iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053615

UUCD1 version

UUC-LoA-00790

Ensembl Protein ID

ENSLAFP00000022257.1

UniProt Accession

G3U349; G3U349_LOXAF

Protein Name

Uncharacterized protein

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000012139.3	ENSLAFT00000033623.1	ENSLAFP00000022257.1
ENSLAFG00000012139.3	ENSLAFT00000012139.3	ENSLAFP00000010144.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-107	360.8	565	891

Active Site

Position(s)	Description	Evidence
860	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 565  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKVFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 648
           689********************************************9999887.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v l+ 
   Q: 649  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVGLYS 735
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 736  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 824
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 825  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 891
           *****************...8888866666**************************************97 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

LFIAAFNKIL SLKSCHAIFK CVLSESGTLQ SKYIKGNKRK RAAAKHLIER YYHQLTEGCG 60
NEVCTNEFCA SCPTFRRMDN NAAAIKALEL YKINAKLCDP HPSKKGASSA YLENNSKGAH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATCACCCG GAGAACCTCA GTCTGACGAC ATTGAAGCTA GCCGAATGTA AGTTTAATTT 60
GGTTGAGGCT GTGGTGTCTT TTAAGTTGCC CTAGGATTTT TTTTTTTAGA CTACTGTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	97.08	0.00e+00	1600.00
IUUC-Atr-003144	Amborella trichopoda	45.80	6.00e-96	344.00
IUUC-Apl-003742	Anas platyrhynchos	92.75	0.00e+00	1586.00
IUUC-Aca-004873	Anolis carolinensis	93.26	0.00e+00	1602.00
IUUC-Ame-011166	Astyanax mexicanus	86.11	0.00e+00	1459.00
IUUC-Bta-013286	Bos taurus	95.51	0.00e+00	1553.00
IUUC-Cja-019707	Callithrix jacchus	94.97	0.00e+00	1599.00
IUUC-Cfa-020154	Canis familiaris	94.59	0.00e+00	1582.00
IUUC-Cpo-021292	Cavia porcellus	96.03	0.00e+00	1582.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	1.00e-82	299.00
IUUC-Csa-023378	Chlorocebus sabaeus	96.08	0.00e+00	1602.00
IUUC-Cho-025059	Choloepus hoffmanni	93.22	0.00e+00	1512.00
IUUC-Cin-025643	Ciona intestinalis	44.88	0.00e+00	711.00
IUUC-Csv-026282	Ciona savignyi	45.18	0.00e+00	679.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	5.00e-101	362.00
IUUC-Dre-027901	Danio rerio	85.63	0.00e+00	1446.00
IUUC-Dno-029320	Dasypus novemcinctus	96.31	0.00e+00	1605.00
IUUC-Dor-030756	Dipodomys ordii	94.05	0.00e+00	735.00
IUUC-Dme-032035	Drosophila melanogaster	43.09	2.00e-166	579.00
IUUC-Eca-033843	Equus caballus	96.61	0.00e+00	1555.00
IUUC-Eeu-035109	Erinaceus europaeus	95.31	0.00e+00	1548.00
IUUC-Fca-036344	Felis catus	94.59	0.00e+00	1582.00
IUUC-Fal-036747	Ficedula albicollis	93.80	0.00e+00	1583.00
IUUC-Gmo-038840	Gadus morhua	63.78	0.00e+00	1106.00
IUUC-Gga-040399	Gallus gallus	93.69	0.00e+00	1582.00
IUUC-Gac-041933	Gasterosteus aculeatus	84.36	0.00e+00	1379.00
IUUC-Ggo-044804	Gorilla gorilla	96.08	0.00e+00	1602.00
IUUC-Hsa-045727	Homo sapiens	96.08	0.00e+00	1602.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	92.87	0.00e+00	1496.00
IUUC-Lch-050197	Latimeria chalumnae	90.48	0.00e+00	1539.00
IUUC-Loc-052743	Lepisosteus oculatus	88.41	0.00e+00	1513.00
IUUC-Lma-053245	Leptosphaeria maculans	34.13	1.00e-57	218.00
IUUC-Mcc-054934	Macaca mulatta	96.08	0.00e+00	1600.00
IUUC-Meu-056061	Macropus eugenii	95.88	0.00e+00	1352.00
IUUC-Mga-059271	Meleagris gallopavo	94.76	0.00e+00	1577.00
IUUC-Mmr-061288	Microcebus murinus	95.62	0.00e+00	1599.00
IUUC-Mdo-062975	Monodelphis domestica	95.05	0.00e+00	1595.00
IUUC-Mmu-063674	Mus musculus	93.76	0.00e+00	1542.00
IUUC-Mpu-066568	Mustela putorius furo	96.31	0.00e+00	1607.00
IUUC-Mlu-067522	Myotis lucifugus	86.34	0.00e+00	1465.00
IUUC-Nle-069505	Nomascus leucogenys	96.08	0.00e+00	1602.00
IUUC-Opr-070570	Ochotona princeps	89.07	0.00e+00	1447.00
IUUC-Ont-071527	Oreochromis niloticus	85.50	0.00e+00	1460.00
IUUC-Oan-073446	Ornithorhynchus anatinus	89.32	0.00e+00	1038.00
IUUC-Ocu-074922	Oryctolagus cuniculus	94.06	0.00e+00	1588.00
IUUC-Ola-086996	Oryzias latipes	83.62	0.00e+00	1474.00
IUUC-Oga-088261	Otolemur garnettii	97.07	0.00e+00	1594.00
IUUC-Oar-090024	Ovis aries	95.51	0.00e+00	1553.00
IUUC-Ptr-090455	Pan troglodytes	96.08	0.00e+00	1602.00
IUUC-Pan-092509	Papio anubis	96.74	0.00e+00	1437.00
IUUC-Psi-092974	Pelodiscus sinensis	92.29	0.00e+00	1557.00
IUUC-Pma-094643	Petromyzon marinus	70.99	0.00e+00	1260.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	7.00e-58	219.00
IUUC-Pfo-096905	Poecilia formosa	84.69	0.00e+00	1445.00
IUUC-Pab-097840	Pongo abelii	94.84	0.00e+00	1550.00
IUUC-Pca-100869	Procavia capensis	98.13	0.00e+00	1625.00
IUUC-Pva-103040	Pteropus vampyrus	96.73	0.00e+00	666.00
IUUC-Rno-105453	Rattus norvegicus	93.89	0.00e+00	1548.00
IUUC-Sha-107651	Sarcophilus harrisii	95.05	0.00e+00	1597.00
IUUC-Smo-108858	Selaginella moellendorffii	49.88	3.00e-116	412.00
IUUC-Sar-113293	Sorex araneus	95.79	0.00e+00	1574.00
IUUC-Ssc-115979	Sus scrofa	96.37	0.00e+00	1584.00
IUUC-Tgu-116901	Taeniopygia guttata	92.75	0.00e+00	1586.00
IUUC-Tru-118368	Takifugu rubripes	85.45	0.00e+00	1451.00
IUUC-Tsy-119516	Tarsius syrichta	92.97	0.00e+00	1485.00
IUUC-Tni-120143	Tetraodon nigroviridis	84.65	0.00e+00	1439.00
IUUC-Tbe-127484	Tupaia belangeri	90.88	0.00e+00	1087.00
IUUC-Ttr-129078	Tursiops truncatus	96.26	0.00e+00	1557.00
IUUC-Vpa-130312	Vicugna pacos	88.59	0.00e+00	1335.00
IUUC-Xtr-132881	Xenopus tropicalis	91.24	0.00e+00	1553.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence