iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118442

UUCD1 version

UUC-TaR-00613

Ensembl Protein ID

ENSTRUP00000029096.1

UniProt Accession

H2TWN7; H2TWN7_TAKRU

Protein Name

E3 ubiquitin-protein ligase

Gene Name

itchb; itch

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000011522.1	ENSTRUT00000029209.1	ENSTRUP00000029093.1
ENSTRUG00000011522.1	ENSTRUT00000029210.1	ENSTRUP00000029094.1
ENSTRUG00000011522.1	ENSTRUT00000029211.1	ENSTRUP00000029095.1
ENSTRUG00000011522.1	ENSTRUT00000029212.1	ENSTRUP00000029096.1
ENSTRUG00000011522.1	ENSTRUT00000029213.1	ENSTRUP00000029097.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.70e-136	455.2	547	879

Active Site

Position(s)	Description	Evidence
848	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 547  AQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFKFIGRFIAMALFHGKFIDT 634
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l l+dle++dpe+y+sl++ik+n   +iee++l++ fsv+++ilge++++eLkpgG +i+Vt+eNkeeY+klv+e
   Q: 635  GFSLPFYKRILNKPLALKDLESIDPEFYNSLMWIKDN---NIEECDLEMFFSVDKDILGEITTHELKPGGGDIQVTEENKEEYIKLVAE 720
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++eid+ d++++t y++ y ++s++i wFw++++e+++e+r ++LqFv
   Q: 721  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLTDWQRNTIYRH-YARNSKQIMWFWQFIKEMDNEKRMRLLQFV 808
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +g++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekL++Aieet+gF++
   Q: 809  SGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLMFAIEETEGFGQ 879
           *********************************************************************96 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

LLVSVISAKL KENKKNWFGP SPYVEVIVDG QSKKTEKCNN THSPKWKQPL TVIVTPFSKL 60
VFRVWSHQTL KSDVLLGMAT LDVSDTLKSN DMKISEVVQT LQLRDQTDAV GDLSVCLDGM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAGTG GAGTCACCCA AGCAAGCACT TCCAATGGTC ACCCTATGAA GGCACAGCTA 60
CAAATTATTG GTATGTTTTA GAATTCATGG TAACACAACA CAGTAACACA TTGTAAGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0048920--P:posterior lateral line neuromast primordium migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	71.44	0.00e+00	1293.00
IUUC-Apl-003752	Anas platyrhynchos	88.39	0.00e+00	1121.00
IUUC-Aca-005338	Anolis carolinensis	70.55	0.00e+00	1290.00
IUUC-Ame-010601	Astyanax mexicanus	90.83	0.00e+00	1136.00
IUUC-Bgr-012148	Blumeria graminis	46.92	2.00e-151	530.00
IUUC-Bta-012782	Bos taurus	89.01	0.00e+00	1115.00
IUUC-Cja-018899	Callithrix jacchus	88.75	0.00e+00	1117.00
IUUC-Cfa-020648	Canis familiaris	70.42	0.00e+00	1258.00
IUUC-Cpo-022073	Cavia porcellus	89.10	0.00e+00	1125.00
IUUC-Csa-023252	Chlorocebus sabaeus	71.56	0.00e+00	1283.00
IUUC-Cho-024695	Choloepus hoffmanni	70.03	0.00e+00	1239.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.51	5.00e-155	541.00
IUUC-Cne-026849	Cryptococcus neoformans	48.12	2.00e-160	559.00
IUUC-Dre-028451	Danio rerio	77.77	0.00e+00	1378.00
IUUC-Dno-029884	Dasypus novemcinctus	71.75	0.00e+00	1293.00
IUUC-Dse-031241	Dothistroma septosporum	47.63	3.00e-155	542.00
IUUC-Eca-033793	Equus caballus	88.83	0.00e+00	1116.00
IUUC-Fca-035605	Felis catus	73.11	0.00e+00	1310.00
IUUC-Fal-037126	Ficedula albicollis	88.91	0.00e+00	1124.00
IUUC-Gga-040832	Gallus gallus	88.91	0.00e+00	1123.00
IUUC-Gac-041658	Gasterosteus aculeatus	89.50	0.00e+00	1195.00
IUUC-Ggo-044535	Gorilla gorilla	70.62	0.00e+00	1269.00
IUUC-Hsa-046564	Homo sapiens	89.27	0.00e+00	1130.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	88.24	0.00e+00	1115.00
IUUC-Kpa-049273	Komagataella pastoris	48.54	4.00e-161	561.00
IUUC-Lch-050454	Latimeria chalumnae	89.08	0.00e+00	1118.00
IUUC-Loc-052647	Lepisosteus oculatus	74.81	0.00e+00	1388.00
IUUC-Laf-054383	Loxodonta africana	88.75	0.00e+00	1122.00
IUUC-Mcc-055532	Macaca mulatta	71.67	0.00e+00	1285.00
IUUC-Mla-058996	Melampsora laricipopulina	45.31	8.00e-152	531.00
IUUC-Mga-059661	Meleagris gallopavo	88.91	0.00e+00	1122.00
IUUC-Mmr-061135	Microcebus murinus	89.10	0.00e+00	1127.00
IUUC-Mdo-062505	Monodelphis domestica	89.27	0.00e+00	1126.00
IUUC-Mmu-063375	Mus musculus	88.93	0.00e+00	1124.00
IUUC-Mpu-066203	Mustela putorius furo	71.56	0.00e+00	1290.00
IUUC-Mlu-067837	Myotis lucifugus	71.33	0.00e+00	1294.00
IUUC-Nle-069244	Nomascus leucogenys	88.06	0.00e+00	1112.00
IUUC-Opr-070585	Ochotona princeps	88.41	0.00e+00	1112.00
IUUC-Ont-071822	Oreochromis niloticus	77.19	0.00e+00	1415.00
IUUC-Ocu-074298	Oryctolagus cuniculus	89.10	0.00e+00	1126.00
IUUC-Ola-086526	Oryzias latipes	77.69	0.00e+00	1394.00
IUUC-Oga-088167	Otolemur garnettii	67.12	0.00e+00	1199.00
IUUC-Ptr-090819	Pan troglodytes	87.89	0.00e+00	1089.00
IUUC-Pan-092454	Papio anubis	71.67	0.00e+00	1285.00
IUUC-Psi-093319	Pelodiscus sinensis	71.95	0.00e+00	1266.00
IUUC-Pfo-096937	Poecilia formosa	92.55	0.00e+00	1149.00
IUUC-Pab-097580	Pongo abelii	80.38	0.00e+00	989.00
IUUC-Pca-100923	Procavia capensis	73.43	0.00e+00	984.00
IUUC-Pva-103209	Pteropus vampyrus	71.33	0.00e+00	1246.00
IUUC-Pte-104016	Pyrenophora teres	47.43	7.00e-155	541.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	47.43	7.00e-155	541.00
IUUC-Rno-104924	Rattus norvegicus	88.93	0.00e+00	1124.00
IUUC-Sce-106289	Saccharomyces cerevisiae	47.86	6.00e-160	558.00
IUUC-Sha-107175	Sarcophilus harrisii	88.58	0.00e+00	1123.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	49.21	1.00e-160	560.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.35	3.00e-163	568.00
IUUC-Sar-113761	Sorex araneus	88.66	0.00e+00	1109.00
IUUC-Sre-114929	Sporisorium reilianum	47.21	4.00e-157	548.00
IUUC-Tgu-116632	Taeniopygia guttata	84.06	0.00e+00	1036.00
IUUC-Tsy-119198	Tarsius syrichta	65.88	0.00e+00	1157.00
IUUC-Tre-122203	Trichoderma reesei	46.53	7.00e-153	534.00
IUUC-Vda-129753	Verticillium dahliae	46.59	1.00e-152	533.00
IUUC-Vpa-130103	Vicugna pacos	76.39	0.00e+00	935.00
IUUC-Xtr-132885	Xenopus tropicalis	89.43	0.00e+00	1130.00
IUUC-Xma-133987	Xiphophorus maculatus	92.39	0.00e+00	1149.00
IUUC-Yli-134668	Yarrowia lipolytica	46.66	1.00e-156	547.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence