC-Rno-105381 Rattus norvegicus 93.89 0.00e+00 1652.00
IUUC-Sha-107574 Sarcophilus harrisii 85.80 0.00e+00 1499.00
IUUC-Sar-113500 Sorex araneus 78.00 0.00e+00 1265.00
IUUC-Ssc-115856 Sus scrofa 88.62 0.00e+00 1353.00
IUUC-Tgu-116866 Taeniopygia guttata 82.73 0.00e+00 1419.00
IUUC-Tru-118579 Takifugu rubripes 86.15 0.00e+00 886.00
IUUC-Tsy-119167 Tarsius syrichta 78.59 0.00e+00 1307.00
IUUC-Tni-120788 Tetraodon nigroviridis 85.03 0.00e+00 897.00
IUUC-Tbe-127830 Tupaia belangeri 91.64 0.00e+00 1147.00
IUUC-Ttr-128631 Tursiops truncatus 90.44 0.00e+00 1598.00
IUUC-Vpa-130713 Vicugna pacos 94.31 0.00e+00 1386.00
Created Date 25-Jun-2017

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