iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061851

UUCD1 version

UUC-MoD-00518

Ensembl Protein ID

ENSMODP00000022488.3

UniProt Accession

F6ZWF2; F6ZWF2_MONDO

Protein Name

Uncharacterized protein

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000018036.3	ENSMODT00000022880.3	ENSMODP00000022488.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-119	398.8	609	938

Active Site

Position(s)	Description	Evidence
909	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 609  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 694
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG++i Vt++Nk eYv+lv+e+
   Q: 695  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQDNKAEYVQLVTEL 780
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++d+p++qwFwev+e++++eer  +LqFvT
   Q: 781  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYERDDPVVQWFWEVVESITQEERVLLLQFVT 869
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 870  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 938
           ******************8888888868888********************************986555 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTGTACT TGATTGGTTT ATTTCTTGTT TGCAAATTAT TTCCTAAACA CTTATGAAAT 60
ATTTGTGTTC CACGTTATCA ATATGTTTAA TTTTTAATGG TAATCATTAT CATTTTTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF00023--Ank
PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	92.91	0.00e+00	1806.00
IUUC-Apl-003400	Anas platyrhynchos	93.07	0.00e+00	1249.00
IUUC-Aca-005375	Anolis carolinensis	88.85	0.00e+00	1743.00
IUUC-Ame-011847	Astyanax mexicanus	84.87	0.00e+00	1660.00
IUUC-Bta-012831	Bos taurus	92.62	0.00e+00	1767.00
IUUC-Cja-019160	Callithrix jacchus	93.43	0.00e+00	1820.00
IUUC-Cfa-020346	Canis familiaris	93.21	0.00e+00	1819.00
IUUC-Cpo-021766	Cavia porcellus	92.46	0.00e+00	1813.00
IUUC-Csa-023768	Chlorocebus sabaeus	93.42	0.00e+00	1822.00
IUUC-Cho-024688	Choloepus hoffmanni	87.70	0.00e+00	1148.00
IUUC-Cin-025417	Ciona intestinalis	50.21	4.00e-139	488.00
IUUC-Csv-025993	Ciona savignyi	45.14	2.00e-136	479.00
IUUC-Dre-027819	Danio rerio	82.77	0.00e+00	1621.00
IUUC-Dno-029027	Dasypus novemcinctus	93.14	0.00e+00	1818.00
IUUC-Dor-030327	Dipodomys ordii	85.81	0.00e+00	1587.00
IUUC-Ete-032966	Echinops telfairi	85.77	0.00e+00	1663.00
IUUC-Eca-034339	Equus caballus	93.21	0.00e+00	1818.00
IUUC-Eeu-034544	Erinaceus europaeus	80.44	2.00e-146	513.00
IUUC-Fca-035617	Felis catus	91.04	0.00e+00	1281.00
IUUC-Fal-036687	Ficedula albicollis	94.37	0.00e+00	1853.00
IUUC-Gmo-039508	Gadus morhua	88.38	0.00e+00	832.00
IUUC-Gga-040845	Gallus gallus	94.90	0.00e+00	1880.00
IUUC-Gac-041894	Gasterosteus aculeatus	82.41	0.00e+00	1573.00
IUUC-Ggo-044465	Gorilla gorilla	89.95	0.00e+00	1745.00
IUUC-Hsa-045731	Homo sapiens	93.52	0.00e+00	1825.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	93.63	0.00e+00	1822.00
IUUC-Lch-050436	Latimeria chalumnae	86.39	0.00e+00	1696.00
IUUC-Loc-052287	Lepisosteus oculatus	86.43	0.00e+00	1711.00
IUUC-Laf-053846	Loxodonta africana	93.42	0.00e+00	1826.00
IUUC-Mcc-055845	Macaca mulatta	93.52	0.00e+00	1824.00
IUUC-Meu-056060	Macropus eugenii	91.03	0.00e+00	699.00
IUUC-Mga-059935	Meleagris gallopavo	91.20	0.00e+00	1765.00
IUUC-Mmr-060960	Microcebus murinus	93.84	0.00e+00	1831.00
IUUC-Mmu-063657	Mus musculus	91.72	0.00e+00	1797.00
IUUC-Mpu-066161	Mustela putorius furo	97.99	0.00e+00	823.00
IUUC-Mlu-067354	Myotis lucifugus	91.28	0.00e+00	1740.00
IUUC-Nle-069112	Nomascus leucogenys	93.42	0.00e+00	1822.00
IUUC-Opr-070686	Ochotona princeps	88.15	0.00e+00	805.00
IUUC-Ont-072398	Oreochromis niloticus	81.83	0.00e+00	1571.00
IUUC-Oan-073194	Ornithorhynchus anatinus	91.74	0.00e+00	1729.00
IUUC-Ocu-074397	Oryctolagus cuniculus	82.26	0.00e+00	1547.00
IUUC-Ola-086777	Oryzias latipes	82.86	0.00e+00	1583.00
IUUC-Oga-088684	Otolemur garnettii	93.53	0.00e+00	1822.00
IUUC-Oar-089428	Ovis aries	92.25	0.00e+00	1771.00
IUUC-Ptr-090529	Pan troglodytes	93.42	0.00e+00	1823.00
IUUC-Pan-091702	Papio anubis	93.42	0.00e+00	1823.00
IUUC-Psi-093969	Pelodiscus sinensis	94.93	0.00e+00	1811.00
IUUC-Pfo-097364	Poecilia formosa	83.40	0.00e+00	1600.00
IUUC-Pab-098574	Pongo abelii	93.52	0.00e+00	1825.00
IUUC-Pca-100525	Procavia capensis	86.03	9.00e-178	617.00
IUUC-Pva-102365	Pteropus vampyrus	82.06	0.00e+00	1546.00
IUUC-Rno-105153	Rattus norvegicus	91.72	0.00e+00	1799.00
IUUC-Sha-107319	Sarcophilus harrisii	99.04	0.00e+00	1956.00
IUUC-Sar-113449	Sorex araneus	72.47	5.00e-166	578.00
IUUC-Ssc-115865	Sus scrofa	93.21	0.00e+00	1819.00
IUUC-Tgu-117225	Taeniopygia guttata	94.48	0.00e+00	1871.00
IUUC-Tru-118026	Takifugu rubripes	81.94	0.00e+00	1573.00
IUUC-Tsy-119407	Tarsius syrichta	80.68	0.00e+00	1517.00
IUUC-Tni-120234	Tetraodon nigroviridis	81.02	0.00e+00	1264.00
IUUC-Tur-126774	Triticum urartu	29.66	2.00e-46	181.00
IUUC-Tbe-127708	Tupaia belangeri	81.27	0.00e+00	842.00
IUUC-Ttr-128667	Tursiops truncatus	92.89	0.00e+00	1816.00
IUUC-Vpa-130200	Vicugna pacos	92.79	0.00e+00	1758.00
IUUC-Xtr-132176	Xenopus tropicalis	89.62	0.00e+00	1764.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence