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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046833
Ensembl Protein ID ENSP00000347244.4
UniProt Accession Q9NZM3; O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9ULG4; ITSN2_HUMAN
Genbank Protein ID AAF59903.1; AAF59904.1; AAF63600.1; BAA86570.1; BAB13841.1; BAA91068.1; AAD00899.1; AAC50593.1
Protein Name Intersectin-2; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein
Genbank Nucleotide ID AF182198; AF182199; AF248540; AB033082; AC008073; AK000302; AF001630; U61167
Gene Name ITSN2; KIAA1256; SH3D1B; SWAP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198399.14 ENST00000355123.8 ENSP00000347244.4
ENSG00000198399.14 ENST00000427234.5 ENSP00000395682.1
ENSG00000198399.14 ENST00000449392.1 ENSP00000411319.1
ENSG00000198399.14 ENST00000406921.7 ENSP00000384499.3
ENSG00000198399.14 ENST00000416160.1 ENSP00000389013.1
ENSG00000198399.14 ENST00000412011.5 ENSP00000391224.1
ENSG00000198399.14 ENST00000622089.4 ENSP00000479408.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.70e-60 202.5 1131 1183
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v+++ydy a+n+deL++ kG  + v+  ++ d +W++g  e +g  GlfP+n+v+ 
   Q: 1131 QVIAMYDYAANNEDELSFSKGQLINVM--NKDDPDWWQG--EINGVTGLFPSNYVKM 1183
           6899**********************9..8899******..9*************85 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
 Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Protein Sequence
(Fasta)
MMAQFPTAMN GGPNMWAITS EERTKHDRQF DNLKPSGGYI TGDQARNFFL QSGLPAPVLA 60
EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP PIMKQPPMFS PLISARFGMG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046833|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCTTCGGACC CGACCGACTC GGAGCAGACC TTCAGGGTTC AATGCCCCGG AACTCCTGGG 60
GCGAGGAGCC ACGCCCGGGC AGTTTCGGGC TCCGGAGGGT GGGGAGTCGG TGCCCGGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046833|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0254--Endocytosis
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR000008--C2_dom
IPR000219--DH-domain
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR027029--Intersectin-2
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50004--C2
PS50010--DH_2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF00168--C2
PF12763--EF-hand_4
PF16652--PH_13
PF00621--RhoGEF
PF00018--SH3_1
PF07653--SH3_2
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00239--C2
SM00054--EFh
SM00027--EH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005509--F:calcium ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0005070--F:SH3/SH2 adaptor activity
GO:0006897--P:endocytosis
GO:1903861--P:positive regulation of dendrite extension
GO:0035023--P:regulation of Rho protein signal transduction
KEGG hsa:50618
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001455 Ailuropoda melanoleuca 94.13 0.00e+00 2174.00
IUUC-Apl-004205 Anas platyrhynchos 79.76 0.00e+00 2483.00
IUUC-Aca-004287 Anolis carolinensis 80.16 0.00e+00 1675.00
IUUC-Ani-009428 Aspergillus nidulans 43.66 8.00e-11 63.50
IUUC-Ame-011759 Astyanax mexicanus 65.39 0.00e+00 1266.00
IUUC-Bta-013248 Bos taurus 91.76 0.00e+00 2081.00
IUUC-Cel-018490 Caenorhabditis elegans 33.26 3.00e-53 204.00
IUUC-Cfa-020628 Canis familiaris 94.54 0.00e+00 2189.00
IUUC-Cpo-022427 Cavia porcellus 81.20 0.00e+00 2627.00
IUUC-Csa-023122 Chlorocebus sabaeus 95.60 0.00e+00 2236.00
IUUC-Cgl-026697 Colletotrichum gloeosporioides 28.46 3.00e-08 54.70
IUUC-Cne-026918 Cryptococcus neoformans 35.53 3.00e-38 155.00
IUUC-Dre-027849 Danio rerio 65.18 0.00e+00 1218.00
IUUC-Dno-029419 Dasypus novemcinctus 93.80 0.00e+00 2174.00
IUUC-Dor-030504 Dipodomys ordii 78.57 0.00e+00 1753.00
IUUC-Dme-032099 Drosophila melanogaster 33.19 1.00e-57 219.00
IUUC-Eca-034196 Equus caballus 92.25 0.00e+00 2075.00
IUUC-Eeu-034972 Erinaceus europaeus 68.87 0.00e+00 641.00
IUUC-Fca-035757 Felis catus 93.88 0.00e+00 2187.00
IUUC-Fal-037531 Ficedula albicollis 87.06 0.00e+00 1766.00
IUUC-Gga-041012 Gallus gallus 79.69 0.00e+00 1925.00
IUUC-Ggo-045405 Gorilla gorilla 94.86 0.00e+00 2809.00
IUUC-Lch-050094 Latimeria chalumnae 74.72 0.00e+00 1699.00
IUUC-Loc-052646 Lepisosteus oculatus 71.65 0.00e+00 1462.00
IUUC-Laf-053798 Loxodonta africana 87.51 0.00e+00 1439.00
IUUC-Mcc-054709 Macaca mulatta 99.02 0.00e+00 2257.00
IUUC-Meu-056396 Macropus eugenii 80.26 0.00e+00 1548.00
IUUC-Mga-059997 Meleagris gallopavo 84.18 0.00e+00 2057.00
IUUC-Mvi-060268 Microbotryum violaceum 30.33 5.00e-46 181.00
IUUC-Mmr-060891 Microcebus murinus 93.47 0.00e+00 2226.00
IUUC-Mmu-064226 Mus musculus 87.59 0.00e+00 2154.00
IUUC-Mpu-066431 Mustela putorius furo 91.44 0.00e+00 2157.00
IUUC-Mlu-068190 Myotis lucifugus 94.05 0.00e+00 2174.00
IUUC-Nle-070116 Nomascus leucogenys 96.76 0.00e+00 1814.00
IUUC-Opr-070815 Ochotona princeps 79.63 0.00e+00 1786.00
IUUC-Ont-072464 Oreochromis niloticus 65.44 0.00e+00 1252.00
IUUC-Ola-086482 Oryzias latipes 61.33 0.00e+00 1238.00
IUUC-Oga-088449 Otolemur garnettii 93.47 0.00e+00 2135.00
IUUC-Oar-090275 Ovis aries 92.33 0.00e+00 2123.00
IUUC-Ptr-091667 Pan troglodytes 99.02 0.00e+00 2218.00
IUUC-Pan-091723 Papio anubis 92.56 0.00e+00 1908.00
IUUC-Psi-093136 Pelodiscus sinensis 82.75 0.00e+00 1971.00
IUUC-Pab-098755 Pongo abelii 96.90 0.00e+00 2155.00
IUUC-Pca-101134 Procavia capensis 86.35 0.00e+00 1506.00
IUUC-Pva-102433 Pteropus vampyrus 83.77 0.00e+00 1911.00
IUUC-Pgr-103473 Puccinia graminis 29.97 5.00e-38 154.00
IUUC-Ptt-103973 Puccinia triticina 25.26 5.00e-27 117.00
IUUC-Rno-105691 Rattus norvegicus 92.09 0.00e+00 2217.00
IUUC-Sar-112978 Sorex araneus 90.22 0.00e+00 1428.00
IUUC-Sre-115028 Sporisorium reilianum 36.71 2.00e-33 139.00
IUUC-Ssc-115562 Sus scrofa 86.78 0.00e+00 1947.00
IUUC-Tgu-116758 Taeniopygia guttata 83.56 0.00e+00 2034.00
IUUC-Tni-119752 Tetraodon nigroviridis 58.87 0.00e+00 1333.00
IUUC-Tbe-127477 Tupaia belangeri 92.50 0.00e+00 761.00
IUUC-Ttr-129196 Tursiops truncatus 91.78 0.00e+00 2084.00
Created Date 25-Jun-2017

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