iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093434

Ensembl Protein ID

ENSPSIP00000004470.1

UniProt Accession

K7F8W0; K7F8W0_PELSI

Genbank Protein ID

ENSPSIP00000004470

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AGCU01032278

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000004166.1	ENSPSIT00000004495.1	ENSPSIP00000004470.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	78.49	0.00e+00	913.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pelodiscus sinensis

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKTS GVAMLHQIQG NELEPLNRPQ LKIPLDRTLS EMYVESNKTG VFNYPEGTTY 60
DFATAAPVYS STSLSYAPAS ESFGSSSLGG FHSLNNVPPS PVLFLQTTPQ LSPFIHHHSQ 120

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Nucleotide Sequence
(Fasta)

GGGGCCTTTA AGGTTTATGA TAGTTTTTCC ATCCCTAGGC GAATGGTGGT GCTAGTACTT 60
TATTTTTCAG TCACTGTGTT TCCTCATTTC ATGGTCATAT CAGCCTCCTG GTTACTGCCA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0008584--P:male gonad development
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	85.08	0.00e+00	731.00
IUUC-Apl-003688	Anas platyrhynchos	89.85	0.00e+00	927.00
IUUC-Aca-005222	Anolis carolinensis	83.19	0.00e+00	963.00
IUUC-Ame-010731	Astyanax mexicanus	53.01	3.00e-137	481.00
IUUC-Bta-013112	Bos taurus	75.50	0.00e+00	850.00
IUUC-Cja-019408	Callithrix jacchus	79.66	0.00e+00	882.00
IUUC-Cfa-020694	Canis familiaris	77.01	0.00e+00	850.00
IUUC-Cpo-021426	Cavia porcellus	74.66	0.00e+00	823.00
IUUC-Csa-023736	Chlorocebus sabaeus	82.96	0.00e+00	783.00
IUUC-Dre-027698	Danio rerio	50.55	4.00e-139	488.00
IUUC-Dno-029477	Dasypus novemcinctus	81.10	0.00e+00	712.00
IUUC-Dor-030572	Dipodomys ordii	84.46	0.00e+00	699.00
IUUC-Ete-032849	Echinops telfairi	64.99	7.00e-176	610.00
IUUC-Eca-033605	Equus caballus	75.13	0.00e+00	831.00
IUUC-Eeu-034683	Erinaceus europaeus	85.05	3.00e-100	358.00
IUUC-Fca-035928	Felis catus	84.79	0.00e+00	723.00
IUUC-Fal-036754	Ficedula albicollis	87.95	0.00e+00	1025.00
IUUC-Gmo-038872	Gadus morhua	59.09	3.00e-114	405.00
IUUC-Gga-040988	Gallus gallus	87.78	0.00e+00	1006.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.63	9.00e-128	450.00
IUUC-Ggo-044749	Gorilla gorilla	80.17	0.00e+00	884.00
IUUC-Hsa-046944	Homo sapiens	79.33	0.00e+00	876.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	78.99	0.00e+00	875.00
IUUC-Lpe-051460	Leersia perrieri	29.70	3.70e-02	34.70
IUUC-Loc-052414	Lepisosteus oculatus	60.32	0.00e+00	669.00
IUUC-Mcc-054781	Macaca mulatta	79.66	0.00e+00	880.00
IUUC-Meu-056232	Macropus eugenii	82.85	0.00e+00	930.00
IUUC-Mga-059319	Meleagris gallopavo	87.78	0.00e+00	1006.00
IUUC-Mmr-061636	Microcebus murinus	75.00	1.00e-145	509.00
IUUC-Mdo-062661	Monodelphis domestica	84.72	0.00e+00	958.00
IUUC-Mmu-063330	Mus musculus	77.13	0.00e+00	835.00
IUUC-Mpu-065757	Mustela putorius furo	77.09	0.00e+00	873.00
IUUC-Mlu-067712	Myotis lucifugus	77.45	0.00e+00	765.00
IUUC-Nle-069283	Nomascus leucogenys	78.66	0.00e+00	849.00
IUUC-Opr-070391	Ochotona princeps	77.07	0.00e+00	877.00
IUUC-Ont-071369	Oreochromis niloticus	52.18	2.00e-123	436.00
IUUC-Oan-073734	Ornithorhynchus anatinus	72.81	3.00e-132	464.00
IUUC-Ocu-074292	Oryctolagus cuniculus	79.26	0.00e+00	882.00
IUUC-Oba-075103	Oryza barthii	26.92	1.40e-02	34.30
IUUC-Ogu-079042	Oryza glumaepatula	26.92	4.00e-03	36.20
IUUC-Olo-080944	Oryza longistaminata	26.92	6.00e-03	33.50
IUUC-Oni-082560	Oryza nivara	26.92	1.20e-02	34.30
IUUC-Ola-087052	Oryzias latipes	51.87	3.00e-133	468.00
IUUC-Oga-088586	Otolemur garnettii	78.43	0.00e+00	861.00
IUUC-Oar-090156	Ovis aries	79.33	0.00e+00	752.00
IUUC-Ptr-091321	Pan troglodytes	80.00	0.00e+00	884.00
IUUC-Pan-092851	Papio anubis	79.50	0.00e+00	879.00
IUUC-Pfo-097379	Poecilia formosa	57.83	3.00e-138	484.00
IUUC-Pab-097735	Pongo abelii	79.83	0.00e+00	882.00
IUUC-Pva-102125	Pteropus vampyrus	76.43	0.00e+00	853.00
IUUC-Rno-106121	Rattus norvegicus	77.17	0.00e+00	837.00
IUUC-Sha-107547	Sarcophilus harrisii	84.38	0.00e+00	953.00
IUUC-Sar-113650	Sorex araneus	70.05	1.00e-161	562.00
IUUC-Tgu-117175	Taeniopygia guttata	87.44	0.00e+00	1021.00
IUUC-Tru-117545	Takifugu rubripes	53.47	1.00e-140	494.00
IUUC-Tsy-119586	Tarsius syrichta	66.61	0.00e+00	733.00
IUUC-Tni-120121	Tetraodon nigroviridis	52.27	7.00e-143	500.00
IUUC-Tbe-127548	Tupaia belangeri	73.87	2.00e-165	575.00
IUUC-Ttr-128374	Tursiops truncatus	72.10	0.00e+00	770.00
IUUC-Vpa-130464	Vicugna pacos	75.68	2.00e-143	501.00
IUUC-Xtr-132171	Xenopus tropicalis	75.21	0.00e+00	802.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence