iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00008419	D2030.9a.1	D2030.9a.1
WBGene00008419	D2030.9b.1	D2030.9b.1
WBGene00008419	D2030.9c	D2030.9c

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	19273594

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.00e-26	92.2	310	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf....sdtllvsGsdDgtikvWDl 30
           H+d+v++++f    s +l+ s++dDg +kvWD 
   Q: 310  HEDDVNSVCFadlgS-NLIYSAGDDGLVKVWDK 341
           ***********9643.9***************6 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Involved in regulation of lifespan (PubMed:17411345). Required for dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876).

Protein Sequence
(Fasta)

MGNWITSTFL RFDLFQRHQP NRFLEYTRVQ HSNQSPAYSV RTAAEIVAHQ RMKPNHSNDS 60
DTDFSSDDEG CPKMTPHEEQ QMFEREQHIA FSGRCHIGDP ESCTQLRNEI NSRCGPRPST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCTTCGCCC TATGCTCGAA TGGGCAACTG GATAACGTCG ACGTTCCTCC GATTTGATCT 60
TTTTCAACGT CATCAGCCCA ACCGATTTCT CGAATATACA AGAGGTAAGC GAGAAGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017399--DCAF11/LEC14B
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0055120--C:striated muscle dense body
GO:0008021--C:synaptic vesicle
GO:0008134--F:transcription factor binding
GO:0008340--P:determination of adult lifespan
GO:1905803--P:negative regulation of cellular response to manganese ion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0040018--P:positive regulation of multicellular organism growth
GO:1901216--P:positive regulation of neuron death
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0080135--P:regulation of cellular response to stress

KEGG

cel:CELE_D2030.9

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000659	Aegilops tauschii	43.33	6.00e-51	193.00
IUUC-Aml-001732	Ailuropoda melanoleuca	39.90	4.00e-87	314.00
IUUC-Atr-002856	Amborella trichopoda	34.25	8.00e-53	199.00
IUUC-Aca-005081	Anolis carolinensis	42.82	9.00e-88	316.00
IUUC-Aly-006571	Arabidopsis lyrata	39.12	2.00e-64	238.00
IUUC-Ath-007313	Arabidopsis thaliana	38.86	7.00e-65	239.00
IUUC-Acl-008126	Aspergillus clavatus	33.07	1.00e-50	193.00
IUUC-Afl-008513	Aspergillus flavus	34.41	6.00e-56	211.00
IUUC-Afu-008765	Aspergillus fumigatus	33.86	8.00e-52	197.00
IUUC-Ani-009456	Aspergillus nidulans	34.28	1.00e-59	223.00
IUUC-Ang-009781	Aspergillus niger	30.22	1.00e-46	179.00
IUUC-Aor-010093	Aspergillus oryzae	34.41	6.00e-56	211.00
IUUC-Ate-010456	Aspergillus terreus	33.86	8.00e-52	197.00
IUUC-Ame-011825	Astyanax mexicanus	40.10	6.00e-80	290.00
IUUC-Bgr-012310	Blumeria graminis	31.45	1.00e-47	182.00
IUUC-Bta-013043	Bos taurus	40.75	4.00e-87	314.00
IUUC-Bci-013758	Botrytis cinerea	31.70	1.00e-48	186.00
IUUC-Bdi-014379	Brachypodium distachyon	35.25	3.00e-60	224.00
IUUC-Bol-016065	Brassica oleracea	39.12	2.00e-65	241.00
IUUC-Bra-017541	Brassica rapa	39.12	3.00e-65	241.00
IUUC-Cja-018940	Callithrix jacchus	39.14	2.00e-86	311.00
IUUC-Cfa-020064	Canis familiaris	39.90	7.00e-87	313.00
IUUC-Cpo-022220	Cavia porcellus	42.05	6.00e-86	310.00
IUUC-Cre-022728	Chlamydomonas reinhardtii	42.62	3.00e-48	183.00
IUUC-Csa-023158	Chlorocebus sabaeus	42.59	1.00e-86	312.00
IUUC-Cho-024797	Choloepus hoffmanni	57.43	5.00e-30	124.00
IUUC-Cgl-026444	Colletotrichum gloeosporioides	34.22	8.00e-52	197.00
IUUC-Cne-026917	Cryptococcus neoformans	28.81	3.00e-34	139.00
IUUC-Cme-027273	Cyanidioschyzon merolae	30.99	2.00e-43	169.00
IUUC-Dre-028711	Danio rerio	43.16	7.00e-86	310.00
IUUC-Dno-029851	Dasypus novemcinctus	42.32	5.00e-86	310.00
IUUC-Dor-030952	Dipodomys ordii	42.05	2.00e-82	298.00
IUUC-Dse-031288	Dothistroma septosporum	30.79	5.00e-50	191.00
IUUC-Dme-031925	Drosophila melanogaster	37.38	3.00e-70	257.00
IUUC-Ete-032983	Echinops telfairi	38.19	8.00e-83	299.00
IUUC-Eca-033499	Equus caballus	40.50	6.00e-87	313.00
IUUC-Eeu-035179	Erinaceus europaeus	42.14	7.00e-70	256.00
IUUC-Fca-035615	Felis catus	41.86	9.00e-87	312.00
IUUC-Fox-037867	Fusarium oxysporum	31.56	1.00e-44	172.00
IUUC-Fso-038274	Fusarium solani	31.35	1.00e-45	176.00
IUUC-Gmo-038731	Gadus morhua	43.42	1.00e-86	312.00
IUUC-Ggr-039861	Gaeumannomyces graminis	32.14	1.00e-47	182.00
IUUC-Gac-041615	Gasterosteus aculeatus	43.42	3.00e-87	314.00
IUUC-Gma-043167	Glycine max	38.93	5.00e-66	243.00
IUUC-Hsa-046061	Homo sapiens	42.59	6.00e-87	313.00
IUUC-Hvu-047177	Hordeum vulgare	47.76	2.00e-47	180.00
IUUC-Itr-048985	Ictidomys tridecemlineatus	39.41	6.00e-88	317.00
IUUC-Lch-050257	Latimeria chalumnae	32.54	5.00e-49	187.00
IUUC-Lpe-051521	Leersia perrieri	35.64	3.00e-60	224.00
IUUC-Lma-053067	Leptosphaeria maculans	34.69	3.00e-42	165.00
IUUC-Laf-054259	Loxodonta africana	42.59	1.00e-86	312.00
IUUC-Mcc-054958	Macaca mulatta	39.14	7.00e-87	313.00
IUUC-Meu-056889	Macropus eugenii	38.90	2.00e-86	311.00
IUUC-Mor-057196	Magnaporthe oryzae	32.90	2.00e-50	192.00
IUUC-Mpo-057340	Magnaporthe poae	32.49	3.00e-47	182.00
IUUC-Mtr-058464	Medicago truncatula	39.89	8.00e-65	239.00
IUUC-Mla-058873	Melampsora laricipopulina	30.19	1.00e-38	153.00
IUUC-Mvi-060439	Microbotryum violaceum	29.52	5.00e-45	174.00
IUUC-Mmr-061329	Microcebus murinus	41.89	2.00e-83	301.00
IUUC-Mdo-062123	Monodelphis domestica	38.90	3.00e-87	314.00
IUUC-Mmu-063616	Mus musculus	42.59	8.00e-87	313.00
IUUC-Mac-064473	Musa acuminata	37.03	2.00e-61	228.00
IUUC-Mpu-066351	Mustela putorius furo	41.28	7.00e-72	263.00
IUUC-Mlu-067043	Myotis lucifugus	42.59	7.00e-87	313.00
IUUC-Nfi-068552	Neosartorya fischeri	33.60	7.00e-52	197.00
IUUC-Ncr-068715	Neurospora crassa	34.15	9.00e-50	190.00
IUUC-Nle-070052	Nomascus leucogenys	39.95	9.00e-87	312.00
IUUC-Opr-070605	Ochotona princeps	42.86	2.00e-86	311.00
IUUC-Ont-072411	Oreochromis niloticus	43.95	2.00e-82	298.00
IUUC-Ocu-074078	Oryctolagus cuniculus	39.14	3.00e-87	314.00
IUUC-Oba-075609	Oryza barthii	34.67	3.00e-60	224.00
IUUC-Obr-076556	Oryza brachyantha	33.81	2.00e-60	225.00
IUUC-Ogl-077227	Oryza glaberrima	36.17	2.00e-60	224.00
IUUC-Ogu-078264	Oryza glumaepatula	36.27	3.00e-59	221.00
IUUC-Oin-079655	Oryza indica	36.17	1.00e-60	226.00
IUUC-Olo-080362	Oryza longistaminata	34.40	3.00e-51	194.00
IUUC-Ome-081712	Oryza meridionalis	36.63	2.00e-60	225.00
IUUC-Oni-083108	Oryza nivara	36.17	1.00e-60	226.00
IUUC-Opu-084070	Oryza punctata	36.27	1.00e-61	229.00
IUUC-Oru-085194	Oryza rufipogon	36.17	1.00e-60	226.00
IUUC-Osa-086287	Oryza sativa	34.43	4.00e-59	220.00
IUUC-Ola-086329	Oryzias latipes	44.36	7.00e-87	313.00
IUUC-Oga-088779	Otolemur garnettii	42.86	5.00e-87	313.00
IUUC-Oar-089262	Ovis aries	40.75	3.00e-87	314.00
IUUC-Ptr-091346	Pan troglodytes	42.59	6.00e-87	313.00
IUUC-Pan-092716	Papio anubis	39.14	8.00e-87	313.00
IUUC-Pma-094148	Petromyzon marinus	51.76	4.00e-75	273.00
IUUC-Pno-095116	Phaeosphaeria nodorum	31.96	3.00e-40	158.00
IUUC-Ppa-095260	Physcomitrella patens	35.48	4.00e-63	234.00
IUUC-Pfo-096424	Poecilia formosa	42.82	1.00e-86	312.00
IUUC-Pab-098091	Pongo abelii	40.97	4.00e-82	297.00
IUUC-Pop-099597	Populus trichocarpa	37.68	4.00e-65	241.00
IUUC-Pca-100153	Procavia capensis	42.05	3.00e-85	307.00
IUUC-Ppe-102075	Prunus persica	37.66	4.00e-62	230.00
IUUC-Pva-102598	Pteropus vampyrus	39.43	2.00e-86	311.00
IUUC-Pgr-103327	Puccinia graminis	29.95	8.00e-40	157.00
IUUC-Ptt-103861	Puccinia triticina	28.71	2.00e-14	72.00
IUUC-Pte-104286	Pyrenophora teres	32.82	6.00e-50	191.00
IUUC-Pyt-104745	Pyrenophora triticirepentis	34.01	3.00e-44	171.00
IUUC-Rno-104890	Rattus norvegicus	42.59	4.00e-87	314.00
IUUC-Sha-106540	Sarcophilus harrisii	38.95	1.00e-84	306.00
IUUC-Ssl-108528	Sclerotinia sclerotiorum	28.71	2.00e-36	146.00
IUUC-Smo-109115	Selaginella moellendorffii	34.31	3.00e-58	217.00
IUUC-Sit-109840	Setaria italica	32.51	6.00e-62	230.00
IUUC-Sly-110856	Solanum lycopersicum	39.06	7.00e-67	246.00
IUUC-Stu-112589	Solanum tuberosum	37.57	8.00e-58	216.00
IUUC-Sar-113742	Sorex araneus	39.82	6.00e-87	313.00
IUUC-Sbi-114505	Sorghum bicolor	40.32	3.00e-53	200.00
IUUC-Sre-115073	Sporisorium reilianum	28.64	8.00e-37	147.00
IUUC-Ssc-116019	Sus scrofa	39.67	5.00e-87	313.00
IUUC-Tru-118536	Takifugu rubripes	40.33	4.00e-86	310.00
IUUC-Tsy-119518	Tarsius syrichta	40.10	1.00e-86	311.00
IUUC-Tni-120264	Tetraodon nigroviridis	40.33	6.00e-86	310.00
IUUC-Tca-121554	Theobroma cacao	39.06	1.00e-64	239.00
IUUC-Tre-122144	Trichoderma reesei	32.45	3.00e-43	167.00
IUUC-Tvi-122472	Trichoderma virens	30.79	3.00e-46	178.00
IUUC-Tae-123212	Triticum aestivum	34.88	2.00e-60	224.00
IUUC-Tur-126484	Triticum urartu	47.37	3.00e-53	201.00
IUUC-Tme-127050	Tuber melanosporum	34.20	1.00e-50	192.00
IUUC-Tbe-127495	Tupaia belangeri	37.72	5.00e-87	313.00
IUUC-Ttr-128553	Tursiops truncatus	40.50	5.00e-87	313.00
IUUC-Uma-129557	Ustilago maydis	29.72	2.00e-36	146.00
IUUC-Vda-129951	Verticillium dahliae	33.25	2.00e-54	205.00
IUUC-Vpa-130542	Vicugna pacos	51.09	2.00e-39	155.00
IUUC-Vvi-131266	Vitis vinifera	36.19	4.00e-63	234.00
IUUC-Xtr-132525	Xenopus tropicalis	42.56	8.00e-86	309.00
IUUC-Xma-133165	Xiphophorus maculatus	42.63	1.00e-86	312.00
IUUC-Yli-134635	Yarrowia lipolytica	23.96	5.00e-17	82.00
IUUC-Zma-135833	Zea mays	36.49	1.00e-58	219.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence