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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063163
Ensembl Protein ID ENSMUSP00000123588.1
UniProt Accession A2AHJ4; Q3TQR7; Q3UTB6; Q640P3; Q8C7D5; BRWD3_MOUSE
Genbank Protein ID BAC34314.1; BAE24064.1; BAE37315.1; CAM25065.1; CAM25065.1; CAM26827.1; CAM26827.1; CAM26828.1; AAH82562.1
Protein Name Bromodomain and WD repeat-containing protein 3
Genbank Nucleotide ID AK050539; AK139563; AK163354; BX000698; AL731764; AL731764; BX000698; AL731764; BC082562
Gene Name Brwd3; Gm596
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000063663.11 ENSMUST00000150434.7 ENSMUSP00000123588.1
ENSMUSG00000063663.11 ENSMUST00000041866.11 ENSMUSP00000134621.1
ENSMUSG00000063663.11 ENSMUST00000101283.3 ENSMUSP00000098841.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-31 108.0 178 215
UBD/Beta-Prp 4.50e-52 178.2 280 539
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+af  s++++ +GsdD+ +k+W +++g+ll
   Q: 178  GHLSSVYCVAFdrSGRRIFTGSDDCLVKIWATDDGRLL 215
           8**********96669******************9987 PP
   

   UBD/Beta-Prp
   S: 22   ksllatgsrdgtikvwdvttgkl........lrslsgheae..vtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvl 98
           +++l+++++dgti  w+++ +++        + + s    +  +++ +fs+ g ++ tgs+D++i+++    + ++ +  l+ h+d+v+
   Q: 280  TRYLTSTGADGTICFWQWHVKTMkfrdrpvkFTERSRP--GvqISCSSFSSGGMFITTGSTDHVIRIYylGSEIPEKIAELESHTDKVV 366
           589*************9998777667776433333333..35599***********************7777899************** PP
   S: 99   slsfspsg..dklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktg 169
           +++f+ +g   ++vsGs+d t+r+w+ +++++ +                  +++++  v++v+++  +  ++++ ++  +++W++ tg
   Q: 367  AVQFCNNGdsLRFVSGSRDGTARIWQYQQQEWKSIvldmatkmsgnnltsaEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSVTG 455
           ******8832468*******************999************999989999999****************************** PP
   S: 170  kllrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiri 248
           +ll+tl+g h+d v  l+   fd+  + ++s+++dg + +wdl +g+ +r + +         v + +fsp++++++++ s+g + +
   Q: 456  QLLHTLSG-HDDEVFVLEahpFDQ--RIILSAGHDGNIFIWDLDRGTKIRNYFNMIegqghGAVFDCKFSPDGNHFACTDSHGHLLL 539
           *******9.*********555555..99********************98887755455567788899999***9999999988766 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).
 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).
Protein Sequence
(Fasta)
MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG KEHRRSFEDL 60
VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV GRQSLLRDAK DCKSTLWNGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063163|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCAGCTCCTC CCTCTCCTTC TCTCTTGCTC TCCTTCCTCC TCCGCCTCCT CAGCTCTTGG 60
GCTAGAATAT CTATGGGTCG AAACGTGATG CGATGAATCC GAGAGAGACC GAAACTGGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063163|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR001487--Bromodomain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00439--Bromodomain
PF00400--WD40
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00320--WD40
Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
KEGG mmu:382236
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001881 Ailuropoda melanoleuca 94.78 0.00e+00 3079.00
IUUC-Apl-004016 Anas platyrhynchos 79.74 0.00e+00 2251.00
IUUC-Aca-004722 Anolis carolinensis 78.48 0.00e+00 2197.00
IUUC-Ame-010602 Astyanax mexicanus 76.92 0.00e+00 1147.00
IUUC-Bta-013198 Bos taurus 93.43 0.00e+00 2804.00
IUUC-Cfa-020963 Canis familiaris 94.56 0.00e+00 3067.00
IUUC-Cpo-022448 Cavia porcellus 87.85 0.00e+00 2774.00
IUUC-Csa-023166 Chlorocebus sabaeus 94.52 0.00e+00 2919.00
IUUC-Cin-025553 Ciona intestinalis 39.34 6.00e-112 398.00
IUUC-Csv-025813 Ciona savignyi 43.69 0.00e+00 649.00
IUUC-Dre-028508 Danio rerio 66.20 0.00e+00 1887.00
IUUC-Dno-030070 Dasypus novemcinctus 91.51 0.00e+00 2952.00
IUUC-Dor-031052 Dipodomys ordii 88.90 0.00e+00 1169.00
IUUC-Ete-032650 Echinops telfairi 84.81 0.00e+00 1808.00
IUUC-Eca-033953 Equus caballus 94.54 0.00e+00 2743.00
IUUC-Eeu-034871 Erinaceus europaeus 82.23 0.00e+00 1340.00
IUUC-Fca-036099 Felis catus 94.45 0.00e+00 3066.00
IUUC-Fal-037246 Ficedula albicollis 81.96 0.00e+00 2414.00
IUUC-Gga-041097 Gallus gallus 82.84 0.00e+00 2518.00
IUUC-Gac-042435 Gasterosteus aculeatus 65.29 0.00e+00 1845.00
IUUC-Hsa-045666 Homo sapiens 94.46 0.00e+00 2921.00
IUUC-Loc-051802 Lepisosteus oculatus 69.90 0.00e+00 2081.00
IUUC-Laf-053942 Loxodonta africana 94.39 0.00e+00 2958.00
IUUC-Mcc-054645 Macaca mulatta 94.64 0.00e+00 2924.00
IUUC-Meu-056321 Macropus eugenii 76.10 0.00e+00 1110.00
IUUC-Mga-060063 Meleagris gallopavo 82.76 0.00e+00 2472.00
IUUC-Mmr-061262 Microcebus murinus 94.39 0.00e+00 2924.00
IUUC-Mdo-062320 Monodelphis domestica 74.41 0.00e+00 2264.00
IUUC-Mpu-066628 Mustela putorius furo 94.33 0.00e+00 3091.00
IUUC-Mlu-068082 Myotis lucifugus 94.40 0.00e+00 2880.00
IUUC-Nle-069609 Nomascus leucogenys 94.52 0.00e+00 2928.00
IUUC-Ont-071589 Oreochromis niloticus 66.44 0.00e+00 1819.00
IUUC-Ocu-074122 Oryctolagus cuniculus 92.53 0.00e+00 2069.00
IUUC-Oni-082991 Oryza nivara 28.17 3.00e-43 171.00
IUUC-Ola-086580 Oryzias latipes 66.16 0.00e+00 1883.00
IUUC-Oga-089053 Otolemur garnettii 93.89 0.00e+00 3053.00
IUUC-Oar-090042 Ovis aries 94.17 0.00e+00 3082.00
IUUC-Ptr-091268 Pan troglodytes 93.55 0.00e+00 2870.00
IUUC-Pan-092376 Papio anubis 94.58 0.00e+00 2922.00
IUUC-Psi-093408 Pelodiscus sinensis 81.37 0.00e+00 2509.00
IUUC-Pfo-096515 Poecilia formosa 66.25 0.00e+00 1778.00
IUUC-Pab-097672 Pongo abelii 92.47 0.00e+00 2904.00
IUUC-Pva-102512 Pteropus vampyrus 96.50 0.00e+00 2323.00
IUUC-Rno-105797 Rattus norvegicus 97.71 0.00e+00 3001.00
IUUC-Sha-107061 Sarcophilus harrisii 76.04 0.00e+00 2263.00
IUUC-Sit-110017 Setaria italica 28.85 1.00e-56 215.00
IUUC-Sar-113004 Sorex araneus 82.43 0.00e+00 1592.00
IUUC-Tgu-117254 Taeniopygia guttata 82.25 0.00e+00 2420.00
IUUC-Tru-118186 Takifugu rubripes 66.05 0.00e+00 1835.00
IUUC-Tsy-119003 Tarsius syrichta 88.17 0.00e+00 2689.00
IUUC-Tni-120110 Tetraodon nigroviridis 65.84 0.00e+00 1807.00
IUUC-Tbe-127813 Tupaia belangeri 74.86 0.00e+00 879.00
IUUC-Ttr-129265 Tursiops truncatus 90.84 0.00e+00 2787.00
Created Date 25-Jun-2017

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