iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054604

Ensembl Protein ID

ENSMMUP00000052515.1

UniProt Accession

F7EZL0; F7EZL0_MACMU

Genbank Protein ID

AFE64522.1; AFH27727.1; AFI35028.1

Protein Name

Mitochondrial ubiquitin ligase activator of NFKB 1

Genbank Nucleotide ID

JSUE03000576; JU470923; JV044957

Gene Name

MUL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000038859.1	ENSMMUT00000078123.1	ENSMMUP00000052515.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.72	0.00e+00	726.00	IUUC-Hsa-046597

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MENGGRPSLC QFILLGTTSV VTAALYSVYR QKARVSQELK GAKKVHLGED LKSILSEAPG 60
KCVPYAVIEG AVRSVKETLN SQFVENCKGV IQRLTLQEHK MVWNRTTHLW NDCSKIIHQR 120

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Nucleotide Sequence
(Fasta)

TCGTGCGTCA TCGTTGGGCG ACTGATTTCG AGTTTTCGGT CCGGTTTGTC TAGGGGGTGC 60
GGTCCTGGTC GGAAGGAGGT GGAGAGTAGG GGGCCACTAG GCGTATCCTC TGCGTCACAG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR022170--GIDE
IPR001841--Znf_RING

PROSITE

PS50089--ZF_RING_2

Pfam

PF12483--GIDE

Gene Ontology

GO:0030424--C:axon
GO:0031307--C:integral component of mitochondrial outer membrane
GO:0043025--C:neuronal cell body
GO:0005777--C:peroxisome
GO:0016874--F:ligase activity
GO:0004871--F:signal transducer activity
GO:0019789--F:SUMO transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257--P:activation of JUN kinase activity
GO:0071360--P:cellular response to exogenous dsRNA
GO:0000266--P:mitochondrial fission
GO:0051646--P:mitochondrion localization
GO:0030308--P:negative regulation of cell growth
GO:0071650--P:negative regulation of chemokine (C-C motif) ligand 5 production
GO:0050689--P:negative regulation of defense response to virus by host
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0060339--P:negative regulation of type I interferon-mediated signaling pathway
GO:1903861--P:positive regulation of dendrite extension
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0090141--P:positive regulation of mitochondrial fission
GO:1904925--P:positive regulation of mitophagy in response to mitochondrial depolarization
GO:0033235--P:positive regulation of protein sumoylation
GO:0031648--P:protein destabilization
GO:0050821--P:protein stabilization
GO:0051881--P:regulation of mitochondrial membrane potential
GO:1901028--P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

KEGG

mcc:705429

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000342	Aegilops tauschii	25.32	6.00e-13	69.70
IUUC-Aml-002287	Ailuropoda melanoleuca	92.61	0.00e+00	651.00
IUUC-Atr-002698	Amborella trichopoda	24.58	4.00e-09	55.50
IUUC-Aca-005039	Anolis carolinensis	37.79	1.00e-63	236.00
IUUC-Aly-006181	Arabidopsis lyrata	28.65	2.00e-22	99.80
IUUC-Ath-007438	Arabidopsis thaliana	28.94	2.00e-23	102.00
IUUC-Ame-010671	Astyanax mexicanus	62.22	4.00e-132	464.00
IUUC-Bta-012407	Bos taurus	80.45	4.00e-166	577.00
IUUC-Bdi-014735	Brachypodium distachyon	25.15	8.00e-18	84.30
IUUC-Bol-015493	Brassica oleracea	27.22	6.00e-24	104.00
IUUC-Bra-016933	Brassica rapa	26.95	3.00e-20	92.40
IUUC-Cja-019709	Callithrix jacchus	98.13	0.00e+00	655.00
IUUC-Cfa-020818	Canis familiaris	93.75	0.00e+00	665.00
IUUC-Cpo-022490	Cavia porcellus	93.18	0.00e+00	638.00
IUUC-Csa-023259	Chlorocebus sabaeus	99.72	0.00e+00	726.00
IUUC-Cho-024730	Choloepus hoffmanni	94.32	0.00e+00	687.00
IUUC-Cin-025301	Ciona intestinalis	30.82	2.00e-44	172.00
IUUC-Dre-028644	Danio rerio	62.50	7.00e-134	469.00
IUUC-Dno-028925	Dasypus novemcinctus	92.05	0.00e+00	681.00
IUUC-Dor-030692	Dipodomys ordii	92.05	0.00e+00	643.00
IUUC-Dme-031761	Drosophila melanogaster	30.72	3.00e-33	135.00
IUUC-Ete-032329	Echinops telfairi	82.10	2.00e-155	541.00
IUUC-Eca-034008	Equus caballus	89.77	0.00e+00	668.00
IUUC-Eeu-034895	Erinaceus europaeus	75.96	1.00e-121	429.00
IUUC-Fca-036104	Felis catus	93.47	0.00e+00	667.00
IUUC-Fal-036900	Ficedula albicollis	73.76	5.00e-140	490.00
IUUC-Gmo-039049	Gadus morhua	58.81	8.00e-107	380.00
IUUC-Gga-040254	Gallus gallus	71.88	5.00e-147	513.00
IUUC-Gac-042277	Gasterosteus aculeatus	59.94	1.00e-133	469.00
IUUC-Gma-043979	Glycine max	27.19	1.00e-20	94.00
IUUC-Ggo-045509	Gorilla gorilla	99.72	0.00e+00	726.00
IUUC-Hsa-046597	Homo sapiens	99.72	0.00e+00	726.00
IUUC-Hvu-047335	Hordeum vulgare	25.36	4.00e-18	84.70
IUUC-Itr-048691	Ictidomys tridecemlineatus	93.75	0.00e+00	654.00
IUUC-Lch-050344	Latimeria chalumnae	68.75	8.00e-147	513.00
IUUC-Lpe-051343	Leersia perrieri	28.19	3.00e-14	72.40
IUUC-Loc-052376	Lepisosteus oculatus	67.33	3.00e-150	524.00
IUUC-Laf-054414	Loxodonta africana	94.03	0.00e+00	689.00
IUUC-Meu-056087	Macropus eugenii	85.51	6.00e-174	603.00
IUUC-Mtr-057779	Medicago truncatula	27.35	4.00e-20	92.00
IUUC-Mga-060188	Meleagris gallopavo	73.08	2.00e-144	504.00
IUUC-Mmr-060704	Microcebus murinus	96.59	0.00e+00	705.00
IUUC-Mdo-062842	Monodelphis domestica	84.94	2.00e-166	578.00
IUUC-Mmu-064324	Mus musculus	89.49	1.00e-178	618.00
IUUC-Mpu-065940	Mustela putorius furo	89.77	1.00e-179	622.00
IUUC-Mlu-067028	Myotis lucifugus	93.18	0.00e+00	685.00
IUUC-Nle-069254	Nomascus leucogenys	91.81	0.00e+00	666.00
IUUC-Opr-070827	Ochotona princeps	87.78	0.00e+00	651.00
IUUC-Ont-072008	Oreochromis niloticus	61.93	3.00e-138	484.00
IUUC-Oan-072935	Ornithorhynchus anatinus	79.55	3.00e-168	584.00
IUUC-Ocu-074526	Oryctolagus cuniculus	92.33	0.00e+00	637.00
IUUC-Oba-075954	Oryza barthii	28.19	4.00e-14	72.00
IUUC-Obr-076592	Oryza brachyantha	27.25	4.00e-22	99.00
IUUC-Ogl-077732	Oryza glaberrima	27.62	6.00e-22	98.20
IUUC-Ogu-078565	Oryza glumaepatula	28.19	3.00e-14	72.40
IUUC-Oin-080188	Oryza indica	27.62	6.00e-22	98.20
IUUC-Olo-080705	Oryza longistaminata	25.31	6.00e-13	68.90
IUUC-Ome-081154	Oryza meridionalis	27.86	3.00e-14	72.80
IUUC-Oni-082201	Oryza nivara	28.19	4.00e-14	72.00
IUUC-Opu-083497	Oryza punctata	26.97	3.00e-14	72.80
IUUC-Oru-084332	Oryza rufipogon	28.19	4.00e-14	72.00
IUUC-Osa-086059	Oryza sativa	28.19	1.00e-14	73.20
IUUC-Ola-087288	Oryzias latipes	57.95	5.00e-126	444.00
IUUC-Oga-088402	Otolemur garnettii	94.32	0.00e+00	692.00
IUUC-Oar-089851	Ovis aries	91.36	4.00e-88	316.00
IUUC-Ptr-091226	Pan troglodytes	99.43	0.00e+00	725.00
IUUC-Pan-092575	Papio anubis	99.72	0.00e+00	727.00
IUUC-Psi-094062	Pelodiscus sinensis	76.99	4.00e-165	573.00
IUUC-Pma-094501	Petromyzon marinus	35.59	1.00e-44	174.00
IUUC-Ppa-095285	Physcomitrella patens	25.86	4.00e-16	79.00
IUUC-Pfo-096146	Poecilia formosa	56.53	4.00e-121	427.00
IUUC-Pab-098524	Pongo abelii	99.43	0.00e+00	725.00
IUUC-Pop-099864	Populus trichocarpa	27.48	3.00e-19	89.40
IUUC-Pca-100314	Procavia capensis	92.61	0.00e+00	681.00
IUUC-Ppe-101663	Prunus persica	25.45	3.00e-17	82.40
IUUC-Pva-102947	Pteropus vampyrus	92.33	0.00e+00	679.00
IUUC-Rno-105024	Rattus norvegicus	89.77	0.00e+00	629.00
IUUC-Sha-107500	Sarcophilus harrisii	69.85	3.00e-125	441.00
IUUC-Smo-109194	Selaginella moellendorffii	26.99	1.00e-19	90.50
IUUC-Sit-109922	Setaria italica	26.02	4.00e-21	95.50
IUUC-Sly-111826	Solanum lycopersicum	26.65	4.00e-20	92.40
IUUC-Stu-112907	Solanum tuberosum	26.27	3.00e-19	89.00
IUUC-Sar-113522	Sorex araneus	90.71	2.00e-168	584.00
IUUC-Sbi-114536	Sorghum bicolor	27.62	5.00e-23	101.00
IUUC-Ssc-115445	Sus scrofa	94.03	0.00e+00	645.00
IUUC-Tgu-116551	Taeniopygia guttata	72.73	6.00e-137	479.00
IUUC-Tru-118407	Takifugu rubripes	57.10	8.00e-116	410.00
IUUC-Tsy-118794	Tarsius syrichta	91.48	0.00e+00	669.00
IUUC-Tni-120128	Tetraodon nigroviridis	64.83	9.00e-94	336.00
IUUC-Tca-121508	Theobroma cacao	27.67	7.00e-22	97.80
IUUC-Tae-125185	Triticum aestivum	25.94	9.00e-22	97.80
IUUC-Tur-126470	Triticum urartu	25.65	1.00e-21	97.10
IUUC-Tbe-127432	Tupaia belangeri	95.45	0.00e+00	646.00
IUUC-Ttr-128573	Tursiops truncatus	90.06	0.00e+00	649.00
IUUC-Vpa-130583	Vicugna pacos	92.95	7.00e-177	612.00
IUUC-Vvi-131710	Vitis vinifera	26.57	3.00e-17	82.80
IUUC-Xtr-132009	Xenopus tropicalis	61.58	2.00e-135	475.00
IUUC-Xma-134121	Xiphophorus maculatus	57.51	3.00e-126	444.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence