iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-117175

Ensembl Protein ID

ENSTGUP00000011604.1

UniProt Accession

H0ZLY1; H0ZLY1_TAEGU

Genbank Protein ID

ENSTGUP00000011604

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

ABQF01000036

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000011249.1	ENSTGUT00000011730.1	ENSTGUP00000011604.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	78.27	0.00e+00	883.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Taeniopygia guttata

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

LTMTLHTKTS GVTLLHQIQG TELETLSRPQ LKIPLERSLS DMYVETNKTG VFNYPEGATY 60
DFGTTAPVYS STTLSYAPTS ESFGSSSLAG FHSLNSVPPS PVVFLQTAPQ LSPFIHHHSQ 120

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Nucleotide Sequence
(Fasta)

CTGACCATGA CCCTTCACAC CAAAACCTCT GGAGTTACCC TGCTGCACCA GATTCAAGGC 60
ACTGAACTGG AGACACTGAG CAGACCTCAG CTGAAGATTC CCCTGGAAAG ATCTCTCAGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0030284--F:estrogen receptor activity
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0008584--P:male gonad development
GO:0048747--P:muscle fiber development
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0010628--P:positive regulation of gene expression
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	86.76	0.00e+00	733.00
IUUC-Apl-003688	Anas platyrhynchos	96.99	0.00e+00	991.00
IUUC-Aca-005222	Anolis carolinensis	83.36	0.00e+00	962.00
IUUC-Ame-010731	Astyanax mexicanus	51.93	3.00e-140	491.00
IUUC-Bta-013112	Bos taurus	73.70	0.00e+00	831.00
IUUC-Cja-019408	Callithrix jacchus	79.46	0.00e+00	873.00
IUUC-Cfa-020694	Canis familiaris	76.05	0.00e+00	849.00
IUUC-Cpo-021426	Cavia porcellus	74.20	0.00e+00	816.00
IUUC-Csa-023736	Chlorocebus sabaeus	83.78	0.00e+00	787.00
IUUC-Dre-027698	Danio rerio	51.80	1.00e-138	486.00
IUUC-Dno-029477	Dasypus novemcinctus	80.89	0.00e+00	725.00
IUUC-Dor-030572	Dipodomys ordii	84.04	0.00e+00	699.00
IUUC-Ete-032849	Echinops telfairi	61.54	1.00e-168	585.00
IUUC-Eca-033605	Equus caballus	75.34	0.00e+00	834.00
IUUC-Eeu-034683	Erinaceus europaeus	82.71	8.00e-99	353.00
IUUC-Fca-035928	Felis catus	87.61	0.00e+00	730.00
IUUC-Fal-036754	Ficedula albicollis	98.47	0.00e+00	1136.00
IUUC-Gmo-038872	Gadus morhua	59.52	4.00e-113	401.00
IUUC-Gga-040988	Gallus gallus	97.28	0.00e+00	1107.00
IUUC-Gac-042015	Gasterosteus aculeatus	64.08	2.00e-129	455.00
IUUC-Ggo-044749	Gorilla gorilla	79.12	0.00e+00	868.00
IUUC-Hsa-046944	Homo sapiens	78.27	0.00e+00	857.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	78.19	0.00e+00	868.00
IUUC-Lpe-051460	Leersia perrieri	29.70	5.40e-02	33.90
IUUC-Loc-052414	Lepisosteus oculatus	61.31	0.00e+00	693.00
IUUC-Mcc-054781	Macaca mulatta	79.29	0.00e+00	869.00
IUUC-Meu-056232	Macropus eugenii	82.33	0.00e+00	918.00
IUUC-Mga-059319	Meleagris gallopavo	96.94	0.00e+00	1105.00
IUUC-Mmr-061636	Microcebus murinus	72.83	4.00e-141	494.00
IUUC-Mdo-062661	Monodelphis domestica	83.05	0.00e+00	936.00
IUUC-Mmu-063330	Mus musculus	76.46	0.00e+00	840.00
IUUC-Mpu-065757	Mustela putorius furo	76.57	0.00e+00	863.00
IUUC-Mlu-067712	Myotis lucifugus	78.77	0.00e+00	776.00
IUUC-Nle-069283	Nomascus leucogenys	78.27	0.00e+00	842.00
IUUC-Opr-070391	Ochotona princeps	76.68	0.00e+00	879.00
IUUC-Ont-071369	Oreochromis niloticus	51.91	1.00e-124	439.00
IUUC-Oan-073734	Ornithorhynchus anatinus	72.30	1.00e-129	455.00
IUUC-Ocu-074292	Oryctolagus cuniculus	78.92	0.00e+00	873.00
IUUC-Oba-075103	Oryza barthii	26.92	1.10e-02	34.30
IUUC-Ogu-079042	Oryza glumaepatula	26.92	3.00e-03	36.20
IUUC-Olo-080944	Oryza longistaminata	26.92	4.00e-03	34.30
IUUC-Oni-082560	Oryza nivara	26.92	9.00e-03	34.70
IUUC-Ola-087052	Oryzias latipes	53.31	2.00e-134	472.00
IUUC-Oga-088586	Otolemur garnettii	78.38	0.00e+00	850.00
IUUC-Oar-090156	Ovis aries	78.63	0.00e+00	749.00
IUUC-Ptr-091321	Pan troglodytes	79.12	0.00e+00	868.00
IUUC-Pan-092851	Papio anubis	79.12	0.00e+00	868.00
IUUC-Psi-093434	Pelodiscus sinensis	87.44	0.00e+00	1027.00
IUUC-Pfo-097379	Poecilia formosa	57.76	6.00e-140	490.00
IUUC-Pab-097735	Pongo abelii	78.95	0.00e+00	866.00
IUUC-Pva-102125	Pteropus vampyrus	76.97	0.00e+00	853.00
IUUC-Rno-106121	Rattus norvegicus	76.67	0.00e+00	840.00
IUUC-Sha-107547	Sarcophilus harrisii	84.05	0.00e+00	935.00
IUUC-Sar-113650	Sorex araneus	67.79	2.00e-158	551.00
IUUC-Tru-117545	Takifugu rubripes	53.30	4.00e-143	501.00
IUUC-Tsy-119586	Tarsius syrichta	68.64	0.00e+00	733.00
IUUC-Tni-120121	Tetraodon nigroviridis	51.91	2.00e-145	509.00
IUUC-Tbe-127548	Tupaia belangeri	73.65	9.00e-169	586.00
IUUC-Ttr-128374	Tursiops truncatus	70.30	0.00e+00	751.00
IUUC-Vpa-130464	Vicugna pacos	74.86	8.00e-141	493.00
IUUC-Xtr-132171	Xenopus tropicalis	76.31	0.00e+00	816.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence